Plain words, straight from the source. Every item links to the original document. No news outlets, no hot takes.
This preprint, not yet reviewed by other scientists, combines data from people with diabetes, human artery samples, and experiments in mice and cells. It reports that Rev-erbα is lower in calcified areas of human artery plaques, and that mice without Rev-erb develop faster atherosclerosis and vascular calcification.
This preprint, not yet reviewed by other scientists, followed toddlers aged 18 to 24 months through a memory test, with retrieval up to six months later. It reports that memories were not simply erased: many toddlers kept only part of a memory, and the authors say early memories persist in an increasingly inaccessible form.
This temporary emergency rule, in effect from October 1, 2026, sets up a limited community access program with the Department of Social and Health Services (DSHS). It continues state-funded long-term services and supports for people whose immigration status makes them ineligible for federally funded medical assistance, and the agency will use standard rule-making to make the changes permanent.
How to weigh in: No comment period: this is a final rule.
This is a final rule, effective November 7, 2026. The Health Care Authority removes outdated language to align with federal requirements and with the department of children, youth, and family's policies, and it provides that children entering out-of-home placement may, instead of must, receive an initial health screen within five days.
How to weigh in: No comment period: this is a final rule.
This is a preprint, not yet reviewed by other scientists, and it is a study in male mice. Researchers introduced the human IL6RA variant into mice, report that it changes soluble IL6RA levels as in humans, and say it significantly prevents atherosclerosis and abdominal aortic aneurysm (AAA).
This preprint, not yet reviewed by other scientists, reports a randomized, placebo-controlled phase 2 trial in 62 adults with obesity, type 2 diabetes and metabolic dysfunction-associated steatohepatitis (MASH). Taken by mouth with semaglutide for 16 weeks, linafexor led to 6.17% weight loss versus 2.91% with placebo, with gastrointestinal side effects similar in both groups (23.3% vs. 18.8%).
This preprint, not yet reviewed by other scientists, examines how governments in Sub-Saharan Africa responded to disruption of President's Emergency Plan for AIDS Relief (PEPFAR) funding after the suspension of United States foreign aid. It finds that higher Human Development Index (HDI) scores were significantly associated with stronger government responses, while links for gross domestic product (GDP) per capita and HIV prevalence were not significant after adjustment for multiple comparisons.
This preprint, not yet reviewed by other scientists, is a cross-sectional observational study of 14,378 women in six Indian states who were eligible for the Pradhan Mantri Jan Arogya Yojana (PM-JAY) publicly funded health insurance scheme. It shows a link, not a cause: high women's empowerment was associated with higher odds of completing PM-JAY verification, but not with outpatient service use.
This preprint, not yet reviewed by other scientists, combines spatial, single-cell, protein and other data from breast cancer. It reports that chemotherapy depleted the pretreatment cell states and repeatedly favored a restricted set of survivors, and that the capacity to reach those survivor states was partly present before treatment.
This preprint, not yet reviewed by other scientists, is a laboratory study of lipid nanoparticles (LNP), the carriers used to deliver messenger RNA (mRNA). It reports that adding more DSPC lipid changed particle shape from spherical to non-spherical, and that non-spherical particles gave higher and more sustained protein expression, a difference the authors say uptake alone does not explain.
This preprint, not yet reviewed by other scientists, is an observational study of participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, which shows a link, not a cause. It finds that people who kept higher diet quality and higher physical activity through young adulthood had much higher odds of high midlife cardiovascular health, and the combined association was larger than either factor alone.
This preprint, not yet reviewed by other scientists, estimates annual direct healthcare costs of community acquired pneumonia (CAP) among adults in the United States, using 2023 Medical Expenditure Panel Survey data. Most of the cost is hospital care, and the authors also link higher pneumococcal vaccination uptake to lower pneumonia mortality across states.
This preprint, not yet reviewed by other scientists, audits drug-safety warnings for 33 drugs in English, Russian, Arabic and Hebrew Wikipedia, using large language models as a measuring tool. It estimates that warnings were weaker in the Russian, Arabic and Hebrew editions than in English, but the uncertainty ranges include no difference, and the model codes are not yet checked against human coding.
This preprint, not yet reviewed by other scientists, is a mouse study in which male UM-HET3 mice, a genetically heterogeneous stock, were castrated at 20, 60 or 240 days of age. Castration at each age prevented early excess male mortality and increased median lifespan, and the authors say the responsible testicular factors act rapidly and their continued presence is needed to sustain higher male mortality.
This preprint, not yet reviewed by other scientists, tests two decision-only AI models, Jev and OpenAI Decisions, alone and paired with the language model GPT-6 Luna, using clinical case presentations. The authors report that pairing reduced decision changes caused by added labels or pressure cues, that triage accuracy stayed near 81% to 82%, and they describe the work as a proof of concept.
This preprint, not yet reviewed by other scientists, uses a data-driven agent-based model of malaria infection and transmission to examine primaquine, a drug that targets mature gametocytes, the stage that passes malaria from humans to mosquitoes. The authors report that differences in how people adhere to multi-round mass drug administration (MDA) campaigns could explain conflicting earlier results, and they predict that primaquine in routine case management could significantly reduce the prevalence of infection.
This is a draft UK statutory instrument, laid before Parliament, so it is not law yet. If approved and made, it would disqualify from certain social security benefits people detained in hospital under section 37 of the Mental Health Act 1983 after a conviction for a serious offence, and it would keep similar people disqualified after their release date, until discharge from hospital, if they were detained under sections 45A or 47.
This preprint, not yet reviewed by other scientists, describes how the authors used AI retrosynthesis software with expert chemist knowledge to propose a new synthetic route to ganaplacide, a drug candidate against malaria. The AI suggested a non-evident two-step synthesis of the molecule's core, and the authors also present a Synthetic Confidence Score that assesses the level of risk in each disconnection.
This is UK law, made on October 19, 2026, which comes into force on January 4, 2027. It amends the Marine Licensing (Exempted Activities) Order 2011 and the Marine Licensing (Application Fees) Regulations 2014.
This preprint, not yet reviewed by other scientists, fuses satellite ozone observations with ground measurements, using a Bayesian Maximum Entropy framework, to build a global 0.1° surface ozone dataset for 2005 to 2022. The authors estimate that the share of the global population exposed to ozone above 50 parts per billion (ppb) rose from 17.2% to 41.0% over this period.
This temporary emergency rule, in effect from September 26, 2026, allows two nonmark selective Chinook retention days from Buoy 10 upstream to the Highway 395 Bridge, and opens coho fisheries three days earlier than scheduled from the west end of Puget Island to the Highway 395 Bridge. The Washington Department of Fish and Wildlife says enough Chinook Endangered Species Act (ESA) impact remains available for this.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from October 1, 2026, returns recreational fishing seasons in the mainstem Stillaguamish River to permanent rules. It keeps a previously announced recreational fishing closure in the lower North Fork Stillaguamish River in place.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from October 1, 2026, opens fishing seasons in upper areas of the Skagit River and Cascade River. It also reduces the daily limit for the upper Skagit River, prohibits bait, requires single-point barbless hooks for salmon, and schedules two temporary closures during tribal fisheries.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from October 5, 2026, opens commercial harvest of red sea urchins in District 5, green sea urchins in Districts 1, 3, 4, 5, 6 and 7, and purple sea urchins in Districts 3, 4 and 5. It sets a weekly trip limit of 1,550 pounds per species per license, because there is insufficient time to adopt permanent rules.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from September 30, 2026, opens recreational salmon seasons targeting coho in the Icicle River. It says expected returns of coho bound for the river are sufficient to meet conservation objectives and provide for sport angler harvest.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from September 30, 2026, opens coho retention on the Columbia River from Priest Rapids Dam to Rock Island Dam. It says returns of upper Columbia River-bound coho are sufficient to meet conservation objectives and provide for sport angler harvest.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from September 30, 2026, extends recreational clam, mussel and oyster harvest at Belfair State Park, Point Whitney Tidelands and Point Whitney Lagoon. It makes up for lost opportunity this summer caused by a biotoxin closure.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from October 3, 2026, closes recreational fishing seasons in the Snohomish River. It cites uncertainty and concern that the 2026 coho return is below preseason expectation, after the 2025 return fell below the escapement goal.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from October 2, 2026, opens commercial crab fishing in Puget Sound until further notice. The season is structured to meet harvest allocation objectives negotiated with applicable treaty tribes, and it may be adjusted as updated harvest data come in.
How to weigh in: No comment period: this is a final rule.
This temporary emergency rule, in effect from October 6, 2026, opens recreational fishing in the Quillayute River with a bait prohibition for all species and reduced daily limits for salmon. It is meant to extend fall salmon fishing while reducing impacts on salmon heading to spawning grounds.
How to weigh in: No comment period: this is a final rule.
This temporary rule, in effect from October 21, 2026, prohibits directed fishing for pollock in Statistical Area 620 in the Gulf of Alaska. The National Oceanic and Atmospheric Administration (NOAA) says this is needed to prevent exceeding the annual 2026 total allowable catch of pollock in that area.
How to weigh in: No comment period: this is a final rule.
This preprint, not yet reviewed by other scientists, is a model-based estimate calibrated to public measurements. It estimates that a proposed electrolyte and cathode package could make an iPhone 17-type cell last about 1.38 times as long as the baseline (range 1.10 to 1.93) in a defined hot-climate usage profile, and the authors say the main uncertainty is the benefit over additives already in commercial electrolytes.
Pew Research Center reports that a growing share of U.S. adults say social media is an important way for them to keep up with the news, and 58% now say so. This is the institution's own announcement of its findings.
This preprint, not yet reviewed by other scientists, reports two-dimensional polyaramids, a family related to Kevlar, that conduct electricity across stacked layers but remain insulating in the plane of the film. The authors describe the films as stable through more than 10,000 cycles at pH 2 and suggest them as electrodes for energy storage.
This preprint, not yet reviewed by other scientists, describes making Na3V2(PO4)3, a sodium-ion battery cathode material, directly from desalination brine, a hypersaline byproduct of water treatment. The authors report that crystallization took 45 minutes in an open crucible, where conventional routes typically need 2 to 4 hours under inert gas.
This is a proposed rule, not yet adopted. The University of Washington would amend chapter 478-124 WAC, the General conduct code for the University of Washington, and has extended the comment period to December 10, 2026.
How to weigh in: Comment by December 10, 2026.
This is a final rule, effective January 1, 2027. The California Board of Forestry and Fire Protection amends its regulations on the timing, use and termination of notices of exemption.
How to weigh in: No comment period: this is a final rule.
This is a final rule, effective November 1, 2026, adopted by the Texas Juvenile Justice Department (TJJD). It amends rules on major and minor rule violations and parole rule violations for youth in Residential Facilities and on parole, and adds an Egregious Behavior Protocol covering safety-based measures and youth returning to regular programming.
How to weigh in: No comment period: this is a final rule.