Plain words, straight from the source. Every item links to the original document. No news outlets, no hot takes.
A preprint, not yet reviewed by other scientists, led by S. Hur and colleagues, describing a compound called MA2. It is a laboratory study in which the authors report that MA2 selectively activates MDA5, enhances antiviral activity, and helps natural killer cells kill tumor cells.
A preprint, not yet reviewed by other scientists, led by B. Ghosh and colleagues. The study uses mice and cultured cells, and reports that removing soluble epoxide hydrolase (sEH) from astrocytes reduced amyloid pathology and microglial STING activation in mice. The authors report that the molecule 11,12-EET dampened inflammatory signaling in cultured microglia.
A preprint, not yet reviewed by other scientists, led by M. J. Tudball and colleagues. Using computer simulations and two population cohorts, the authors show how trial eligibility rules can make treatment benefit appear to depend on polygenic risk scores. They say the apparent effect may reflect bias from eligibility rather than biology.
This final rule from the Washington Department of Social and Health Services takes effect on October 31, 2026. It removes references to the inventory for client and agency planning and adds an acceptable adaptive test. The abstract does not say who is affected.
How to weigh in: No comment period: this is a final rule.
The Washington Department of Social and Health Services (DSHS) proposes amendments to its rule on whether people must be interviewed to get cash and basic food benefits. The changes align with a modification by the United States Department of Agriculture (USDA) Food and Nutrition Administration (FNA) to Washington's elderly simplified application project (ESAP). If adopted, the project would be limited to adults who are disabled or 65 years of age or older, so people aged 60-64 would no longer be eligible.
How to weigh in: Comment by November 10, 2026.
The Washington Department of Social and Health Services (DSHS) proposes amendments to its rule on who is exempt from work registration while receiving basic food. The changes would align the rule with federal rules on the exemption for people caring for an incapacitated person.
How to weigh in: Comment by November 10, 2026.
A preprint, not yet reviewed by other scientists, led by S. Upadhyay and colleagues. The study combines laboratory work with mice and reports that DELC2, a compound found by screening a large DNA-encoded library, reached the brain when given orally. In 5xFAD mice, the authors report it improved cognitive performance and reduced several amyloid species.
A preprint, not yet reviewed by other scientists, led by E. Viippola and colleagues. Using plasma proteomics data from 51,310 people in six cohorts, it proposes the Proteomic Sex Index (PSI), which measures how far a person's protein profile lies from what is typical for their chromosomal sex. The authors report links to some sex-enriched traits and diseases, and a higher index in Klinefelter syndrome (XXY).
A preprint, not yet reviewed by other scientists, led by J. H. Tay and colleagues. It is a systematic review and meta-analysis of 125 articles on DNA methylation age and death risk in adults. The authors report that higher DNA methylation ages were associated with higher risks of all-cause, cardiovascular and cancer mortality, which is an association rather than proof of cause.
A preprint, not yet reviewed by other scientists, led by P. P. Sahoo and colleagues. It is a laboratory study in cell cultures, which finds that Snail lowers ACE2 expression and so reduces SARS-CoV-2 entry. The authors also report that infection depletes Snail protein in cell models.
A preprint, not yet reviewed by other scientists, led by C. Choy and colleagues. It reports a single-cell atlas of blood immune cells from 345 people across 13 Indigenous South American populations, at baseline and after stimulation. The authors find that genetic ancestry affects gene expression more than age or sex does.
A preprint, not yet reviewed by other scientists, led by G. M. Serratto and colleagues. It argues that a strong brain immune pattern, previously seen as an Alzheimer's-specific subtype, also exists in neurologically healthy people and is linked to amyloid pathology. The authors suggest this could allow people to be identified earlier for targeted prevention.
A preprint, not yet reviewed by other scientists, led by N. Swartwood and colleagues. It is a systematic review and meta-analysis of 104 studies of costs faced by households with tuberculosis (TB) in low- and middle-income countries. Estimated per-episode costs of rifampin-susceptible TB ranged from $668 to $9,156 in 2025 International Dollars, with indirect and continuation treatment costs the largest shares.
A preprint, not yet reviewed by other scientists, led by Z. Fang and colleagues. It describes laboratory and mouse studies of new small-molecule inhibitors of CYP8B1, a liver enzyme that controls 12-hydroxylated bile acid synthesis. The lead compound altered bile acid composition, remodeled the gut microbiota and corrected metabolic disease in a mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD).
The executive commissioner of the Texas Health and Human Services Commission, on behalf of the Texas Department of State Health Services (DSHS), proposes amending section 289.228 on radiation safety requirements for industrial radiation machines. The proposal would update and reorganize the rules for non-healing arts radiation generating devices (RGDs), which are used in cargo inspection, law enforcement and security screening. It aims to align the rules with current inspection criteria.
How to weigh in: Comment by November 23, 2026.
A preprint, not yet reviewed by other scientists, led by I. Craparotta and colleagues. It finds that the molecule miR-29 rises with ageing and falls during two routes to rejuvenation. The authors report that blocking it opposes transcriptional ageing and lowers epigenetic-clock estimates, and that low miR-29 expression marks some tumors with younger epigenetic age.
This rule from the Texas Comptroller of Public Accounts has been in effect since October 25, 2026. It adds a 'lessee' definition, modifies the 'property owner' definition, and adopts a revised request form with an option for lessees. The amendments implement the Tax Code §41A.011 right of a person leasing property to appeal.
How to weigh in: No comment period: this is a final rule.
This rule from the Texas Comptroller of Public Accounts has been in effect since October 25, 2026. It clarifies and updates how lessees appeal an appraisal review board order on a property value protest through regular binding arbitration. It also adds instances where an arbitrator must dismiss a request for lack of jurisdiction.
How to weigh in: No comment period: this is a final rule.
This is a peer-reviewed study published in Science, describing the Virtual Biotech, a team of AI agents led by a Chief Scientific Officer agent that hands queries to domain-specialized scientist agents. In one application, the study says the agents analyzed outcomes from 55,984 clinical trials and found that drugs targeting cell-type-specific genes were 40% more likely to progress from Phase I to Phase II. The authors present the system as a way to speed early-stage drug discovery while keeping human scientists in the loop.
A preprint, not yet reviewed by other scientists, led by Tengyi Liu and colleagues. It is a laboratory study of an electrochemical catalyst that combines copper phthalocyanine (CuPc) with carbon made from cellulose, converting carbon dioxide (CO2) to methane (CH4). The authors report 67.9% methane selectivity and stable operation for over 49 h.
The National Oceanic and Atmospheric Administration (NOAA), part of the Commerce Department, proposes two technical changes to rules for groundfish fisheries in the Bering Sea and Aleutian Islands and the Gulf of Alaska. If adopted, the rule would let NOAA set the opening and closing times of the sablefish season, taking into account the halibut season set by the International Pacific Halibut Commission, and would let it change the time of day a groundfish fishery closes.
How to weigh in: Comment by November 20, 2026.
This temporary rule from the Washington Department of Fish and Wildlife has been in effect since September 23, 2026. It sets a fall season for treaty Indian commercial gillnet fisheries in Zone 6 of the Columbia River, while protecting salmon listed under the Endangered Species Act (ESA). It also allows treaty commercial sales to nontreaty buyers in 2026.
How to weigh in: No comment period: this is a final rule.
This temporary rule from the Washington Department of Fish and Wildlife has been in effect since September 23, 2026. It adds fishing periods for the nontreaty mainstem commercial drift net fishery in Zones 4-5 of the Columbia River. The rule says sufficient Chinook impacts remain available to the commercial sector under the Endangered Species Act (ESA).
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule from the Washington Department of Fish and Wildlife has been in effect since October 1, 2026. It opens the recreational crab harvest in many Puget Sound marine areas for winter seasons. Some areas, including Marine Areas 8-1 and 8-2, stay closed.
How to weigh in: No comment period: this is a final rule.
This temporary rule from the Washington Department of Fish and Wildlife sets fall-season treaty commercial gillnet fisheries in Zone 6 of the Columbia River and keeps earlier treaty fisheries in place. It allows treaty commercial sales to nontreaty buyers in 2026. The document does not give a start date for the rule.
How to weigh in: No comment period: this is a final rule.
The Washington Department of Agriculture proposes to update its shell egg rules on standards, grades and weight classes, and on the facility, operation, storage and labeling requirements for egg facilities. The rule was adopted decades ago, and the changes would align state law with current federal requirements. The federal egg inspection law bars states from moving eggs into interstate or foreign commerce under standards that differ from the official ones.
How to weigh in: Comment by November 3, 2026.
The Washington Department of Fish and Wildlife (WDFW) proposes closing recreational scallop harvest year-round in all areas, except where an emergency regulation opens it. The proposal is to protect the public from biotoxin risks, because recent samples from the Strait of Juan de Fuca exceeded safe-consumption standards in both the adductor muscle and the viscera.
How to weigh in: Comment by November 22, 2026.
The Washington Department of Fish and Wildlife proposes allowing two-pole fishing for all game fish in the Washington portions of the Snake and Columbia rivers, following a rule petition accepted by its director. The change would target walleye, bass, channel catfish, northern pikeminnow and, on the Snake River, hatchery steelhead. The proposal does not change seasons, minimum sizes or daily limits.
How to weigh in: Comment by December 7, 2026.
The National Oceanic and Atmospheric Administration (NOAA), part of the Commerce Department, announces eleven inseason actions for 2026-2027 ocean salmon fisheries. The actions modified commercial salmon fisheries from the United States/Canada border to Cape Falcon, OR. This is a final rule, and the document gives no start date for it.
How to weigh in: No comment period: this is a final rule.
A preprint, not yet reviewed by other scientists, led by Nestor Iwanojko and colleagues. It is a laboratory study of 70 trimetallic catalysts, covering all 210 possible bimetallic pairs from 21 elements, tested on a robotic platform for carbon dioxide (CO2) hydrogenation. It reports a highly active FeGaRu catalyst that keeps its activity when simplified to FeRu with Ga.
This is a peer-reviewed study published in Nature. It describes multifunctional digital fibres that integrate display, touch sensing, computation and multimodal input and output. The authors say the fibres enable flexible, washable garments with interactive graphical interfaces and wireless multimedia.
A preprint, not yet reviewed by other scientists, led by Lin Chen and colleagues. It is a laboratory study of water-soluble biopolymer binders, guar gum and ι-carrageenan, in sodium-ion battery electrodes. The authors report high capacity retention and rate capability with hard carbon electrodes.
This is an announcement by Pew Research Center, which reports its own analysis. It says men's employment grew faster than women's in occupations most exposed to AI, a gap driven largely by workers without a bachelor's degree.
A preprint on arXiv, not yet reviewed by other scientists. It is a simulation study of large language model (LLM) populations playing a naming game on fully connected, random and heterogeneous networks. The authors find that sparse networks can slow consensus up to twelvefold, and that networked populations are easier to tip than fully mixed ones.
This final rule from the Washington Department of Retirement Systems takes effect on November 1, 2026. It clarifies that, under the law enforcement officers' and firefighters' Plan 2, medical expense reimbursement payments are fringe benefits instead of basic salary.
How to weigh in: No comment period: this is a final rule.
This temporary rule from the Washington Department of Children, Youth, and Families has been in effect since October 1, 2026. It amends the working connections child care (WCCC) program rules on providers' responsibilities and billing requirements. The changes implement HB [SHB] 2689.
How to weigh in: No comment period: this is a final rule.
The Washington Department of Children, Youth, and Families proposes to amend its foster home licensing rules to align them with the D.S. Settlement Agreement and the DeGross permanent injunction. The aim is to make the rules more developmentally appropriate and flexible for children and youth. The rule-making used negotiated rule-making with foster parents, tribal nations, agency employees and people with lived experience in care.
How to weigh in: Comment by November 10, 2026.
This rulemaking from the California Department of Corrections and Rehabilitation has been in effect since October 12, 2026. It repeals prior rules on familiarity and permits employees to engage in dynamic security.
How to weigh in: No comment period: this is a final rule.
The Texas Funeral Service Commission proposes a new section 206.13 to replace the existing standards for anatomical facilities and other anatomical use locations. It would cover health, safety, security, dignity, custody and record-keeping at every location where anatomical material is present, including permanent, mobile and temporary sites. It would also require a willed body program or non-transplant anatomical donation organization that directly accepts donated bodies in Texas to employ or contract with a Texas-licensed funeral director, and require embalming to be done by a licensed embalmer.
How to weigh in: Comment by November 22, 2026.