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A peer-reviewed study reports that tau, a protein that forms clumps in neurodegenerative diseases called tauopathies, builds its clumps through one dominant contact point. The study reports that blocking this point disrupted clumping and led to shorter fibrils.
A preprint, not yet reviewed by other scientists, reports experiments in mice in which removing the interferon-gamma receptor from one type of neuron, called somatostatin interneurons, increased anxiety-like behavior. The authors also report that inflammation lowered several molecular markers in control mice, and that this drop was not significant in mice without the receptor.
A preprint, not yet reviewed by other scientists, uses the short-lived killifish to study how lifelong mating affects organ aging. The authors report that mating dampened inflammation and reduced lipid buildup in old female livers, and that it was associated with better resilience to the liver toxin acetaminophen.
A preprint, not yet reviewed by other scientists, is a retrospective cohort study of 4,269 adults in a telemedicine obesity program. Over 12 months, people who received individualized nutritional therapy alongside incretin-based obesity medications lost more weight than those on medication alone. As an observational comparison, it shows an association, not proof that the therapy caused the difference.
A preprint, not yet reviewed by other scientists, tested the Xpert MTB/RIF Ultra test for Mycobacterium tuberculosis in sputum samples with added bacteria. Leaving samples in reagent beyond the manufacturer's recommended 4-hour limit, or at higher temperatures, produced false rifampin resistance results at low bacterial levels. The authors note that freezing samples may reduce this risk, but it is not yet an approved procedure.
A preprint, not yet reviewed by other scientists, analyzes public tumor gene data across cancer types. It reports that tumors raised both reactive oxygen species (ROS) generation and antioxidant defense compared with normal tissue, and that the antioxidant arm was linked to adverse outcome while generation was not. The authors say the link between the balance score and immune infiltration comes from how that score is defined.
A preprint, not yet reviewed by other scientists, describes a 65-million-parameter clinical foundation model trained on electronic health records from 3.77 million patients at a single hospital. For five-year chronic kidney disease, fatty liver and diabetes risk, predictors built on patient representations outperformed estimates from generated clinical event sequences. The generated approach did better at predicting same-day diagnoses, prescriptions and procedures.
A CDC report estimates five cardiovascular health measures among U.S. high school students: diet, physical activity, nicotine exposure, sleep health and body mass index (BMI). The estimates come from the Youth Risk Behavior Survey for 2025.
A peer-reviewed study reports that shading increased selenium (Se) accumulation in tea leaves when selenium supply was sufficient, based on field experiments. The authors link this to a gene pathway that converts selenium forms, and note that limited selenium in crops contributes to widespread dietary Se deficiency.
A preprint, not yet reviewed by other scientists, studies locus coeruleus neurons in young 3xTg mice, a model of Alzheimer's disease, before substantial neurodegeneration. The authors report reduced excitatory and increased inhibitory synaptic input, and changes in potassium and sodium currents that they say may alter how these cells fire. They note the locus coeruleus is among the earliest brain regions affected in Alzheimer's disease.
A preprint, not yet reviewed by other scientists, combines reconstruction experiments, computational modeling and a cell system to suggest that alpha-synuclein can phase separate with an interacting partner to form Lewy body-like structures. The authors report these structures associate with redistributed actin and mitochondria, and propose a seed-independent route to insoluble fibrils. They say the framework may guide the design of new therapeutic interventions.
A preprint, not yet reviewed by other scientists, analyzes data from the Framingham Heart Study Offspring cohort. Slower quick walking speed was associated with incident dementia over 10-year follow-up, while usual walking speed was not. The authors also report links between slower walking and worse executive function and stroke, mostly in men; these are associations, not proof of cause.
A preprint, not yet reviewed by other scientists, describes a long short-term memory-based system that suggests initial prescriptions and daily basal and bolus titration for people with type 2 diabetes on insulin pumps. In 97 patients from the model-directed arm of a randomized trial, median time in range was 84.5%, with low hypoglycemic exposure. The authors say higher mean glucose in the first 24 hours was linked to poorer control later.
A preprint, not yet reviewed by other scientists, reports a meta-analysis of melanoma genetic studies covering 69,871 cases and 1,616,233 controls. It identifies 156 independent signals at 116 risk loci, and says about 22% of loci include potential causal genes in the WNT/beta-catenin signaling pathway. The authors also report a new risk score that improved prediction beyond age and sex.
A preprint, not yet reviewed by other scientists, is a cross-sectional online survey of 4,883 completed responses from users of the Tata 1mg digital healthcare platform in India, on antimicrobial resistance (AMR). Attitudes scored lower than knowledge, and 42.0% said their last antibiotic did not come on a doctor's recommendation. The authors say a survey of platform users cannot establish what drives antibiotic use.
A preprint, not yet reviewed by other scientists, measures oxygen levels in awake rTg4510 and THY-Tau22 mice. The authors report that in rTg4510 mice, capillary oxygen was elevated at 6 months but reduced at 9 months, and that tissue oxygen was lower in tangle-positive areas. They suggest neuronal loss may reflect a global reduction in cortical oxygenation rather than local oxygen levels.
A preprint, not yet reviewed by other scientists, uses a model calibrated to Ontario incidence and hospital admissions before Omicron. Its simulations found that vaccination combined with workplace and community contact restrictions kept projected severe-case demand within an illustrative capacity benchmark, while relaxing either setting produced large surges. School-only changes had smaller effects on severe disease.
A preprint, not yet reviewed by other scientists, examines records covering 4.95 million patients in 21 health systems. Adults with a first outpatient Z59 social-needs code, which records hardship such as housing, food or transportation problems, had 67% more emergency department visits and 43% more hospital admissions in the next year than similar uncoded patients. The authors say the code added no increment to risk prediction models.
A preprint, not yet reviewed by other scientists, studies breast cancer cells with different metabolic profiles. The authors report that glycolysis reduces DTWD2, which lowers glycoRNA on the cell surface and weakens immune activation, and that restoring glycoRNA enhanced the effect of PD-1 blockade in their experiments. They also report that lower glycoRNA abundance is associated with tumor stage and prognosis.
A preprint, not yet reviewed by other scientists, analyzes 4,999 verbal autopsy records for deaths at ages 12 years or older from a national sample of registered deaths in South Africa. Supervised models using the questionnaire, the free-text narrative or both improved on InSilicoVA, a current automated method, by 8.5-15.9 percentage points in top-1 accuracy. Physician-assigned causes were the reference standard.
A preprint, not yet reviewed by other scientists, reports that delivering messenger RNA (mRNA) for an autoactivated cGAS (cyclic GMP-AMP synthase) mutant with membrane-tethered interleukin-12 (IL-12) suppressed distal tumors across multiple mouse models. The authors report the combination reduced regulatory T cells, restored effector function in tumor-infiltrating T cells and enhanced response to PD-L1 blockade. They describe the strategy as clinically translatable, but all of the evidence comes from mouse models.
A preprint, not yet reviewed by other scientists, reports experiments in male rats fed a high-cholesterol diet for 120 days. From day 90 to 120, atorvastatin combined with Bifidobacterium longum gave greater improvement in liver and aortic tissue, and in markers of oxidative stress and inflammation, than atorvastatin alone. The authors describe this as multi-targeted synergy, and all of the evidence comes from rats.
A preprint, not yet reviewed by other scientists, is a cross-sectional analysis of 172,173 adults aged 19-74 in the German National Cohort (NAKO). Exposure to childhood and adolescent adversity, measured with a trauma screener, was associated with higher odds of smoking, heavier drinking among drinkers and lifetime illicit drug use, with the strongest links for opioid and stimulant use. These are associations, not evidence of cause.
A preprint, not yet reviewed by other scientists, reports experiments in mice on lateral hypothalamic neurons that co-express the neuropeptides 26RFa and orexin. The authors found that activating these neurons unexpectedly worsened glucose-induced hyperglycemia, and attribute most of this effect to orexin signaling, while 26RFa signaling regulates orexin expression.
A preprint, not yet reviewed by other scientists, tests combinations of H. lupulus and G. biloba extracts on naturally aged human skin cells and on skin explants exposed to UVC irradiation. The authors report a dose-dependent senomorphic effect of up to 45% in aged dermal fibroblasts and a 50% decrease in DNA damage load. They say these are cell and tissue results, not clinical outcomes.
Pew Research Center reports that White evangelical Protestants and White Catholics favor Republicans in the 2026 midterms. The center says other religious groups split or lean Democratic.
A preprint, not yet reviewed by other scientists, analyzes spatial trends in armed conflict across North and West Africa. It reports that violence rose in 2025, is concentrated in Nigeria, Cameroon, Mali, Burkina Faso and Niger, and is spreading outward from conflict zones. Projections in the paper expect more than 15,000 incidents and more than 32,500 deaths in 2026.
A preprint, not yet reviewed by other scientists, uses in silico modeling to design covalent organic frameworks with internal polarization for single-component organic photovoltaics. The authors report that polarization helps excitons dissociate into separated charges, and predict an almost 40-fold increase in charge-carrier lifetime for the new designs. These are computer predictions, not measured results.
A preprint, not yet reviewed by other scientists, applies a deep learning framework called DKO to predict cell-specific virtual gene perturbation effects in single-cell data from humans, mice, Drosophila and C. elegans. The authors report that responses to the same gene became more heterogeneous across cells with age, and that cells with more somatic mutations showed greater variability.
A peer-reviewed study reports that molecular cancer articles sharing features with retracted papers from paper mills received 50 to 100% more citations 1 to 3 years after publication, yet attracted fewer readers. The authors say these citations measurably inflated journal citation metrics, and describe the pattern as suspected rather than confirmed manipulation.
The Max Planck Society announces computer vision technology that uses just a few smartphone cameras to create dancing avatars, eliminating the need for marker suits in motion capture.
MIT News reports on the State of Supply Chain Sustainability Report from MIT's Center for Transportation and Logistics. It says corporate sustainability commitment is at a record high, but governance gaps and external disruptions prevent execution.
A preprint, not yet reviewed by other scientists, tests whether ensemble spread from Long Short-Term Memory streamflow forecasts still signals uncertainty under high flows. It reports that prediction error is about 2 times the corrected spread at ordinary flows and up to 4 times at the highest flows, so the spread understates risk in extreme conditions. The authors note that the spread still ranks errors informatively.
A preprint, not yet reviewed by other scientists, uses simplified ring-network power-grid models to study how a long-range shortcut transmission link affects synchronization. The authors report that center-to-center shortcuts raised mean basin stability by up to 75% when producers and consumers formed two separated clusters, while peripheral shortcuts reduced it by up to 28% in some configurations.
A preprint, not yet reviewed by other scientists, introduces SurvICL, a foundation model that predicts survival curves in context, without tuning. The authors report it outperformed 20 tree-based, deep and foundation-model baselines on 63 held-out datasets, and was the first to rank above the Cox model on small datasets. Because the authors designed and benchmarked the model, these are their own reported results.
Pew Research Center reports that 86% of Latino registered voters say the economy is very important to their vote for Congress in the 2026 midterms.
MIT News reports new research that can help artificial intelligence (AI) models understand crystalline materials in 3D and reason about their properties.
The U.S. Government Accountability Office (GAO) reports limited available information on the full extent of foreign investment in mining on federal lands. The 1872 Mining Law generally requires claimants to be U.S. citizens or businesses incorporated in the U.S., so foreign companies can qualify through a U.S. subsidiary. GAO determined ownership for 32 of 43 companies it reviewed and found 14 were foreign subsidiaries, none with a Chinese-owned parent company.