The Daily Trickle

Oregon proposes reorganized billing rules and updated Agreement to Pay form

The Oregon Health Authority has proposed reorganizing its billing rules and updating the Agreement to Pay form (OHP 3165), in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. The proposal would be set out in Oregon Administrative Rules chapter 410, and the notice does not say who would be affected.

Published

Nov 2, 2026

How to weigh in: No comment deadline is listed; see the document.

Oregon proposes rules on medical marijuana patients, caregivers and dispensaries

The Oregon Health Authority, Public Health Division, has proposed rules covering medical marijuana patients, caregivers, dispensaries and processing sites, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. The proposal would be set out in Oregon Administrative Rules chapter 333.

Published

Nov 2, 2026

How to weigh in: No comment deadline is listed; see the document.

Preprint tests a cheap AI model as a judge of medical AI answers

A preprint, not yet reviewed by other scientists, reports a pre-registered test of a cheap, fast decision-only model as a judge of answers from medical AI systems, across five validated clinical benchmarks. M. Omar and colleagues report that it agreed with expert labels about as often as two frontier judges on most tasks, at a small fraction of their cost, but it missed more planted omissions than one of them.

Published

Nov 2, 2026

Preprint maps long-read genetic data from 1,490 Hispanic/Latino participants

A preprint, not yet reviewed by other scientists, uses long-read sequencing to study genetic variation and DNA methylation in 1,490 self-identified Hispanic/Latino participants in the All of Us Research Program. A. C. English and colleagues report 10 million novel variants and more than 100 candidate phenotype associations, which they say show the value of long-read sequencing for diverse populations.

Published

Nov 2, 2026

Preprint links the TREM2 pathway to regression of atherosclerotic plaque in mice

A preprint, not yet reviewed by other scientists, reports a study in mice in which TREM2 expression on plaque macrophages was required for plaque regression as cholesterol was lowered. H. Hillman and colleagues report that boosting TREM2 signalling sped up the clearing of dead cells and plaque regression, and they suggest the pathway could be a strategy for stabilizing plaques.

Published

Nov 2, 2026

Preprint reports a compound that reverses liver metabolic dysfunction in obese mice

A preprint, not yet reviewed by other scientists, describes a study in mice of ME610, a synthetic LRH-1 agonist that the authors report improved insulin sensitivity and reduced liver fat in a mouse model of diet-induced obesity. S. G. Mays and colleagues say the work uncovers new pathways for LRH-1 metabolism and suggests synthetic LRH-1 agonists may have therapeutic potential in obesity-associated metabolic diseases.

Published

Nov 3, 2026

Preprint finds where a heart receptor sits in a cell shapes its effect

A preprint, not yet reviewed by other scientists, reports in cells and in rodent and human hearts that the beta1-adrenergic receptor engages different signalling pathways depending on whether it sits in the T-tubular membrane or the outer membrane of cardiomyocytes. A. Froese and colleagues say that beta-blockers acting only on the outer membrane could reduce hypertrophy and cardiac remodeling without reducing contractility, in cells and in animals.

Published

Nov 3, 2026

Preprint: medication history predicts who stops blood pressure drugs

A preprint, not yet reviewed by other scientists, analyzes three aging cohorts from China, Europe and the US, covering 4,532, 26,128 and 9,495 participants. S. Wang and colleagues report that a 3-feature medication-history score predicted treatment stopping about as well as a full model and transferred across health systems, while clinical profiles did not.

Published

Nov 4, 2026

Science study describes ultrahigh-throughput screening for molecular modulators

A peer-reviewed study published in Science describes FIND (Functional Interaction-based Nanoswitch Discovery), which combines DNA nanoswitch selection with next-generation sequencing to screen for compounds that induce or increase protein-protein interactions. The study reports discovering nanobodies that stabilize the interaction between angiotensin-converting enzyme 2 and the receptor-binding domain of severe acute respiratory syndrome coronavirus 2, and agonists of peroxisome proliferator-activated receptor gamma, and the authors say the method could lead to new therapeutics.

Published

Nov 5, 2026

Preprint links childhood poverty to lower quality of life in later life

A preprint, not yet reviewed by other scientists, analyzes data from 59,569 adults aged over 50 in 29 countries and reports that childhood poverty is associated with a 0.7-point lower score on CASP (control, autonomy, self-realisation and pleasure) after full adjustment. G. Tampubolon says the penalty appears in every country studied and remains after accounting for education, partnership and wealth.

Published

Nov 5, 2026

Preprint finds waist-to-height ratio flags risk that body mass index misses

A preprint, not yet reviewed by other scientists, studies 308,600 adults in the All of Us Research Program and reports that waist-to-height ratio was associated with eight cardiometabolic outcomes beyond body mass index (BMI) classification. A. W. Potter and colleagues report that among adults with normal BMI, a higher ratio was linked to diabetes, myocardial infarction and ischemic stroke. As an observational study, it shows links, not causes.

Published

Nov 5, 2026

Nature study reports durable lipid lowering from CRISPR base editing

A peer-reviewed study in Nature reports in vivo CRISPR base editing of ANGPTL3 for durable lipid lowering, according to its title. The published abstract given here only repeats that title, so this summary cannot say more; see the original.

Published

Nov 6, 2026

Oregon proposes updates to its Student Success and Completion Model

The Oregon Higher Education Coordinating Commission has proposed updates to the Student Success and Completion Model, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. If adopted, the changes would be set out in Oregon Administrative Rules chapter 715.

Published

Nov 2, 2026

How to weigh in: No comment deadline is listed; see the document.

Oregon proposes updates to how community college funding is distributed

The Office of Community Colleges and Workforce Development, part of the Oregon Higher Education Coordinating Commission, has proposed updates to community college funding distribution, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. The proposal would be set out in Oregon Administrative Rules chapter 589, and the rule covers how community college funding is distributed.

Published

Nov 2, 2026

How to weigh in: No comment deadline is listed; see the document.

Preprint says tariffs on digital products could raise more than digital services taxes

A preprint, not yet reviewed by other scientists, combines trade data for 31 digital product categories with digital services taxes and tariffs on physical analogues, and simulates alternative fiscal regimes. The authors say that tariff equivalents could raise more revenue than digital services taxes at a modest cost in trade, after the WTO moratorium on customs duties on electronic transmissions lapsed in March 2026.

Published

Nov 5, 2026

Texas proposes applied sciences pathway program for high school students

The Texas Education Agency (TEA) proposes a new section, 74.1035, to set up an applied sciences pathway program, under which eligible students could concurrently earn high school diplomas and certificates from institutions of higher education. It would implement House Bill (HB) 20 from the 89th Texas Legislature, Regular Session, 2025, and set out program approval, course substitution and student participation requirements.

Published

Nov 6, 2026

How to weigh in: No comment deadline is listed; see the document.

Texas charter school operations rules take effect November 15, 2026

The Texas Education Agency (TEA) has issued a final rule on charter school operations, Division 7, which takes effect on November 15, 2026. The published text is only the division heading, so this summary cannot say more; see the original.

Published

Nov 6, 2026

Effective

Nov 15, 2026

How to weigh in: No comment period: this is a final rule.

Oregon updates its prevailing wage rate determination

The Oregon Bureau of Labor and Industries has issued a final rule, published in the Oregon Bulletin on November 2, 2026, that amends Oregon Administrative Rules chapter 839 to update the Prevailing Wage Rate Determination. The abstract gives no effective date, and it does not say who is affected.

Published

Nov 2, 2026

How to weigh in: No comment period: this is a final rule.

Oregon proposes changes to signature requirements, eligibility and federal adjustments

The Oregon Department of Human Services, Self-Sufficiency Programs, has proposed changes to signature requirements, eligibility, and annual federal adjustments, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. If adopted, the changes would be set out in Oregon Administrative Rules chapter 461.

Published

Nov 2, 2026

How to weigh in: No comment deadline is listed; see the document.

Washington electrical rule changes take effect November 20, 2026

The Washington Department of Labor and Industries has adopted amendments to its electrical rules under chapter 296-46B WAC, effective November 20, 2026, and published on November 4, 2026. The changes affect requirements for installing electric vehicle supply equipment and the competency examinations for electricians and electrical administrators.

Published

Nov 4, 2026

Effective

Nov 20, 2026

How to weigh in: No comment period: this is a final rule.

Washington proposes labor standards for domestic workers

The Washington Department of Labor and Industries proposes rules to implement SHB 2355, which creates new protections for domestic workers and new compliance requirements for entities that hire them. The rules would clarify and enforce the labor standards in that law, and comments are due by December 4, 2026.

Published

Nov 4, 2026

Comments close

Dec 4, 2026

How to weigh in: Comment by December 4, 2026.

UK seafarers wages and working conditions regulations take effect December 1, 2026

The Seafarers (Wages and Working Conditions) Regulations 2026 are UK law, made on November 2, 2026, and they come into force on December 1, 2026. They cover wages and working conditions for seafarers, and are made under the Seafarers (Wages and Working Conditions) Act 2023.

Published

Nov 4, 2026

Made

Nov 2, 2026

Effective

Dec 1, 2026

Labor Department removes affirmative action rules for apprenticeship programs

The Labor Department (DOL) has issued a final rule, effective January 5, 2027, that removes the affirmative action requirements previously imposed on Registered Apprenticeship program sponsors. It also streamlines nondiscrimination obligations for all sponsors and says sponsors are accountable for compliance with federal and state nondiscrimination protections.

Published

Nov 6, 2026

Effective

Jan 5, 2027

How to weigh in: No comment period: this is a final rule.

Preprint: surface reconstruction makes rutile IrO2 catalysts more active

A preprint, not yet reviewed by other scientists, reports computer simulations suggesting that the bridge sites of rutile IrO2(110) reconstruct under anodic polarization into single-atom-like centers. Muhammad Usama, Stephan N. Steinmann and Kai S. Exner say these sites are more active for the oxygen evolution reaction (OER) than the sites usually assumed to be active, and that they remain durable.

Published

Nov 3, 2026

EPA proposes approving California's San Joaquin Valley ozone plan

The U.S. Environmental Protection Agency (EPA) proposes to approve California's state implementation plan (SIP) revisions for meeting the 2015 8-hour ozone standards in the San Joaquin Valley. It also proposes to approve statewide consumer products rules that the plan relies on, which limit volatile organic compounds (VOC) from deodorants, antiperspirants and aerosol coating products. Comments are due by December 7, 2026.

Published

Nov 5, 2026

Comments close

Dec 7, 2026

How to weigh in: Comment by December 7, 2026.

Washington moves to repeal emergency wildfire wildlife rules in Eastern Washington

A temporary rule from the Washington Department of Fish and Wildlife covers repealing the current emergency wildlife rules for wildfire in Benton, Franklin, Kittitas, Yakima, Adams, Chelan, Douglas, Grant and Okanogan counties. The filing says the repeal is needed because the recent increase in precipitation in Eastern Washington has significantly decreased the threat of wildfires, and the rule is in effect from October 16, 2026.

Published

Nov 4, 2026

Effective

Oct 16, 2026

How to weigh in: No comment period: this is a final rule.

UK brings specified provisions of the Crime and Policing Act 2026 into force

These UK regulations were made on November 3, 2026, and they bring specified provisions of the Crime and Policing Act 2026 into force. They are the fifth commencement regulations made under that Act, and the abstract does not give the date on which the provisions start.

Published

Nov 3, 2026

Made

Nov 3, 2026

UK export controls amended for dual-use items from December 1, 2026

The Export Control (Amendment) Regulations 2026 are UK law, made on October 29, 2026, and they come into force on December 1, 2026. They amend the Export Control Order 2008 and the assimilated Dual-Use Regulation, Council Regulation (EC) No 428/2009, which control the export, transfer, brokering and transit of dual-use items.

Published

Nov 3, 2026

Made

Oct 29, 2026

Effective

Dec 1, 2026

Preprint says hydrogen delivered-cost estimates understate market prices

A preprint, not yet reviewed by other scientists, uses an 81-region model of the global hydrogen market to show that delivered-cost estimates can understate the market price of hydrogen imports. The 2045 price-cost gap averages 63 EUR/MWh on a demand-weighted basis, and the authors say hydrogen strategies should distinguish delivered-cost benchmarks from market-price expectations.

Published

Nov 2, 2026

Preprint compares two pressing methods for solid-state battery cathodes

A preprint, not yet reviewed by other scientists, compares warm isostatic pressing with cold uniaxial pressing for the cathodes of all-solid-state lithium batteries. Siwar Ben Hadj Ali and colleagues report, from a combined experimental and computer-modelling study, that the warm-pressed cathode was denser and kept higher accessible capacity at C/2, with the two methods behaving similarly at C/10.

Published

Nov 2, 2026

Preprint argues generative models can avoid collapse with some real data

A preprint, not yet reviewed by other scientists, argues with theory and experiments that iterative training on generated data does not necessarily cause model collapse, the degradation seen in earlier work. It says consistency holds for any fixed share of real data above zero, and even for a share that shrinks over iterations, though more real data or curation still matters at practical finite times.

Published

Nov 3, 2026

Preprint models how uneven vaccination can sustain regional spread of disease

A preprint, not yet reviewed by other scientists, presents a mathematical model of a vaccine-preventable infectious disease spreading between residents and travellers across linked areas. Using a numerical example based on the 2003-2004 poliomyelitis resurgence in western and central Africa, it shows how heterogeneous vaccine coverage can sustain widespread regional transmission that classic metapopulation models predict to be much smaller.

Published

Nov 3, 2026

Preprint finds a Community Notes algorithm change reduced ideological polarization

A preprint, not yet reviewed by other scientists, compares 8,805 notes and 4,367 contributors on X's Community Notes before and after the platform replaced simple majority voting with an algorithm that rewards agreement across ideological viewpoints. The authors report that measured ideological polarization fell, although negative interactions increased, and that contributors became less structurally aligned along partisan lines.

Published

Nov 3, 2026

MIT team receives up to $38 million for a wearable early-detection monitor

MIT News reports that an MIT-led team has been awarded up to $38 million from ARPA-H to develop a low-power, noninvasive sensor patch that measures heart failure and sepsis biomarkers in real time. The announcement is the institution's own account, and the team aims to create the sensor rather than having shown that it works.

Published

Nov 4, 2026

Oregon finalizes provisional licensing for internationally trained physicians

The Oregon Medical Board has issued a final rule, published in the Oregon Bulletin on November 2, 2026, to implement the 2025 bill SB 476 and establish provisional licenses for internationally trained physicians. It is set out in Oregon Administrative Rules chapter 847, and the abstract gives no date from which it applies.

Published

Nov 2, 2026

How to weigh in: No comment period: this is a final rule.

Washington proposes driver training school rules on young driver safety

The Washington Department of Licensing proposes amending chapter 308-108 WAC, which covers driver training schools, to carry out provisions of ESHB 1878 on young driver safety, passed in the 2025 legislative session. Comments are due by November 24, 2026.

Published

Nov 4, 2026

Comments close

Nov 24, 2026

How to weigh in: Comment by November 24, 2026.

California proposes updated fire hazard zone map for state responsibility areas

The California Office of the State Fire Marshal (OSFM) proposes amending section 2201 of Title 19 of the California Code of Regulations (CCR) to adopt updated Fire Hazard Severity Zones in the State Responsibility Area (SRA), by updating the map that the section incorporates by reference. Building code requirements will depend on the hazard zone in which a building is located, and comments are due by January 8, 2027.

Published

Nov 6, 2026

Comments close

Jan 8, 2027

How to weigh in: Comment by January 8, 2027.