https://trickle.news/Plain-language summaries of primary documents, each checked against its source.Sun, 08 Nov 2026 13:02:36 +0000https://trickle.news/2026-w45-p4/#item-OR-N164021322026-w45-p4/OR-N16402132Proposed. The Oregon Health Authority has proposed reorganizing its billing rules and updating the Agreement to Pay form (OHP 3165), in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. The proposal would be set out in Oregon Administrative Rules chapter 410, and the notice does not say who would be affected.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-OR-N164203242026-w45-p4/OR-N16420324Proposed. The Oregon Health Authority, Public Health Division, has proposed rules covering medical marijuana patients, caregivers, dispensaries and processing sites, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. The proposal would be set out in Oregon Administrative Rules chapter 333.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.64898/2026.10.30.263669392026-w45-p4/doi:10.64898/2026.10.30.26366939Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a pre-registered test of a cheap, fast decision-only model as a judge of answers from medical AI systems, across five validated clinical benchmarks. M. Omar and colleagues report that it agreed with expert labels about as often as two frontier judges on most tasks, at a small fraction of their cost, but it missed more planted omissions than one of them.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.64898/2026.10.30.7631912026-w45-p4/doi:10.64898/2026.10.30.763191Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses long-read sequencing to study genetic variation and DNA methylation in 1,490 self-identified Hispanic/Latino participants in the All of Us Research Program. A. C. English and colleagues report 10 million novel variants and more than 100 candidate phenotype associations, which they say show the value of long-read sequencing for diverse populations.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.64898/2026.10.31.7633302026-w45-p4/doi:10.64898/2026.10.31.763330Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a study in mice in which TREM2 expression on plaque macrophages was required for plaque regression as cholesterol was lowered. H. Hillman and colleagues report that boosting TREM2 signalling sped up the clearing of dead cells and plaque regression, and they suggest the pathway could be a strategy for stabilizing plaques.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.64898/2026.10.28.7619332026-w45-p4/doi:10.64898/2026.10.28.761933Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a study in mice of ME610, a synthetic LRH-1 agonist that the authors report improved insulin sensitivity and reduced liver fat in a mouse model of diet-induced obesity. S. G. Mays and colleagues say the work uncovers new pathways for LRH-1 metabolism and suggests synthetic LRH-1 agonists may have therapeutic potential in obesity-associated metabolic diseases.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.64898/2026.10.30.7630442026-w45-p4/doi:10.64898/2026.10.30.763044Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports in cells and in rodent and human hearts that the beta1-adrenergic receptor engages different signalling pathways depending on whether it sits in the T-tubular membrane or the outer membrane of cardiomyocytes. A. Froese and colleagues say that beta-blockers acting only on the outer membrane could reduce hypertrophy and cardiac remodeling without reducing contractility, in cells and in animals.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.64898/2026.11.02.263671452026-w45-p4/doi:10.64898/2026.11.02.26367145Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes three aging cohorts from China, Europe and the US, covering 4,532, 26,128 and 9,495 participants. S. Wang and colleagues report that a 3-feature medication-history score predicted treatment stopping about as well as a full model and transferred across health systems, while clinical profiles did not.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.1126/science.adt71852026-w45-p4/doi:10.1126/science.adt7185Peer-reviewed study. A peer-reviewed study published in Science describes FIND (Functional Interaction-based Nanoswitch Discovery), which combines DNA nanoswitch selection with next-generation sequencing to screen for compounds that induce or increase protein-protein interactions. The study reports discovering nanobodies that stabilize the interaction between angiotensin-converting enzyme 2 and the receptor-binding domain of severe acute respiratory syndrome coronavirus 2, and agonists of peroxisome proliferator-activated receptor gamma, and the authors say the method could lead to new therapeutics.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.64898/2026.11.04.263672872026-w45-p4/doi:10.64898/2026.11.04.26367287Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes data from 59,569 adults aged over 50 in 29 countries and reports that childhood poverty is associated with a 0.7-point lower score on CASP (control, autonomy, self-realisation and pleasure) after full adjustment. G. Tampubolon says the penalty appears in every country studied and remains after accounting for education, partnership and wealth.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.64898/2026.11.04.263673252026-w45-p4/doi:10.64898/2026.11.04.26367325Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies 308,600 adults in the All of Us Research Program and reports that waist-to-height ratio was associated with eight cardiometabolic outcomes beyond body mass index (BMI) classification. A. W. Potter and colleagues report that among adults with normal BMI, a higher ratio was linked to diabetes, myocardial infarction and ischemic stroke. As an observational study, it shows links, not causes.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.1038/s41586-026-11233-92026-w45-p4/doi:10.1038/s41586-026-11233-9Peer-reviewed study. A peer-reviewed study in Nature reports in vivo CRISPR base editing of ANGPTL3 for durable lipid lowering, according to its title. The published abstract given here only repeats that title, so this summary cannot say more; see the original.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-OR-N164021312026-w45-p4/OR-N16402131Proposed. The Oregon Higher Education Coordinating Commission has proposed updates to the Student Success and Completion Model, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. If adopted, the changes would be set out in Oregon Administrative Rules chapter 715.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-OR-N164021332026-w45-p4/OR-N16402133Proposed. The Office of Community Colleges and Workforce Development, part of the Oregon Higher Education Coordinating Commission, has proposed updates to community college funding distribution, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. The proposal would be set out in Oregon Administrative Rules chapter 589, and the rule covers how community college funding is distributed.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-arxiv:2611.057142026-w45-p4/arxiv:2611.05714Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines trade data for 31 digital product categories with digital services taxes and tariffs on physical analogues, and simulates alternative fiscal regimes. The authors say that tariff equivalents could raise more revenue than digital services taxes at a modest cost in trade, after the WTO moratorium on customs duties on electronic transmissions lapsed in March 2026.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-TX-TRD-2026045192026-w45-p4/TX-TRD-202604519Proposed. The Texas Education Agency (TEA) proposes a new section, 74.1035, to set up an applied sciences pathway program, under which eligible students could concurrently earn high school diplomas and certificates from institutions of higher education. It would implement House Bill (HB) 20 from the 89th Texas Legislature, Regular Session, 2025, and set out program approval, course substitution and student participation requirements.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-TX-TRD-2026045212026-w45-p4/TX-TRD-202604521Final rule. The Texas Education Agency (TEA) has issued a final rule on charter school operations, Division 7, which takes effect on November 15, 2026. The published text is only the division heading, so this summary cannot say more; see the original.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-OR-BLI-10-20262026-w45-p4/OR-BLI-10-2026Final rule. The Oregon Bureau of Labor and Industries has issued a final rule, published in the Oregon Bulletin on November 2, 2026, that amends Oregon Administrative Rules chapter 839 to update the Prevailing Wage Rate Determination. The abstract gives no effective date, and it does not say who is affected.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-OR-N164181232026-w45-p4/OR-N16418123Proposed. The Oregon Department of Human Services, Self-Sufficiency Programs, has proposed changes to signature requirements, eligibility, and annual federal adjustments, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. If adopted, the changes would be set out in Oregon Administrative Rules chapter 461.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-WA-26-21-0732026-w45-p4/WA-26-21-073Final rule. The Washington Department of Labor and Industries has adopted amendments to its electrical rules under chapter 296-46B WAC, effective November 20, 2026, and published on November 4, 2026. The changes affect requirements for installing electric vehicle supply equipment and the competency examinations for electricians and electrical administrators.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-WA-26-21-0742026-w45-p4/WA-26-21-074Proposed. The Washington Department of Labor and Industries proposes rules to implement SHB 2355, which creates new protections for domestic workers and new compliance requirements for entities that hire them. The rules would clarify and enforce the labor standards in that law, and comments are due by December 4, 2026.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-uksi-2026-11602026-w45-p4/uksi-2026-1160Final rule. The Seafarers (Wages and Working Conditions) Regulations 2026 are UK law, made on November 2, 2026, and they come into force on December 1, 2026. They cover wages and working conditions for seafarers, and are made under the Seafarers (Wages and Working Conditions) Act 2023.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-2026-226802026-w45-p4/2026-22680Final rule. The Labor Department (DOL) has issued a final rule, effective January 5, 2027, that removes the affirmative action requirements previously imposed on Registered Apprenticeship program sponsors. It also streamlines nondiscrimination obligations for all sponsors and says sponsors are accountable for compliance with federal and state nondiscrimination protections.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.26434/chemrxiv.15011549/v22026-w45-p4/doi:10.26434/chemrxiv.15011549/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports computer simulations suggesting that the bridge sites of rutile IrO2(110) reconstruct under anodic polarization into single-atom-like centers. Muhammad Usama, Stephan N. Steinmann and Kai S. Exner say these sites are more active for the oxygen evolution reaction (OER) than the sites usually assumed to be active, and that they remain durable.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-2026-225882026-w45-p4/2026-22588Proposed. The U.S. Environmental Protection Agency (EPA) proposes to approve California's state implementation plan (SIP) revisions for meeting the 2015 8-hour ozone standards in the San Joaquin Valley. It also proposes to approve statewide consumer products rules that the plan relies on, which limit volatile organic compounds (VOC) from deodorants, antiperspirants and aerosol coating products. Comments are due by December 7, 2026.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-WA-26-21-0582026-w45-p4/WA-26-21-058In effect. A temporary rule from the Washington Department of Fish and Wildlife covers repealing the current emergency wildlife rules for wildfire in Benton, Franklin, Kittitas, Yakima, Adams, Chelan, Douglas, Grant and Okanogan counties. The filing says the repeal is needed because the recent increase in precipitation in Eastern Washington has significantly decreased the threat of wildfires, and the rule is in effect from October 16, 2026.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-uksi-2026-11582026-w45-p4/uksi-2026-1158Final rule. These UK regulations were made on November 3, 2026, and they bring specified provisions of the Crime and Policing Act 2026 into force. They are the fifth commencement regulations made under that Act, and the abstract does not give the date on which the provisions start.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-uksi-2026-11502026-w45-p4/uksi-2026-1150Final rule. The Export Control (Amendment) Regulations 2026 are UK law, made on October 29, 2026, and they come into force on December 1, 2026. They amend the Export Control Order 2008 and the assimilated Dual-Use Regulation, Council Regulation (EC) No 428/2009, which control the export, transfer, brokering and transit of dual-use items.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-arxiv:2610.414472026-w45-p4/arxiv:2610.41447Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses an 81-region model of the global hydrogen market to show that delivered-cost estimates can understate the market price of hydrogen imports. The 2045 price-cost gap averages 63 EUR/MWh on a demand-weighted basis, and the authors say hydrogen strategies should distinguish delivered-cost benchmarks from market-price expectations.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-doi:10.26434/chemrxiv.15011566/v12026-w45-p4/doi:10.26434/chemrxiv.15011566/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, compares warm isostatic pressing with cold uniaxial pressing for the cathodes of all-solid-state lithium batteries. Siwar Ben Hadj Ali and colleagues report, from a combined experimental and computer-modelling study, that the warm-pressed cathode was denser and kept higher accessible capacity at C/2, with the two methods behaving similarly at C/10.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-arxiv:2611.002592026-w45-p4/arxiv:2611.00259Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, argues with theory and experiments that iterative training on generated data does not necessarily cause model collapse, the degradation seen in earlier work. It says consistency holds for any fixed share of real data above zero, and even for a share that shrinks over iterations, though more real data or curation still matters at practical finite times.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-arxiv:2611.015552026-w45-p4/arxiv:2611.01555Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, presents a mathematical model of a vaccine-preventable infectious disease spreading between residents and travellers across linked areas. Using a numerical example based on the 2003-2004 poliomyelitis resurgence in western and central Africa, it shows how heterogeneous vaccine coverage can sustain widespread regional transmission that classic metapopulation models predict to be much smaller.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-arxiv:2611.030722026-w45-p4/arxiv:2611.03072Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, compares 8,805 notes and 4,367 contributors on X's Community Notes before and after the platform replaced simple majority voting with an algorithm that rewards agreement across ideological viewpoints. The authors report that measured ideological polarization fell, although negative interactions increased, and that contributors became less structurally aligned along partisan lines.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-mit-research:a18234610a072026-w45-p4/mit-research:a18234610a07Announcement. MIT News reports that an MIT-led team has been awarded up to $38 million from ARPA-H to develop a low-power, noninvasive sensor patch that measures heart failure and sepsis biomarkers in real time. The announcement is the institution's own account, and the team aims to create the sensor rather than having shown that it works.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-OR-OMB-15-20262026-w45-p4/OR-OMB-15-2026Final rule. The Oregon Medical Board has issued a final rule, published in the Oregon Bulletin on November 2, 2026, to implement the 2025 bill SB 476 and establish provisional licenses for internationally trained physicians. It is set out in Oregon Administrative Rules chapter 847, and the abstract gives no date from which it applies.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-WA-26-21-1022026-w45-p4/WA-26-21-102Proposed. The Washington Department of Licensing proposes amending chapter 308-108 WAC, which covers driver training schools, to carry out provisions of ESHB 1878 on young driver safety, passed in the 2025 legislative session. Comments are due by November 24, 2026.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p4/#item-CA-Z2026-1022-012026-w45-p4/CA-Z2026-1022-01Proposed. The California Office of the State Fire Marshal (OSFM) proposes amending section 2201 of Title 19 of the California Code of Regulations (CCR) to adopt updated Fire Hazard Severity Zones in the State Responsibility Area (SRA), by updating the map that the section incorporates by reference. Building code requirements will depend on the hazard zone in which a building is located, and comments are due by January 8, 2027.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-DMAP-45-20262026-w45-p3/OR-DMAP-45-2026Final rule. The Oregon Health Authority, through its Medical Assistance Programs, has filed a temporary rule to adopt a new High-Cost Drug Carve-Out List. It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 410. The abstract does not give a start date or say which drugs are on the list.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-DMAP-46-20262026-w45-p3/OR-DMAP-46-2026Final rule. The Oregon Health Authority has filed a final rule that clarifies its health-related social needs (HRSN) rules and adds requirements for the Nutrition and Housing benefits. It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 410. The abstract does not give an effective date or say who must meet the new requirements.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-DMAP-50-20262026-w45-p3/OR-DMAP-50-2026Final rule. The Oregon Health Authority has filed a final rule amending the outpatient and inpatient assessment rates for diagnosis-related group (DRG) hospitals. It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 410. The abstract does not give the new rates or a start date.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-N163823892026-w45-p3/OR-N16382389Proposed. The Oregon Board of Pharmacy has proposed a rule on pharmacy prescription lockers, in a notice of proposed rulemaking published in the Oregon Bulletin on November 2, 2026. The proposal falls under Oregon Administrative Rules chapter 855, and the abstract does not say what it would require.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-N164204052026-w45-p3/OR-N16420405Proposed. The Oregon Health Authority, through its Public Health Division, has proposed a process and form for a nonopioid directive, implementing House Bill 3211 (2025). The notice was published in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 333. The abstract does not explain what a nonopioid directive is or who would use it.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-N164226332026-w45-p3/OR-N16422633Proposed. The Oregon Health Authority, through its Medical Assistance Programs, has proposed updating and clarifying its rule on disenrollment from Coordinated Care Organizations, reflecting a comprehensive review. The proposal was published in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 410. The abstract does not say what would change for members or the organizations.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-PH-32-20262026-w45-p3/OR-PH-32-2026Final rule. The Oregon Health Authority, through its Public Health Division, has filed a final rule adopting the revised dust-lead standards of the U.S. Environmental Protection Agency by reference. It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 333. The abstract does not say what the standards require or give a start date.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.64898/2026.10.31.263669782026-w45-p3/doi:10.64898/2026.10.31.26366978Preprint, not peer-reviewed. A preprint by A. Vannacci and colleagues, not yet peer-reviewed, compares how often general-purpose language models recommended seeing a professional. The authors analyzed 4,346 responses from 53 model configurations to 82 investigator-written messages, and report referral in 74.7% of health and 46.3% of non-health responses. Where raters judged contact unnecessary, 64.5% of health responses still recommended a professional, against 27.6% outside health.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.64898/2026.11.01.7631372026-w45-p3/doi:10.64898/2026.11.01.763137Preprint, not peer-reviewed. A preprint by Z. Zhao and colleagues, not yet peer-reviewed, examines how Langya virus enters cells. The authors describe it as a zoonotic parahenipavirus that causes acute febrile illness in people. They report that endothelial protein C receptor (EPCR) acts as an entry receptor for Langya and two related viruses, and that natural variation in the receptor predicts receptor compatibility across 26 animal species.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-2026-223802026-w45-p3/2026-22380Final rule. The Health and Human Services Department (HHS) has issued a final rule, effective January 4, 2027, revising its regulation under section 504 of the Rehabilitation Act of 1973 on disability for recipients of HHS funding. The rule clarifies that HHS reads the statutory exclusion of “gender identity disorders not resulting from physical impairments” as covering “gender dysphoria not resulting from a physical impairment” for the regulation. It was published on November 3, 2026.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.1073/pnas.26179061232026-w45-p3/doi:10.1073/pnas.2617906123Peer-reviewed study. A peer-reviewed study in PNAS, led by Paolo S. Turano, reports that senescent CD8 T effector memory cells, a type of immune cell, are less able to proliferate, make cytokines and clear senescent cells in human samples. The authors also report that these cells are more common in older people, in patients with age-related disorders and cancer, and in smokers, and that they can limit the response to immune checkpoint blockade, a form of immunotherapy.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.64898/2026.10.29.7627962026-w45-p3/doi:10.64898/2026.10.29.762796Preprint, not peer-reviewed. A preprint by A. W. Simonson and colleagues, not yet peer-reviewed, describes a study in non-human primates. It reports that depleting CD8 cells before a second Mycobacterium tuberculosis exposure left the animals unable to limit spread of the infection, with lymph node involvement, unlike depleting CD4 cells.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.64898/2026.11.02.263671352026-w45-p3/doi:10.64898/2026.11.02.26367135Preprint, not peer-reviewed. A preprint by A. D. Gibson and colleagues, not yet peer-reviewed, is an observational meta-research study, meaning a study of published studies, which shows patterns and links rather than causes. The authors examined 2,001 clinical prediction model articles from 2025 in high-ranking journals, and found a striking excess of area under the receiver operating characteristic curve (AUC) values near perfect and at multiples of five and ten. They say this indicates likely manipulated data, methods or publication bias.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-WA-26-21-0402026-w45-p3/WA-26-21-040Final rule. The Washington Department of Health has adopted a final rule updating the osteopathic physician and surgeon fees in Washington Administrative Code (WAC) 246-853-990. The rule is effective March 2, 2027.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.1038/s41586-026-11212-02026-w45-p3/doi:10.1038/s41586-026-11212-0Peer-reviewed study. A peer-reviewed study in Nature uses a high-throughput CRISPR-interference platform to map interactions between essential genes in Mycobacterium tuberculosis. The abstract says it reveals many previously unknown genetic interactions and gives insight into gene function and drug–target relationships that could enable new tuberculosis therapies.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.64898/2026.11.03.7640122026-w45-p3/doi:10.64898/2026.11.03.764012Preprint, not peer-reviewed. A preprint by M. J. Granoski and colleagues, not yet peer-reviewed, studies mice and human bronchial epithelial cells. The authors report that Toll-like Receptor-7 (TLR7) helps respiratory syncytial virus (RSV) and influenza replicate in these cells, and that blocking TLR7 or its downstream signaling reduced replication in experiments. They also report higher viral loads in females than in males in mouse and human studies.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.64898/2026.11.04.7639812026-w45-p3/doi:10.64898/2026.11.04.763981Preprint, not peer-reviewed. A preprint by C. K. Mickelson and colleagues, not yet peer-reviewed, builds a library of primary fibroblast cells from 86 mammal species to compare how arboviruses, which infect diverse mammals including humans, replicate in each. The authors report that some barriers to replication are set by the immune system and others by incompatibilities with host factors, and they describe conserved and species-specific antiviral responses.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-ODE-50-20262026-w45-p3/OR-ODE-50-2026Final rule. The Oregon Department of Education has filed a final rule revising Division 22 rules to strengthen requirements for high-quality instructional materials (HQIM). It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 581. The abstract does not give a start date or say which schools or materials are covered.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-ODE-51-20262026-w45-p3/OR-ODE-51-2026Final rule. The Oregon Department of Education has filed a final rule implementing House Bill 4154 (2026) on periodic attendance. It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 581. The abstract does not give a start date or say what the attendance rule requires.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-arxiv:2611.022652026-w45-p3/arxiv:2611.02265Preprint, not peer-reviewed. A preprint, not yet peer-reviewed, models peer review to study how generative AI, by making research cheaper to produce, could weaken scientific verification. The authors find that beyond a technological threshold, reviewer capacity and verified knowledge weakly decline, even under optimal editorial decisions.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-arxiv:2611.084302026-w45-p3/arxiv:2611.08430Preprint, not peer-reviewed. A preprint, not yet peer-reviewed, in which the author estimates how cross-border ownership shapes the lithium supply chain, using global data on mines and refineries. It examines divesting Chinese stakes in overseas producers and banning ore exports to China. It reports that divestiture increased spot ore supply but left lithium output nearly unchanged, while the export ban reduces global lithium supply.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-N164191562026-w45-p3/OR-N16419156Proposed. The Oregon Department of Human Services, through its Self-Sufficiency Programs, has proposed changes to hardship waivers, medical eligibility, payment calculations and annual federal adjustments. The proposal was published in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 461. The abstract does not say who would be affected or what would change for them.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-SSP-38-20262026-w45-p3/OR-SSP-38-2026Final rule. The Oregon Department of Human Services, through its Self-Sufficiency Programs, has filed a temporary rule on annual federal cost of living adjustments. It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 461. The abstract does not say which programs or payments the adjustments change.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-WCD-6-20262026-w45-p3/OR-WCD-6-2026Final rule. The Oregon Department of Consumer and Business Services, through its Workers' Compensation Division, has filed a final rule implementing House Bill 2800 (2025). It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 436. The abstract does not give a start date or say what the bill changes.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.1126/science.aej17652026-w45-p3/doi:10.1126/science.aej1765Peer-reviewed study. A peer-reviewed study in Science introduces BlueDown, a postprocessing method that reduces errors in 2020 Census data, which was built with differential privacy, a method that adds calibrated noise to protect individual confidentiality. The authors report error reductions of 21 to 36% for county-level groupings by race and 38 to 61% for tract-level groupings by housing type, at no cost to confidentiality or computational efficiency.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-N164230062026-w45-p3/OR-N16423006Proposed. The Oregon Land Conservation and Development Department has proposed a rule titled “Housing in Unincorporated Areas”, published as a notice of proposed rulemaking in the Oregon Bulletin on November 2, 2026. It falls under Oregon Administrative Rules chapter 660. The abstract does not say what the rule would require or who it would cover.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.1073/pnas.26168331232026-w45-p3/doi:10.1073/pnas.2616833123Peer-reviewed study. A peer-reviewed study in PNAS, led by Xingrui Cai, identifies municipal sludge disposal as a major source of atmospheric mercury, estimating it emitted about 42 megagrams (Mg) in China in 2024. The authors say that is more than 10% of national anthropogenic emissions, ranking third after cement production and nonferrous metal smelting. They report these emissions have risen nearly a thousandfold since the 1970s, concentrated in dense urban areas.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-uksi-2026-11642026-w45-p3/uksi-2026-1164Final rule. This is UK law: the Strategic Planning (Consequential and Miscellaneous Amendments) Regulations 2026, made on November 4, 2026. The regulations revoke and amend secondary legislation relating to strategic planning and come into force on November 26, 2026.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-OR-DOA-114-20262026-w45-p3/OR-DOA-114-2026Final rule. The Oregon Department of Agriculture has filed a final rule adopting the 2025 revision of the Grade A Pasteurized Milk Ordinance (PMO). It was filed in the Oregon Bulletin on November 2, 2026, under Oregon Administrative Rules chapter 603. The abstract does not give a start date.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.26434/chemrxiv.15011180/v42026-w45-p3/doi:10.26434/chemrxiv.15011180/v4Preprint, not peer-reviewed. A preprint by William Brandler, not yet peer-reviewed, argues that the LINE-1 retrotransposon, a virus-like genomic element, could be inhibited to address diseases such as cancer and autoimmunity. It suggests reverse transcriptase inhibitors, originally developed for HIV, might be used for this, though novel inhibitors may be needed. It cites preclinical studies showing that LINE-1 inhibitors slowed the progression of otherwise unrelated diseases.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.26434/chemrxiv.15011516/v12026-w45-p3/doi:10.26434/chemrxiv.15011516/v1Preprint, not peer-reviewed. A preprint by Arghya Patra and colleagues, not yet peer-reviewed, studies how the lithium content of textured LiCoO2 battery electrodes affects ion movement and degradation. The authors report that electrodes with too little or too much lithium degrade in different ways, while balanced lithium content gave both good ion transport and structural stability.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.26434/chemrxiv.15011560/v12026-w45-p3/doi:10.26434/chemrxiv.15011560/v1Preprint, not peer-reviewed. A preprint led by Kyra M. K. Yap, not yet peer-reviewed, measures how lithium ions move through poly(ethylene oxide) (PEO) and poly(pentyl malonate) (PPM) electrolytes. The authors report that lithium ions hop between polymer chains much more often in PPM than in PEO, and say this improves lithium transport.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-arxiv:2611.004622026-w45-p3/arxiv:2611.00462Preprint, not peer-reviewed. A preprint, not yet peer-reviewed, uses a national energy systems model across 16 U.S. regions to study how much new large electricity loads, such as data centers, could connect to the grid if they cut consumption at high-stress times. It estimates that 50 gigawatts (GW) could be served while curtailing less than 0.1% of annual energy, but that most regions would need curtailment deeper than 90% in at least one hour.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-arxiv:2611.013122026-w45-p3/arxiv:2611.01312Preprint, not peer-reviewed. A preprint, not yet peer-reviewed, argues that medical AI models should not report only their most likely label, because that can understate a patient's risk. In a hypothetical chest-pain example, the authors say reporting only the benign leading diagnosis greatly understates the risk of death or cardiac arrest. They propose guardrails for developers, regulatory reviewers and health insurers.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.1073/pnas.26254741232026-w45-p3/doi:10.1073/pnas.2625474123Peer-reviewed study. A peer-reviewed study in PNAS, led by James P. Ziliak, compares income inequality in 17 North American and European countries from 1995 to 2021. The authors find strong convergence in disposable income inequality, while redistribution through taxes and transfers has become more similar across countries and lower on average. As a result, average disposable income inequality is higher.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-arxiv:2611.036632026-w45-p3/arxiv:2611.03663Preprint, not peer-reviewed. A preprint, not yet peer-reviewed, develops a Bayesian statistical method to estimate age-specific COVID-19 transmission in near real time. Applied to surveillance data from Ireland during the Omicron dominant period, the authors report that older adults had higher susceptibility, while younger and working-age groups contributed more to transmission because of higher contact rates.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p3/#item-doi:10.1038/s41586-026-11336-32026-w45-p3/doi:10.1038/s41586-026-11336-3Peer-reviewed study. A peer-reviewed study in Nature on opportunistically detecting signs of hypertension from a consumer smartwatch. The abstract provided is only the title, so it does not say how well the approach works.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-DMAP-42-20262026-w45-p2/OR-DMAP-42-2026Final rule. The Oregon Health Authority's Health Systems Division, Medical Assistance Programs, has issued a final rule adopting a new High-Cost Drug Carve-Out List under Oregon Administrative Rules chapter 410. The rule was filed in the Oregon Bulletin on November 2, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-DMAP-47-20262026-w45-p2/OR-DMAP-47-2026Final rule. This document is technical; see the original.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-N163824732026-w45-p2/OR-N16382473Proposed. The Oregon Board of Pharmacy has proposed a rule under which Pharmacy Technicians may administer an influenza vaccine to people six months of age or older. It was published in the Oregon Bulletin on November 2, 2026, and it is a proposal, so it would take effect only if adopted.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-N164152292026-w45-p2/OR-N16415229Proposed. The Oregon Health Authority's Health Systems Division, Medical Assistance Programs, has proposed amending a rule to include nondiscrimination language from SB 729 (2025). The proposal was published in the Oregon Bulletin on November 2, 2026, and would take effect only if adopted.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-N164176772026-w45-p2/OR-N16417677Proposed. The Oregon Health Authority's Health Systems Division, Medical Assistance Programs, has proposed Work or Activity Rules for the Medicaid Expansion and 1115 waiver program population, in Oregon Administrative Rules chapter 410. The proposal was published in the Oregon Bulletin on November 2, 2026, and would take effect only if adopted.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-N164209082026-w45-p2/OR-N16420908Proposed. The Oregon Health Authority's Health Systems Division, Medical Assistance Programs, has proposed revisions under its Benefit Update Project (BUP), including improved clarity and reimbursement changes. The proposal was published in the Oregon Bulletin on November 2, 2026, and would take effect only if adopted.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-N164230112026-w45-p2/OR-N16423011Proposed. The Oregon Health Authority's Public Health Division has proposed rules to implement the Toxic Free Cosmetics Program under SB 546 (2023). The proposal was published in the Oregon Bulletin on November 2, 2026, and would take effect only if adopted.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1016/j.cell.2026.10.0142026-w45-p2/doi:10.1016/j.cell.2026.10.014Peer-reviewed study. A peer-reviewed study in Cell analyzes genomes of gut bacteria from globally diverse sources. It reports that gut bacteria evolved convergent genome changes across an industrialization gradient, and that industrialization is linked to more gene acquisition and larger genomes. The study shows a link, not a cause.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.64898/2026.10.28.7625022026-w45-p2/doi:10.64898/2026.10.28.762502Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports an experimental mRNA vaccine encoding the CagW protein of Helicobacter pylori, a bacterium the abstract says the World Health Organization classifies as a group I carcinogen. In mice, the authors report that vaccinated animals carried markedly fewer gastric bacteria after challenge than controls, and they say the platform warrants further preclinical development.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.64898/2026.10.30.7632082026-w45-p2/doi:10.64898/2026.10.30.763208Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that memory T cells passed from mothers protected offspring from a lethal respiratory viral infection, independently of maternal antibodies. The authors say maternal vaccination gave similar protection.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.64898/2026.10.30.7632332026-w45-p2/doi:10.64898/2026.10.30.763233Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports germ granule-like structures in rat spermatozoa that show prion-like propagation in lab tests. The authors propose that such structures could pass environmentally caused information to offspring; this is a proposal, not a demonstrated finding.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.64898/2026.11.01.7634002026-w45-p2/doi:10.64898/2026.11.01.763400Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models aging across 10 organelles using proteins from plasma and cerebrospinal fluid of 61,931 people. The authors report that people with four or more prematurely aged compartments had up to 22-fold higher kidney disease risk and up to 8-fold higher mortality risk.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-WA-26-21-0802026-w45-p2/WA-26-21-080Proposed. The Washington Health Care Authority has proposed new rules for contingency management services in chapter 182-567. The program would complement other substance use disorder treatment by giving eligible clients motivational incentives, and the comment deadline is November 24, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.64898/2026.11.02.263671182026-w45-p2/doi:10.64898/2026.11.02.26367118Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, presents the Global Atlas of Immune Alleles (GAIA), built from whole-genome sequencing data from 20,248 people. The authors report that Human Leukocyte Antigen (HLA) variants occur at different frequencies across groups, and that reaching 90% HLA-B coverage for vaccine design needs up to 2.7 times more alleles in underrepresented groups.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1371/journal.pmed.10047722026-w45-p2/doi:10.1371/journal.pmed.1004772Peer-reviewed study. A peer-reviewed study in PLOS Medicine is a model-based economic evaluation of COVID-19 vaccines in the first year of the vaccination programme. Vaccine development and delivery cost $79.4 billion, and the authors estimate a return of $59.7 to $809 per dollar invested in the base case.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.64898/2026.11.04.7638202026-w45-p2/doi:10.64898/2026.11.04.763820Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies immune cells in people 4-6 days after symptoms began with acute SARS-CoV-2 infection. The authors report that faster clearance of infectious virus was associated with stronger activation of certain T and B cells in unvaccinated people.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.64898/2026.11.05.263672132026-w45-p2/doi:10.64898/2026.11.05.26367213Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes SARS-CoV-2 transmission across 126 countries to isolate the effect of public health and social measures (PHSMs). The authors report that these measures often explained a substantial share of transmission variation, with reductions of 60-80% or more in countries with strong evidence.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-uksi-2026-11682026-w45-p2/uksi-2026-1168Final rule. This is UK law, made on November 4, 2026, under the Births and Deaths Registration Act 1953, and it comes into force on November 9, 2026. It sets specified requirements that, if complied with, count as signing the register in person for births, deaths and still-births in England and Wales.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-2026-227392026-w45-p2/2026-22739Final rule. The Centers for Medicare & Medicaid Services (CMS) has issued a final rule that updates Medicare payments under the Hospital Outpatient Prospective Payment System (OPPS) and the Ambulatory Surgical Center payment system for calendar year 2027, effective January 1, 2027. It expands prior authorization to additional Botulinum Toxin Injection services and implements certain Consolidated Appropriations Act, 2026 provisions for off-campus outpatient departments.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-ODE-49-20262026-w45-p2/OR-ODE-49-2026Final rule. The Oregon Department of Education has issued a final rule implementing Executive Order 26-06, Preserving Instructional Time, and SB 1596 (2026), with a focus on Play-Based Learning. The rule was filed in the Oregon Bulletin on November 2, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-arxiv:2611.066292026-w45-p2/arxiv:2611.06629Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies whether early access to Claude Mythos Preview, a model for finding software vulnerabilities, affected cyber defense at a group of large US tech firms. The author reports that those firms disclosed more high-impact vulnerabilities, while the share of flaws exploited within a month of disclosure fell.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-N164062732026-w45-p2/OR-N16406273Proposed. The Oregon Department of Consumer and Business Services, Insurance Regulation, has proposed repealing a rule on Primary Care Provider Assignment in Oregon Administrative Rules chapter 836. It was published in the Oregon Bulletin on November 2, 2026, and the repeal would apply only if adopted.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-N164196062026-w45-p2/OR-N16419606Proposed. The Oregon Employment Department has proposed amending and adopting administrative rules for Paid Leave Oregon, in Oregon Administrative Rules chapter 471. The proposal was published in the Oregon Bulletin on November 2, 2026, and would take effect only if adopted.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-OR-N164193902026-w45-p2/OR-N16419390Proposed. The Oregon Land Conservation and Development Department has proposed updates to its Transportation Planning Rules, in Oregon Administrative Rules chapter 660. The proposal was published in the Oregon Bulletin on November 2, 2026, and would take effect only if adopted.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1073/pnas.26154091232026-w45-p2/doi:10.1073/pnas.2615409123Peer-reviewed study. A peer-reviewed study in PNAS compares children's ambient heat exposure in China between 1989 to 1991 and 2019 to 2021, covering 250 million children. It finds that children's average annual exposure to moderate or stronger heat increased, and that both rising temperatures and shifts in where children live contributed. The first author is Kai Feng.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.26434/chemrxiv.15011549/v12026-w45-p2/doi:10.26434/chemrxiv.15011549/v1Preprint, not peer-reviewed. This document is technical; see the original.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.64898/2026.10.30.7629152026-w45-p2/doi:10.64898/2026.10.30.762915Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies 121 people across four cohorts after broad-spectrum antibiotics. The authors report that under the mildest course, the recovered gut community was closer to each person's own pre-treatment mix than to others' in more than 90% of people.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1126/science.adu95932026-w45-p2/doi:10.1126/science.adu9593Peer-reviewed study. A peer-reviewed study in Science is a meta-analysis of 214 experimental studies on 177 aquatic and terrestrial species. It finds that noise altered at least one physiological, developmental, or behavioral trait in 80% of species, with declines in fitness and abundance and disruptions of predator-prey interactions.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-2026-224502026-w45-p2/2026-22450Proposed. The Federal Aviation Administration (FAA) has issued a supplemental proposal to update its Passenger Facility Charge (PFC) regulations to reflect the FAA Reauthorization Act of 2024. It would reduce PFC turnback, add two new PFC-eligible projects, restrict eligible projects, and change review and submittal requirements.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-2026-226792026-w45-p2/2026-22679Final rule. The Food and Nutrition Administration (FNA) has issued a final rule, effective December 7, 2026, that changes the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). It allows online ordering and internet-based transactions and streamlines food delivery rules as the program completes its transition to electronic benefit transfer (EBT).Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-2026-227352026-w45-p2/2026-22735Final rule. U.S. Customs and Border Protection (CBP) has issued a final rule, effective January 5, 2027, that sets new requirements for foreign importers of record when making entry. It also sets out responsibilities for licensed customs brokers with regard to their clients, and consequences for foreign importers and brokers who fail to comply.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1002/9781394326303.ch182026-w45-p2/doi:10.1002/9781394326303.ch18Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a modelling study of how group structures across network layers affect the spread of disease. It reports that correlated group structures can make outbreaks longer but milder, and that immunizing central nodes reduces outbreak size faster than in uncorrelated networks.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1038/s41586-026-11226-82026-w45-p2/doi:10.1038/s41586-026-11226-8Peer-reviewed study. A peer-reviewed study in Nature reports that engineered molecular conjugation lets self-assembled molecules form highly ordered layers. The authors use these layers to make higher-performance perovskite/silicon tandem solar cells.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1073/pnas.26222601232026-w45-p2/doi:10.1073/pnas.2622260123Peer-reviewed study. A peer-reviewed study in PNAS analyzes 20 waves of a national survey in the US conducted during the COVID-19 pandemic. It finds that institutional trust, especially trust in the US Centers for Disease Control and Prevention (CDC), was a strong predictor of protective behaviors such as mask wearing, more than age, income, education, and partisan affiliation combined. It is a survey study, which shows an association, not a cause.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1126/science.aeh70742026-w45-p2/doi:10.1126/science.aeh7074Peer-reviewed study. A peer-reviewed study in Science describes a stamping and stacking method for making porous nitinol (NiTi) structures for Elastocaloric cooling, a method that uses shape memory alloys. The authors say the structures withstand many compression cycles and that the method cuts fabrication costs by one order of magnitude.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-doi:10.1073/pnas.25368201232026-w45-p2/doi:10.1073/pnas.2536820123Peer-reviewed study. A peer-reviewed study in PNAS describes Beth-2, a computational framework that predicts key SARS-CoV-2 mutations from within-host deep sequencing data. The authors report that 98.6% of key receptor binding domain mutations were detected in retrospective validation, a median of 9 months before they became predominant.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-WA-26-21-0342026-w45-p2/WA-26-21-034Final rule. The Washington Superintendent of Public Instruction (OSPI) has issued a final rule that will take effect November 14, 2026, amending rules for special education services. Changes include the age of eligibility under SSB 5253 (2025), how students placed in private or educational service district settings are administered, and state special education safety net funding.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45-p2/#item-WA-26-21-0482026-w45-p2/WA-26-21-048In effect. The Washington Superintendent of Public Instruction (OSPI) has adopted temporary rules, in effect since October 16, 2026, that let local education agencies charge sliding scale fees for the transition to kindergarten (TK) program. The rules also set how state funding is allocated for TK programs in the 2026-27 school year.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-OR-DMAP-44-20262026-w45/OR-DMAP-44-2026Final rule. The Oregon Health Authority has filed a temporary rule in the Oregon Bulletin that amends the prior authorization (PA) criteria and the preferred drug list (PDL) under Oregon Administrative Rules chapter 410. The change implements recommendations from a drug utilization review and pharmacy and therapeutics (DUR/P&T) action. The filing does not describe the specific changes.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-OR-DMAP-49-20262026-w45/OR-DMAP-49-2026Final rule. The Oregon Health Authority has filed a permanent rule in the Oregon Bulletin on Oregon's transition from using the Federally Facilitated Marketplace to a State-Based Marketplace, under Oregon Administrative Rules chapter 410. The filing describes only the subject and does not give a start date.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-OR-N163823862026-w45/OR-N16382386Proposed. The Oregon Board of Pharmacy has proposed rules on prescribing pursuant to protocol, covering COVID-19, influenza and respiratory syncytial virus (RSV) vaccine protocols and standard vaccination protocols. The notice appears in the Oregon Bulletin under Oregon Administrative Rules chapter 855. If adopted, the rules would govern prescribing under these protocols.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-OR-N164214822026-w45/OR-N16421482Proposed. The Oregon Health Authority has proposed amendments to its preferred drug list (PDL) and prior authorization (PA) criteria, implementing recommendations from a drug utilization review and pharmacy and therapeutics (DUR/P&T) action. The notice is under Oregon Administrative Rules chapter 410 and does not describe the specific changes.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.1016/j.cell.2026.10.0162026-w45/doi:10.1016/j.cell.2026.10.016Peer-reviewed study. A peer-reviewed study in the journal Cell combined microbiome and host data from populations around the world. The authors report that industrialization restructures gut microbial ecosystems, reducing microbial diversity, and alters intestinal immune and physiological responses. They also found that microbiome-based disease predictors had limited portability across populations.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.1371/journal.pmed.10049922026-w45/doi:10.1371/journal.pmed.1004992Peer-reviewed study. A peer-reviewed modeling study in PLOS Medicine, led by Nir Gavish, compared pandemic influenza antiviral stockpiles with hospital capacity in the United Kingdom, Japan and the United States. The authors report that stockpiles kept demand manageable in moderate scenarios, but in high-severity scenarios the daily surge of patients exceeded available hospital capacity by a factor of 5–9, even with perfect distribution of antivirals. They say their optimistic assumptions make the structural failures a lower-bound estimate, and they argue for a capacity-based approach to planning.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.64898/2026.10.28.7604162026-w45/doi:10.64898/2026.10.28.760416Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, led by J. Finney uses in vitro immunoassays and structural imaging to study a class of broadly protective human antibodies that binds a conserved site on influenza hemagglutinin. The authors report that recognition depends on specific germline gene variants of the antibody gene IGHV1-2, and that most people carry the necessary variants. They conclude that an immunogen displaying this site might reliably elicit broadly protective influenza antibodies in most humans.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.64898/2026.11.02.263671012026-w45/doi:10.64898/2026.11.02.26367101Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, led by K. V. Parag argues that public health interventions reshape generation times, the intervals between successive infections, for directly transmitted diseases. The authors say that ignoring this can under- or over-estimate intervention effectiveness by as much as 100% under realistic settings. They argue this bias can limit model-driven public health policy and pandemic preparedness.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.64898/2026.11.03.7638422026-w45/doi:10.64898/2026.11.03.763842Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, led by S. Hen-Avivi examined how clinically used antibiotics affect the activation of primary human immune cells. The authors report that ciprofloxacin impaired the expansion and activation of human T-cells and changed mitochondrial function, and that immune activation changed in mice after a single antibiotic dose. They conclude that antibiotics can directly affect host immunity.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-WA-26-21-0702026-w45/WA-26-21-070Proposed. The Washington Department of Health proposes to update chapter 246-453 WAC to align hospital charity care rules with chapter 70.170 RCW, which changed after legislation in 2018 and 2022. The stated goal is to set uniform standards for charity care procedures and processes. The proposal would give more flexibility on when a responsible party can apply, raise income thresholds for eligibility, remove the sliding fee schedule of discounts, and allow assets to be considered when reducing a discount.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.64898/2026.11.02.263670992026-w45/doi:10.64898/2026.11.02.26367099Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, led by E. Gustani-Buss analyzes genetic data on respiratory syncytial virus (RSV) before and after the COVID-19 pandemic. The authors report new RSV-A genotypes and an expanded RSV-B genotype after the pandemic, and say air-travel volume was the strongest predictor of global spread. They also report positive selection at 20 sites in key viral proteins.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.64898/2026.11.03.263672172026-w45/doi:10.64898/2026.11.03.26367217Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, led by P. Gangwar describes VaccineScout, a computational framework that recommends SARS-CoV-2 vaccine candidates by minimizing spike amino acid distances to forecast variant prevalence. The authors report that over half of spike sequences seen in the six months after vaccine selection were already circulating at the time, compared with 5–10% later. In retrospective analyses, its recommendations either matched U.S. Food and Drug Administration (FDA) recommendations or had lower spike distances to future variants.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-nber:8044c4c645f72026-w45/nber:8044c4c645f7Preprint, not peer-reviewed. A preprint from NBER, not yet peer-reviewed, argues that post-Covid inflation in the United States and the Euro Area was driven mainly by unexpectedly strong demand rather than supply shocks. The paper says that demand reflected pent-up demand after pandemic restrictions, stronger-than-expected expansionary fiscal policy and an unusually accommodative monetary stance. These forces cushioned the recessionary effects of supply shocks, at the cost of higher inflation.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-nber:ef2f3be6bcc32026-w45/nber:ef2f3be6bcc3Preprint, not peer-reviewed. A preprint from NBER, not yet peer-reviewed, argues that globalisation's frontier has moved from manufacturing to services trade, which it calls the Global Office. It reports that all of the world's export-linked net job creation from 2008 to 2022 occurred in digitally delivered services rather than manufacturing. The paper also finds that each hour of time-zone separation reduces Office exports by roughly 4%.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-nber:fdd5bdcdef1a2026-w45/nber:fdd5bdcdef1aPreprint, not peer-reviewed. A preprint from NBER, not yet peer-reviewed, argues that in a standard task model of automation, the amount of capital accumulated sets the size of the growth boom, while the task structure sets how long it lasts. The paper says the same technology produces 11.7% annual growth with optimal household saving but only 2.2% when the saving rate is fixed at 23%, so slow growth may reflect too little capital accumulation. It also says the ten-year real yield would jump from 5.1% to 13.6% on impact.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-uksi-2026-11522026-w45/uksi-2026-1152Final rule. The Data-gathering (Ongoing Data: Interest and Payment Card Transactions) Regulations 2026 are UK law, made on November 2, 2026. They require persons of specified descriptions to provide specified data to His Majesty’s Revenue and Customs (HMRC) on an ongoing basis. The regulations come into force on March 1, 2028.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-WA-26-21-0762026-w45/WA-26-21-076Proposed. The Washington Office of the Insurance Commissioner (OIC) proposes rules to implement E2SHB 1432 (2025), which improves access to appropriate mental health and substance use disorder services. The proposal would create new sections and update existing chapters of health care and insurance rules so they match the law. The rules are intended to help affected entities understand their rights and obligations.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-arxiv:2611.042662026-w45/arxiv:2611.04266Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists, argues that frontier AI labs race because each gains from arriving first but bears only part of the catastrophe hazard its speed adds. In an illustrative model, three racing labs get through the takeoff period in 18 months, compared with 69 months under a common rule on research shares. The paper says the White House Accord on Super Intelligence, which audits safety but sets no limit on speed, would not slow the race in the model.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-arxiv:2611.042722026-w45/arxiv:2611.04272Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists, asks what an agreement to pause frontier AI would need. The paper argues that as compute grows during a pause, a secret advance reaches the frozen frontier sooner, which shrinks the response window. In its example, cooperation is supportable through month 18.9, extended to month 25.5 with verified matched safety research and to month 31.8 with half the monitoring cost.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-arxiv:2611.054172026-w45/arxiv:2611.05417Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists, models how advances in AI could change organizations, the key unit of economic production. The paper says that when AI is more capable than the average human, organizations of complementary humans can still outperform AI, and that as AI coordination improves, the market could shift toward large, concentrated AI-heavy firms. It also says wage changes come from a technology effect and a reorganization effect, and that reorganization can reverse the technology effect.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-2026-223062026-w45/2026-22306Final rule. The Labor Department's Employee Benefits Security Administration has issued a final rule requiring providers of pharmacy benefit management services, and affiliated brokerage and consulting providers, to disclose their compensation to fiduciaries of large, self-insured group health plans covered by the Employee Retirement Income Security Act (ERISA). The rule takes effect on January 4, 2027, and is meant so that fiduciaries can assess whether these service arrangements and their fees are reasonable. It affects plan sponsors and other fiduciaries of those plans, and certain service providers to them.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-OR-DO-1-20262026-w45/OR-DO-1-2026Final rule. The Oregon Department of Consumer and Business Services has adopted 2027 workers' compensation premium assessment rates in a permanent rule published in the Oregon Bulletin. The rule is in Oregon Administrative Rules chapter 440. The filing does not state the rates themselves or a start date.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-OR-OSHA-3-20262026-w45/OR-OSHA-3-2026Final rule. The Oregon Occupational Safety and Health Division, part of the Oregon Department of Consumer and Business Services, has adopted permanent rules on workplace violence prevention for health care employers. The rules are in Oregon Administrative Rules chapter 437 and were published in the Oregon Bulletin. The filing gives no effective date.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-OR-WCD-5-20262026-w45/OR-WCD-5-2026Final rule. The Oregon Department of Consumer and Business Services, Workers' Compensation Division, has adopted the 2027 workers' benefit fund assessment rate in a permanent rule published in the Oregon Bulletin. It is in Oregon Administrative Rules chapter 436. The filing does not state the rate or a start date.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-ukdsi-2026-97803482885992026-w45/ukdsi-2026-9780348288599Proposed. This UK draft statutory instrument has been laid before Parliament and would become law only if approved and made. It would create a new, independent body, the Adult Social Care Negotiating Body England (ASCNB), under the Employment Rights Act 2025, and set out the body's operational framework. The title places the body in England.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-WA-26-21-0172026-w45/WA-26-21-017Proposed. The Washington Employment Security Department proposes rules for the WA Cares fund program on penalties and interest for unpaid premiums, implementing parts of ESSB 5291 from the 2025 legislative session. The proposal would also clarify exemption application requirements and premium payment timelines for out-of-state participants.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-2026-223372026-w45/2026-22337Proposed. The Federal Communications Commission (FCC) proposes to update its rules for ultra-wideband (UWB) devices, first adopted in 2002, to reflect how the technology has matured. The Commission says the existing rules have not kept pace, which has led to a growing number of waiver requests for modern devices. The proposal would give more flexibility for future applications while protecting incumbent federal and non-federal spectrum users.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-OR-N164200122026-w45/OR-N16420012Proposed. The Oregon Land Conservation and Development Department has proposed an update to its Middle Housing Model Code, in a notice of proposed rulemaking published in the Oregon Bulletin. The notice is under Oregon Administrative Rules chapter 660 and does not describe the specific changes.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.1073/pnas.26236231232026-w45/doi:10.1073/pnas.2623623123Peer-reviewed study. A peer-reviewed study in PNAS, led by Irene Repeto-Deudero, analyzed land-use change, satellite fire records and climate data for 67,248 patches in temperate regions, using satellite records starting in 2001. On average, afforestation (converting non-forest land to planted forest) increased fire occurrence by 26% and burned area by 23%. The effect varied sharply by biome, from a near-threefold rise in fire occurrence in temperate conifer forests to an 18% reduction in temperate grasslands, savannas and shrublands.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.26434/chemrxiv.15011598/v12026-w45/doi:10.26434/chemrxiv.15011598/v1Preprint, not peer-reviewed. A computational preprint on ChemRxiv, not yet reviewed by other scientists, led by Oliver Kratz, examines copper-lead surface alloys as catalysts for electrochemical carbon dioxide reduction. The authors report that, through strain and ligand effects, these alloys could be favorable catalysts for valuable hydrocarbons. The work is based on density functional theory calculations.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.64898/2026.10.31.7632962026-w45/doi:10.64898/2026.10.31.763296Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, led by M. Ferriere tests whether lime and ground waste concrete can supply calcium and alkalinity to cultures of the coccolithophore Chrysotila sp. In a 26-day experiment, the authors report that lime and concrete did not inhibit growth or calcification, and that the added alkalinity could offset the CO2 released by calcification. They describe the results as proof of concept for coupling this cultivation with concrete waste reuse.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-uksi-2026-11512026-w45/uksi-2026-1151Final rule. The Contracts for Difference (Electricity Supplier Obligations) (Amendment) Regulations 2026 are UK law, made on November 2, 2026, and come into force on November 24, 2026. They broaden the circumstances in which government funds can be paid into the Contracts for Difference scheme to reduce the levy that supports it. The change responds to a decision to provide financial assistance under section 13 of the Energy Prices Act 2022 through the scheme’s counterparty.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.26434/chemrxiv.15011563/v12026-w45/doi:10.26434/chemrxiv.15011563/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, led by Isaiah Borne reports that a hydrogen bonded organic framework (HOF) can switch between porous and non-porous phases using amine vapour and alcohol exposure. The authors say the vapour assisted phase swing adsorption (VAPSA) process they demonstrate, with repeated CO2 adsorption and release, needs near-zero direct energy input.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.1073/pnas.26194201232026-w45/doi:10.1073/pnas.2619420123Peer-reviewed study. A peer-reviewed study in PNAS, led by Tessa E. S. Charlesworth, analyzed implicit and explicit intergroup attitudes from 2.8 million U.S. respondents surveyed from 2021 to 2025. The authors report that bias, which declined steadily from 2007 to 2020, has stalled or reversed, with the largest increases for sexuality, transgender, race and skin-tone bias. They suggest that 2020 to 2021 marked a turning point in the sociopolitical climate.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.1073/pnas.26224001232026-w45/doi:10.1073/pnas.2622400123Peer-reviewed study. A peer-reviewed study in PNAS, led by Aijun Xing, combined a global time-series dataset from 38 long-term experiments in forests and grasslands. It found that the response of soil respiration to nitrogen addition moves from a transient increase lasting about 2 years to a sustained suppression, with a mean effect of −6%. The suppression was associated with soil acidification and changes in microbial properties, and it appeared once cumulative nitrogen inputs exceeded about 100 kg N per hectare.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w45/#item-doi:10.1038/s41586-026-11351-42026-w45/doi:10.1038/s41586-026-11351-4Peer-reviewed study. A peer-reviewed study in Nature is titled 'Hydrogen Derivatives Enable Cost-Effective Carbon Neutrality in China'. The abstract available here only repeats that title, so this item does not describe the study's methods or results.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.22.263662602026-w44-p8/doi:10.64898/2026.10.22.26366260Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. The authors introduce LocPA, a method that uses 24-hour wearable accelerometer data from the UK Biobank to find physical activity patterns that occur more often in people with particular diseases. Among people with hypertension and diabetes, a sleep-disrupted pattern was linked to greater disease burden and less favorable clinical and metabolic profiles. The authors describe potential uses in disease risk characterization and personalized behavioral interventions.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.24.263660552026-w44-p8/doi:10.64898/2026.10.24.26366055Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Using a detector called GPTZero, the authors scored 15,268 abstracts from 12 general medical journals to estimate how much generative artificial intelligence (AI) text they contain. Estimated prevalence rose after 2022 and varied widely, from 5.7% in the New England Journal of Medicine to 83.5% in Frontiers in Medicine, and the authors say the findings support standardized, transparent AI reporting in medical publishing.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1371/journal.pbio.30040412026-w44-p8/doi:10.1371/journal.pbio.3004041Peer-reviewed study. This peer-reviewed study found that disrupting the male-specific isoform of the fruitless gene in Aedes aegypti mosquitoes abolished males' attraction to female flight sounds, so mutant males failed to locate females for mating. The mutant males' ears amplified female flight sounds poorly and sent much weaker electrical signals to the brain than control males. The authors say the work identifies hearing genes shaped by this gene, which support male-specific hearing for mating.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.23.7613352026-w44-p8/doi:10.64898/2026.10.23.761335Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In human cells, the authors report that SMIM1 mediates iron uptake through clathrin-dependent endocytosis of hemoglobin, which is carried to lysosomes where iron is released. They also say SMIM1 expression suppresses the iron deficiency caused by loss of the transferrin receptor, and that SMIM1-deficient mice show iron deficiency in early erythroid precursors under erythropoietic stress.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.23.7613892026-w44-p8/doi:10.64898/2026.10.23.761389Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. The authors introduce CROP-1, a model that combines DNA sequence, transcription factor binding motifs and measured expression to predict gene activity across biological states. On a held-out test set spanning six plant species, its median per-gene correlation was 0.831, compared with 0.486 for a sequence-only counterpart. The authors report that in soybean and tomato, edits of 1-20 nucleotide substitutions produced strong predicted responses in the target context, with much smaller changes elsewhere.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.24.7615702026-w44-p8/doi:10.64898/2026.10.24.761570Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In vitro, supplementing alpha-ketoglutarate (aKG) restored T cell effector cytokine production and cytotoxic capacity despite chronic antigen stimulation and hypoxia. In mouse models of non-small cell lung cancer (NSCLC), dietary calcium-aKG supplements raised aKG levels in serum and tumors and significantly increased the effect of immunotherapy. The authors also report that lower serum aKG levels were associated with poor immunotherapy response in patient samples.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.25.7616472026-w44-p8/doi:10.64898/2026.10.25.761647Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Measuring sulfur metabolites in tumor interstitial fluid, matched healthy organs and serum in mouse models of cancer, the authors find the tumor microenvironment is chemically reduced, with free cysteine predominating over cystine, especially in the lung. In a medium matched to lung tumor fluid, the authors report that cells became independent of cystine import, and they suggest standard culture conditions may overestimate cancer cells' dependence on cystine uptake.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.27.263660082026-w44-p8/doi:10.64898/2026.10.27.26366008Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Using a family-based genetic design, the study compares population-based estimates of the effects of genetic liability to attention-deficit/hyperactivity disorder (ADHD) with within-sibship estimates from up to 164,220 siblings. The effects on smoking, alcohol use and depressive symptoms weakened in family-based analyses. The authors suggest much of the excess burden attributed to ADHD may reflect family and environmental context, so interventions targeting only the individual might not reduce these outcomes as much as expected.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1038/s41586-026-11182-32026-w44-p8/doi:10.1038/s41586-026-11182-3Peer-reviewed study. This peer-reviewed study, in mouse heart muscle, shows that glucose oxidation persists when the mitochondrial pyruvate carrier is absent. The authors report that mitochondrial MCT1 imports lactate and LDHB oxidizes it to pyruvate, sustaining cardiac energetics and preventing stress-induced heart failure in mice.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1038/s41586-026-11203-12026-w44-p8/doi:10.1038/s41586-026-11203-1Peer-reviewed study. This peer-reviewed study analysed 40 task-based functional magnetic resonance imaging (fMRI) datasets from a preregistered consortium of 2,175 participants. It found that three common indicators of reappraisal capacity, namely trait questionnaires, task-based affective ratings and amygdala down-regulation, do not converge on a common core and do not show the expected associations with prefrontal regulatory circuits. The authors caution against using activity in putatively regulatory brain regions to infer how well a person regulates emotions.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.27.263665542026-w44-p8/doi:10.64898/2026.10.27.26366554Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Using NHS England Emergency Care Data Set records from 2021 to 2024, the authors classified urgent and emergency care sites by the rurality and coastal proximity of the areas their patients live in, rather than by hospital location. Rural-coastal sites had lower average attendance with pronounced summer increases, while urban sites had higher proportions of ambulance arrivals and high-acuity attendances. The authors say the typology gives a transparent basis for service planning and for monitoring geographical inequalities.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.27.263666012026-w44-p8/doi:10.64898/2026.10.27.26366601Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In a cross-sectional analysis of AI-READI data, continuous glucose monitoring (CGM) profiles were compared for 261 matched pairs of lean adults and adults with obesity, whose mean glucose and glycated hemoglobin (HbA1c) were comparable. Obesity was associated with higher nighttime glucose and lower afternoon glucose, which the authors say persisted in sensitivity analyses with tighter matching. They conclude that glucose timing should be examined alongside conventional measures of average glycemia.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.27.7622682026-w44-p8/doi:10.64898/2026.10.27.762268Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) treated with endothelin-1 (ET-1) to model heart failure, the authors delivered the Cav1.3 C-terminus with AAV6 (adeno-associated virus type 6). The authors report that this restored CACNA1D and KCNH2 gene expression and normalized calcium and potassium currents and action potential duration, while restoring beating rate and contraction amplitude to control levels. The study was done in cell monolayers and describes the approach as a potential therapeutic strategy for heart failure.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1073/pnas.26093221232026-w44-p8/doi:10.1073/pnas.2609322123Peer-reviewed study. This peer-reviewed study shows that endothelial programmed cell death ligand-1 (PD-L1) expression depends on leptin receptor signaling in male mice, and that leptin resistance affects it. The authors report that a lack of leptin receptors causes PD-L1 degradation in vascular endothelial cells, and that silencing or deleting endothelial PD-L1 slows cell cycle progression and proliferation through inactivation of RAS/MAPK signaling. In obesity, the authors say endothelial PD-L1 deficiency impairs endothelial turnover and worsens vascular function.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1126/science.aed25252026-w44-p8/doi:10.1126/science.aed2525Peer-reviewed study. This peer-reviewed study describes stimulated protein degradation (SPD), which uses agonists of stress-responsive E3 ubiquitin ligases to boost degradation of several pathogenic factors at once. The authors report that activators of the CUL2 FEM1B ligase improve mitochondrial import and electron transport chain assembly. In models of neurodegenerative COX deficiency syndrome and Friedreich’s ataxia, they say these compounds preserved mitochondrial function and neuronal survival.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.21.7604992026-w44-p8/doi:10.64898/2026.10.21.760499Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Using cryogenic electron microscopy (cryo-EM) structures of the Toll/IL-1R homology (TIR) domain of MyD88, both wild-type and the cancer-specific L252P mutant, the authors show that the filaments bind double-stranded DNA. The authors report that MyD88 directly binds DNA and promotes inflammatory cytokine expression after DNA transfection or viral infection, and that about half of cGAS-dependent genes are also MyD88-dependent. They say the findings support a role for MyD88 in cytosolic DNA sensing, cooperating with cGAS.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.26.263665622026-w44-p8/doi:10.64898/2026.10.26.26366562Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. The authors built DiaBench, a benchmark of 96 question-and-answer pairs from real patient encounters, converted into multiple-choice questions, to test seven large language models (LLMs) on type 2 diabetes (T2D) patient education. Most models reached high accuracy on the first two configurations, but all models degraded on the third, and Mistral-Large-2.0, Llama 4 and Perplexity Sonar showed lower self-consistency. The authors say Gemini, GPT-5 and DeepSeek-R1 performed strongly, while the other models were suboptimal.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.27.7615792026-w44-p8/doi:10.64898/2026.10.27.761579Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. The authors describe a bacterial strain, called a tumorobe, with reduced immunogenicity, tumour-restricted growth and enhanced payload release, which expanded the maximum tolerated dose by up to 1,000-fold depending on route. In mouse models of colorectal cancer and glioblastoma, the authors report strong antitumour efficacy, and complete responses in up to 75% of colorectal tumours when the strain was armed with a cytokine payload.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.27.7623132026-w44-p8/doi:10.64898/2026.10.27.762313Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. The authors engineered probiotic Escherichia coli Nissle 1917 (EcN) to colonize granulomas and release antimycobacterial payloads in response to the hypoxic environment. In mice, the engineered probiotics reduced mycobacterial burden, and in a rifampicin-resistant infection model, combination with pretomanid achieved greater bacterial reduction than either drug alone.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.27.7623652026-w44-p8/doi:10.64898/2026.10.27.762365Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Using airway epithelial stem cells from patients with chronic obstructive pulmonary disease (COPD), the authors exposed air-liquid interface cultures to high-tar conventional smoke, low-tar slim smoke or filtered air. Both smokes induced IL-1β inflammation, ciliary changes and oxidative stress, but conventional smoke produced stronger effects across ciliated, basal and secretory cells in single-cell RNA sequencing, which the authors say shows greater influence than slim smoke.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.25.7616422026-w44-p8/doi:10.64898/2026.10.25.761642Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In mice performing a decision-making task with shifting reward size, the authors found that pupil-linked arousal and dopaminergic utility coding predict transitions between engagement states along separable axes. Orexin antagonism with almorexant disengaged mice at low reward, an effect the authors say was mediated by arousal rather than dopamine. A glucagon-like peptide-1 (GLP-1) receptor agonist, semaglutide, reduced how accumbal dopamine integrates reward history, which predicted progressive disengagement.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.26.7618422026-w44-p8/doi:10.64898/2026.10.26.761842Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In isogenic human neuronal cultures derived from stem cells, the authors report that the homozygous CC genotype of the rs28834970 variant in PTK2B reduced total PYK2 levels by more than 80%, while increasing the phosphorylated, activated fraction. The authors also report higher Tau phosphorylation and amyloid-β levels, and say the variant links Alzheimer's susceptibility to these changes, though the work was done in cultured neurons.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.27.7622052026-w44-p8/doi:10.64898/2026.10.27.762205Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. The study examines how phosphorylation levels change the phase separation and aggregation of Tau, a protein involved in tauopathies including Alzheimer's disease. The authors report that phosphorylation enhances droplet formation and fibrillation, while the molecular chaperone-like Bri2 BRICHOS domain shifts phase boundaries and inhibits fibril formation regardless of phosphorylation level, which they say may facilitate future treatment strategies using chaperone-based inhibitors.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.64898/2026.10.29.263665262026-w44-p8/doi:10.64898/2026.10.29.26366526Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In a longitudinal neuroimaging study of 94 cognitively healthy adults over a 3-year period, higher repetitive negative thinking (RNT) was associated with faster accumulation of cortical amyloid, even after accounting for anxiety and depression symptoms. The faster accumulation was seen in regions vulnerable to early amyloid build-up in Alzheimer's disease, such as the precuneus, and RNT was not associated with change in glucose metabolism or brain atrophy. The authors say RNT may be an early marker or driver of Alzheimer's pathology, and that future research is needed to test whether modifying RNT reduces risk.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-arxiv:2610.316932026-w44-p8/arxiv:2610.31693Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In a computer simulation of two competing sellers that learn prices, the study tests whether lower costs of running artificial intelligence (AI) models lead to lower prices, and how delays in seeing rivals' prices affect buyers. In the main setting, average price reductions equal 55.6% and 44.0% of the imposed cost reduction for the two firms. The authors say the findings do not establish collusion or describe the pricing of actual AI providers.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1073/pnas.23211501222026-w44-p8/doi:10.1073/pnas.2321150122Peer-reviewed study. This peer-reviewed study tests whether subseasonal to seasonal (S2S) climate predictors, alone or combined with socioeconomic indicators, can predict child birth weight in West Africa. Models using only climate predictors performed about as well as models using the full set of Demographic and Health Survey (DHS) indicators. The authors say the approach could support early warning systems for birth weight in data-sparse regions, with models tested in Burkina Faso, Mali and Senegal.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.26434/chemrxiv.15011030/v12026-w44-p8/doi:10.26434/chemrxiv.15011030/v1Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Using a state network of 309 sensor stations across all 23 districts of West Bengal, India, the authors compare pollutant levels in urban and rural locations from 2022 to 2026. They find urban-rural differences are narrow and smaller than the variation between nearby stations, and say regional pollution rivals local sources, which supports an airshed approach.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1073/pnas.26128241232026-w44-p8/doi:10.1073/pnas.2612824123Peer-reviewed study. This peer-reviewed study revisits how sulfuric acid forms in the atmosphere, combining coupled-cluster calculations, reaction rate theory and a global chemistry transport model. The authors report that the overall kinetics is controlled by a loose transition state, which reverses a recent view that acid catalysis dominates SO3 hydration in favor of water catalysis. Adding the revised kinetics to the GEOS-Chem atmospheric model shows no significant impact of acid-catalyzed SO3 hydration on simulated sulfuric acid concentrations.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1371/journal.pbio.30040532026-w44-p8/doi:10.1371/journal.pbio.3004053Peer-reviewed study. This peer-reviewed study synthesizes 86 years of experimental infections, involving 54 viruses, 85 host species and over 5,600 animals. It found that the occurrence, likelihood of mortality and severity of overt disease in bats were indistinguishable from those in rodents. The authors say disease outcomes were shaped by experimental design, viral host range and evolutionary context, rather than by unusual antiviral defenses in bats.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-arxiv:2610.329962026-w44-p8/arxiv:2610.32996Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. The authors tested a multimodal machine learning framework that combines genomic sequences, epidemiological indicators, wastewater surveillance and clinical rash images, using public data. Genomic features dominated predictions of transmission linkage, while wastewater positivity was the strongest predictor of outbreak risk. Measles resurged in the United States during 2025-2026, and the authors say prospective validation and real-world workflows are needed before deployment.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-arxiv:2610.329982026-w44-p8/arxiv:2610.32998Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Trained on 7.5 million culture-antibiotic observations from four academic medical centers, the models estimate susceptibility to individual antibiotics from electronic health record data. In tests on inpatient urine and blood cultures, the authors report that chronological retraining reduced performance somewhat, and that the model would flag many ceftriaxone-resistant observations for broader coverage. The authors say independent calibration, threshold setting and prospective validation are required before clinical use.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1073/pnas.26177831232026-w44-p8/doi:10.1073/pnas.2617783123Peer-reviewed study. This peer-reviewed study presents a general framework for how phenotypic plasticity gives rise to drug persisters, cells that survive targeted therapy and can eventually lead to mutants with true resistance. The framework predicts an optimum drug concentration and an optimum drug holiday schedule to minimize this persistence-based threat.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.26434/chemrxiv-2025-m0l72/v22026-w44-p8/doi:10.26434/chemrxiv-2025-m0l72/v2Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. Using robotic high-throughput synthesis, automated spectral diagnosis and machine-learning-assisted screening, the authors study how Dion-Jacobson quasi-two-dimensional (2D) halide perovskites crystallize and change composition. They report that a selected formulation applied to perovskite interfaces yields solar cells with markedly improved thermal stability. The authors describe the work as a strategy for durable halide perovskite optoelectronics.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-arxiv:2610.358882026-w44-p8/arxiv:2610.35888Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. The paper is a theoretical analysis of oracle networks, including decentralised physical infrastructure networks (DePINs), in which a data source can manipulate what is measured, such as soil organic carbon (SOC) at a carbon project. The authors show a settlement rule can identify and deter source manipulation only if sensors respond to the manipulation by different amounts, and in a test with eight calibrated SOC models on 37,280 real European soil spectra, shift-naive aggregators over-credited by up to 57%.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-doi:10.1073/pnas.26187161232026-w44-p8/doi:10.1073/pnas.2618716123Peer-reviewed study. This peer-reviewed study uses a standardized deep proteomic database of 42 nanomaterials to examine the protein corona, the layer of proteins that forms on nanoparticles in physiological fluids. The authors report that surface charge affects uptake through a charge-corona-receptor chain, PEGylation depletes specific complement and coagulation factors, and particle geometry selects proteins by features such as lysine content. The authors also say material-specific coronas can rebalance the serum proteome and help detect low-abundance disease biomarkers.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-arxiv:2610.390652026-w44-p8/arxiv:2610.39065Preprint, not peer-reviewed. This is a preprint, not peer-reviewed. In a pre-registered simulation with known true risks, the authors compared three tabular foundation models with Firth logistic regression with intercept correction (FLIC), a conventional method. The authors report that the foundation models were not a shortcut to calibration, matching FLIC in most core scenarios and being better only at 200 patients with a 3% event rate, and that even 3,000 patients were often not enough. On real data, they say recalibration on 500 local patients largely repaired changes in event rate between populations.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p8/#item-mit-research:072e5999ff912026-w44-p8/mit-research:072e5999ff91Announcement. This is an announcement from MIT News, the institution's own account of its work, not a peer-reviewed study. It describes the particles as carrying a customized dose of cancer antigens that can provoke a strong immune response against tumors.Sun, 08 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.1038/s41586-026-10438-22026-w44-p7/doi:10.1038/s41586-026-10438-2Peer-reviewed study. A peer-reviewed study in Nature. Using whole-genome sequencing and gene expression measurements in individual cells, it finds that differences in the length of tandem repeats (stretches of repeated DNA) in the human genome contribute to differences in gene activity between immune cell types, and to the architecture of complex traits.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.1038/s41586-026-11178-z2026-w44-p7/doi:10.1038/s41586-026-11178-zPeer-reviewed study. A peer-reviewed study in Nature. The researchers describe STM9005, a highly selective inhibitor of the enzyme METTL1, which blocks growth of cancer cells including leukaemia, melanoma and pancreatic carcinoma cell models. In multiple mouse cancer models, the authors report that it impaired tumour growth and significantly prolonged survival.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.1038/s41586-026-11181-42026-w44-p7/doi:10.1038/s41586-026-11181-4Peer-reviewed study. A peer-reviewed study in Nature, in mice. A high-fat diet during a 4-day window at the start of skin inflammation made the disease worse, to levels comparable with chronic obesity, and the inflammation returned more strongly on later recurrence even after the mice went back to a low-fat diet. Switching obese mice to a low-fat diet during that window blunted the amplification.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.1073/pnas.26020161232026-w44-p7/doi:10.1073/pnas.2602016123Peer-reviewed study. A peer-reviewed study in PNAS. It tests an environmental RNA method that detects Schistosoma mansoni parasites in water samples and distinguishes the stages that infect snails from the free-living cercariae that infect humans. In field tests at six endemic sites in Brazil, the authors report that it detected cercariae better than environmental DNA tests and conventional snail surveys.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.1073/pnas.26115631232026-w44-p7/doi:10.1073/pnas.2611563123Peer-reviewed study. A peer-reviewed study in PNAS, in mice. The bacterial protease SspA breaks down skin barrier junctions, and combined with house dust mite extract it caused atopic dermatitis-like disease driven by interleukin-22 (IL-22). Chemically removing the skin's nerve fibers reversed the disease.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.23.7612772026-w44-p7/doi:10.64898/2026.10.23.761277Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists. In mouse models, the authors report that cancer cells take mitochondria from a subset of T cells, and that blocking this transfer, by knocking down CD38 and inhibiting S100a4, markedly suppressed tumor growth.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.26434/chemrxiv.15011281/v12026-w44-p7/doi:10.26434/chemrxiv.15011281/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists. It describes compound 2-1, a covalent inhibitor of Pyk2 (also known as FAK2) that engages a cysteine (Cys545) absent from the related FAK1. In a model of carotid artery thrombosis, the authors report it tripled the effect of a clot-busting drug (recombinant tissue plasminogen activator) without increasing bleeding risks.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.26.263660872026-w44-p7/doi:10.64898/2026.10.26.26366087Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists. It describes HELIOS, an AI tool that transfers cell identities from spatial omics studies into routine haematoxylin and eosin (H&E) slides. In colorectal, breast and lung cancers, the authors report that its features were linked to outcomes even after adjustment for clinicopathological and molecular variables.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.27.7622452026-w44-p7/doi:10.64898/2026.10.27.762245Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists. In long-term laboratory co-culture experiments, cancer cells grown with fibroblasts underwent the epithelial-mesenchymal transition and became more drug tolerant, while those grown with macrophages showed more stress and hypoxia responses and enhanced tumorigenicity. The authors say the changes were partly reversible and could not be explained by clonal selection.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.29.263663242026-w44-p7/doi:10.64898/2026.10.29.26366324Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists. In an experiment, 155 physicians estimated sepsis probability in clinical vignettes before and after AI advice, under strict and lenient time limits. The authors report that time pressure increased uptake of incorrect advice and reduced selectivity, and argue that human oversight of AI, which the EU AI Act requires, should be evaluated under acute-care time constraints.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.29.263666282026-w44-p7/doi:10.64898/2026.10.29.26366628Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists. Coach-BP is a computer vision system, trained on clinician labels, that detects technique errors in video of blood pressure measurements against five American Heart Association criteria. In 408 encounters from 225 participants at an academic cardiovascular prevention center, the authors report an average AUROC (area under the receiver operating characteristic curve) of 0.93 against expert clinician ratings.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.24.7614812026-w44-p7/doi:10.64898/2026.10.24.761481Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists. It proposes that the CD3ε subunit of the T cell receptor (TCR) initiates activation by releasing its intracellular domain and forming condensates with the kinase Lck. The authors report engineered 'triggering molecules', lacking standard signaling parts, that activated both T cells and natural killer (NK) cells.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.26.7619472026-w44-p7/doi:10.64898/2026.10.26.761947Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, in mice. Researchers expressed a human circular RNA from the tau gene (circTau 12->7) in mouse brains and found it was translated into protein only in neurons. The protein formed aggregates resembling neurofibrillary tangles that included mouse tau, and the authors say this could contribute to tauopathies, including Alzheimer's disease.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.27.263663282026-w44-p7/doi:10.64898/2026.10.27.26366328Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, using mouse models and human aortic cells. Mice with reduced function of the CCM2 gene (Cerebral Cavernous Malformation 2) had less atherosclerosis after 12 weeks on a high-fat, high-cholesterol diet, but more after 20 weeks on an atherogenic diet. The authors say the effect depends on disease context and stage.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.29.263666092026-w44-p7/doi:10.64898/2026.10.29.26366609Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists. Combining 30 transcriptomic (gene activity) datasets of 2,578 samples from 18 countries, plus 927 new samples, the authors identified a CD16 monocyte-associated gene module that marks people carrying parasites without symptoms, independent of parasite density. In children, the authors report that this module was associated with protection from future malaria burden.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.29.7626532026-w44-p7/doi:10.64898/2026.10.29.762653Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists. It profiles subchondral bone (the bone beneath cartilage) from human knees graded by osteoarthritis severity. The authors report that osteoprogenitor and osteocyte cells rose as a share of cells with severity, along with a rise in a TGF-β-linked SMAD2/3 signal in osteocytes.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.29.7627042026-w44-p7/doi:10.64898/2026.10.29.762704Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, in mice. In a mouse model of dengue virus serotype 2 (DV-2) infection, the researchers report that a neutrophil subset expressing FGL2 appeared as disease progressed, and that FGL2 suppressed T cell activity in spleen cell experiments. The authors also report that serum FGL2 was elevated in dengue-positive human patients.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.29.7627402026-w44-p7/doi:10.64898/2026.10.29.762740Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, based on cell studies. The authors report that cholesterol delivered by high-density lipoproteins (HDLs) through the SR-B1 pathway moves from the plasma membrane to the endoplasmic reticulum (ER), where it promotes assembly of mitochondria-associated ER membranes (MAMs). They say these membranes coordinate ER-mitochondria communication and the handling of excess cholesterol.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.29.7628122026-w44-p7/doi:10.64898/2026.10.29.762812Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, in mouse and non-human primate models. The authors report microparticles that slowly release erythropoietin (EPO) and reduce oxidative stress, preserving neurons in both models. They say the approach works independently of intraocular pressure (IOP), which current treatments target.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-nber:4d6912719b5e2026-w44-p7/nber:4d6912719b5ePreprint, not peer-reviewed. A working paper from NBER, a preprint not yet reviewed by other scientists. In a large field experiment, agents were randomly assigned at the market level to several incentive contracts, and the best performer raised weekly firm profit by over 55% against the status quo, although managers ranked it lower. The authors find managers underestimate the top-performing contracts, while standard contract theory ranks them more accurately.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-arxiv:2610.388962026-w44-p7/arxiv:2610.38896Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists. Using generative AI, the authors estimate how much 'soft' infrastructure that supports citizens' preparedness reduces flood losses in cities, compared with 'hard' infrastructure such as sewage systems and seawalls. They report that soft infrastructure can significantly reduce losses, with an impact on par with hard infrastructure.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-arxiv:2610.406502026-w44-p7/arxiv:2610.40650Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists. It analyzes how a customer's solar panels and energy storage interact under net energy metering (NEM) and time-based tariffs, and when they complement or substitute for each other. In a Massachusetts case study, the authors find that when investment costs exceed the cost of serving the customer, no tariff lets solar or storage investment lower bills for customers who do not invest.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-2026-221652026-w44-p7/2026-22165Final rule. This is a final rule from the Homeland Security Department, effective November 30, 2026. It updates the Department of Homeland Security (DHS) rules on fees for Freedom of Information Act (FOIA) and Privacy Act of 1974 requests, adding an option to pay electronically through the department's FOIA processing system, including by pay.gov.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-CA-Z2026-1019-042026-w44-p7/CA-Z2026-1019-04Proposed. A proposal by the California Occupational Safety and Health Standards Board to adopt rules for snow avalanche control blasting in the General Industry Safety Orders (GISO) of Title 8 of the California Code of Regulations. It would require employers to have written blasting procedures and allow only licensed or supervised, trained blasters to deploy handcharges, and it would allow remote avalanche control systems (RACS) that deploy explosive charges, subject to safety requirements.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-uksi-2026-11462026-w44-p7/uksi-2026-1146Final rule. This is UK law: a UK statutory instrument, listed as a final rule. Its title says it amends the Pneumoconiosis etc. (Workers’ Compensation) (Payment of Claims) Regulations 2026, but the record has no abstract and no effective date, so this summary cannot say what changes or when it applies.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.1073/pnas.23211551232026-w44-p7/doi:10.1073/pnas.2321155123Peer-reviewed study. A peer-reviewed study in PNAS, and a modeling study with case studies in Ethiopia and Mali. It uses a multiplayer microeconomic model to trace how a drought, a national export restriction, solar-powered groundwater irrigation and food aid each spread through markets, infrastructure and economic actors. The authors say this can inform food security strategies in a changing climate.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.26434/chemrxiv.15011063/v12026-w44-p7/doi:10.26434/chemrxiv.15011063/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, on ChemRxiv. The authors describe hybrids of gold nanorods and a metal-organic framework (UiO-66-NH2) that use near-infrared light to convert carbon dioxide into carbon monoxide (CO), reporting a CO production rate of 152.3 μmol g-1 h-1 and selectivity above 90% under 808 nm light.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.1126/science.aeb79102026-w44-p7/doi:10.1126/science.aeb7910Peer-reviewed study. A peer-reviewed study in Science. It maps 45 threats across 21,490 freshwater species of amphibians, fish, mammals, odonates and reptiles, and finds that species in highly developed and water-managed regions are strongly affected by multiple overlapping threats. The authors report that higher threat probabilities raise extinction risk and population declines, and that freshwater species face greater threat intensity than terrestrial species.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.29.7628682026-w44-p7/doi:10.64898/2026.10.29.762868Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, from laboratory work. The authors grow Trametes versicolor fungus and Sporosarcina pasteurii bacteria inside a scaffold made from lignocellulosic biomass (plant material), so calcium carbonate forms throughout it. They report that compressive Young's modulus rose 7-14-fold and ultimate strength 5-fold compared with unmineralized mycelium composites, and that the material can self-heal without adhesives.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.28.7623002026-w44-p7/doi:10.64898/2026.10.28.762300Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, from a full-factorial pot experiment growing rice under two soil arsenic levels and four climate conditions. Under combined arsenic contamination and future climate, the authors report grain cadmium was two-fold higher and grain zinc fell by 25%, while grain iron fell only slightly with arsenic.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-2026-222172026-w44-p7/2026-22217In effect. This is a temporary rule, in effect from October 29, 2026. The National Oceanic and Atmospheric Administration (NOAA) announces that Rhode Island is transferring part of its 2026 commercial bluefish quota to North Carolina, to comply with the Atlantic Bluefish Fishery Management Plan (FMP), and sets the revised 2026 commercial bluefish quotas for both states.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-TX-TRD-2026043782026-w44-p7/TX-TRD-202604378Proposed. The Texas Department of Public Safety proposes amendments to its breath alcohol testing rules in 37 Texas Administrative Code (TAC), Chapter 19, Subchapter A. The changes would clarify that applicants must disclose certain information, allow a technical supervisor's certification to be inactivated for cause, and require course providers to ensure student eligibility and request approval for curriculum changes.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-CA-Z2026-1020-092026-w44-p7/CA-Z2026-1020-09Proposed. The California Department of Cannabis Control proposes changes that would let a licensee holding one license with both medicinal (M) and adult-use (A) designations be issued separate medicinal and adult-use licenses through an expedited process. The licenses could go to a different legal entity if certain conditions are met, and those conditions would keep the resulting medical cannabis businesses compliant with existing requirements.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.64898/2026.10.27.7623572026-w44-p7/doi:10.64898/2026.10.27.762357Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists. The authors trap gas inside metal-organic framework nanocrystals in water so the gas stays stable and oscillates under ultrasound. They report that the particles enabled long-term ultrasound imaging and sustained, non-invasive neuromodulation in vitro and in vivo.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-arxiv:2610.385642026-w44-p7/arxiv:2610.38564Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists. Using birdsong, the authors show that auditory objects can be recognized from ultra-sparse spike streams, with error rates below 5% on Bengalese finch songs. They implemented the method on Intel's Loihi neuromorphic chip, where response latency stayed at about 17 ms per syllable regardless of the number of templates.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.26434/chemrxiv.15011313/v12026-w44-p7/doi:10.26434/chemrxiv.15011313/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists. It reports that the overlap between a material's photoluminescence and absorption spectra predicts how much efficiency falls at high brightness in organic light-emitting diodes (OLEDs) using thermally activated delayed fluorescent (TADF) emitters, through singlet exciton diffusion. The authors suggest materials with a larger Stokes shift could reduce the loss while keeping narrow emission.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-pew:99ad57631b572026-w44-p7/pew:99ad57631b57Announcement. Pew Research Center reports that gas prices have surged amid the Iran conflict, but adjusted for inflation and wages, 2008 was costlier. The item is the center's own announcement, so these are its claims.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.26434/chemrxiv.15011437/v12026-w44-p7/doi:10.26434/chemrxiv.15011437/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists. Using in-situ gas cell transmission electron microscopy at 550 °C, the authors study platinum-nickel (PtNi) nanoparticles during super-dry reforming of methane, which couples dry reforming with the reverse water gas shift reaction. They report that the ordered L10 phase resists nickel segregation and coke formation, lowering the kinetic barrier for methane activation by 27 kJ/mol compared with the disordered phase.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-doi:10.26434/chemrxiv.15011451/v12026-w44-p7/doi:10.26434/chemrxiv.15011451/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists. The authors grew ultrathin molybdenum carbide (MoCx) films by plasma-enhanced atomic layer deposition as a liner-free barrier for copper (Cu) interconnects. Films under 5 nm reached resistivities as low as about 230 μΩ·cm without annealing, and the authors say current tantalum/tantalum nitride (Ta/TaN) layers typically exceed 500 μΩ·cm at that thickness.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p7/#item-CA-Z2026-1020-012026-w44-p7/CA-Z2026-1020-01Proposed. A proposed California rule concerns 1,3-Dichloropropene (1,3-D), a soil fumigant used against nematodes, insects and disease organisms, which is a restricted material and a toxic air contaminant. It covers the 'tree-hole' application method, used for spot treatments in existing orchards when dead or diseased trees are replaced. The text provided is cut off before it sets out the specific changes, so this summary does not describe them.Sat, 07 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.1038/s41586-026-11206-y2026-w44-p6/doi:10.1038/s41586-026-11206-yPeer-reviewed study. A peer-reviewed study in Nature looks at the genetics of Alzheimer's disease across people of many ancestries. It identifies new risk loci and potential drug targets, implicates microglia and neurons, and finds a larger common-variant contribution than previously estimated.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.27.263665372026-w44-p6/doi:10.64898/2026.10.27.26366537Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, analyzes NHANES survey data from 1999 to 2002. It reports that higher dietary protein intake is associated with a lower likelihood of accelerated biological aging and a lower risk of death from all causes, an association rather than proof of cause.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.27.263666172026-w44-p6/doi:10.64898/2026.10.27.26366617Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, uses a computer model of tuberculosis (TB) in India to study how failures in care prolong infectiousness. In the simulation, episodes with treatment failure were infectious for a median of 16 months, compared with 3 months for episodes with neither failure type. The authors project that combined support measures would cut incidence by 34% by 2035, still short of the 90% End TB target.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.27.263666252026-w44-p6/doi:10.64898/2026.10.27.26366625Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, uses data from the All of Us cohort to study how social conditions change the link between polygenic risk scores and chronic disease. It reports that for cardiometabolic diseases such as type 2 diabetes, coronary heart disease and chronic kidney disease, genetic associations were weaker among more socially vulnerable people. The authors say combining genetic and social information improves prediction.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.27.7622832026-w44-p6/doi:10.64898/2026.10.27.762283Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, reports an animal study in which starting amoxicillin during influenza A infection increased deaths from influenza A. It also found that the antibiotic made secondary bacterial pneumonia more severe, and that this effect was more pronounced in males.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.28.7621822026-w44-p6/doi:10.64898/2026.10.28.762182Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, reports that gut microbiota from Indigenous Brazilian Yanomami donors, transplanted into germ-free mice on a high-fat diet, reduced weight gain and diabetes compared with microbiota from urban Belgian donors. It is a study in mice, and the authors describe the microbes as potential targets for microbiota-inspired therapeutics.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.26.7619802026-w44-p6/doi:10.64898/2026.10.26.761980Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, reports a study of more than 140 mice in which loss of the SORL1 gene produced an age-dependent pattern of brain shrinkage resembling Alzheimer's disease. The shrinkage was prevented by restoring SORL1, and postmortem studies showed it reflects neuron loss. The authors describe the pathway as one that could be amenable to therapy.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.27.263666332026-w44-p6/doi:10.64898/2026.10.27.26366633Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, reports that in healthy individuals insulin secretion anticipates future blood glucose, but that obesity and pre-diabetes are associated with its premature decline. In the study, the drug semaglutide raised insulin secretion and curbed high blood glucose, but it removed the anticipatory pattern.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.29.263668662026-w44-p6/doi:10.64898/2026.10.29.26366866Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, describes a fully automated pipeline that builds knee models from a single magnetic resonance imaging (MRI) scan and simulates gait. Applied to 756 knees from the Osteoarthritis Initiative, it reports that medial tibial pressure falls from healthy knees to incident and mild osteoarthritis, and that within knees the cartilage thinned fastest over six years in the regions of highest pressure.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.64898/2026.10.29.7628062026-w44-p6/doi:10.64898/2026.10.29.762806Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, reports a xanthine-based compound, SRI-38841, that inhibited West Nile virus and also dengue, Zika and Japanese encephalitis viruses in its tests. The authors report that it disrupts an interaction between two viral proteins and blocks the formation of replication organelles in infected cells.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-uksi-2026-11332026-w44-p6/uksi-2026-1133Final rule. This is UK law, made on October 27, 2026. The Wireless Telegraphy (Exemption) (Amendment) (No. 3) Regulations 2026 amend the 2021 Regulations, which exempt certain wireless telegraphy stations and apparatus that meet set terms from the need to be licensed under the Wireless Telegraphy Act 2006, and they come into force on November 10, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.26434/chemrxiv.15011429/v12026-w44-p6/doi:10.26434/chemrxiv.15011429/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, reports that a computer screen of approved drugs against the ClpP1 protease of Mycobacterium tuberculosis identified saquinavir and raltegravir as candidates. In tests against the H37Ra strain, saquinavir showed stronger activity than raltegravir, and the authors call both repurposable for further study.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-2026-221762026-w44-p6/2026-22176In effect. The Environmental Protection Agency (EPA) has issued a rule that exempts dimethyl sulfoxide, used as an inert ingredient (solvent or cosolvent) in pesticide formulations, from the requirement of a 'tolerance'. The exemption covers pesticides used on growing crops, raw agricultural commodities and animals, and antimicrobial products used on food-contact surfaces. The rule is in effect from October 30, 2026, and it removes the need for maximum permissible levels for residues of the substance under those terms.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-CA-2026-1006-022026-w44-p6/CA-2026-1006-02In effect. The California State Water Resources Control Board has taken an emergency regulatory action that adjusts the annual fees for individuals issued waste discharge permits for fiscal year 2026-27. The fees are set to match revenue levels in the Budget Act, and the rule is in effect from October 15, 2026, until the board revises it.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-uksi-2026-11372026-w44-p6/uksi-2026-1137Final rule. This is UK law, made on October 26, 2026. The Transport Infrastructure (Fees) Regulations 2026 let prescribed public authorities charge fees for services connected with certain transport infrastructure projects, under powers added to the Highways Act 1980 and the Transport and Works Act 1992 by the Planning and Infrastructure Act 2025. They come into force on November 20, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-uksi-2026-11422026-w44-p6/uksi-2026-1142Final rule. This is UK law, made on October 28, 2026. The Sea Fisheries (Amendment and Transitional Provision) Regulations 2026 amend assimilated law on sea fisheries and include a transitional provision, and they come into force on November 26, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-2026-222182026-w44-p6/2026-22218In effect. The National Oceanic and Atmospheric Administration (NOAA) temporarily prohibits directed fishing for pollock in Statistical Area 630 in the Gulf of Alaska. The aim is to prevent exceeding the 2026 total allowable catch of pollock in that area. The temporary rule has been in effect since October 28, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-CA-2026-0910-012026-w44-p6/CA-2026-0910-01In effect. Under this certificate of compliance, the California Department of Food and Agriculture removes Oregon from its Japanese beetle exterior quarantine area, in effect from October 21, 2026. The notice text itself uses the word 'proposes' for the change.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-TX-TRD-2026043862026-w44-p6/TX-TRD-202604386Proposed. A proposal from the Texas Department of Public Safety would change continuing education requirements under the rules implementing the Private Security chapter of the Texas Occupations Code. The required one hour of ethics would become either one hour of ethics or code compliance updates, a change recommended by the Private Security Advisory Board.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.1073/pnas.26115281232026-w44-p6/doi:10.1073/pnas.2611528123Peer-reviewed study. A peer-reviewed study in PNAS, led by Zheng Qiao, describes a soft microneedle sensor patch that monitors several biomarkers in interstitial fluid under the skin. The authors report that the design reduces signal variability 14-fold compared with conventional designs, and that in a living subject it tracked glucose, tissue pH and temperature in real time. They say its continuous glucose readings reach clinical-grade accuracy, with a mean absolute relative difference of 10.8%.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-mit-research:f5cf24b3e5312026-w44-p6/mit-research:f5cf24b3e531Announcement. In an MIT News announcement, MIT researchers report that the APOE4 gene variant, which MIT calls the biggest Alzheimer's risk gene, suppresses molecular signaling that oligodendrocytes need to myelinate neurons. They also report a proof-of-concept fix. This is MIT's own account of its work.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.26434/chemrxiv.15011240/v12026-w44-p6/doi:10.26434/chemrxiv.15011240/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, reports that the two mirror-image forms of propylene carbonate (PC) behave differently at a charged graphite surface. In the authors' tests, one form allowed reversible lithiation of graphite while the other exfoliated it, and they say this opens a new dimension for electrolyte design.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-pew:cafabe43ba6f2026-w44-p6/pew:cafabe43ba6fAnnouncement. Pew Research Center reports that Americans are generally open to artificial intelligence (AI) handling administrative and medical tasks in healthcare, but largely do not want AI operating without human oversight. Pew says 47% expect AI to make the relationship between patients and their doctors worse, compared with 10% who expect it to make it better.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-arxiv:2610.376722026-w44-p6/arxiv:2610.37672Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists, reports exploratory experiments with large language model (LLM) agents that share one symmetric environment. The authors report that asymmetry and a hierarchy of value emerged among agents that are otherwise equivalent, and they argue that aligning AI with human values cannot rely on engineering individual agents alone.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-arxiv:2610.378642026-w44-p6/arxiv:2610.37864Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists, uses a model fitted to the Italian Twitter debate from 2018 to 2022 to simulate interventions. The authors report that behavioural interventions such as prebunking and accuracy prompts reduced engagement, and that a chronological feed would increase attention diversity and reduce segregation. They also design a recommender change that raises engagement and diversity while reducing segregation, though with about a tenth of the chronological feed's gains.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.26434/chemrxiv.15011240/v22026-w44-p6/doi:10.26434/chemrxiv.15011240/v2Preprint, not peer-reviewed. A revised preprint (version 2) on ChemRxiv, not yet reviewed by other scientists, reports that the mirror-image forms of propylene carbonate (PC) behave differently at a charged graphite surface. The authors say high lithium salt concentration and a charged interface together break that symmetry, with one form enabling reversible graphite lithiation and the other exfoliating graphite.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.26434/chemrxiv.15011313/v22026-w44-p6/doi:10.26434/chemrxiv.15011313/v2Preprint, not peer-reviewed. A revised preprint on ChemRxiv, not yet reviewed by other scientists, reports that overlap between photoluminescence and absorption spectra drives singlet exciton diffusion and is a strong predictor of efficiency roll-off in thermally activated delayed fluorescent (TADF) organic light-emitting diodes (OLEDs). The authors suggest that TADF emitters with a larger Stokes shift could limit the drop while keeping bright, narrow emission.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-doi:10.26434/chemrxiv.15011441/v12026-w44-p6/doi:10.26434/chemrxiv.15011441/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, reports that removing ethylene carbonate (EC) from the electrolyte speeds degradation of the LMFP64 cathode, while it helps the NCM811 cathode. The authors link the opposite effects to differences in how transition metals bond with oxygen in each material.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-CA-Z2026-1015-012026-w44-p6/CA-Z2026-1015-01Proposed. The California Department of Real Estate has proposed a rule titled 'Annual Fee Review'. The notice text available does not say which fees would change or by how much.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-CA-Z2026-1020-042026-w44-p6/CA-Z2026-1020-04Proposed. A proposal from the California Bureau of Automotive Repair would change rules for automotive repair dealers (ARDs). Under it, registration applications would list any 'doing business as' (DBA) name, renewals would require that application information be kept current, and online advertising could meet the business name and registration number requirement by linking to other advertising that shows them.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-CA-Z2026-1020-062026-w44-p6/CA-Z2026-1020-06Proposed. A proposal from the California Veterinary Medical Board would change rules on veterinary records, including the minimum contents of records and how long premises must keep them. The background text says that veterinarians providing telehealth must keep and make available a copy or summary of the record, and that copies must be provided within five days of a request. The text provided is cut off before the specific changes, so they are not shown here.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-CA-Z2026-1020-072026-w44-p6/CA-Z2026-1020-07Proposed. A proposal from the California Veterinary Medical Board would change the alternate pathway to becoming a Registered Veterinary Technician (RVT). The pathway defines what counts as the equivalent of a two-year animal health technology program, including formal coursework, and requires at least 4,416 hours of directed clinical practice under a California-licensed veterinarian. The text provided is cut off before it lists the proposed changes.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-CA-Z2026-1020-082026-w44-p6/CA-Z2026-1020-08Proposed. A proposal from the California Veterinary Medical Board would change rules on handling animal remains at small animal veterinary premises. Under the existing rule, premises must keep a deceased animal in a freezer for at least 14 days if the owner has not authorized disposal; the proposal would move that duty from the individual veterinarian to the premises and use the term 'deceased animal' instead of 'body'.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-TX-TRD-2026043522026-w44-p6/TX-TRD-202604352Proposed. The Texas General Land Office would certify beach user fee (BUF) increases in the dune protection and beach access plans of the City of Port Aransas, the City of Corpus Christi and Nueces County. Each would raise the fee from $12.00 to $20.00 per calendar year, and the local governments say rising costs of beach services, such as litter abatement and restroom maintenance, exceed the fee revenue.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-TX-TRD-2026043942026-w44-p6/TX-TRD-202604394Proposed. A proposal from the Finance Commission of Texas would change rules on motor vehicle installment sales. Its main purpose is to move licensing of motor vehicle sales finance companies onto the Nationwide Multistate Licensing System (NMLS), an online platform used by state financial regulators, and it would also make technical changes to licensing and recordkeeping and repeal several rules.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-TX-TRD-2026043992026-w44-p6/TX-TRD-202604399Proposed. A proposal from the Texas Office of Consumer Credit Commissioner would change plain language model clauses for secured consumer installment loan contracts. The changes cover how the amount financed is itemized when an administrative fee is financed or paid in cash, and include a sample contract using the true daily earnings method.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-TX-TRD-2026044092026-w44-p6/TX-TRD-202604409In effect. The Finance Commission of Texas has adopted changes to rules for credit access businesses, in effect from November 5, 2026. They move licensing onto the Nationwide Multistate Licensing System (NMLS), remove text no longer needed, and make technical corrections. Some adopted sections changed after proposal, and the commission says they will be republished in the Texas Register.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-TX-TRD-2026044102026-w44-p6/TX-TRD-202604410In effect. The Texas Office of Consumer Credit Commissioner has adopted changes to rules for regulated lenders and credit access businesses under Chapter 393 of the Texas Finance Code. The changes require that information be submitted through NMLS where the rules call for it, and they are in effect from November 5, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-TX-TRD-2026044112026-w44-p6/TX-TRD-202604411In effect. The Texas Office of Consumer Credit Commissioner has adopted changes to the license section of its rules for regulated lenders under Chapter 393 of the Texas Finance Code. Its legal basis cites the move to NMLS, and the changes are in effect from November 5, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p6/#item-TX-TRD-2026044132026-w44-p6/TX-TRD-202604413In effect. The Texas Office of Consumer Credit Commissioner has adopted changes to the operational requirements section of its rules for regulated lenders under Chapter 393 of the Texas Finance Code. Its legal basis also cites the move to NMLS, and the changes are in effect from November 5, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.1073/pnas.26081851232026-w44-p5/doi:10.1073/pnas.2608185123Peer-reviewed study. A peer-reviewed study in PNAS by Priscilla Turelli and colleagues examines BA.2.87.1, a variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with many mutations in its spike protein. The authors report that changes to its N-terminal domain weaken the ability of human convalescent antibodies to engage it, which may reduce protection.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.1016/j.cell.2026.10.0042026-w44-p5/doi:10.1016/j.cell.2026.10.004Peer-reviewed study. A peer-reviewed study in Cell reports that viral replication requires more than one unit of viral genomes, a threshold that varies with the virus and cell type. The authors say these genome levels switch on negative feedback regulators of innate immune sensors, which suppresses the immune response and allows replication.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.64898/2026.10.27.263644982026-w44-p5/doi:10.64898/2026.10.27.26364498Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, compares statistical methods for detecting an epidemic from routinely collected blood test results. Using simulated data and real-world C-reactive protein (CRP) data from Russia, the authors report that the methods' performance depends on how much data is available. Composite biomarkers from complete blood count (CBC) results increased the chance of detecting an outbreak compared with CRP alone.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.64898/2026.10.28.263667232026-w44-p5/doi:10.64898/2026.10.28.26366723Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, describes PhenOM, a generative artificial intelligence (AI) foundation model trained on longitudinal medical-event data from more than 400 million patient records. The authors report that the single model has been used to complete and validate thousands of predictive tasks covering more than 1,770 outcomes. They say 80 percent of tasks reached an area under the receiver operating characteristic curve (AUROC) of at least 0.70, and 30 percent reached at least 0.80.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.64898/2026.10.28.7618752026-w44-p5/doi:10.64898/2026.10.28.761875Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, examines 6-ethyl-modified 7-deazaadenosine (EDA), an inhibitor of coronaviruses. The authors report that EDA is incorporated by the coronavirus RNA-dependent RNA polymerase (RdRp) as a mimic of one natural building block, stalling it, and they say it does not induce virus mutagenesis. They tested the mechanism with cryo-EM structures, antiviral studies and mutant viruses.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.64898/2026.10.28.7625992026-w44-p5/doi:10.64898/2026.10.28.762599Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, by K. M. Esvelt and colleagues proposes adding Societal Safety Levels (SSLs) to biosafety levels. The SSLs would set thresholds for expected public fatalities per year and would apply only to laboratory research with replication-competent potential pandemic pathogens. The authors say applying a standard of 0.1 expected deaths per facility-year would require marked safety improvements.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-2026-221942026-w44-p5/2026-22194Final rule. The Centers for Medicare & Medicaid Services (CMS), within the Health and Human Services Department, has issued a final rule updating the End-Stage Renal Disease (ESRD) Prospective Payment System for calendar year 2027. The rule also updates the payment rate for dialysis services furnished to individuals with acute kidney injury, and the ESRD Quality Incentive Program. It takes effect on January 1, 2027.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-CA-Z2026-1016-012026-w44-p5/CA-Z2026-1016-01Proposed. The California Department of Public Health (CDPH) proposes to permanently adopt emergency regulations for hospice agencies, setting patient care and business practice standards. The proposal would adopt nurse-to-patient staffing ratios, limit hospices to care in specified Geographical Service Areas, and require detailed background information for prospective owners and administrators. The Department says these measures aim to combat Medicare and Medi-Cal fraud.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-TX-TRD-2026043552026-w44-p5/TX-TRD-202604355In effect. The Texas Health and Human Services Commission (HHSC) has adopted an amendment to section 550.1301 of its rules on inspections and visits. It reduces inspections from annually to at least once every three years, to align with licensure renewal timeframes, and reduces administrative and operational burdens for providers. The rule takes effect on November 2, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.64898/2026.10.28.263667442026-w44-p5/doi:10.64898/2026.10.28.26366744Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, by S. Orsinelli-Rivers and colleagues reports a phase 4 clinical trial of a heterologous prime-boost, in which the booster contains an updated H3N2 strain. The authors say the booster reduced the proportion of people with negligible antibody responses, with no H3N2 non-responders among those who received the prime and boost, compared with 29% for H1N1. They suggest multi-strain exposures may reduce the share of people who do not mount an antibody response in a season.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.64898/2026.10.28.7626522026-w44-p5/doi:10.64898/2026.10.28.762652Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, by G. Admans and colleagues describes 'Duality vaccination', which delivers activating and inhibitory immunogens together to focus antibody responses. The authors say the design can tailor elicited antibodies to down-modulate undesired B cell responses. They say the effects depend on timing, spacing, valency and linker flexibility, and they tested it with model targets and coronavirus antigens.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-uksi-2026-11282026-w44-p5/uksi-2026-1128Final rule. This UK statutory instrument, made on October 25, 2026, brings specified provisions of the Leasehold and Freehold Reform Act 2024 into force in England. It is UK law, and no start date is stated in its data, so this summary does not give one. The instrument also includes a saving provision.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-uksi-2026-11382026-w44-p5/uksi-2026-1138Final rule. This UK statutory instrument, made on October 28, 2026, amends the Local Government Pension Scheme Regulations 2013 as a consequence of the English Devolution and Community Empowerment Act 2026. It comes into force on November 23, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-uksi-2026-11392026-w44-p5/uksi-2026-1139Final rule. This UK statutory instrument, made on October 27, 2026, amends several earlier student support regulations, including the Education (Postgraduate Master's Degree Loans) Regulations 2016 and the Lifelong Learning (Student Support) Regulations 2026. It comes into force on November 19, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-2026-221742026-w44-p5/2026-22174Final rule. The Education Department's final rule revises its regulations on recognition of accrediting agencies, to carry out Executive Order 14279, 'Reforming Accreditation to Strengthen Higher Education,' and to align the rules more closely with statute. The rule also covers institutional eligibility under the Higher Education Act of 1965. It takes effect on July 1, 2027.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-TX-TRD-2026044292026-w44-p5/TX-TRD-202604429Proposed. The Texas Comptroller of Public Accounts proposes amending its rule on information services to treat electronic health record (EHR) and electronic medical record (EMR) systems used by doctors and hospitals as nontaxable information services. The change is prospective: transactions before the rule's effective date remain subject to sales or use tax as previously enforced, and no refunds will be processed for those charges. The Comptroller estimates losses to the General Revenue Fund of $18,248,000 in fiscal year 2027.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-arxiv:2610.393752026-w44-p5/arxiv:2610.39375Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists, reports an original survey of 8,234 working-age adults in the UK, US, Denmark and India. The author reports that a majority in all four countries are strongly motivated by the non-monetary parts of their jobs, and that 81% are satisfied with their job. The paper argues that a basic income may fail to compensate workers for losses of these non-monetary benefits.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-CA-Z2026-1012-022026-w44-p5/CA-Z2026-1012-02Proposed. The California Occupational Safety and Health Standards Board proposes to reduce the trichloroethylene permissible exposure limit (PEL) to 0.24 parts per million (ppm), and to withdraw the existing short-term exposure limit (STEL) and ceiling limits. The Board says the revised limit meets its 1:1000 cancer risk threshold. The proposal is a draft and would take effect only if approved.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-openai:c7606af40dbb2026-w44-p5/openai:c7606af40dbbAnnouncement. OpenAI says it is strengthening violence prevention in ChatGPT with expanded safeguards and earlier interventions. The company also announces new protections for teens and a commitment to public safety reporting. This is OpenAI's own account of its work, not an independent assessment.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-uksi-2026-11322026-w44-p5/uksi-2026-1132Final rule. This UK statutory instrument, made on October 27, 2026, exempts dynamic spectrum access devices operating in the 5925 to 7125 MHz radio band from the requirement to be licensed under section 8(1) of the Wireless Telegraphy Act 2006. It comes into force on November 10, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.26434/chemrxiv.15007838/v22026-w44-p5/doi:10.26434/chemrxiv.15007838/v2Preprint, not peer-reviewed. A preprint from ChemRxiv, not yet reviewed by other scientists, tests a platinum-based catalyst with an ordered intermetallic structure against a disordered alloy. The authors report higher activity for oxygen reduction, a key reaction in proton exchange membrane (PEM) fuel cells, and less loss of 3d metal, which they attribute to strain in the intermetallic lattice. They say the activity losses come mainly from catalyst-layer degradation rather than particle collapse.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-CA-Z2026-1020-102026-w44-p5/CA-Z2026-1020-10Proposed. The California Air Resources Board (CARB) proposes amendments and new sections to its carbon capture, removal, utilization and storage regulation, under SB 905. The proposal amends and adopts sections across several articles, including ones on carbon storage and the Low Carbon Fuel Standard. The Board says the proposal responds to increasing climate impacts and calls for long-term carbon-management solutions.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-TX-TRD-2026043732026-w44-p5/TX-TRD-202604373In effect. The Public Utility Commission of Texas has adopted a new rule, 16 TAC §25.58, on contracts for electric energy storage. It lets transmission and distribution utilities contract with power generation companies for electric energy storage facility capacity to ensure reliable service to distribution customers. The rule implements Public Utility Regulatory Act §35.153 as enacted by Senate Bill 415, and takes effect on November 4, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.26434/chemrxiv.15011180/v22026-w44-p5/doi:10.26434/chemrxiv.15011180/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, by William Brandler argues that inhibitors of LINE-1, a retrotransposon (a mobile genetic element), could be extended to various diseases. The author notes that reverse transcriptase inhibitors developed for a different virus can reduce LINE-1 activity. The author says preclinical studies have shown LINE-1 inhibitors slow the progression of some unrelated diseases.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.26434/chemrxiv.15011180/v32026-w44-p5/doi:10.26434/chemrxiv.15011180/v3Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, by William Brandler argues that inhibitors of LINE-1, a retrotransposon (a mobile genetic element), could be extended to various diseases. The author notes that reverse transcriptase inhibitors developed for a different virus can reduce LINE-1 activity. The author says preclinical studies have shown LINE-1 inhibitors slow the progression of some unrelated diseases.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-2026-222132026-w44-p5/2026-22213Final rule. The Consumer Product Safety Commission (CPSC) has issued a direct final rule amending its mandatory safety regulation for automatic residential garage door operators to align with changes to the entrapment protection provisions of UL 325. The changes were accepted under the Consumer Product Safety Improvement Act of 1990 in October 2025. The rule takes effect on December 29, 2026.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-TX-TRD-2026043762026-w44-p5/TX-TRD-202604376Proposed. The Texas Department of Public Safety proposes new rules creating a Texas Power Outage Alert System. The rules would set procedures for issuing a power outage alert to notify the public when the system-wide power supply in one or more Texas power regions may be inadequate to meet demand. The rules would implement Senate Bill 3 of the 87th Legislature, Regular Session (2021).Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-TX-TRD-2026043772026-w44-p5/TX-TRD-202604377Proposed. The Texas Department of Public Safety proposes new rules for a Texas Active Shooter Alert System. The rules would set procedures for issuing an active shooter alert to notify the public in proximity to an active shooter situation. The rules would implement House Bill 103 of the 87th Legislature, Regular Session (2021).Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.1038/s41586-026-11199-82026-w44-p5/doi:10.1038/s41586-026-11199-8Peer-reviewed study. A peer-reviewed study in Nature estimates water demand across Africa for 2020, split across six sectors at high spatial resolution. Irrigation accounts for 225 cubic kilometers (65%) of the 347 cubic kilometer total, and estimated demand rose 26% between 2010 and 2020. The authors say the figures are harmonized estimates rather than direct measurements of water actually used.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.1038/s41586-026-11223-x2026-w44-p5/doi:10.1038/s41586-026-11223-xPeer-reviewed study. A peer-reviewed study in Nature reports that bismuth sulfide, a semiconductor, has a 'pseudo-direct bandgap' that delays electron-hole recombination compared with classic direct semiconductors. The authors say this could help overcome limits on solar energy conversion, a possibility they describe rather than a finished device.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.26434/chemrxiv.15011227/v12026-w44-p5/doi:10.26434/chemrxiv.15011227/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, by Michael J. Rix and Alexander Mitsos compares emerging ways to make ammonia with the mature process of water electrolysis combined with the Haber-Bosch process. The authors argue that many pathways in the literature, such as metal-mediated electrolysis, have energy demands above that process, so they cannot produce ammonia at competitive costs. They say any new pathway must use simple, energy-effective chemistry to cut costs substantially.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.26434/chemrxiv.15011238/v12026-w44-p5/doi:10.26434/chemrxiv.15011238/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, by Wonjoon Suk and colleagues presents a method called MAPLE (Multichannel Acquisition of Parallel-particle Level Electrochemistry) to map current into individual battery particles in real time. The authors say uneven charging in layered oxide cathodes comes from a fluorinated cathode electrolyte interphase that forms before cycling, not from bulk properties. They report that this layer impedes ion transport, and that particles with grain boundaries are less affected.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.26434/chemrxiv.15011255/v12026-w44-p5/doi:10.26434/chemrxiv.15011255/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, by Hina Goyal and colleagues analyzes about 86 thousand organic light-emitting diode (OLED) documents from 2016 to 2026 in the CAS Content Collection. It finds that intellectual property and development are concentrated in East Asia, and that device designs are shifting toward application-driven optimization. The authors also note persistent problems, such as blue-emitter instability.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-doi:10.26434/chemrxiv.15011322/v12026-w44-p5/doi:10.26434/chemrxiv.15011322/v1Preprint, not peer-reviewed. A preprint from ChemRxiv, not yet reviewed by other scientists, by Marco Gigantino and colleagues proposes a solar-powered, farm-scale system that turns livestock manure and crop residues into stable solid carbon. The authors estimate a sequestration potential of about 596 Mt C a year, and say the cost estimates assume no revenue from the carbon product. They also say products such as carbon black or graphene could in principle sell for more than the sequestration cost.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-mit-research:d7d67016a7ee2026-w44-p5/mit-research:d7d67016a7eeAnnouncement. MIT News says a study pinpoints the states with the steepest warming trends since 1980. According to the announcement, the findings indicate where adaptive measures are needed most around the United States.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-CA-Z2026-1020-052026-w44-p5/CA-Z2026-1020-05Proposed. The California Bureau of Automotive Repair proposes rules for automotive repair dealers (ARDs) that perform or arrange towing. Under the proposal, towing fees must be disclosed and authorized by the customer before towing is performed, and dealers with a motor carrier permit must obtain towing authorization on a separate document from any repair authorization. Invoices would list storage-related and towing-related charges as separate line items.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-CA-Z2026-1020-112026-w44-p5/CA-Z2026-1020-11Proposed. The California Underground Facilities Safe Excavation Board proposes to remove its $7,000,000 cap on its annual fee to operators, who own, operate or maintain underground installations. The proposal would also set a payment due date and late fees. The Board says a fixed-dollar cap is no longer reasonable because the Legislature has increased its appropriations.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p5/#item-TX-TRD-2026043982026-w44-p5/TX-TRD-202604398Proposed. The Finance Commission of Texas proposes changes to plain language rules for loan contracts of regulated lenders under Texas Finance Code Chapter 342. One proposal would raise the maximum Flesch-Kincaid grade level for certain loan contracts from 8 to 9. Another would combine two versions of a model clause on the itemization of the amount financed into a single figure.Fri, 06 Nov 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.1073/pnas.26011681232026-w44-p4/doi:10.1073/pnas.2601168123Peer-reviewed study. A peer-reviewed study compared isolated pancreatic delta cells from deceased donors with and without type-2 diabetes. In diabetes, inhibition of the cells by somatostatin and adrenaline was impaired and their somatostatin receptor levels on the surface were markedly reduced, which the authors say may dysregulate somatostatin signaling within the islets.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.1073/pnas.26023351232026-w44-p4/doi:10.1073/pnas.2602335123Peer-reviewed study. A peer-reviewed study finds that a porin protein called PPE1 in Mycobacterium tuberculosis helps the bacterium secrete metallophores and also lets in the drug isoniazid (INH). Mutant strains without PPE1 took up less isoniazid and were more tolerant to it, and in a mouse infection model they showed reduced virulence.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.1073/pnas.26044141232026-w44-p4/doi:10.1073/pnas.2604414123Peer-reviewed study. A peer-reviewed study of insurance claims from US patients compares people who were tested for COVID-19, with test-positive and test-negative results. It finds that most long-term effects attributed to COVID-19 in designs without this restriction likely reflect bias from selective testing. The authors say this does not show that symptoms beyond one year are not genuine, only that their link to COVID-19 is uncertain.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.1073/pnas.26106721232026-w44-p4/doi:10.1073/pnas.2610672123Peer-reviewed study. A peer-reviewed study of 4,685 metagenomic datasets from 296 mammal species finds that carnivores carry human-associated viruses more often than bats do, challenging the idea that bats are special reservoirs. The authors report that life-history traits such as longevity and urban land use are key ecological drivers of virus richness and sharing.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.25.7616402026-w44-p4/doi:10.64898/2026.10.25.761640Preprint, not peer-reviewed. A preprint, not peer-reviewed, describes PLASTIC, a computational framework that quantifies cellular plasticity and epigenetic reprogramming from single-cell RNA-seq data. The authors report that the high cancer risk state in pre-cancerous tissue shows increased dedifferentiation, and that the tool predicted metaplasia in lung cells from smokers, which they validated in independent data.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.18.263658492026-w44-p4/doi:10.64898/2026.10.18.26365849Preprint, not peer-reviewed. A preprint, not peer-reviewed, measured antibody responses in 81 malaria-naive adults after a controlled human malaria infection with Plasmodium falciparum. It reports a strong hierarchy among merozoite antigens for immunoglobulin G (IgG), a broader pattern for immunoglobulin M (IgM), and distinct groups of people by their antibody responses, which the authors suggest begins at first exposure.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.23.263663722026-w44-p4/doi:10.64898/2026.10.23.26366372Preprint, not peer-reviewed. A preprint, not peer-reviewed, combines proteomic scores, polygenic scores and DNA methylation scores into four MEGASCOREs for myocardial infarction, atrial fibrillation, heart failure and cardiovascular mortality. The authors report that the scores were associated with these outcomes and improved prediction beyond conventional clinical models, including stronger discrimination than SCORE2 for cardiovascular mortality.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.25.263664282026-w44-p4/doi:10.64898/2026.10.25.26366428Preprint, not peer-reviewed. A preprint, not peer-reviewed, follows 1,396 adults aged 36 to 108 and finds that five modifiable factors, including education, diabetes, low motor function, hearing loss and low vision, are associated with cognitive performance but not with its rate of decline. The authors report that plasma markers of Alzheimer's pathology were associated with faster decline.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.25.263664552026-w44-p4/doi:10.64898/2026.10.25.26366455Preprint, not peer-reviewed. A preprint, not peer-reviewed, tests 15 large language models (LLMs) on methodological errors inserted into clinical trial reports. Their detection scores for major errors ranged from 53% to 96%, compared with a mean of 27% for untrained human reviewers in an earlier experiment, and the models also flagged some errors in control reports that had none inserted.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.26.263664512026-w44-p4/doi:10.64898/2026.10.26.26366451Preprint, not peer-reviewed. A preprint, not peer-reviewed, pools three cohort studies of adults aged 50 or older in China, the US and Europe, finding that gastrointestinal medication use was associated with a higher risk of new depressive symptoms. The authors report that psychiatric medicines, used as a positive control, showed the expected strong association, and they say the findings support routine affective screening in medication reviews for older adults.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.26.263665422026-w44-p4/doi:10.64898/2026.10.26.26366542Preprint, not peer-reviewed. A preprint, not peer-reviewed, uses a microsimulation of Americans aged 55 and older to model expanded access to GLP-1 drugs under the Medicare GLP-1 Bridge demonstration. The authors report positive net social value and lower Medicare net spending in every scenario over 10 years, and say the eligible population mattered more than how long people stayed on therapy.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.27.263666502026-w44-p4/doi:10.64898/2026.10.27.26366650Preprint, not peer-reviewed. A preprint, not peer-reviewed, introduces EM-BENCH, a benchmark of 210 yes-or-no clinical vignettes based on guidelines from the American College of Emergency Physicians (ACEP). The highest configuration answered 207 of the vignettes correctly, closed-access models outperformed open-weight models, and extra reasoning did not consistently improve accuracy.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.27.7620962026-w44-p4/doi:10.64898/2026.10.27.762096Preprint, not peer-reviewed. A preprint, not peer-reviewed, links an interferon gamma and CXCL9 pathway to T-cell recruitment and fibrosis in muscle among ageing adults with physical frailty. The authors report the findings in human cohorts and in laboratory co-cultures, where blocking CXCL9 or its receptor CXCR3 reduced immune cell migration.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-arxiv:2610.359862026-w44-p4/arxiv:2610.35986Preprint, not peer-reviewed. A preprint, not peer-reviewed, examines how increases in most-favored-nation (MFN) tariffs change the relative market access of competing exporters. Using a structural gravity model and domestic and international trade data, it reports that higher MFN protection reduces imports and redirects trade toward preferential exporters, with the largest losses in intermediate and capital goods.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-arxiv:2610.360082026-w44-p4/arxiv:2610.36008Preprint, not peer-reviewed. A preprint, not peer-reviewed, compares occupations in the top and bottom quartiles of a pre-ChatGPT exposure index, using US Current Population Survey earnings data. It reports that after ChatGPT's public release the return to a year of schooling fell by 0.55 log points in exposed occupations, and the authors say this reflects a repricing of human capital within those occupations.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-ukdsi-2026-97803482881862026-w44-p4/ukdsi-2026-9780348288186Proposed. This is a draft UK statutory instrument. It would create a new public pension scheme for members of the AWE Pension Scheme and enable the Secretary of State to issue directions requiring the transfer of its assets to central government, under the Pension Schemes Act 2026. It would become law only if approved and made.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-2026-221212026-w44-p4/2026-22121Proposed. The Health and Human Services Department (HHS) proposes to revise its Mandatory Guidelines for Federal Workplace Drug Testing Programs Using Oral Fluid. This is a proposal, and comments are due by December 28, 2026.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-2026-221222026-w44-p4/2026-22122Proposed. The Health and Human Services Department (HHS) proposes to revise its Mandatory Guidelines for Federal Workplace Drug Testing Programs Using Urine (UrMG). This is a proposal, and comments are due by December 28, 2026.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.1073/pnas.25336391232026-w44-p4/doi:10.1073/pnas.2533639123Peer-reviewed study. A peer-reviewed study in PNAS estimates how much methane microbes consume at marine cold seeps, using a chemical signature in carbonates formed from methane. The authors say cold seeps play an important role in the global marine methane cycle despite their small footprint.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.1371/journal.pbio.30040792026-w44-p4/doi:10.1371/journal.pbio.3004079Peer-reviewed study. A peer-reviewed study of a marine bivalve (Mercenaria mercenaria) finds that its tolerance to ocean acidification at the larval stage and after metamorphosis are strongly negatively correlated. The authors argue that forecasts based on a single life stage can get the answer wrong, because the stages can respond in opposite directions.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.1073/pnas.25380101232026-w44-p4/doi:10.1073/pnas.2538010123Peer-reviewed study. A peer-reviewed study combines a climate model simulation with a compilation of 304 temperature reconstructions to identify a repeating climate oscillation in the Holocene. The authors say the cycle is shaped by interactions between tropical and Antarctic ocean and atmosphere, and that future warming may increase the risk of rapid climate transformation.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-2026-220822026-w44-p4/2026-22082Proposed. The Environmental Protection Agency (EPA) proposes amendments to standards for new and existing oil and natural gas sources, and the proposal would rescind the Super Emitter Program. It would also change requirements for well sites, liquids unloading, pumps, storage vessels and equipment leaks at gas plants. Comments are due by November 30, 2026.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-uksi-2026-11362026-w44-p4/uksi-2026-1136Final rule. These UK regulations, made on October 26, 2026, bring specified provisions of the Bus Services Act 2025 into force in England. They are the third commencement regulations made under that Act and include transitional provisions.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-2026-220382026-w44-p4/2026-22038Final rule. The Rural Housing Service, a Rural Development agency of the United States Department of Agriculture (USDA), is amending the Single Family Housing Guaranteed Loan Program. The change permits financing of single family homes with income-producing accessory dwelling units (ADUs) and clarifies eligibility for homes with features designed for home-based operations. The rule takes effect on December 28, 2026.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.1073/pnas.26286591232026-w44-p4/doi:10.1073/pnas.2628659123Peer-reviewed study. A peer-reviewed study reports an anthracene-based covalent-organic framework (AntCOF) that acts as a catalyst for reducing singlet oxygen in lithium-oxygen batteries. The authors say it suppresses side reactions and improves cycling performance when used with a RuO 2 catalyst.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.26434/chemrxiv.15011105/v12026-w44-p4/doi:10.26434/chemrxiv.15011105/v1Preprint, not peer-reviewed. A preprint, not peer-reviewed, uses virtual-electrode X-ray photoelectron spectroscopy to study the layer that forms between a lithium metal chloride solid electrolyte and lithium metal anodes. The authors report that oxygen leads to a new Li-Sc-Zr-oxide phase, which they say passivates the interface and allows lithium to be plated and stripped.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-arxiv:2610.358952026-w44-p4/arxiv:2610.35895Preprint, not peer-reviewed. A preprint, not peer-reviewed, applies a gradient boosting model to a panel of 147 sovereign entities and reports that it cut forecast errors by over 39% during extreme macroeconomic events, compared with L1-regularized baselines. The authors say environmental, social and governance (ESG) improvements yield no capital advantage until a foundational regulatory threshold is breached.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.26434/chemrxiv.15011174/v12026-w44-p4/doi:10.26434/chemrxiv.15011174/v1Preprint, not peer-reviewed. A preprint, not peer-reviewed, describes a lung-inspired three-dimensional gyroid membrane contactor for carbon dioxide (CO2) capture. The authors report over 90% CO2 removal from simulated flue gas and over 80% removal from ambient air at contact times below one second.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.26434/chemrxiv.15011175/v12026-w44-p4/doi:10.26434/chemrxiv.15011175/v1Preprint, not peer-reviewed. A preprint, not peer-reviewed, reviews regulations from all 50 U.S. states for disinfecting onsite sewage treatment and disposal systems. The authors say only 24 states include specific disinfection provisions, and that the evidence is insufficient to confirm that minimum requirements reliably achieve adequate microbial reduction under routine conditions.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.26434/chemrxiv.15011180/v12026-w44-p4/doi:10.26434/chemrxiv.15011180/v1Preprint, not peer-reviewed. A preprint, not peer-reviewed, argues that LINE-1 retrotransposons, virus-like genetic elements, could be inhibited therapeutically in diseases including cancer, autoimmunity and neurodegeneration. The author notes that reverse transcriptase inhibitors originally developed for HIV have been shown in preclinical studies to slow the progression of otherwise unrelated diseases.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.25.7617102026-w44-p4/doi:10.64898/2026.10.25.761710Preprint, not peer-reviewed. A preprint, not peer-reviewed, describes an enzyme that directed evolution turned into one that also degrades polyurethane, in addition to the polyesters it already breaks down. The authors say the change widened the enzyme's substrate pocket while keeping its catalytic residues in place, and describe it as the first demonstration of directed evolution of a multimodal plastic degrading enzyme.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.25.7617282026-w44-p4/doi:10.64898/2026.10.25.761728Preprint, not peer-reviewed. A preprint, not peer-reviewed, reports that chimeric antigen receptor (CAR) macrophages, engineered to target fibroblast-like synoviocytes, reduced joint damage in mouse models of rheumatoid arthritis (RA) and osteoarthritis (OA). The authors report no overt acute toxicity and describe the results as preclinical proof of concept.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.26.7614232026-w44-p4/doi:10.64898/2026.10.26.761423Preprint, not peer-reviewed. A preprint, not peer-reviewed, reports that nucleosome positions in circulating cell-free DNA reveal histone modifications, and that a model built from fragments covering a tiny fraction of the genome tracks tumor fraction. The authors say it separated samples with a tumor fraction of 3% or more from those with 0% across prostate, breast and lung cancers, and that it can also flag neuroendocrine transformation of prostate cancer.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.26.7617632026-w44-p4/doi:10.64898/2026.10.26.761763Preprint, not peer-reviewed. A preprint, not peer-reviewed, introduces AbRiDGed, a computational method for finding self-cleaving ribozymes, and reports about 150 new classes of them. The authors say the molecules appear in all domains of life and in humans, and that in experiments they influenced organismal fitness by regulating gene expression.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.26.7619212026-w44-p4/doi:10.64898/2026.10.26.761921Preprint, not peer-reviewed. A preprint, not peer-reviewed, reports that acetylation of NDUFA13 at lysine 7 acts as a switch that disrupts prohibitin scaffolds and cristae in heart cells. In mice with a mutation that mimics this acetylation, the authors report accelerated mortality and cristae loss under pressure overload.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.26.7619552026-w44-p4/doi:10.64898/2026.10.26.761955Preprint, not peer-reviewed. A preprint, not peer-reviewed, reports in mice that maternal folate deficiency impaired self-renewal of adult hematopoietic stem cells in offspring, while folate supplementation enhanced it. The authors link the opposing effects to lasting differences in mitochondrial and chromatin states.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.27.7602302026-w44-p4/doi:10.64898/2026.10.27.760230Preprint, not peer-reviewed. A preprint, not peer-reviewed, introduces the Core Coefficient, a graph theory measure of how dominant a transcription factor is in a regulatory network. The authors report that it predicted changes in network hierarchy and the effect of blocking a specific factor in cancer cell lines, and suggest it could help choose therapeutic targets.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.27.7622652026-w44-p4/doi:10.64898/2026.10.27.762265Preprint, not peer-reviewed. A preprint, not peer-reviewed, reports that mice with a conditional knockout of Frem3 in excitatory neurons showed lower brain volume in middle age than in young adulthood, and that lower genetically regulated FREM3 expression in humans was linked to lower cognitive performance. The authors describe this as cross-species evidence for FREM3's role in brain and cognitive health across aging.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p4/#item-doi:10.64898/2026.10.27.7623772026-w44-p4/doi:10.64898/2026.10.27.762377Preprint, not peer-reviewed. A preprint, not peer-reviewed, infers fitness landscapes for hemagglutinin and neuraminidase in H3N2 and H1N1 influenza viruses from temporal sequence data. The authors report that forward simulations from these landscapes predicted which mutations would fix or be lost, and the future composition of viral populations, better than neutral-evolution models.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.1371/journal.pmed.10051402026-w44-p3/doi:10.1371/journal.pmed.1005140Peer-reviewed study. This peer-reviewed observational study, published in PLOS Medicine on October 26, 2026, used global surveillance data from 2000 to 2018 covering over 30 million bacterial isolates from 114 countries. It estimates that 10% lower antibiotic use across drug classes would be associated with 38,000 fewer annual deaths from antimicrobial resistance (AMR) worldwide, about 0.50% of bacterial disease deaths. Because it relies on ecological relationships, the study shows associations rather than direct cause, and its surveillance data under-represent low-resource settings.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.20.7605952026-w44-p3/doi:10.64898/2026.10.20.760595Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports that a circular RNA called Circ_0074371 was lower in monocytes from patients with active pulmonary tuberculosis. In laboratory experiments, the authors say it reduced survival of Mycobacterium tuberculosis inside macrophages and pushed them toward the M1 polarization state. They propose that it works by sequestering miR-4738-3p, a regulator of AMP-activated protein kinase (AMPK).Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.21.263660092026-w44-p3/doi:10.64898/2026.10.21.26366009Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a modelling study of tuberculosis transmission. The authors report that a gamma-distributed model of time spent in the asymptomatic stage fits the data at least as well as the standard exponential model. For India, it projects a slower decline in incidence under the status quo but a larger reduction when active case finding is used.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.22.263662742026-w44-p3/doi:10.64898/2026.10.22.26366274Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, analyses adults in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018 against the 2026 cardiovascular-kidney-metabolic (CKM) syndrome guideline. The authors estimate it would newly make 7.48 million US adults eligible for glucagon-like peptide-1 receptor agonists (GLP-1RA), mostly people with overweight and lower cardiovascular risk, and no additional adults for sodium-glucose cotransporter 2 inhibitors (SGLT2i). They add that whether treating these adults improves outcomes cost-efficiently remains to be established.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.23.263662912026-w44-p3/doi:10.64898/2026.10.23.26366291Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, tests five large language models (LLMs), which are AI systems that generate text, on six anonymised case descriptions of sepsis, a life-threatening response to infection. The authors compared the models with 353 clinicians and report that after laboratory biomarkers were added, Qwen3.8-27B reached 91% accuracy against 61% for physicians. They also report that language, but not patient sex or age, shifted the models' diagnoses.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.24.263662782026-w44-p3/doi:10.64898/2026.10.24.26366278Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports that a sensitive method for mapping DNA methylation in cell-free DNA from blood can detect differences between people with and without Alzheimer disease. The authors compare age- and sex-matched participants from the Rush Memory and Aging Project and say the blood changes link to brain-specific alterations. They present the approach as a possible non-invasive tool for biomarker research, not a test ready for use.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.24.7615362026-w44-p3/doi:10.64898/2026.10.24.761536Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, analyses magnetic resonance imaging (MRI) and amyloid-beta positron emission tomography (PET) scans from 1,775 cognitively unimpaired older adults. The authors report that greater atrophy in the Alzheimer-related brain network was associated with higher anxiety, independent of depression, and that the anxiety network closely resembles the Alzheimer network. They also say greater atrophy in the anxiety network was associated with cognitive decline over 4.6 years.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.1371/journal.pmed.10052732026-w44-p3/doi:10.1371/journal.pmed.1005273Peer-reviewed study. This peer-reviewed systematic review, published in PLOS Medicine on October 27, 2026, appraised 20 cost-effectiveness studies of guideline-recommended, non-drug, non-surgical treatments for low back pain. The authors report that most interventions are cost-effective at a willingness-to-pay threshold of £20,000, and that some, including fear and stress reduction and self-management support for chronic pain, may save costs compared with usual care. All of the evidence comes from high-income countries, and evidence from low- and middle-income countries remains limited.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.21.263661802026-w44-p3/doi:10.64898/2026.10.21.26366180Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, pools data from global aging cohorts covering 28,242 participants, with a mean follow-up of 6.5 years. The authors report that advanced stages (3 and 4) of cardiovascular-kidney-metabolic (CKM) syndrome were associated with faster decline in attention, executive function and language, and with depressive symptoms among cognitively unimpaired people. They estimate modifiable factors accounted for 24.8% of cognitive impairment risk, mainly social isolation, depressive symptoms and physical inactivity.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.22.7604782026-w44-p3/doi:10.64898/2026.10.22.760478Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, builds a Human NK-cell Atlas (HNKA) from more than 1 million NK cells from 1,632 donors with 50 diseases. The authors report disease-linked shifts in specific NK-cell states, such as interferon-related signals in infection and autoimmunity. They also describe a model, NKceiver, that distinguished 18 diseases and predicted COVID-19 severity from NK-cell expression profiles.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.22.7610222026-w44-p3/doi:10.64898/2026.10.22.761022Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a study in mice infected with influenza A that profiles gene activity across the lungs and aorta. The authors report that influenza drove inflammation in both organs and that lung changes were linked to changes in the aorta. They say this may destabilize atherosclerotic plaque during the recovery period after infection.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.25.7616872026-w44-p3/doi:10.64898/2026.10.25.761687Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, analyses blood samples from people with tuberculosis at baseline and four weeks into treatment across three South African cohorts. The authors report 63 consistently changed genes, including fewer neutrophils, and a signature called EARLY5 that predicted sputum culture conversion by week 4 with a cross-validated area under the curve (AUC) of 0.76. They say the results support further testing in independent cohorts.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.26.7603662026-w44-p3/doi:10.64898/2026.10.26.760366Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, describes DDU384, a compound the authors call a preclinical candidate for tuberculosis after testing in mouse models of infection. The authors say it was effective alone and in drug combinations, and showed potential to shorten treatment in a relapse model. Toxicology studies are under way before any first-in-human trial.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-ukdsi-2026-97803482882542026-w44-p3/ukdsi-2026-9780348288254Proposed. This is a draft UK statutory instrument, not yet law, which would become law only if approved and made. If made, it would bring certain drugs under the Misuse of Drugs Act 1971 in line with recommendations from the Advisory Council on the Misuse of Drugs, by amending Schedule 2 to the Act, which sets the Class A, Class B and Class C classification of controlled drugs. The document states that a drug's classification affects the criminal penalties for offences relating to it.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-2026-219432026-w44-p3/2026-21943Final rule. This final rule, from the Health and Human Services Department (HHS), deregulates health information technology standards and certification programs by removing and revising certain certification criteria and regulatory provisions. The rule says it reduces burden on developers and providers and takes effect on December 28, 2026.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-nber:169ee148c53e2026-w44-p3/nber:169ee148c53ePreprint, not peer-reviewed. This working paper from NBER, not yet peer-reviewed, is an economic theory paper on why governments regulate foreign ownership of domestic firms to protect national security. The authors argue that ownership changes who controls firm decisions, which matters for geopolitical outcomes when contracts cannot settle those decisions. They say US regulation has tightened with rising geopolitical tensions and is tighter in sectors with more exposure to defense demand.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-nber:794c5590f9402026-w44-p3/nber:794c5590f940Preprint, not peer-reviewed. This working paper, not yet peer-reviewed, uses generative artificial intelligence (AI) to extract managers' economic expectations from over 120,000 corporate conference call transcripts. The authors say the resulting AI Economy Score predicts gross domestic product (GDP) growth, production, employment and wages five or more quarters ahead, beyond survey forecasts and other measures. They argue the predictive power reflects information rather than noise.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-arxiv:2610.331022026-w44-p3/arxiv:2610.33102Preprint, not peer-reviewed. This preprint, not yet peer-reviewed, is a theoretical model of a firm with junior and senior staff, asking what happens to expertise when codified work is automated. Its baseline scenario shows junior demand falling first and the time to develop an expert rising from about five years to nine, and a manager with a three-year horizon could cut the wage bill by 21 percent while the firm's capacity on work AI cannot do falls by two-fifths. The authors stress that these are scenarios, not forecasts, because two key parameters are not yet measured.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-arxiv:2610.334472026-w44-p3/arxiv:2610.33447Preprint, not peer-reviewed. This preprint, not yet peer-reviewed, is an economic model of whether AI progress can feed back into AI research fast enough for a self-sustaining acceleration, which the author calls a software-driven intelligence explosion (SIE). Calibrated to recent AI progress, the author finds an SIE occurs in 49% of Monte Carlo simulation draws, with capability progress likely fast enough and efficiency progress on a knife-edge. The author says better data on efficiency progress is essential for judging how likely an SIE is.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-arxiv:2610.341332026-w44-p3/arxiv:2610.34133Preprint, not peer-reviewed. This preprint, not yet peer-reviewed, simulates price-optimized electric vehicle (EV) charging using real-time prices calibrated to German 2025 data. The authors report that adding a model of how charging feeds back into wholesale prices reduces the increase in the local grid's import peak from 260% to 5%. They note that rebound peaks remain possible where vehicle adoption runs ahead of the national average or charging power is high.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-arxiv:2610.345082026-w44-p3/arxiv:2610.34508Preprint, not peer-reviewed. This preprint, not yet peer-reviewed, is a theoretical study of how an employer should hire when generative artificial intelligence (AI) makes application materials more polished without improving skills. The authors argue that as manipulation ability becomes more dispersed among applicants with the same observable quality, the socially best hiring rule converges to selection on observable quality alone, which they call strategic feature collapse. They also propose a dual-track mechanism that admits some high-quality applicants directly and gives others a report-based route, which they say is asymptotically optimal under additional regularity.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-uksi-2026-11192026-w44-p3/uksi-2026-1119Final rule. This is UK law, made on October 22, 2026, and it comes into force on March 31, 2027. It replaces the technical standards referred to in Commission Delegated Regulation (EU) 305/2013 so that they include Next Generation (4G/5G) eCall. It also saves existing standards until 2G networks cease operation.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-uksi-2026-11212026-w44-p3/uksi-2026-1121In effect. This is UK law, made on October 21, 2026, and it came into force on October 22, 2026. It amends section 100 of the Energy Act 2008 and makes minor amendments to the Boiler Upgrade Scheme (England and Wales) Regulations 2022.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-uksi-2026-11222026-w44-p3/uksi-2026-1122Final rule. This is a final UK statutory instrument that amends the Pedicabs (London) regulations, which cover pedicabs in London. The official text provided has no summary, so the specific changes are not described here; the original gives the detail.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-2026-220032026-w44-p3/2026-22003In effect. This temporary rule, in effect since October 27, 2026, is a notice from the National Oceanic and Atmospheric Administration (NOAA) that Virginia is transferring part of its 2026 commercial summer flounder quota to New Jersey. The transfer follows the quota transfer provisions of the Summer Flounder, Scup, and Black Sea Bass Fishery Management Plan and revises the 2026 commercial quotas for both states.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-2026-220072026-w44-p3/2026-22007In effect. This temporary rule, in effect since October 27, 2026, is a notice from the National Oceanic and Atmospheric Administration (NOAA) that New York is transferring part of its 2026 commercial bluefish quota to North Carolina. The transfer follows the quota transfer provisions of the Atlantic Bluefish Fishery Management Plan and revises the 2026 commercial bluefish quotas for both states.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-arxiv:2610.327262026-w44-p3/arxiv:2610.32726Preprint, not peer-reviewed. This preprint, not yet peer-reviewed, runs the iterated Prisoner's Dilemma among open-weight large language models (LLMs), in pairs and in networks. The authors report that cooperation is highly sensitive to model mix and small wording changes, and that models which cooperate with identical peers can shift to defection in mixed groups. They say this challenges the idea that cooperation is a stable property of a model.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.26434/chemrxiv.15011034/v12026-w44-p3/doi:10.26434/chemrxiv.15011034/v1Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports a laboratory study of solid electrolytes for batteries. The authors say fluorine added at selected oxygen sites raised the oxidation onset from 4.08 to 4.27 volts while keeping ionic conductivity of about 10 mS per cm. The aim is better voltage stability without slowing lithium-ion transport.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.23.7610712026-w44-p3/doi:10.64898/2026.10.23.761071Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a laboratory study of cartilage cells from mice and cattle. The authors report that losing the protein Tpm3.1 reduced cortical F-actin and shifted chondrocytes toward a catabolic gene pattern. They link this to the transcription factors Yes-associated protein (YAP) and Myocardin-related transcription factor A (MRTF).Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-arxiv:2610.338192026-w44-p3/arxiv:2610.33819Preprint, not peer-reviewed. This preprint, not yet peer-reviewed, is a mathematical model of how pharmaceutical firms, regulators and public scrutiny interact, fitted to composite indices for 2010 to 2024. The authors argue that ethical compliance is an oscillating state rather than a permanent one, and that it collapses once bureaucratic friction passes a threshold; the empirical friction index crosses both thresholds between 2016 and 2020. They also report that, relative to revenue, penalties were highest for firms with the lowest research and development (R&D) intensity.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-arxiv:2610.340262026-w44-p3/arxiv:2610.34026Preprint, not peer-reviewed. This preprint, not yet peer-reviewed, is a conceptual physical framework arguing that long-term sustainability depends on rates, such as power density and how fast dispersed materials can be recycled under diffuse solar flux, rather than on total energy use or material stocks. The authors argue that many technologies remain viable only through stock drawdown and high-power buffering, and that long-term sustainability requires reducing aggregate industrial throughput.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.26434/chemrxiv.15010980/v22026-w44-p3/doi:10.26434/chemrxiv.15010980/v2Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a laboratory study of polyamide membranes, which are widely used in freshwater production. The authors report that sequential chlorination and alkaline treatment more than doubled water permeance while the membrane still blocked salt. They attribute this to changes in swelling and to entropic barriers to salt transport.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.26434/chemrxiv.15011108/v12026-w44-p3/doi:10.26434/chemrxiv.15011108/v1Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a computer-model study of series sodium-ion battery packs at sub-zero temperatures. The authors report that cells with higher resistance heat more and catch up with lower-resistance cells, flattening capacity differences by 39.7% at minus 30 degrees Celsius at 0.5C. They also report the effect held after 500 cycles.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.26434/chemrxiv.15011130/v12026-w44-p3/doi:10.26434/chemrxiv.15011130/v1Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a global model of where to site solid-sorbent direct air capture with carbon dioxide (CO2) storage (DACCS), a technology that removes CO2 from the air. The authors estimate that the cheapest near-term sites cost about 1,100 to 1,200 USD per tonne of CO2, in the central United States and western Australia. By 2050 they estimate about 98% of sites would fall below 1,000 USD per tonne.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.23.7614452026-w44-p3/doi:10.64898/2026.10.23.761445Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports laboratory work on polymer-based replacements for some lipid components of lipid nanoparticles (LNPs), which deliver messenger RNA (mRNA). The authors say their first-generation polymers functionally replaced standard polyethylene glycol (PEG) lipid and ionizable lipid components in vitro and in vivo. Some formulations gave expression comparable to, or in some cases higher than, conventional lipid formulations.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.23.7614592026-w44-p3/doi:10.64898/2026.10.23.761459Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, combines a mathematical model with experiments on induced muscle wasting (IMW) in wounds and chronic disease. The authors hypothesize that IMW helps wounds heal and that, when a wound does not heal, prolonged wasting leads to cachexia. They report acute wound healing was about 2 to 6 times longer when IMW was inhibited, and that inhibiting it prevented muscle loss more effectively than nutritional support alone.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.23.7614692026-w44-p3/doi:10.64898/2026.10.23.761469Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports laboratory scaffolds made by melt electrowriting (MEW) from polycaprolactone (PCL), shaped like bone marrow trabeculae. The authors say the scaffolds let cells grow at higher density and produced more erythroid cells than standard designs. The aim is to cut the cost of cultured red blood cells for transfusion, and the authors report a 74% increase in supernatant cell numbers compared with liquid culture.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-doi:10.64898/2026.10.26.7618912026-w44-p3/doi:10.64898/2026.10.26.761891Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports an experiment in which an H3N2 influenza A virus was passaged for 1,200 generations in 12 culture lines of human airway epithelium, with immune selection removed. The authors found variant accumulation rates differed between lines but parallel evolution was minimal. They suggest influenza evolution is shaped more by the selective context than by fixed functional limits.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p3/#item-uksi-2026-11182026-w44-p3/uksi-2026-1118Final rule. This is UK law, made on October 22, 2026, and it comes into force in England on November 13, 2026. It amends the arrangements under which mayoral combined authorities and mayoral combined county authorities issue precepts. It removes the restriction, in Section 12 of the English Devolution and Community Empowerment Act 2026, under which precepts could be issued only in respect of mayoral functions.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.21.7606792026-w44-p2/doi:10.64898/2026.10.21.760679Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports results from the IAVI C107/C110 single-arm, open-label trial in humans, a trial of a vaccine against HIV-1 (human immunodeficiency virus type 1). The authors say a boost with a second vaccine reactivated primed immune cells, which matured into three antibodies that neutralized 18% to 31% of 119 viruses in a globally diverse panel. The antibodies were tested in the laboratory.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.22.263660292026-w44-p2/doi:10.64898/2026.10.22.26366029Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses brain imaging and plasma proteomics in UK Biobank participants to identify circulating proteins linked to brain structure, which it calls a 'neurostructural proteome'. The authors say this signature predicted later cognitive decline, dementia and Alzheimer's pathology across independent cohorts followed for up to two decades.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.22.263662472026-w44-p2/doi:10.64898/2026.10.22.26366247Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a cross-sectional study of 5,176 patients at a rural hospital in Gujarat, India. It tested a deep learning model that uses smartphone images of the conjunctiva (the inner eyelid lining) and clinical data to estimate hemoglobin (Hb) without a blood test. The authors report that it caught 90% of severe anemia cases in testing, compared with 70% for any anemia, and say further validation is needed before community use.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.23.263659552026-w44-p2/doi:10.64898/2026.10.23.26365955Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes uHp-seq, a method that reconstructs the genomes of Helicobacter pylori, a bacterium that infects the stomach, directly from gastric biopsies without culturing it. The authors report that one person can carry several strains at once, and that resistance-linked variants for six commonly used antibiotics were identified more accurately than by commercial testing panels. They say the approach can give resistance profiles from minimally invasive stomach samples without endoscopy.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.23.263663022026-w44-p2/doi:10.64898/2026.10.23.26366302Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines single-cell immune data with population genetics to study major depressive disorder (MDD), using psoriasis as a comparison. The authors report that genetic risk for depression was concentrated in natural killer (NK) cells, while psoriasis risk was concentrated in activated lymphocytes. They suggest NK cell signalling could be a target for immune-based treatments.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.24.263663572026-w44-p2/doi:10.64898/2026.10.24.26366357Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a metapopulation model and incidence data from the USA and Nigeria to study how measles persists. The authors say that as vaccination reduces local infections, colonization and extinction events between connected areas dominate, and cases spread more evenly through the year. They propose a new measure called 'roundness', which in Nigeria was correlated with vaccine coverage (Pearson's r of 0.70).Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-2026-218912026-w44-p2/2026-21891Proposed. This is a proposed rule, not a final one. It would implement new requirements under the Working Families Tax Cut (WFTC) legislation for Exchange eligibility and verification, and update inconsistency periods, annual and in-year eligibility redeterminations, enrollment methods during verification, and coverage effective dates. The abstract does not say who would be affected beyond these areas.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-arxiv:2610.323552026-w44-p2/arxiv:2610.32355Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, builds a theoretical model in which artificial intelligence (AI) lowers the cost of writing papers faster than the cost of reading them. The authors argue that as writing gets cheaper, fewer papers are verified, and that AI summaries of the literature inherit the AI's errors once too many papers are written with the same AI.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-arxiv:2610.324552026-w44-p2/arxiv:2610.32455Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models how China's gradual delayed-retirement reform, which began in 2025, affects older workers, transfers to adult children and fertility. Its simulations show the reform raises older employment and money transfers, but reduces grandparental childcare, so fertility and older adults' welfare would decline. The authors say childcare subsidies could offset those declines.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-arxiv:2610.329452026-w44-p2/arxiv:2610.32945Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, builds a theoretical model of a large language model (LLM) platform that chooses response quality, advertising levels and subscription prices. The authors find that partly ad-supported plans can fund useful service for users who would otherwise get none, and that an intermediate advertising cap can maximize consumer surplus. The model is theoretical rather than a study of any actual platform's pricing.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:04958cb818a92026-w44-p2/nber:04958cb818a9Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a new macro-historical database to show that tax collections relative to tax administration spending rise sharply with GDP per capita. Its growth model, in which labor is needed to collect taxes, predicts that raising tax productivity in low-income economies could lift GDP per capita substantially more than Hulten's theorem suggests.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:14bbac5111582026-w44-p2/nber:14bbac511158Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies why mutual funds rarely switch the money market funds (MMFs) they hold cash in, using holdings data from 2010 to 2024. It finds that funds with less attentive investor bases earn higher profits and survive more often. The authors model a case where AI-driven automation reduced inattention: fees would roughly halve, but flows and the risk of fire sales and MMF runs would rise sharply.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:1ed2a67dcc822026-w44-p2/nber:1ed2a67dcc82Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines a 2000 Medicare expansion that covered clinical trial costs for elderly participants, a group historically underrepresented in drug development. The authors report an immediate and large increase in trials for diseases common among the elderly, and more use of newly tested drugs among elderly people. They also analyze trial results, adverse events and drug approvals.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:312c5861b0a82026-w44-p2/nber:312c5861b0a8Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models a worker who can shirk, cooperate with training, or obstruct training of an AI system that will replace them. Its authors find that dismissal is a weaker penalty for shirking, so firms must raise the worker's rent (surplus pay), and that firms paying only wages may slow training. They suggest a completion bonus equal to that rent would remove both the gain and the slowdown.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:3a6c3ffd1ff32026-w44-p2/nber:3a6c3ffd1ff3Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses Luxembourg Income Study and International Social Survey Programme data for 27 countries from 1986 to 2019 to estimate how family-friendly policies affect gender gaps. The authors find that longer parental leave generally lowers gaps in wages, employment and earnings, except at high levels of leave, and that higher government spending on childcare lowers employment and earnings gaps. They estimate that expansion of these policies accounts for 24% to 33% of the fall in employment and earnings gaps in their sample.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:566f2f49d01e2026-w44-p2/nber:566f2f49d01ePreprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models how uncertainty and economies of scale shape regional specialization and gains from trade, calibrated with US commuting zone and international trade data. Relative to a benchmark without uncertainty, the authors estimate that uncertainty shifts employment away from riskier sectors and locations, lowering aggregate US gains from trade by around 20 percent.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:6ead6d4caed02026-w44-p2/nber:6ead6d4caed0Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a dynamic model of college enrollment and completion estimated from longitudinal surveys, quasi-experiments and randomized controlled trials. It finds that most unconditional financial policies have moderate effects on attendance and small effects on completion, while merit-based incentives such as forgiving student loans upon graduation have larger effects but benefit wealthier students more. The authors conclude that the greatest potential for raising attainment may come from better preparing students for college.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:8a5f01bfd5022026-w44-p2/nber:8a5f01bfd502Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a simulated model of the labor market to test two policies: gender-free applications for skilled jobs, and gender-free compensation. The authors find that gender-free applications eliminate wage gaps in the short run, but the effect is reduced once education choices adjust. Gender-free compensation reverses the wage gap in skilled markets and eliminates it in unskilled markets, even after education adjusts.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:8f0c669c170d2026-w44-p2/nber:8f0c669c170dPreprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models two hegemons (dominant powers) that trade with each other while competing for influence over the rest of the world. Its authors find that containment, where one limits sales of its inputs to the rival and pressures other countries to stop sourcing from it, arises when the two hegemons' exports are more substitutable, less interdependent and more directly rivals. The model also suggests containment can worsen the efficiency of global production.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:9930be62f6a22026-w44-p2/nber:9930be62f6a2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a new survey and a quantitative model of household energy use, which accounts for about one third of US emissions, to test subsidies for electric vehicles, heat pumps and residential solar. The authors find that solar gets the highest subsidy rate and accounts for over one third of emissions cuts, and that restricting subsidies to lower-income households saves only small costs. They also estimate household emissions would be over 15 percent higher without environmental preferences.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:c34ccf32c0242026-w44-p2/nber:c34ccf32c024Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses card transaction data from 174 million consumers to estimate that about 2.9% of US consumers pay for at least one major generative AI service, nearly all on basic plans costing $30 or less a month. The authors report low switching costs: annual retention rates range from 20% to 45%, and switching rises around major model releases. Their structural model suggests strong competitive pressure, with consumers highly price sensitive.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-nber:c7bcd6624f442026-w44-p2/nber:c7bcd6624f44Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reviews how researchers' understanding of health care utilization varying across the United States has evolved since the late 2000s, when it helped shape the Affordable Care Act. The authors say supply-side and demand-side factors both matter for regional differences, that health care productivity varies substantially across providers, and that the sources of area-level productivity differences are still poorly understood.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-ukdsi-2026-97803482881792026-w44-p2/ukdsi-2026-9780348288179Proposed. This is a draft UK statutory instrument covering Northern Ireland, which has been laid before Parliament and would become UK law only if approved and made. It would modify election law so that polls for the Northern Ireland Assembly and Northern Ireland local elections can be taken together in 2027, if the Chief Electoral Officer directs that they should be.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-2026-219232026-w44-p2/2026-21923Final rule. This final rule takes effect November 27, 2026, and adopts, with minor non-substantive changes, an earlier interim final rule that implements the HAVANA Act of 2021. The HAVANA Act lets agency heads provide payments to certain people with qualifying brain injuries. The rule covers current and former Justice Department employees and their dependents, and changes the titles of some officials in the payment review process and the earliest eligibility date for claims.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-openai:64d59b55a8fb2026-w44-p2/openai:64d59b55a8fbAnnouncement. OpenAI says in its announcement that OpenAI Signals data covers 165 work activities across nearly 100 countries. The company says the data shows how people use ChatGPT for work and how that usage changes over time.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-2026-218492026-w44-p2/2026-21849In effect. This is a final rule that takes effect October 27, 2026, and revises federal regulations on hunting and trapping seasons, harvest limits, and methods for taking wildlife for subsistence uses on public lands in Alaska. It covers the 2026-27 and 2027-28 regulatory years and is issued by the Federal Subsistence Board, which also addresses customary and traditional use determinations and makes administrative corrections. The abstract does not say who is affected beyond the subsistence uses it covers.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-2026-219222026-w44-p2/2026-21922Proposed. This is a proposed rule from the Pipeline and Hazardous Materials Safety Administration (PHMSA) in the Transportation Department. It would update the Hazardous Materials Regulations to adopt certain international regulations and standards on shipping names, hazard classes, packing groups, packaging, air transport quantity limits and vessel stowage. The agency says the aim is consistency with international rules and lower costs.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-2026-218882026-w44-p2/2026-21888In effect. This is a temporary rule that took effect October 23, 2026, from the National Oceanic and Atmospheric Administration (NOAA). It prohibits directed fishing (fishing aimed at that species) for Pacific cod by vessels using pot gear in the Western Regulatory Area of the Gulf of Alaska. The stated purpose is to prevent exceeding the 2026 total allowable catch for that gear.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-2026-219202026-w44-p2/2026-21920Final rule. This final rule takes effect November 27, 2026, and amends Justice Department regulations on the National Instant Criminal Background Check System (NICS) of the Federal Bureau of Investigation (FBI). It allows Federal Firearm Licensees (FFLs) to use NICS to voluntarily run employment background checks on certain current or prospective employees, which the rule calls firearm handler background checks.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-ukdsi-2026-97803482881482026-w44-p2/ukdsi-2026-9780348288148Proposed. This is a draft UK statutory instrument, which has been laid before Parliament and would become UK law only if approved and made. It would raise the maximum penalty that may be set for contravening a relevant customs rule from £2,500 to £10,000, by amending section 26(5) of the Finance Act 2003. The abstract does not say who would be affected.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-arxiv:2610.316732026-w44-p2/arxiv:2610.31673Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines a susceptible-exposed-infectious-recovered (SEIR) epidemic model with a Temporal Fusion Transformer, a deep learning model, to forecast COVID-19 infections across regions. The authors say it was more stable and accurate than a calibrated standalone SEIR model. They use SHAP (SHapley Additive exPlanations) to show which factors drove surges and slowdowns in each region.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-arxiv:2610.324612026-w44-p2/arxiv:2610.32461Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tracked more than 12,000 knowledge workers for 13 months during a staged rollout of Microsoft Copilot, an AI-powered assistant. Using two quasi-experimental methods, the authors estimate that generative AI increased collaboration time and the number of colleagues people worked with. They also found that users concentrated more collaboration on colleagues they already trusted, and suggest AI may not replace human-to-human interaction.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.1073/pnas.23211521222026-w44-p2/doi:10.1073/pnas.2321152122Peer-reviewed study. A peer-reviewed study in PNAS used household health surveys and weather data from 1983 to 2016 to examine how humid heat affects fertility in Nigeria. It found that a 1 °C rise in humid heat was linked to fewer conceptions at the time, while heat one to two months earlier was linked to more conceptions, and heat during pregnancy was linked to more pregnancy terminations. This is an observational study, which shows a link, not a cause, and the authors say the net effect is more births, though timing may shift.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.1073/pnas.23211531222026-w44-p2/doi:10.1073/pnas.2321153122Peer-reviewed study. A peer-reviewed study using European Social Survey data from 25 countries, covering 2012 to 2022, links warm spells to more worry about climate change and more votes for Green parties and coalitions. For each extra degree of excess temperature during warm spells over the previous 12 months, the probability of being worried about climate change rose by about 4.0 percentage points and of voting Green by about 2.8 points. The increase was largest for low-educated men, who had the lowest concern to start with. This is an observational study, which shows a link, not a cause.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.1073/pnas.26027471232026-w44-p2/doi:10.1073/pnas.2602747123Peer-reviewed study. A peer-reviewed study reports that a circular RNA (circRNA) called circEPSTI1 is raised in dengue patients and helps the virus multiply by blocking another RNA, miR-942-5p. In cell experiments, the compound Tiplaxtinin reduced virus replication by lowering circEPSTI1. The authors say the findings point to therapeutic potential for dengue, and the work is laboratory research.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.26434/chemrxiv.15009696/v22026-w44-p2/doi:10.26434/chemrxiv.15009696/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that pulsed Joule heating, a method using short electrical heating pulses, produces light olefins from complex hydrocarbons without a catalyst. The authors say the yields are comparable to those of catalytic cracking, and that crude oil treated this way gave a light olefin yield of approximately 38 wt%. They say the framework could inform electrified industrial olefin production.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.26434/chemrxiv.15011001/v22026-w44-p2/doi:10.26434/chemrxiv.15011001/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines satellite and ground measurements of ozone into a global dataset covering 2005 to 2022. It estimates that the share of the world population exposed to ozone above 50 parts per billion (ppb) rose from 17.2% to 41.0% over that period. The authors say satellite data adds little where monitoring is dense but reduces uncertainty across large unmonitored gaps.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.21.7605732026-w44-p2/doi:10.64898/2026.10.21.760573Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a design pipeline built around a generative model called Pythia-1. The authors say screening up to 48 designed candidates for each of 22 therapeutic targets yielded antibodies with single-digit nanomolar affinities, and some with agonist (switching on) or antagonist (blocking) activity against G protein-coupled receptors (GPCRs). They have released the sequences of their lead candidates so others can test them independently.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.22.7612802026-w44-p2/doi:10.64898/2026.10.22.761280Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies how ivermectin (IVM) affects immune responses to the coronavirus behind COVID-19, using human cell co-cultures and hamsters. The authors report that blocking the 7nAChR or P2X4 receptors removed ivermectin's benefit in hamsters, while positive allosteric modulators (drugs that enhance receptor activity) reduced lung pathology and loss of smell (anosmia). They say these receptors and the CXCL10 and CXCL5 signalling axis are promising targets for host-directed therapy.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44-p2/#item-doi:10.64898/2026.10.24.7615852026-w44-p2/doi:10.64898/2026.10.24.761585Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes high-throughput cell-free synthesis of signaling proteins, which the authors used to measure how primary human immune cells respond to every cytokine encoded in the human genome. The authors say Growth Differentiation Factor 9 (GDF9), an ovary-produced cytokine, mimics some protein-level responses and cancer-killing effects of interleukin-2 (IL-2). They also built computational methods to prioritize drivers of disease-linked gene signatures and drug targets.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44/#item-2026-218102026-w44/2026-21810Proposed. The Federal Communications Commission (FCC) has a petition for reconsideration filed in one of its rulemaking proceedings. Harold Feld filed the petition on behalf of Public Knowledge and others. The abstract does not say which action the petition challenges or what it asks the FCC to do, and the item is listed as proposed, so it is not a final rule.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44/#item-2026-218212026-w44/2026-21821Final rule. The Federal Communications Commission (FCC) has issued a final rule, effective November 25, 2026, that changes how consumers can revoke consent to robocalls. It lets callers treat a revocation request as applying only to the specific category of informational robocalls it was directed at, and lets them designate one exclusive means for consumers to revoke consent. It also amends the consent exemption for financial institutions so they can more easily alert customers to fraudulent activity, and delegates review of the robocall rules for clarity to the Consumer and Governmental Affairs Bureau (CGB).Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44/#item-2026-217942026-w44/2026-21794Proposed. The National Highway Traffic Safety Administration (NHTSA) of the Transportation Department proposes to update Federal Motor Vehicle Safety Standard (FMVSS) No. 108, which covers lamps, reflective devices and associated equipment. The changes would remove requirements the agency calls unnecessary and amend the test voltage for integral beam headlamps. For vehicles with Automated Driving Systems (ADS) and no manually operated driving controls, the proposal would limit certain turn signal, hazard warning and beam switching requirements and would allow cyan-colored ADS marker lamps as optional equipment.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44/#item-2026-218052026-w44/2026-21805In effect. The National Oceanic and Atmospheric Administration (NOAA) has issued a temporary rule, in effect from October 26, 2026, that reallocates projected unused Pacific cod from catcher vessels using trawl gear to catcher vessels under 60 feet (18.3 meters) length overall that use hook-and-line or pot gear, and to American Fisheries Act trawl catcher/processors. The action covers the Bering Sea and Aleutian Islands management area. It is needed so the 2026 total allowable catch of Pacific cod in that area can be harvested.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w44/#item-2026-217862026-w44/2026-21786Proposed. The Treasury Department's Investment Security Office has proposed regulations to implement Subtitle C of the Comprehensive Outbound Investment National Security Act. The proposal would require United States persons to notify the Treasury Department about certain transactions involving foreign persons engaged in notifiable technologies. It would also prohibit certain other transactions involving foreign persons engaged in prohibited technologies.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1073/pnas.26052091232026-w43-p9/doi:10.1073/pnas.2605209123Peer-reviewed study. A peer-reviewed study in human brain organoids (lab models of brain tissue) found that CD8-positive T cells, a type of immune cell, drove injury to neurons when amyloid-beta, a protein linked to Alzheimer's disease, was present. The T cells were drawn in through the CX3CL1–CX3CR1 axis, and neutralizing their cytokines and cytotoxic molecules rescued the tissue.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1371/journal.pmed.10052652026-w43-p9/doi:10.1371/journal.pmed.1005265Peer-reviewed study. A peer-reviewed cohort study in PLOS Medicine tested protein risk scores for atherosclerosis progression, meaning the worsening of artery disease, in a community population. Added to a guideline-recommended traditional risk score, the scores reclassified 18.6% of intermediate-risk individuals into the high-risk category. The authors say the scores need larger external validation before wider use.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.26434/chemrxiv.15010694/v12026-w43-p9/doi:10.26434/chemrxiv.15010694/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, reports the first complete three-dimensional, atomic-level structure of an amorphous solid dispersion, a drug (AZD5462) mixed into a copovidone polymer. The authors say the polymer reshapes the hydrogen-bonding network, which may explain why the formulation stayed physically stable for over two years while the pure drug recrystallized within hours.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.15.263651072026-w43-p9/doi:10.64898/2026.10.15.26365107Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, found that gut microbiota changes after ischemic stroke persisted for up to three months in two patient cohorts and in experimental models. In a randomized, double-blind trial, a multispecies probiotic led to microbiome changes and significantly improved functional recovery compared with placebo, and the authors call for larger Phase III trials to validate it.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.16.7595412026-w43-p9/doi:10.64898/2026.10.16.759541Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, followed a symbiont called Microsporidia MB in wild Anopheles arabiensis mosquitoes in western Kenya over 30 months. The authors report that infection was associated with approximately 50% lower odds of Plasmodium falciparum infection, and approximately 60% lower odds for high-intensity symbiont infections.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.18.7599912026-w43-p9/doi:10.64898/2026.10.18.759991Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, describes a method that collects neuron-rich cells from the nose with a soft brush swab and measures phosphorylated tau with single-cell Western blotting. The authors report that for Alzheimer's disease this approach had superior diagnostic capacity compared with blood-based approaches.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.19.263659062026-w43-p9/doi:10.64898/2026.10.19.26365906Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, pooled three cohort studies with 11,563 participants and found that long sleep, 9 hours or more, and insomnia were associated with lower global cognitive function at baseline. Sleep measures were not associated with change in cognitive function over follow-up, and the authors suggest cognition may be linked to distinct sleep patterns.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1073/pnas.26107661232026-w43-p9/doi:10.1073/pnas.2610766123Peer-reviewed study. A peer-reviewed PNAS study links cerebrospinal fluid levels of 4E-BP1 to neurodegeneration in amyloid-positive people and shows in mouse microglia that amyloid-beta inactivates 4E-BP1. The authors report that deleting 4E-BP1 and 4E-BP2 increased mitochondrial mass, reduced inflammatory signaling and protected microglia from amyloid-induced cell death.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1073/pnas.26137761232026-w43-p9/doi:10.1073/pnas.2613776123Peer-reviewed study. A peer-reviewed PNAS study validated some of the genes identified in a companion paper as affecting weight gain on a high-fat diet in male C57BL/6N mice. Tissue-specific inhibition of several of them made the mice resistant to diet-induced obesity or glucose intolerance, and the authors note that eight of the genes were previously implicated in human obesity.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1371/journal.pmed.10048782026-w43-p9/doi:10.1371/journal.pmed.1004878Peer-reviewed study. A peer-reviewed simulation study in PLOS Medicine modeled Shigella vaccine trials under different assumptions about natural immunity and trial designs. Only one design, active surveillance for infection with single-outcome models, was consistently unbiased, while the other five could underestimate vaccine efficacy by up to an absolute 20%.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.16.263657122026-w43-p9/doi:10.64898/2026.10.16.26365712Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, followed children from a randomized trial in which families received a liquefied petroleum gas (LPG) cookstove and free fuel during pregnancy and infancy. Measured at ages 2 to 5 years in India, Rwanda and Guatemala, the study found no statistically significant effect on height-for-age or stunting despite substantial reductions in air pollution during the trial.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1016/j.cell.2026.09.0582026-w43-p9/doi:10.1016/j.cell.2026.09.058Peer-reviewed study. A peer-reviewed Cell study found that the MCT6 transporter is the route by which the metabolite Lac-Phe exits intestinal cells and enters the blood. Mice lacking gut MCT6 could not maintain normal circulating Lac-Phe levels and showed resistance to metformin-associated weight loss.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.16.7595512026-w43-p9/doi:10.64898/2026.10.16.759551Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, found that fewer than 1% of peptides identified as HLA-A*02:01 binders were detectably presented on MHC class I by human macrophages infected with Mycobacterium tuberculosis. The authors built a neural-network model using gene expression and neighboring amino acids, and used it to identify additional antigens.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.21.7603132026-w43-p9/doi:10.64898/2026.10.21.760313Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, argues that many reported microbe-disease associations in low-biomass samples appear to measure sample biomass rather than disease. The authors judged 6,175 claims from 175 studies and propose TRUEDA, a method that reports how much contamination each difference could tolerate before it stops holding.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.21.7605842026-w43-p9/doi:10.64898/2026.10.21.760584Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, compared N-acetylglucosamine with glucosamine hydrochloride in a rat model of knee osteoarthritis. The authors report higher peak serum concentrations, less cartilage degeneration and better results for N-acetylglucosamine, and say it warrants further clinical study.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.21.7606242026-w43-p9/doi:10.64898/2026.10.21.760624Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, reports that enlarged cells redistribute chromatin between nuclear speckles and the nuclear lamina, which changes gene expression and splice isoform usage. The authors say a non-functional MDM4-S variant blocks G1 cell cycle progression, and that reintroducing correctly spliced MDM4 reverted senescent features in enlarged cells.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.19.7596102026-w43-p9/doi:10.64898/2026.10.19.759610Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, analyzed 2.3 million nuclei from 427 donors to identify multicellular patterns linked to Alzheimer's pathology and sex. The authors report that the pattern included changes in RORB-GABRG excitatory neurons and disrupted oligodendrocyte precursor cell signaling, and that it predicted neuropathology in an independent dataset.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.20.263660692026-w43-p9/doi:10.64898/2026.10.20.26366069Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, is a qualitative study of 15 adults who recovered from COVID-19 after hospital isolation in Nairobi, Kenya, interviewed in 2023. Participants described some attentive care, but also brief and distant contact, unnoticed deterioration and ridicule of distress, and the author proposes fear-driven distancing as an additional form of mistreatment.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.21.7607902026-w43-p9/doi:10.64898/2026.10.21.760790Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, reports that the TM6SF2 E167K variant, a loss-of-function variant linked to metabolic dysfunction-associated steatotic liver disease (MASLD), is recognized and degraded through a cellular protein-degradation pathway. The authors identify RNF5 as the ubiquitin ligase that tags it, and say it provides a rational target for MASLD therapy.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.21.263661452026-w43-p9/doi:10.64898/2026.10.21.26366145Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, used electronic health records from the All of Us Research Program to test whether lipid panels that include apolipoprotein B (ApoB) predict a first heart failure event. The authors report an area under the curve (AUC, a measure of prediction accuracy) of 0.624 in men and 0.627 in women for predictions 36 months in advance, and describe LDL cholesterol as a counterintuitive predictor.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.21.263661652026-w43-p9/doi:10.64898/2026.10.21.26366165Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, computed a Route Concordance Index from diffusion MRI scans in 1,706 OASIS-3 sessions, and reports that it declined monotonically across a five-stage trajectory. The authors report that a classifier using these routing features detected conversion to mild cognitive impairment (MCI) or Alzheimer's up to four years before diagnosis, and that the findings replicated in a second dataset called ADNI.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.22.7610672026-w43-p9/doi:10.64898/2026.10.22.761067Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, applied spatial transcriptomics, which maps gene activity within tissue, to the dorsolateral prefrontal cortex of people with major depressive disorder, bipolar disorder and neurotypical controls. The authors report sex- and diagnosis-specific differences in white matter, vascular-linked cell compartments and neurons, including a signaling pathway tied to genetic risk for mood disorders.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.64898/2026.10.23.7613462026-w43-p9/doi:10.64898/2026.10.23.761346Preprint, not peer-reviewed. A preprint on bioRxiv, not yet reviewed by other scientists, gave adult mice 25% fructose in drinking water for 8 weeks and found robust anxiety-like behavior in males, with memory deficits in both sexes. The authors report that knocking down the fructose transporter Glut5 in microglia prevented the anxiety-like behavior, which they say shows microglial fructose uptake is required for it.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.26434/chemrxiv.15010808/v12026-w43-p9/doi:10.26434/chemrxiv.15010808/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, tests dilute copper and palladium nanoparticles in a zero-gap electrolyzer at current densities of 100 to 300 mA cm-2. The authors report that about 4.5 at.% palladium gave the best balance of stability, performance and palladium efficiency, with less degradation than pure copper at high current.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-TX-TRD-2026042532026-w43-p9/TX-TRD-202604253Proposed. The Railroad Commission of Texas proposes amending 16 Texas Administrative Code §7.351 to remove mail submission for gas utility tax reports and payments. Under the proposal, a report and payment would be timely only if the Gas Services department receives them on or before the deadline, matching the commission's new online payment system.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-2026-215932026-w43-p9/2026-21593In effect. The Coast Guard has set a temporary safety zone in certain navigable waters of Zach's Bay, near Wantagh, NY, which is in effect from October 24, 2026. It protects swimmers, personnel, vessels and the marine environment from hazards linked to a swim event at Jones Beach State Park that was cancelled because of storms. Entry into the zone is prohibited unless the Captain of the Port, Sector Long Island Sound, or a designated representative authorizes it.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-WA-26-20-0262026-w43-p9/WA-26-20-026In effect. The Washington Department of Fish and Wildlife has issued a temporary rule, in effect from October 1, 2026, that changes landing and possession limits for commercial reef net license holders in Area 7 during the current open period. It sets a per-license coho retention limit to redistribute the remaining license quota among the license holders who are actually fishing, and there was not enough time to adopt permanent rules.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1073/pnas.26204061232026-w43-p9/doi:10.1073/pnas.2620406123Peer-reviewed study. A peer-reviewed PNAS study used host-induced gene silencing, which relies on RNAi constructs, to target Aspergillus genes in transgenic maize. Several lines showed significant reductions in aflatoxin accumulation after infection with Aspergillus flavus or Aspergillus parasiticus, while silencing of one target gene was not achieved.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.26434/chemrxiv.15010710/v12026-w43-p9/doi:10.26434/chemrxiv.15010710/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, reports laboratory experiments on a (La, Sr)TiO3-based material whose surface chemistry shifts under electrochemical activation. The authors say this can raise selectivity for C2 products such as ethylene and ethane from methane, a trade-off that has long limited the field.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-mit-research:0df0198fa4f12026-w43-p9/mit-research:0df0198fa4f1Announcement. MIT News reports that researchers in the Chisholm lab found Prochlorococcus, the ocean's most abundant microbe, can switch between drifting alone and living in attached communities. The institution says this could reshape estimates of how much carbon the ocean moves to the deep sea.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1073/pnas.26122731232026-w43-p9/doi:10.1073/pnas.2612273123Peer-reviewed study. A peer-reviewed PNAS study introduces glycerosomes, phosphatidylcholine vesicles containing glycerol, as a boundary lubricant. Measured with a surface force balance, they reached a friction coefficient as low as 10 to the minus 5 at 15.6 MPa, which the authors say is a 20-fold reduction compared with conventional PC liposomes.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.1126/science.aed83192026-w43-p9/doi:10.1126/science.aed8319Peer-reviewed study. A peer-reviewed Science study combined experiments and simulations to show that the self-rotation of functional groups confined in nanochannels can speed molecular transport. The authors say this works by transferring kinetic energy and enabling more efficient molecular relays, improving separation performance beyond current benchmarks.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.26434/chemrxiv.15010710/v22026-w43-p9/doi:10.26434/chemrxiv.15010710/v2Preprint, not peer-reviewed. A second version of a preprint on ChemRxiv, not yet reviewed by other scientists, reports laboratory experiments on a (La, Sr)TiO3-based material whose surface chemistry shifts under electrochemical activation. The authors say this can raise selectivity for C2 products such as ethylene and ethane from methane, a trade-off that has long limited the field.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-doi:10.26434/chemrxiv.15010830/v12026-w43-p9/doi:10.26434/chemrxiv.15010830/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, uses a three-dimensional furnace and reactor model to argue that the spatial distribution of heat flux along the coil controls ethylene yield more than coil outlet temperature. The authors report a 5.86% relative increase in ethylene yield while coil outlet temperature falls by 3.94 kelvin at a fixed total heat input.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-WA-26-20-0082026-w43-p9/WA-26-20-008Proposed. Eastern Washington University proposes changes to its student conduct code, which sets the standards of student behavior and the procedures used in student conduct processes. The changes would give students clearer standards of acceptable behavior and simplify some procedures.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-WA-26-20-0482026-w43-p9/WA-26-20-048Proposed. The University of Washington has proposed amendments to its student conduct code. After receiving comments and holding a public hearing, the university is extending the comment period, and the proposal would change the code only if it is adopted.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-WA-26-20-0782026-w43-p9/WA-26-20-078Proposed. Lower Columbia College proposes revisions to its student conduct code to align student disciplinary processes with Title IX regulations adopted by the United States Department of Education in 2020, after the 2024 regulations were vacated. The revisions also aim to clarify and streamline agency procedures.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p9/#item-WA-26-20-0792026-w43-p9/WA-26-20-079Final rule. Lake Washington Institute of Technology has adopted a final rule that updates its student conduct code for clarity and to bring it into line with federal guidance and amendments to Title IX. The rule adds policies and practices around hazing, and it takes effect on November 5, 2026.Wed, 28 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.14.7586882026-w43-p8/doi:10.64898/2026.10.14.758688Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, combines data from people with diabetes, human artery samples, and experiments in mice and cells. It reports that Rev-erbα is lower in calcified areas of human artery plaques, and that mice without Rev-erb develop faster atherosclerosis and vascular calcification.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.19.7553402026-w43-p8/doi:10.64898/2026.10.19.755340Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, followed toddlers aged 18 to 24 months through a memory test, with retrieval up to six months later. It reports that memories were not simply erased: many toddlers kept only part of a memory, and the authors say early memories persist in an increasingly inaccessible form.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0402026-w43-p8/WA-26-20-040In effect. This temporary emergency rule, in effect from October 1, 2026, sets up a limited community access program with the Department of Social and Health Services (DSHS). It continues state-funded long-term services and supports for people whose immigration status makes them ineligible for federally funded medical assistance, and the agency will use standard rule-making to make the changes permanent.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-1052026-w43-p8/WA-26-20-105Final rule. This is a final rule, effective November 7, 2026. The Health Care Authority removes outdated language to align with federal requirements and with the department of children, youth, and family's policies, and it provides that children entering out-of-home placement may, instead of must, receive an initial health screen within five days.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.16.7593912026-w43-p8/doi:10.64898/2026.10.16.759391Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and it is a study in male mice. Researchers introduced the human IL6RA variant into mice, report that it changes soluble IL6RA levels as in humans, and say it significantly prevents atherosclerosis and abdominal aortic aneurysm (AAA).Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.18.263658212026-w43-p8/doi:10.64898/2026.10.18.26365821Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports a randomized, placebo-controlled phase 2 trial in 62 adults with obesity, type 2 diabetes and metabolic dysfunction-associated steatohepatitis (MASH). Taken by mouth with semaglutide for 16 weeks, linafexor led to 6.17% weight loss versus 2.91% with placebo, with gastrointestinal side effects similar in both groups (23.3% vs. 18.8%).Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.18.263658612026-w43-p8/doi:10.64898/2026.10.18.26365861Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, examines how governments in Sub-Saharan Africa responded to disruption of President's Emergency Plan for AIDS Relief (PEPFAR) funding after the suspension of United States foreign aid. It finds that higher Human Development Index (HDI) scores were significantly associated with stronger government responses, while links for gross domestic product (GDP) per capita and HIV prevalence were not significant after adjustment for multiple comparisons.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.19.263659732026-w43-p8/doi:10.64898/2026.10.19.26365973Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a cross-sectional observational study of 14,378 women in six Indian states who were eligible for the Pradhan Mantri Jan Arogya Yojana (PM-JAY) publicly funded health insurance scheme. It shows a link, not a cause: high women's empowerment was associated with higher odds of completing PM-JAY verification, but not with outpatient service use.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.20.7603932026-w43-p8/doi:10.64898/2026.10.20.760393Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, combines spatial, single-cell, protein and other data from breast cancer. It reports that chemotherapy depleted the pretreatment cell states and repeatedly favored a restricted set of survivors, and that the capacity to reach those survivor states was partly present before treatment.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.18.7598242026-w43-p8/doi:10.64898/2026.10.18.759824Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a laboratory study of lipid nanoparticles (LNP), the carriers used to deliver messenger RNA (mRNA). It reports that adding more DSPC lipid changed particle shape from spherical to non-spherical, and that non-spherical particles gave higher and more sustained protein expression, a difference the authors say uptake alone does not explain.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.19.263659622026-w43-p8/doi:10.64898/2026.10.19.26365962Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is an observational study of participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, which shows a link, not a cause. It finds that people who kept higher diet quality and higher physical activity through young adulthood had much higher odds of high midlife cardiovascular health, and the combined association was larger than either factor alone.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.20.263660312026-w43-p8/doi:10.64898/2026.10.20.26366031Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, estimates annual direct healthcare costs of community acquired pneumonia (CAP) among adults in the United States, using 2023 Medical Expenditure Panel Survey data. Most of the cost is hospital care, and the authors also link higher pneumococcal vaccination uptake to lower pneumonia mortality across states.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.20.263660712026-w43-p8/doi:10.64898/2026.10.20.26366071Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, audits drug-safety warnings for 33 drugs in English, Russian, Arabic and Hebrew Wikipedia, using large language models as a measuring tool. It estimates that warnings were weaker in the Russian, Arabic and Hebrew editions than in English, but the uncertainty ranges include no difference, and the model codes are not yet checked against human coding.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.19.7602672026-w43-p8/doi:10.64898/2026.10.19.760267Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a mouse study in which male UM-HET3 mice, a genetically heterogeneous stock, were castrated at 20, 60 or 240 days of age. Castration at each age prevented early excess male mortality and increased median lifespan, and the authors say the responsible testicular factors act rapidly and their continued presence is needed to sustain higher male mortality.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.21.263661492026-w43-p8/doi:10.64898/2026.10.21.26366149Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, tests two decision-only AI models, Jev and OpenAI Decisions, alone and paired with the language model GPT-6 Luna, using clinical case presentations. The authors report that pairing reduced decision changes caused by added labels or pressure cues, that triage accuracy stayed near 81% to 82%, and they describe the work as a proof of concept.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.64898/2026.10.21.263661662026-w43-p8/doi:10.64898/2026.10.21.26366166Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, uses a data-driven agent-based model of malaria infection and transmission to examine primaquine, a drug that targets mature gametocytes, the stage that passes malaria from humans to mosquitoes. The authors report that differences in how people adhere to multi-round mass drug administration (MDA) campaigns could explain conflicting earlier results, and they predict that primaquine in routine case management could significantly reduce the prevalence of infection.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-ukdsi-2026-97803482879502026-w43-p8/ukdsi-2026-9780348287950Proposed. This is a draft UK statutory instrument, laid before Parliament, so it is not law yet. If approved and made, it would disqualify from certain social security benefits people detained in hospital under section 37 of the Mental Health Act 1983 after a conviction for a serious offence, and it would keep similar people disqualified after their release date, until discharge from hospital, if they were detained under sections 45A or 47.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.26434/chemrxiv.15006146/v32026-w43-p8/doi:10.26434/chemrxiv.15006146/v3Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, describes how the authors used AI retrosynthesis software with expert chemist knowledge to propose a new synthetic route to ganaplacide, a drug candidate against malaria. The AI suggested a non-evident two-step synthesis of the molecule's core, and the authors also present a Synthetic Confidence Score that assesses the level of risk in each disconnection.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-uksi-2026-11102026-w43-p8/uksi-2026-1110Final rule. This is UK law, made on October 19, 2026, which comes into force on January 4, 2027. It amends the Marine Licensing (Exempted Activities) Order 2011 and the Marine Licensing (Application Fees) Regulations 2014.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.26434/chemrxiv.15011001/v12026-w43-p8/doi:10.26434/chemrxiv.15011001/v1Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, fuses satellite ozone observations with ground measurements, using a Bayesian Maximum Entropy framework, to build a global 0.1° surface ozone dataset for 2005 to 2022. The authors estimate that the share of the global population exposed to ozone above 50 parts per billion (ppb) rose from 17.2% to 41.0% over this period.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0132026-w43-p8/WA-26-20-013In effect. This temporary emergency rule, in effect from September 26, 2026, allows two nonmark selective Chinook retention days from Buoy 10 upstream to the Highway 395 Bridge, and opens coho fisheries three days earlier than scheduled from the west end of Puget Island to the Highway 395 Bridge. The Washington Department of Fish and Wildlife says enough Chinook Endangered Species Act (ESA) impact remains available for this.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0162026-w43-p8/WA-26-20-016In effect. This temporary emergency rule, in effect from October 1, 2026, returns recreational fishing seasons in the mainstem Stillaguamish River to permanent rules. It keeps a previously announced recreational fishing closure in the lower North Fork Stillaguamish River in place.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0172026-w43-p8/WA-26-20-017In effect. This temporary emergency rule, in effect from October 1, 2026, opens fishing seasons in upper areas of the Skagit River and Cascade River. It also reduces the daily limit for the upper Skagit River, prohibits bait, requires single-point barbless hooks for salmon, and schedules two temporary closures during tribal fisheries.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0182026-w43-p8/WA-26-20-018In effect. This temporary emergency rule, in effect from October 5, 2026, opens commercial harvest of red sea urchins in District 5, green sea urchins in Districts 1, 3, 4, 5, 6 and 7, and purple sea urchins in Districts 3, 4 and 5. It sets a weekly trip limit of 1,550 pounds per species per license, because there is insufficient time to adopt permanent rules.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0282026-w43-p8/WA-26-20-028In effect. This temporary emergency rule, in effect from September 30, 2026, opens recreational salmon seasons targeting coho in the Icicle River. It says expected returns of coho bound for the river are sufficient to meet conservation objectives and provide for sport angler harvest.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0382026-w43-p8/WA-26-20-038In effect. This temporary emergency rule, in effect from September 30, 2026, opens coho retention on the Columbia River from Priest Rapids Dam to Rock Island Dam. It says returns of upper Columbia River-bound coho are sufficient to meet conservation objectives and provide for sport angler harvest.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0532026-w43-p8/WA-26-20-053In effect. This temporary emergency rule, in effect from September 30, 2026, extends recreational clam, mussel and oyster harvest at Belfair State Park, Point Whitney Tidelands and Point Whitney Lagoon. It makes up for lost opportunity this summer caused by a biotoxin closure.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0632026-w43-p8/WA-26-20-063In effect. This temporary emergency rule, in effect from October 3, 2026, closes recreational fishing seasons in the Snohomish River. It cites uncertainty and concern that the 2026 coho return is below preseason expectation, after the 2025 return fell below the escapement goal.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0722026-w43-p8/WA-26-20-072In effect. This temporary emergency rule, in effect from October 2, 2026, opens commercial crab fishing in Puget Sound until further notice. The season is structured to meet harvest allocation objectives negotiated with applicable treaty tribes, and it may be adjusted as updated harvest data come in.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0862026-w43-p8/WA-26-20-086In effect. This temporary emergency rule, in effect from October 6, 2026, opens recreational fishing in the Quillayute River with a bait prohibition for all species and reduced daily limits for salmon. It is meant to extend fall salmon fishing while reducing impacts on salmon heading to spawning grounds.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-2026-216762026-w43-p8/2026-21676In effect. This temporary rule, in effect from October 21, 2026, prohibits directed fishing for pollock in Statistical Area 620 in the Gulf of Alaska. The National Oceanic and Atmospheric Administration (NOAA) says this is needed to prevent exceeding the annual 2026 total allowable catch of pollock in that area.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.26434/chemrxiv.15010912/v12026-w43-p8/doi:10.26434/chemrxiv.15010912/v1Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a model-based estimate calibrated to public measurements. It estimates that a proposed electrolyte and cathode package could make an iPhone 17-type cell last about 1.38 times as long as the baseline (range 1.10 to 1.93) in a defined hot-climate usage profile, and the authors say the main uncertainty is the benefit over additives already in commercial electrolytes.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-pew:6c70922c665a2026-w43-p8/pew:6c70922c665aAnnouncement. Pew Research Center reports that a growing share of U.S. adults say social media is an important way for them to keep up with the news, and 58% now say so. This is the institution's own announcement of its findings.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.26434/chemrxiv.15011010/v12026-w43-p8/doi:10.26434/chemrxiv.15011010/v1Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports two-dimensional polyaramids, a family related to Kevlar, that conduct electricity across stacked layers but remain insulating in the plane of the film. The authors describe the films as stable through more than 10,000 cycles at pH 2 and suggest them as electrodes for energy storage.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-doi:10.26434/chemrxiv.15011016/v12026-w43-p8/doi:10.26434/chemrxiv.15011016/v1Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, describes making Na3V2(PO4)3, a sodium-ion battery cathode material, directly from desalination brine, a hypersaline byproduct of water treatment. The authors report that crystallization took 45 minutes in an open crucible, where conventional routes typically need 2 to 4 hours under inert gas.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-WA-26-20-0492026-w43-p8/WA-26-20-049Proposed. This is a proposed rule, not yet adopted. The University of Washington would amend chapter 478-124 WAC, the General conduct code for the University of Washington, and has extended the comment period to December 10, 2026.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-CA-2026-0910-022026-w43-p8/CA-2026-0910-02Final rule. This is a final rule, effective January 1, 2027. The California Board of Forestry and Fire Protection amends its regulations on the timing, use and termination of notices of exemption.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p8/#item-TX-TRD-2026042772026-w43-p8/TX-TRD-202604277Final rule. This is a final rule, effective November 1, 2026, adopted by the Texas Juvenile Justice Department (TJJD). It amends rules on major and minor rule violations and parole rule violations for youth in Residential Facilities and on parole, and adds an Egregious Behavior Protocol covering safety-based measures and youth returning to regular programming.Tue, 27 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.14.7591712026-w43-p7/doi:10.64898/2026.10.14.759171Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by S. Hur and colleagues, describing a compound called MA2. It is a laboratory study in which the authors report that MA2 selectively activates MDA5, enhances antiviral activity, and helps natural killer cells kill tumor cells.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.16.7596792026-w43-p7/doi:10.64898/2026.10.16.759679Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by B. Ghosh and colleagues. The study uses mice and cultured cells, and reports that removing soluble epoxide hydrolase (sEH) from astrocytes reduced amyloid pathology and microglial STING activation in mice. The authors report that the molecule 11,12-EET dampened inflammatory signaling in cultured microglia.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.18.263658572026-w43-p7/doi:10.64898/2026.10.18.26365857Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by M. J. Tudball and colleagues. Using computer simulations and two population cohorts, the authors show how trial eligibility rules can make treatment benefit appear to depend on polygenic risk scores. They say the apparent effect may reflect bias from eligibility rather than biology.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0542026-w43-p7/WA-26-20-054Final rule. This final rule from the Washington Department of Social and Health Services takes effect on October 31, 2026. It removes references to the inventory for client and agency planning and adds an acceptable adaptive test. The abstract does not say who is affected.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0762026-w43-p7/WA-26-20-076Proposed. The Washington Department of Social and Health Services (DSHS) proposes amendments to its rule on whether people must be interviewed to get cash and basic food benefits. The changes align with a modification by the United States Department of Agriculture (USDA) Food and Nutrition Administration (FNA) to Washington's elderly simplified application project (ESAP). If adopted, the project would be limited to adults who are disabled or 65 years of age or older, so people aged 60-64 would no longer be eligible.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0772026-w43-p7/WA-26-20-077Proposed. The Washington Department of Social and Health Services (DSHS) proposes amendments to its rule on who is exempt from work registration while receiving basic food. The changes would align the rule with federal rules on the exemption for people caring for an incapacitated person.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.15.7595112026-w43-p7/doi:10.64898/2026.10.15.759511Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by S. Upadhyay and colleagues. The study combines laboratory work with mice and reports that DELC2, a compound found by screening a large DNA-encoded library, reached the brain when given orally. In 5xFAD mice, the authors report it improved cognitive performance and reduced several amyloid species.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.19.263658752026-w43-p7/doi:10.64898/2026.10.19.26365875Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by E. Viippola and colleagues. Using plasma proteomics data from 51,310 people in six cohorts, it proposes the Proteomic Sex Index (PSI), which measures how far a person's protein profile lies from what is typical for their chromosomal sex. The authors report links to some sex-enriched traits and diseases, and a higher index in Klinefelter syndrome (XXY).Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.20.263658642026-w43-p7/doi:10.64898/2026.10.20.26365864Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by J. H. Tay and colleagues. It is a systematic review and meta-analysis of 125 articles on DNA methylation age and death risk in adults. The authors report that higher DNA methylation ages were associated with higher risks of all-cause, cardiovascular and cancer mortality, which is an association rather than proof of cause.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.20.7606092026-w43-p7/doi:10.64898/2026.10.20.760609Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by P. P. Sahoo and colleagues. It is a laboratory study in cell cultures, which finds that Snail lowers ACE2 expression and so reduces SARS-CoV-2 entry. The authors also report that infection depletes Snail protein in cell models.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.21.263656302026-w43-p7/doi:10.64898/2026.10.21.26365630Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by C. Choy and colleagues. It reports a single-cell atlas of blood immune cells from 345 people across 13 Indigenous South American populations, at baseline and after stimulation. The authors find that genetic ancestry affects gene expression more than age or sex does.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.21.7604502026-w43-p7/doi:10.64898/2026.10.21.760450Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by G. M. Serratto and colleagues. It argues that a strong brain immune pattern, previously seen as an Alzheimer's-specific subtype, also exists in neurologically healthy people and is linked to amyloid pathology. The authors suggest this could allow people to be identified earlier for targeted prevention.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.19.263655522026-w43-p7/doi:10.64898/2026.10.19.26365552Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by N. Swartwood and colleagues. It is a systematic review and meta-analysis of 104 studies of costs faced by households with tuberculosis (TB) in low- and middle-income countries. Estimated per-episode costs of rifampin-susceptible TB ranged from $668 to $9,156 in 2025 International Dollars, with indirect and continuation treatment costs the largest shares.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.20.7602532026-w43-p7/doi:10.64898/2026.10.20.760253Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by Z. Fang and colleagues. It describes laboratory and mouse studies of new small-molecule inhibitors of CYP8B1, a liver enzyme that controls 12-hydroxylated bile acid synthesis. The lead compound altered bile acid composition, remodeled the gut microbiota and corrected metabolic disease in a mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD).Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-TX-TRD-2026043272026-w43-p7/TX-TRD-202604327Proposed. The executive commissioner of the Texas Health and Human Services Commission, on behalf of the Texas Department of State Health Services (DSHS), proposes amending section 289.228 on radiation safety requirements for industrial radiation machines. The proposal would update and reorganize the rules for non-healing arts radiation generating devices (RGDs), which are used in cargo inspection, law enforcement and security screening. It aims to align the rules with current inspection criteria.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.64898/2026.10.18.7596162026-w43-p7/doi:10.64898/2026.10.18.759616Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by I. Craparotta and colleagues. It finds that the molecule miR-29 rises with ageing and falls during two routes to rejuvenation. The authors report that blocking it opposes transcriptional ageing and lowers epigenetic-clock estimates, and that low miR-29 expression marks some tumors with younger epigenetic age.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-TX-TRD-2026042432026-w43-p7/TX-TRD-202604243In effect. This rule from the Texas Comptroller of Public Accounts has been in effect since October 25, 2026. It adds a 'lessee' definition, modifies the 'property owner' definition, and adopts a revised request form with an option for lessees. The amendments implement the Tax Code §41A.011 right of a person leasing property to appeal.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-TX-TRD-2026042452026-w43-p7/TX-TRD-202604245In effect. This rule from the Texas Comptroller of Public Accounts has been in effect since October 25, 2026. It clarifies and updates how lessees appeal an appraisal review board order on a property value protest through regular binding arbitration. It also adds instances where an arbitrator must dismiss a request for lack of jurisdiction.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.1126/science.aeg67792026-w43-p7/doi:10.1126/science.aeg6779Peer-reviewed study. This is a peer-reviewed study published in Science, describing the Virtual Biotech, a team of AI agents led by a Chief Scientific Officer agent that hands queries to domain-specialized scientist agents. In one application, the study says the agents analyzed outcomes from 55,984 clinical trials and found that drugs targeting cell-type-specific genes were 40% more likely to progress from Phase I to Phase II. The authors present the system as a way to speed early-stage drug discovery while keeping human scientists in the loop.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.26434/chemrxiv.15010697/v12026-w43-p7/doi:10.26434/chemrxiv.15010697/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by Tengyi Liu and colleagues. It is a laboratory study of an electrochemical catalyst that combines copper phthalocyanine (CuPc) with carbon made from cellulose, converting carbon dioxide (CO2) to methane (CH4). The authors report 67.9% methane selectivity and stable operation for over 49 h.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-2026-215072026-w43-p7/2026-21507Proposed. The National Oceanic and Atmospheric Administration (NOAA), part of the Commerce Department, proposes two technical changes to rules for groundfish fisheries in the Bering Sea and Aleutian Islands and the Gulf of Alaska. If adopted, the rule would let NOAA set the opening and closing times of the sablefish season, taking into account the halibut season set by the International Pacific Halibut Commission, and would let it change the time of day a groundfish fishery closes.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0022026-w43-p7/WA-26-20-002In effect. This temporary rule from the Washington Department of Fish and Wildlife has been in effect since September 23, 2026. It sets a fall season for treaty Indian commercial gillnet fisheries in Zone 6 of the Columbia River, while protecting salmon listed under the Endangered Species Act (ESA). It also allows treaty commercial sales to nontreaty buyers in 2026.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0032026-w43-p7/WA-26-20-003In effect. This temporary rule from the Washington Department of Fish and Wildlife has been in effect since September 23, 2026. It adds fishing periods for the nontreaty mainstem commercial drift net fishery in Zones 4-5 of the Columbia River. The rule says sufficient Chinook impacts remain available to the commercial sector under the Endangered Species Act (ESA).Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0342026-w43-p7/WA-26-20-034In effect. This temporary emergency rule from the Washington Department of Fish and Wildlife has been in effect since October 1, 2026. It opens the recreational crab harvest in many Puget Sound marine areas for winter seasons. Some areas, including Marine Areas 8-1 and 8-2, stay closed.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0572026-w43-p7/WA-26-20-057Final rule. This temporary rule from the Washington Department of Fish and Wildlife sets fall-season treaty commercial gillnet fisheries in Zone 6 of the Columbia River and keeps earlier treaty fisheries in place. It allows treaty commercial sales to nontreaty buyers in 2026. The document does not give a start date for the rule.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0842026-w43-p7/WA-26-20-084Proposed. The Washington Department of Agriculture proposes to update its shell egg rules on standards, grades and weight classes, and on the facility, operation, storage and labeling requirements for egg facilities. The rule was adopted decades ago, and the changes would align state law with current federal requirements. The federal egg inspection law bars states from moving eggs into interstate or foreign commerce under standards that differ from the official ones.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-1072026-w43-p7/WA-26-20-107Proposed. The Washington Department of Fish and Wildlife (WDFW) proposes closing recreational scallop harvest year-round in all areas, except where an emergency regulation opens it. The proposal is to protect the public from biotoxin risks, because recent samples from the Strait of Juan de Fuca exceeded safe-consumption standards in both the adductor muscle and the viscera.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-1082026-w43-p7/WA-26-20-108Proposed. The Washington Department of Fish and Wildlife proposes allowing two-pole fishing for all game fish in the Washington portions of the Snake and Columbia rivers, following a rule petition accepted by its director. The change would target walleye, bass, channel catfish, northern pikeminnow and, on the Snake River, hatchery steelhead. The proposal does not change seasons, minimum sizes or daily limits.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-2026-216072026-w43-p7/2026-21607Final rule. The National Oceanic and Atmospheric Administration (NOAA), part of the Commerce Department, announces eleven inseason actions for 2026-2027 ocean salmon fisheries. The actions modified commercial salmon fisheries from the United States/Canada border to Cape Falcon, OR. This is a final rule, and the document gives no start date for it.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.26434/chemrxiv.15007166/v22026-w43-p7/doi:10.26434/chemrxiv.15007166/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by Nestor Iwanojko and colleagues. It is a laboratory study of 70 trimetallic catalysts, covering all 210 possible bimetallic pairs from 21 elements, tested on a robotic platform for carbon dioxide (CO2) hydrogenation. It reports a highly active FeGaRu catalyst that keeps its activity when simplified to FeRu with Ga.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.1038/s41586-026-11128-92026-w43-p7/doi:10.1038/s41586-026-11128-9Peer-reviewed study. This is a peer-reviewed study published in Nature. It describes multifunctional digital fibres that integrate display, touch sensing, computation and multimodal input and output. The authors say the fibres enable flexible, washable garments with interactive graphical interfaces and wireless multimedia.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-doi:10.26434/chemrxiv.15010776/v12026-w43-p7/doi:10.26434/chemrxiv.15010776/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, led by Lin Chen and colleagues. It is a laboratory study of water-soluble biopolymer binders, guar gum and ι-carrageenan, in sodium-ion battery electrodes. The authors report high capacity retention and rate capability with hard carbon electrodes.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-pew:8c08a623e6972026-w43-p7/pew:8c08a623e697Announcement. This is an announcement by Pew Research Center, which reports its own analysis. It says men's employment grew faster than women's in occupations most exposed to AI, a gap driven largely by workers without a bachelor's degree.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-arxiv:2610.311652026-w43-p7/arxiv:2610.31165Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists. It is a simulation study of large language model (LLM) populations playing a naming game on fully connected, random and heterogeneous networks. The authors find that sparse networks can slow consensus up to twelvefold, and that networked populations are easier to tip than fully mixed ones.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0612026-w43-p7/WA-26-20-061Final rule. This final rule from the Washington Department of Retirement Systems takes effect on November 1, 2026. It clarifies that, under the law enforcement officers' and firefighters' Plan 2, medical expense reimbursement payments are fringe benefits instead of basic salary.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-0622026-w43-p7/WA-26-20-062In effect. This temporary rule from the Washington Department of Children, Youth, and Families has been in effect since October 1, 2026. It amends the working connections child care (WCCC) program rules on providers' responsibilities and billing requirements. The changes implement HB [SHB] 2689.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-WA-26-20-1032026-w43-p7/WA-26-20-103Proposed. The Washington Department of Children, Youth, and Families proposes to amend its foster home licensing rules to align them with the D.S. Settlement Agreement and the DeGross permanent injunction. The aim is to make the rules more developmentally appropriate and flexible for children and youth. The rule-making used negotiated rule-making with foster parents, tribal nations, agency employees and people with lived experience in care.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-CA-2026-0828-022026-w43-p7/CA-2026-0828-02In effect. This rulemaking from the California Department of Corrections and Rehabilitation has been in effect since October 12, 2026. It repeals prior rules on familiarity and permits employees to engage in dynamic security.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p7/#item-TX-TRD-2026043372026-w43-p7/TX-TRD-202604337Proposed. The Texas Funeral Service Commission proposes a new section 206.13 to replace the existing standards for anatomical facilities and other anatomical use locations. It would cover health, safety, security, dignity, custody and record-keeping at every location where anatomical material is present, including permanent, mobile and temporary sites. It would also require a willed body program or non-transplant anatomical donation organization that directly accepts donated bodies in Texas to employ or contract with a Texas-licensed funeral director, and require embalming to be done by a licensed embalmer.Mon, 26 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.64898/2026.10.18.7599422026-w43-p6/doi:10.64898/2026.10.18.759942Preprint, not peer-reviewed. This is a preprint on bioRxiv, not yet reviewed by other scientists. It reports that BNIP3L/NIX-mediated mitophagy, a pathway for mitochondrial clearance, limits Alzheimer disease (AD) pathology and preserves neuronal function in human neurons, in C. elegans and in mouse neurons.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0412026-w43-p6/WA-26-20-041In effect. This is a temporary emergency rule from the Washington Health Care Authority, in effect from October 1, 2026. It applies a federal change so that the definition of qualified noncitizens covers only lawful permanent residents, Cuban/Haitian entrants and compact of free association migrants for federally funded medical assistance. It also lengthens the refugee medical assistance eligibility period from four months to eight months.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0592026-w43-p6/WA-26-20-059Final rule. This is a final rule from the Washington Department of Social and Health Services, effective November 1, 2026. It updates which types of income the department does not count when working out benefits for the RCA program, to follow federal regulations and to make other clarity and policy changes. Related emergency rules are currently in place.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0602026-w43-p6/WA-26-20-060In effect. This is a temporary emergency rule from the Washington Department of Social and Health Services, which took effect October 1, 2026. It applies annual updates from USDA FNA for the upcoming federal fiscal year to the basic food program's standard deduction, shelter and utility deductions, resource limit, and minimum and maximum allotments. The department is also proceeding with permanent rule making.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0942026-w43-p6/WA-26-20-094Proposed. This is a proposed rule from the Washington Department of Health. It would amend chapter 246-70 WAC to align medical cannabis rules with changes to state law from 2SHB 1210 in 2022 and SHB 1453 in 2024, updating terms, label requirements and tax exemptions for medical cannabis products. The department says the changes would help it uphold standards that protect public safety.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0952026-w43-p6/WA-26-20-095Proposed. This is a proposed rule from the Washington Department of Health, phase 2 of a board's comprehensive review of chapter 246-840 WAC. Under RCW 43.70.041, the board must review its rules at least once every five years to simplify, streamline and improve them.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.1073/pnas.26072611232026-w43-p6/doi:10.1073/pnas.2607261123Peer-reviewed study. A peer-reviewed study in PNAS analyzed complete genome assemblies from 151 clinical isolates of Mycobacterium tuberculosis (Mtb). It finds diversity hotspots driven by gene conversion between homologous genes, with over 300 gene conversion events, mostly in virulence-associated PE, PPE and ESX gene families, including the vaccine candidate PPE18.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.64898/2026.10.16.263649862026-w43-p6/doi:10.64898/2026.10.16.26364986Preprint, not peer-reviewed. This is a preprint on medRxiv, not yet reviewed by other scientists. It estimates that Denmark's combined national testing and contact tracing program identified on average about 55 to 60% of infected people in the period studied. It says the program as typically implemented was largely ineffective in controlling the pandemic, though a focused approach helped control one large local outbreak.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.64898/2026.10.19.7602762026-w43-p6/doi:10.64898/2026.10.19.760276Preprint, not peer-reviewed. This is a preprint on bioRxiv, not yet reviewed by other scientists. It describes hEVO, a genomic foundation model trained on haplotype sequences from whole genome sequencing data for 63,809 individuals. The authors report that it ranked first in 18 of 19 primary comparisons with other genomic models, including Evo 2.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.64898/2026.10.20.7605432026-w43-p6/doi:10.64898/2026.10.20.760543Preprint, not peer-reviewed. This is a preprint on bioRxiv, not yet reviewed by other scientists. It reports possible new translation readthrough inducing drugs (TRIDs) for premature termination codon (PTC) diseases, including three Sartans, angiotensin II receptor blockers that are FDA-approved for hypertension. In a laboratory test the Sartans were more potent than ataluren, and the authors suggest these compounds might be more effective than ataluren for some of these diseases.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.1126/science.aeh79302026-w43-p6/doi:10.1126/science.aeh7930Peer-reviewed study. A peer-reviewed study in Science tests frontier language models on sequential diagnosis, where information and tests are selected step by step. In a controlled benchmark, an artificial intelligence (AI) system reached 83.2% accuracy on New England Journal of Medicine clinicopathological conference cases and 80.3% on MIMIC-IV-ED emergency department admissions, compared with 36.1% and 46.8% for generalist physicians.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.1016/j.cell.2026.09.0612026-w43-p6/doi:10.1016/j.cell.2026.09.061Peer-reviewed study. A peer-reviewed study in Cell reports that taurine levels rise with age in mice and humans. In aged mice, boosting taurine further increased health span and dampened inflammation through its regulation of the NLRP3 inflammasome in macrophages. The findings come from mice.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.1073/pnas.25295061232026-w43-p6/doi:10.1073/pnas.2529506123Peer-reviewed study. A peer-reviewed study in PNAS estimates the causal effect of education on Alzheimer's Disease and Related Dementias (ADRD), using a regression discontinuity created by a compulsory schooling reform. It finds education reduces ADRD incidence, and that the reform weakened the relationship between genetics and ADRD incidence.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.64898/2026.10.22.7610472026-w43-p6/doi:10.64898/2026.10.22.761047Preprint, not peer-reviewed. This is a preprint on bioRxiv, not yet reviewed by other scientists, based on experiments in A549 cells that express ACE2. The authors report that Spike-induced ACE2 clustering activates the PIEZO1 channel, which triggers lysosomal exocytosis, and that the resulting ceramide enhances cell-cell fusion.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-arxiv:2610.303242026-w43-p6/arxiv:2610.30324Preprint, not peer-reviewed. This is a preprint on arXiv, not yet reviewed by other scientists. It proposes a publisher content marketplace that pays for individual facts or commentary, called 'lego blocks', used in artificial intelligence (AI) generated answers. It tests three payment rules using 1,974 search-engine queries about a heavily covered news episode, and reports that premium publishers receive 42% of allocated value under equal sharing, compared with 46-50% under a first-publication rule.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0902026-w43-p6/WA-26-20-090Proposed. This is a proposed rule from the Washington Department of Labor and Industries. It would align WAC 296-155-200 on personal protective equipment (PPE) in construction with the federal Occupational Safety and Health Administration (OSHA) update, which states that PPE must fit properly to protect employees.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-TX-TRD-2026042522026-w43-p6/TX-TRD-202604252Proposed. This is a proposed rule from the Texas Workforce Commission. It would amend Subchapter B of Chapter 813, relating to the Supplemental Nutrition Assistance Program Employment and Training, on access to employment and training activities and support services in §813.12.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-ukdsi-2026-97803482880012026-w43-p6/ukdsi-2026-9780348288001Proposed. This is a draft UK statutory instrument, so it would become law only if it is approved and made. It would amend the Environmental Permitting (England and Wales) Regulations 2016 on activities, including waste storage, that can be carried out in England without an environmental permit when operators meet set requirements and conditions.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.1073/pnas.26086561232026-w43-p6/doi:10.1073/pnas.2608656123Peer-reviewed study. A peer-reviewed study in PNAS uses multiyear observations from four oceanic regions to examine precipitation beneath clouds. It reports precipitation beneath marine stratocumulus in over 56% of cloudy columns with liquid water path below 130, rising to more than 84% above that level, and says oceanic cumulus clouds rain less often but produce larger drops.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-CA-2026-0921-062026-w43-p6/CA-2026-0921-06In effect. The California Air Resources Board adopted regulations that further implement the California Climate Corporate Data Accountability Act and the Climate-Related Financial Risk Act. They define terms, set annual fee calculations and procedures, and set a first-year reporting deadline for Scope 1 and 2 emissions, and the regulation took effect October 12, 2026.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-TX-TRD-2026042552026-w43-p6/TX-TRD-202604255Proposed. This is a proposed rule from the Railroad Commission of Texas on anthropogenic carbon dioxide (CO2) storage facilities and injection wells, and on multiple or alternative uses of wells. The excerpt, which is mostly rule text, shows changes such as replacing 'hearing' with 'public meeting' in permit fact sheets and construction requirements for CO2 injection wells.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.26434/chemrxiv.15010980/v12026-w43-p6/doi:10.26434/chemrxiv.15010980/v1Preprint, not peer-reviewed. This is a preprint on ChemRxiv, not yet reviewed by other scientists. It studies how sequential chlorination and alkaline treatment change polyamide membranes used in freshwater production. The authors report the treatment more than doubles water permeance while keeping water-salt selectivity, and say this challenges the view that swelling is detrimental to selectivity.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-TX-TRD-2026043162026-w43-p6/TX-TRD-202604316Final rule. This is a final rule from the Texas Department of Motor Vehicles, effective October 29, 2026. It amends many sections of Chapter 215, Motor Vehicle Distribution, covering licenses, franchised dealers, manufacturers, distributors and converters, general distinguishing numbers, lessors and lease facilitators, and advertising. The department says the review was meant to improve clarity and consistency, remove duplicative language and incorporate statutory changes.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0242026-w43-p6/WA-26-20-024In effect. This is a temporary emergency rule from the Washington Department of Fish and Wildlife, which took effect September 28, 2026. It classifies golden mussels (Limnoperna fortunei), an invasive species established in California, as a prohibited level 1 species, which provides authority to prevent their possession, transport and introduction while permanent rule making continues.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0732026-w43-p6/WA-26-20-073In effect. This is a temporary emergency rule from the Washington Department of Fish and Wildlife, in effect from October 2, 2026. It repeals current emergency wildfire rules in Eastern Washington, but keeps the same rules, except the firearms and target practicing rule in WAC 220-500-140, in place for Benton, Franklin, Kittitas, Yakima, Adams, Chelan, Douglas, Grant and Okanogan counties, where fire danger is still elevated. The department does not plan permanent rule making on this topic.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-TX-TRD-2026042782026-w43-p6/TX-TRD-202604278In effect. This is a temporary emergency rule from the Texas Parks and Wildlife Department, which took effect October 8, 2026. It reinstates deer season, bag limit and restriction provisions for white-tailed deer that were inadvertently removed during recent rulemaking. The department says it will address the issue through normal rulemaking before the 2027-2028 deer seasons.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-1102026-w43-p6/WA-26-20-110Proposed. This is a proposed rule from the Washington Liquor and Cannabis Board on how alcohol products are placed within retailers that sell alcohol for off-premises consumption. The board says the purpose is to reduce product confusion, theft and youth exposure.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.26434/chemrxiv.10001688/v32026-w43-p6/doi:10.26434/chemrxiv.10001688/v3Preprint, not peer-reviewed. This is a preprint on ChemRxiv, not yet reviewed by other scientists. It describes a bionic computing design built from an information metasurface array, and the authors aim it at the energy demands of artificial intelligence (AI) and robotics.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.1073/pnas.25348251232026-w43-p6/doi:10.1073/pnas.2534825123Peer-reviewed study. A peer-reviewed study in PNAS reports economic experiments in which participants traded with others, and found that diverse groups underperformed when the best trades required cross-race exchange. A brief linguistic intervention that gave participants a communicative toolkit increased communication and restored cross-race trade and specialization, closing the performance gap. The authors report its effects were minimal when efficient trade did not need to cross race.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.1126/science.ady85602026-w43-p6/doi:10.1126/science.ady8560Peer-reviewed study. A peer-reviewed study in Science describes an implantable, wirelessly powered electrocatalytic closed-loop health optimization (ECHO) device that oxidizes blood glucose to gluconate, which the kidneys clear. In type 2 diabetic mice, activating the device restored glucose balance within 1 hour and reduced body weight and triglycerides over 6 weeks, with no detectable hypoglycemia.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.1126/science.aef97452026-w43-p6/doi:10.1126/science.aef9745Peer-reviewed study. A peer-reviewed study in Science reports a decoupled deposition strategy for self-assembled monolayers and perovskite on flexible substrates, aimed at improving flexible perovskite solar modules (PSMs). The certified power conversion efficiency (PCE) was 20.2% on modules of 750 cm², and a 22.0% device lost 8% after 1044 hours under maximum power point tracking at 85°C and 65% relative humidity.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-arxiv:2610.305622026-w43-p6/arxiv:2610.30562Preprint, not peer-reviewed. This is a preprint on arXiv, not yet reviewed by other scientists. It introduces continual validation, which tests each proposed version of an artificial intelligence (AI) analyst before deployment using simulated data under the null hypothesis. The authors report Type I error rates reached 0.098 and 0.183 without it, and at most 0.045 and 0.044 with it, while retaining 82% and 96% of the power from optimally selected valid updates.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-arxiv:2610.316622026-w43-p6/arxiv:2610.31662Preprint, not peer-reviewed. This is a preprint on arXiv, not yet reviewed by other scientists. It proposes an online method for deciding whether to accept an artificial intelligence (AI) decision automatically or send it to an expert auditor, aiming to minimize auditing while keeping the share of unaudited AI errors below a set threshold. The authors report valid error control in tests on screening harmful requests to large language models, qualitative text annotation and data labeling.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-doi:10.26434/chemrxiv.15010966/v12026-w43-p6/doi:10.26434/chemrxiv.15010966/v1Preprint, not peer-reviewed. This is a preprint on ChemRxiv, not yet reviewed by other scientists. Using operando X-ray nano-tomography, it tracks pore formation in lithium metal electrodes under stack pressure. The authors suggest that a homogeneous initial lithium deposition in each cycle should be targeted to suppress pore trapping.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0642026-w43-p6/WA-26-20-064In effect. This is a temporary rule from the Washington Department of Children, Youth, and Families, in effect from October 1, 2026. It amends WAC 110-15-0075 on income eligibility and copayment amounts for the working connections child care (WCCC) program to comply with ESSB 5752.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-WA-26-20-0982026-w43-p6/WA-26-20-098Proposed. This is a proposed rule from the Washington Department of Commerce, implementing HB 2338, a 2026 law that lets the department use existing low-income weatherization funds for community scale projects covering multiple dwelling units in one neighborhood or area. Those projects need not have all units occupied by low-income residents, but the department must prioritize projects that serve low-income households.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p6/#item-2026-215982026-w43-p6/2026-21598Final rule. The Federal Retirement Thrift Investment Board issued this final rule, published October 22, 2026, on court orders and legal processes that affect Thrift Savings Plan accounts. The document does not state when the rule takes effect or describe its details.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.64898/2026.10.19.7601852026-w43-p5/doi:10.64898/2026.10.19.760185Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a polymerase chain reaction (PCR) method that uses chiral plasmonic nanoparticles to speed up DNA amplification. The authors say it detects DNA without fluorescent dyes or labelled probes, and they report single-copy detection of a SARS-CoV-2 E-gene plasmid DNA template. They present the approach as a route toward point-of-care molecular diagnostics.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-WA-26-20-0362026-w43-p5/WA-26-20-036Final rule. The Washington Health Care Authority has revised several sections of chapter 182-55 WAC to carry out requirements in RCW 70.14.100 and 70.14.110. Those requirements were amended by SB 5915, a 2026 Washington law. The final rule takes effect on October 30, 2026.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-WA-26-20-0522026-w43-p5/WA-26-20-052In effect. The Washington Department of Social and Health Services (DSHS) has issued a temporary emergency rule creating chapter 388-106H WAC for its health-related social needs (HRSN) program. The rule covers rent and temporary housing, nutrition supports, caregiver respite services, and home accessibility and adaptation devices, so the department can begin these services before permanent rules are filed. The temporary rule has been in effect since September 30, 2026.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.1038/s41586-026-11205-z2026-w43-p5/doi:10.1038/s41586-026-11205-zPeer-reviewed study. A peer-reviewed study in Nature describes Pinal, a 16-billion-parameter artificial intelligence model that designs functional proteins from natural-language descriptions. The authors report experimentally validated activities and improved yields of products from carbon dioxide (CO2) fixation, without iterative optimization.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.64898/2026.10.20.263660332026-w43-p5/doi:10.64898/2026.10.20.26366033Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, argues that pooling case counts over an administrative region is itself a modeling choice that can flatten, delay or split the aggregate epidemic curve. Using two years of US county-level COVID-19 cases, the authors report that communities built from a 2019 mobility network reduced distortion by roughly 25-40% compared with states and Combined Statistical Areas.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.64898/2026.10.21.7607722026-w43-p5/doi:10.64898/2026.10.21.760772Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, introduces ARG-PASS v2.0, a method for finding antibiotic resistance genes that look unlike known ones. In a lake sample from Kolkata, India, 10 of 11 tested candidates were functionally confirmed after expression in Escherichia coli. The authors also report related enzymes in South Korean fermented soybean paste (doenjang) and in gut bacteria from populations that eat these foods, and suggest such genes reach the human gut through resident and generalist hosts.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-CA-Z2026-1007-022026-w43-p5/CA-Z2026-1007-02Proposed. The California State Board of Pharmacy proposes repealing and amending regulations on self-assessments, which Assembly Bill (AB) 1503 now sets out in statute, to avoid duplication. It also proposes replacing prescriptive procedures for services such as emergency contraception, contraception, smoking cessation, opioid antagonists and travel medication with a standard of care model, in which pharmacists rely on professional judgment.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-TX-TRD-2026043302026-w43-p5/TX-TRD-202604330Proposed. The Texas Health and Human Services Commission (HHSC) proposes a new rule on the Medicaid Recovery Audit Contractor (RAC) program, to implement House Bill (HB) 142 from 2025. The program would apply to both fee-for-service and managed care. The proposal sets requirements for records requests, Office of Inspector General approval and deconfliction of reviews, the scope of reviews, notices, appeals and recovery of overpayments.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.64898/2026.10.22.263637492026-w43-p5/doi:10.64898/2026.10.22.26363749Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, proposes that a pressure-peak zone beneath the cuff explains how cuff-based blood pressure measurement works, based on membrane theory. The authors report multimodal experiments in humans. They say their method was more accurate, with lower variability, than auscultation and conventional oscillometry, and was the only one whose estimates did not differ significantly from invasive blood pressure.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.64898/2026.10.22.7608652026-w43-p5/doi:10.64898/2026.10.22.760865Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes engineering human MxA, a protein that helps prevent influenza spillover into humans, so that it restricts human-adapted influenza viruses. The authors report that a modestly re-engineered version restricted a range of influenza viruses, including H5N1 and H7N9, without losing breadth.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-uksi-2026-11152026-w43-p5/uksi-2026-1115Final rule. This is UK law, made on October 21, 2026, and it comes into force on January 1, 2027. The Order amends and modifies the application of provisions of the Building Societies Act 1986. Its title describes assimilation to company law and a change to the funding limit.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-2026-216752026-w43-p5/2026-21675Proposed. The Treasury Department proposes a rule to carry out section 1001 of the 21st Century ROAD to Housing Act (the ROAD Act), which prohibits large institutional investors from buying single-family homes, subject to exceptions. The proposal would clarify key terms, the application of certain exceptions and the statute's enforcement mechanism, before the ROAD Act's effective date.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-2026-217062026-w43-p5/2026-21706Final rule. The Office of the Comptroller of the Currency (OCC) is issuing final regulations implementing the Guiding and Establishing National Innovation for U.S. Stablecoins Act. The rules cover issuance of payment stablecoins by entities under OCC jurisdiction and certain related activities. The rules take effect on January 18, 2027.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-TX-TRD-2026042462026-w43-p5/TX-TRD-202604246Final rule. The Texas Education Agency (TEA) has adopted final rules on preventing and reporting child abuse or neglect, including trafficking of a child. The rules cut the deadline for school districts and open-enrollment charter schools to report abuse or neglect of a student from 48 hours to 24 hours, to align with Senate Bill (SB) 571 from 2025. They also require school policies on digital communications between staff and students, and set procedures for TEA investigations of compliance. The rules take effect on October 25, 2026.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-TX-TRD-2026043422026-w43-p5/TX-TRD-202604342Final rule. The State Board of Education (SBOE) adopts new Texas Essential Knowledge and Skills (TEKS) for social studies, which update the social studies standards. The standards implement House Bill (HB) 27, House Bill (HB) 824 and Senate Bill (SB) 24 from 2025. The new standards take effect on July 1, 2027.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-TX-TRD-2026043452026-w43-p5/TX-TRD-202604345Final rule. The State Board of Education (SBOE) adopts new Texas Essential Knowledge and Skills (TEKS) for a one-credit economics course called Foundations of economics. The course may be used to satisfy revised social studies graduation requirements under House Bill (HB) 27 from 2025. The new standards take effect on November 1, 2026.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-arxiv:2610.307522026-w43-p5/arxiv:2610.30752Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, builds an index of how far tasks across occupations and countries could be handed to artificial intelligence (AI) agents, using 18,796 O*NET task statements and employment data from 146 countries. It estimates that 35.2% of task time is at least partly delegable in 2026, and only 2.5% can be handed over in full. The authors report that delegable employment rises with income, from 22.5% in low-income to 48.7% in high-income countries.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.1073/pnas.26165351232026-w43-p5/doi:10.1073/pnas.2616535123Peer-reviewed study. A peer-reviewed study in PNAS looks at vegetation and cooling in 3,806 urban clusters worldwide over two decades, using satellite observations and ground measurements from 4,855 meteorological stations. It reports that cities in the Global North have expanded green infrastructure but show cooling saturation, while most cities in the Global South show vegetation stagnation or loss. The authors conclude that current greening efforts are insufficient to offset warming.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-WA-26-20-0052026-w43-p5/WA-26-20-005Proposed. The Washington Department of Ecology proposes to align the state's ambient air quality standards with the national standards for fine particulate matter (PM 2.5) and sulfur dioxide (SO 2). For fine particles, the proposal would lower the annual limit from 12 to nine micrograms per cubic meter of air, following a 2024 change by the Environmental Protection Agency (EPA). It would also remove two outdated sulfur dioxide standards that the EPA revoked in 2010.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.1038/s41586-026-11168-12026-w43-p5/doi:10.1038/s41586-026-11168-1Peer-reviewed study. A peer-reviewed study in Nature analyzes 15 years of Amazonian carbon fluxes derived from atmospheric carbon dioxide (CO2) measurements. It reports a net carbon balance of 0.32 PgC per year, with fires the dominant source, and finds that emissions were highest in dry years such as El Niño years. The authors link emissions in years with less climate stress mainly to deforestation and degradation.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.26434/chemrxiv-2025-7xwt2/v22026-w43-p5/doi:10.26434/chemrxiv-2025-7xwt2/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports stimulated geological carbon dioxide reduction, in which natural olivine-rich rock converts supplied bicarbonate into formate within six hours in laboratory experiments. The authors say the measured rate could support significant in-situ production, though this extends laboratory-scale measurements rather than showing a field result.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-TX-TRD-2026042562026-w43-p5/TX-TRD-202604256Proposed. The Railroad Commission of Texas proposes amendments on surface equipment removal and inactive wells to implement Senate Bill (SB) 1150 from 2025. The bill requires operators to plug wells that have been inactive for more than 15 years and were completed more than 25 years before the operator applies for a plugging extension, unless the commission grants an extension, for example because of a compliance plan or a performance bond.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.64898/2026.10.22.7608162026-w43-p5/doi:10.64898/2026.10.22.760816Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, assesses 29,038 studies published from 1990 to 2022 on avoided forest conversion, meaning forests that are not converted to other land uses. The authors used an ensemble of GPT models to review the evidence. They report that 85% of studies show positive human and environmental co-benefits, though some countries facing imminent forest conversion threats have evidence gaps.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-TX-TRD-2026042982026-w43-p5/TX-TRD-202604298Final rule. The Texas Department of Motor Vehicles adopts amendments to its vehicle title and registration rules, including a new option under Transportation Code section 502.0024. Owners of trailers, semitrailers or pole trailers with a gross weight of 7,500 pounds or less can register them for an extended period of up to five years. The rules take effect on October 29, 2026.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-2026-216582026-w43-p5/2026-21658Proposed. The Food and Nutrition Administration (FNA), an agency of the Agriculture Department, proposes changes to Supplemental Nutrition Assistance Program (SNAP) rules to modernize Electronic Benefit Transfer (EBT) technology. The changes would align EBT with consumer payment processing industry standards. The proposal says this would protect benefits from theft and keep them accessible to approved households.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-2026-216002026-w43-p5/2026-21600Final rule. U.S. Customs and Border Protection (CBP) of the Homeland Security Department is extending the compliance date for rules requiring formal entry of certain goods that arrive through the international postal network. The goods covered include those subject to partner government agency requirements, duties under Chapter 98 or Chapter 99 of the Harmonized Tariff Schedule of the United States (HTSUS), or duty-free claims. The agency says the extension gives the public more time to prepare.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.1073/pnas.26123431232026-w43-p5/doi:10.1073/pnas.2612343123Peer-reviewed study. A peer-reviewed study in PNAS models electricity demand from homes and commercial buildings in 183 counties in the United States through 2060. It finds that climate change and the spread of air source heat pumps and insulation together produce effects that differ from adding them up. In cold regions, the study projects peak demand growth up to 10 times larger than from climate change alone by 2060, while in hot regions heat pumps partly offset climate-driven growth.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.1038/s41586-026-11161-82026-w43-p5/doi:10.1038/s41586-026-11161-8Peer-reviewed study. A peer-reviewed study in Nature describes a multi-agent framework that coordinates data science, medical reasoning and health coaching. It uses longitudinal wearable and clinical data, and the framework aims to provide holistic personal health support.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.1038/s41586-026-11192-12026-w43-p5/doi:10.1038/s41586-026-11192-1Peer-reviewed study. A peer-reviewed study in Nature reports that compostable polyesters with embedded enzymes degraded almost completely in the deep sea. The authors say thermal enzyme embedding greatly speeds breakdown across marine environments while preserving material performance. They present it as a possible strategy against persistent ocean plastic pollution.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.26434/chemrxiv.15010806/v12026-w43-p5/doi:10.26434/chemrxiv.15010806/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, proposes that oxygen loss links surface reconstruction of Ni-rich cathodes with transition-metal dissolution in Li-based energy storage devices. The authors base this on X-ray absorption spectroscopy and molecular dynamics simulations. They suggest stabilizing lattice oxygen as a strategy to extend cycling performance.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.26434/chemrxiv.15010874/v12026-w43-p5/doi:10.26434/chemrxiv.15010874/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a computer model that estimates lithium plating inside lithium-ion batteries in real time, and a charging control method built on it. The authors report that over a 10% to 80% charge window, the method cut charging time by 21.7% compared with a conventional constant-current constant-voltage (CC-CV) protocol, while preventing lithium plating in their tests.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.26434/chemrxiv.15010911/v12026-w43-p5/doi:10.26434/chemrxiv.15010911/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a catalyst in which sulfur is added to iron sites to improve durability during carbon dioxide (CO2) electrolysis. The authors report near-unity carbon monoxide (CO) selectivity and a 44% energy efficiency at 500 mA cm-2 in a membrane electrode assembly, and say it surpasses state-of-the-art CO2-to-CO catalysts.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.26434/chemrxiv.15010946/v12026-w43-p5/doi:10.26434/chemrxiv.15010946/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a platform that synthesized 720 crude chloroacetamides within days and screened them against methicillin-resistant Staphylococcus aureus (MRSA). The authors report that almost all hits were confirmed on resynthesis, and that the most promising hits selectively engage the essential enzyme HMG-CoA synthase, which they validated with a co-crystal structure.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.64898/2026.10.21.7607912026-w43-p5/doi:10.64898/2026.10.21.760791Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, applies convergent cross mapping (CCM) to gene activity data from dermal fibroblasts of 490 GTEx donors to predict genes that drive aging. The authors report that single-cell sequencing confirmed 53.8% of testable CCM-predicted interactions in fibroblasts from 55-year-old donors. They also report that the strongest interventions made most old cells resemble cells from 25-year-old donors.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-doi:10.64898/2026.10.22.7611272026-w43-p5/doi:10.64898/2026.10.22.761127Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a coronavirus vaccine that attaches receptor binding domain (RBD) antigens from several betacoronaviruses to the surface of a chimpanzee adenovirus vector (ChAd). The authors report that in mice it induced broader neutralizing antibody responses than an undecorated vector, without compromising T-cell immunity.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-2026-215122026-w43-p5/2026-21512Proposed. The National Credit Union Administration (NCUA) Board is proposing to change how federally insured credit unions (FICUs) must notify members about share insurance coverage. The current rule requires hard copies of certain materials. The proposal would let each FICU choose the notice method, including a link to updated online resources maintained on the NCUA website.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-WA-26-20-1022026-w43-p5/WA-26-20-102Proposed. The Washington State Board of Health proposes to reduce current COVID-19 reporting requirements in chapter 246-101 WAC. Health care providers, facilities and laboratories must now report COVID-19 cases immediately, and the proposal would streamline those duties while keeping timely reporting of outcomes for public health surveillance. The board does not expect the proposal to add new reporting systems or processes.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-CA-2026-0928-032026-w43-p5/CA-2026-0928-03In effect. The California Health Benefit Exchange has readopted, on an emergency basis, rules on eligibility, enrollment and appeals for its Individual Exchange. The temporary rules have been in effect since October 8, 2026. They align definitions with recent changes in federal law and create an automatic enrollment process in a Qualified Health Plan when a consumer moves to a different coverage area.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-CA-2026-1001-032026-w43-p5/CA-2026-1001-03In effect. The California Office of Health Care Affordability (OHCA), within the Department of Health Care Access and Information, has issued an emergency rule in effect since October 12, 2026. It sets up a process for providers, fully integrated delivery systems and labor organizations to request adjustments to health care cost growth targets based on nonsupervisory organized labor costs.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p5/#item-CA-Z2026-1012-052026-w43-p5/CA-Z2026-1012-05Proposed. The Administrative Director of the Division of Workers' Compensation, within the Department of Industrial Relations, proposes amending rules on medical provider networks (MPNs). These networks are set up by employers or insurers to provide medical treatment to injured employees. The changes implement three Senate bills and add definitions, including contracting agent, electronic signature, remote service and telehealth.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.1016/j.cell.2026.09.0152026-w43-p4/doi:10.1016/j.cell.2026.09.015Peer-reviewed study. This peer-reviewed study, published in Cell, reports that the pyrin inflammasome, an immune sensor, detects L-carnitine taken up from outside cells through the OCTN2 transporter. That detection leads to inflammation mediated by IL-1β, and the authors suggest OCTN2 could be a target for reducing this inflammation.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.01.19.263443762026-w43-p4/doi:10.64898/2026.01.19.26344376Preprint, not peer-reviewed. This preprint is not peer-reviewed. Its authors studied 568 prostate magnetic resonance imaging (MRI) scans from seven institutions and found that artificial intelligence (AI) models could perform differently because of acquisition differences that visual checks miss. Training on a balanced set of 60 scans matched performance with 2.3-fold fewer samples, and the authors say it also removed the batch effects.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.12.7583462026-w43-p4/doi:10.64898/2026.10.12.758346Preprint, not peer-reviewed. This preprint is not peer-reviewed. Over an 8-week exposure period, the authors tracked running-wheel laps in mice exposed to vape aerosol, and exposed females ran 32% fewer laps than control females. The reduction in males was 15% and did not reach statistical significance.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.13.7589582026-w43-p4/doi:10.64898/2026.10.13.758958Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors linked the frequency of CXCR3-expressing CD4 memory T cells at enrollment to six-month survival in sepsis without shock. The same cells were linked to better organ function in septic shock but not to survival, and they were more common in people with CMV antibodies, which suggests past infection may matter.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.15.263642842026-w43-p4/doi:10.64898/2026.10.15.26364284Preprint, not peer-reviewed. This preprint is not peer-reviewed. The study followed thirty older adults with mild cognitive impairment (MCI), eighteen of whom were followed for about 29 months. Volume loss in the right parahippocampal gyrus was linked to rising aggression, and rising blood flow in the right hippocampus and parahippocampal gyrus was linked to worsening agitation.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.15.263656362026-w43-p4/doi:10.64898/2026.10.15.26365636Preprint, not peer-reviewed. This preprint is not peer-reviewed. The study measured plasma amyloid beta and tau markers in a Midwestern Amish cohort. It found links with the APOE gene and with newer candidate genes, including MME, VEGFC and LRRTM4, which the authors say point to metabolic, synaptic and immune pathways.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.15.263656542026-w43-p4/doi:10.64898/2026.10.15.26365654Preprint, not peer-reviewed. This preprint is not peer-reviewed. The study analyzed more than 650,000 people in the All of Us and FinnGen cohorts. Autoimmune hypothyroidism was linked to higher skin cancer risk, and a genetic score for hypothyroidism was linked to lower risk, so the authors say combining both scores could help target prevention and surveillance.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.15.263656732026-w43-p4/doi:10.64898/2026.10.15.26365673Preprint, not peer-reviewed. This preprint is not peer-reviewed. The study of 5,062 people in the Democratic Republic of the Congo between 2023 and 2024 found 79.0% general acceptance of Ebola vaccination. Acceptance ranged from 47.6% in Kongo Central province to 92.1% in Tshuapa province, and was highest among healthcare workers.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.15.263656742026-w43-p4/doi:10.64898/2026.10.15.26365674Preprint, not peer-reviewed. This preprint is not peer-reviewed. It is a retrospective observational study of 3,635 adults aged 50 or older with Alzheimer disease and related dementias (ADRD) in the All of Us Research Program. Documented advance care planning was 5.1% among those reporting high shared decision-making and 3.6% among those reporting low, but the link was not statistically significant after full adjustment.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.15.263656942026-w43-p4/doi:10.64898/2026.10.15.26365694Preprint, not peer-reviewed. This preprint is not peer-reviewed. Using linked cancer registry and healthcare records in Wales for people diagnosed with lung, bladder, kidney, or head and neck cancers in 2011 to 2021, the authors found that current smokers had higher one-year net risk of cancer death than never smokers for lung and head and neck cancer. The head and neck difference was larger at 10 years.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.263657192026-w43-p4/doi:10.64898/2026.10.16.26365719Preprint, not peer-reviewed. This preprint is not peer-reviewed. It compared 40 notes from paired simulated consultations in dietetics, physiotherapy, occupational therapy and speech and language therapy, written either by artificial intelligence (AI) scribe Heidi or by the professional. The AI notes scored modestly higher on the PDQI-9 quality measure and had fewer omissions, but the authors say evidence on serious errors was inconclusive.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.263657552026-w43-p4/doi:10.64898/2026.10.16.26365755Preprint, not peer-reviewed. This preprint is not peer-reviewed. It is a secondary analysis of 130 mother-child pairs that looked at added sugars and fructose from pregnancy to 24 months. The authors describe the associations as varying by child sex and developmental window, and say the smaller scan subset of 42 children is exploratory and needs replication.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.263657562026-w43-p4/doi:10.64898/2026.10.16.26365756Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors measured biological aging from routine laboratory results in the electronic health records of 4,313 patients who had cardiothoracic surgery at a large US hospital. Patients who were biologically older before surgery more often died or had adverse outcomes, and postoperative changes were linked to intensive care stays and in-hospital death.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7595362026-w43-p4/doi:10.64898/2026.10.16.759536Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors report that the Kappa prophage gives Vibrio cholerae strains a competitive fitness advantage in vitro and during intestinal infection, through predation on neighboring cells rather than lysogenic conversion. They also found that the BREX and AbiC phage defense systems inhibited Kappa predation and restricted horizontal gene transfer.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7596722026-w43-p4/doi:10.64898/2026.10.16.759672Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors tested how often the working-electrode potential alternated in bioelectrochemical systems that make methane. Alternating every 4 days gave the best overall performance, producing about 250 L/L/kg of cumulative biogas with 96% methane content and a 45% methane yield, and the authors say alternation frequency is a critical parameter.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7597702026-w43-p4/doi:10.64898/2026.10.16.759770Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors report that the agaSY genes are needed for uropathogenic E. coli (UPEC) to use amino sugars, and that deleting them reduced type 1 fimbriae and biofilm formation. In a mouse urinary tract infection model, the mutant colonized the bladder and kidney less, and adding the genes back restored colonization.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.17.263657982026-w43-p4/doi:10.64898/2026.10.17.26365798Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors followed 559 people aged 92 to 107 from three oldest-old cohorts for up to 16 years. Plasma neurofilament light (NfL), a marker of neuroaxonal injury, was the only biomarker consistently linked to mortality, while Alzheimer disease markers were not, and the link held after adjusting for cognition and daily activities.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.17.263658072026-w43-p4/doi:10.64898/2026.10.17.26365807Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors tested eight large language models (LLMs) on 100 neurology board-style multiple-choice questions. Accuracy ranged from 45% to 92%, and confidence was generally overestimated, especially in lower-accuracy models, while consistency-based confidence best separated correct from incorrect answers (pooled AUROC 0.74).Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.17.7598492026-w43-p4/doi:10.64898/2026.10.17.759849Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors report that excess copper selectively impairs respiratory complexes containing c-type cytochromes across pathogenic and environmental bacteria, including Vibrio cholerae and Pseudomonas aeruginosa. They say copper mainly disrupts the assembly of c-type cytochromes, which may contribute to its antimicrobial activity.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.17.7598712026-w43-p4/doi:10.64898/2026.10.17.759871Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors report that systemic autoimmunity expands and reshapes microbiota-reactive CD4 T cells, which accumulate in peripheral tissues as intestinal dendritic cell trafficking is reactivated. T cells conditioned by the lupus-associated pathobiont Enterococcus gallinarum worsened autoimmunity after transfer through IL-21 and IFN-gamma, unlike commensal-reactive cells.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.19.263654872026-w43-p4/doi:10.64898/2026.10.19.26365487Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors analyzed an unweighted web-panel survey of 27,359 Japanese people aged 15 to 69 about visual and numerical body-size ideals. Among normal-weight women, 74.7% to 83.7% chose a smaller ideal silhouette, while most underweight men preferred weight gain, and the authors call for longitudinal and behavioral studies.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.19.7600492026-w43-p4/doi:10.64898/2026.10.19.760049Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors produced a biosurfactant with Paenibacillus dendritiformis using mustard oil mill and dairy wastes in place of pure reagents, which raised performance by 28.23%. Scaling from 100 ml to 1500 ml raised yield from 25 g/L to 68.5 g/L, and the authors estimate a production cost of Rs 18.64 per litre, excluding capital costs.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-nber:b92b852039812026-w43-p4/nber:b92b85203981Preprint, not peer-reviewed. This working paper is not peer-reviewed. It argues that venture capital specializes in firms with high sales and marketing spending relative to revenue, and that this focus on customer capital has grown over the past 30 years. The authors say such investments tolerate substantial failure risk in pursuit of power law returns.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-nber:f041e45e4e602026-w43-p4/nber:f041e45e4e60Preprint, not peer-reviewed. This working paper is not peer-reviewed. It reports a randomized evaluation in which coaches at an adult high school sent text messages encouraging persistence. Assignment to treatment raised graduation by 4.9 percentage points, and the authors estimate an earnings benefit of $149 per treated student over four years.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7571382026-w43-p4/doi:10.64898/2026.10.16.757138Preprint, not peer-reviewed. This preprint is not peer-reviewed. Using camera traps at 115 sites across about 606,000 km2 of Mato Grosso, Brazil, the authors estimated occupancy and abundance of jaguars, white-lipped peccaries and lowland tapirs. Jaguar occupancy rose from 0.33 to 0.87 as forest cover increased from 15% to 65%, and the authors say maintaining Legal Reserve requirements under Brazil's Forest Code matters for large vertebrates.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-arxiv:2610.225772026-w43-p4/arxiv:2610.22577Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors propose a Bayesian hierarchical model that accounts for air quality monitors being placed preferentially in areas with high concentrations. Using yearly maximum PM2.5 in California from 2017 to 2024, they found that ignoring preferential sampling can significantly change conclusions about where exceedances occur.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.12.7585172026-w43-p4/doi:10.64898/2026.10.12.758517Preprint, not peer-reviewed. This preprint is not peer-reviewed. It compared people with autism spectrum disorder (ASD) and neurotypical controls who navigated to briefly shown targets in virtual reality. Detailed movement trajectories separated the groups, and the authors say a lower subjective action cost in ASD could explain more frequent and abrupt movements.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.12.7585852026-w43-p4/doi:10.64898/2026.10.12.758585Preprint, not peer-reviewed. This preprint is not peer-reviewed. The researchers paired optogenetic stimulation of the central amygdala in rats with either the opioid remifentanil or sucrose, and the stimulation focused each rat's choices on whichever reward it was paired with. The authors say opioid motivation can be shaped in a similar way to cocaine or sucrose motivation.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.13.7585382026-w43-p4/doi:10.64898/2026.10.13.758538Preprint, not peer-reviewed. This preprint is not peer-reviewed. Over six weeks, the researchers followed 83 people with alcohol use disorder (AUD) and found that more drinkers around them was linked to higher odds of drinking. People with higher social drinking risk had lower gray matter volume in the pregenual anterior cingulate cortex on structural magnetic resonance imaging (MRI).Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.15.7594922026-w43-p4/doi:10.64898/2026.10.15.759492Preprint, not peer-reviewed. This preprint is not peer-reviewed. It reports that intermittent fasting by both mothers and fathers before mating was associated with cortical changes in fathers and in their offspring, with sex-dependent differences in the offspring. Because the offspring were never fasted themselves, the authors describe the signatures as consistent with intergenerational transmission.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7531492026-w43-p4/doi:10.64898/2026.10.16.753149Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors compared chromatin accessibility in prostatectomy specimens from Black and White men with localized prostate cancer who had equal access to healthcare. Tumors from Black patients showed reduced accessibility of CTCF-associated motifs and more inflammatory and epithelial-mesenchymal transition signals, and CTCF was lower in 99 specimens.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7593772026-w43-p4/doi:10.64898/2026.10.16.759377Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors report that necroptotic MC38 mouse tumor cells lacking the WDD domain of ATG16L1 released more ATP as they died and gave stronger protection against later tumors in mice. The effect depended on secreted ATP and on T cells, and the authors suggest this pathway could be a target to boost anti-tumor immunity.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7596862026-w43-p4/doi:10.64898/2026.10.16.759686Preprint, not peer-reviewed. This preprint is not peer-reviewed. The researchers gave oxytocin (OT) to rats self-administering intravenous oxycodone. Daily oxytocin increased demand elasticity for the opioid in males but not in females, and the authors say its effect on motivation appears independent of how much dopamine oxycodone released in the nucleus accumbens.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7597032026-w43-p4/doi:10.64898/2026.10.16.759703Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors introduce SKyNet, which combines a pan-solid cancer single-cell atlas with TCGA bulk data to find ligand-receptor interactions associated with overall survival in 11 human solid cancers. They describe the results as hypothesis-generating, for example endothelial-pericyte interactions linked to poor outcomes in pancreatic adenocarcinoma.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.16.7597732026-w43-p4/doi:10.64898/2026.10.16.759773Preprint, not peer-reviewed. This preprint is not peer-reviewed. The authors defined a Pyruvate Partitioning Index across colorectal cancer datasets, single-cell atlases and spatial sections. Low-index areas were enriched for SPP1+ macrophages, and microsatellite-unstable tumors had the lowest index, so the authors say the link to immunotherapy response appears cancer-type specific and needs validation in colorectal cohorts.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.17.7597512026-w43-p4/doi:10.64898/2026.10.17.759751Preprint, not peer-reviewed. This preprint is not peer-reviewed. In mouse mammary tumors, the authors report that a minority of qM cancer cells, which have activated epithelial-mesenchymal plasticity (EMP), reduce MHC-I on neighboring cancer cells and so resist CD8+ T cell elimination. They also report that human triple-negative breast cancers with more EMP activation exclude T cells from the tumor core.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-doi:10.64898/2026.10.17.7597972026-w43-p4/doi:10.64898/2026.10.17.759797Preprint, not peer-reviewed. This preprint is not peer-reviewed. It is a retrospective analysis of the guinea pig maternal undernutrition model, in which maternal salivary and serum cortisol stayed elevated throughout pregnancy. The authors say fetal growth restriction reflects maternal stress responses and placental insufficiency together, not nutrient shortage alone.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p4/#item-mit-research:0dbde1ea11532026-w43-p4/mit-research:0dbde1ea1153Announcement. This is an announcement by MIT News, so its claims are the institution's own account rather than established findings. It reports that a model developed by researchers at MIT and Boston Children's Hospital adjusts scans on the fly to track fetal movement, potentially sparing families repeat hospital visits.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.1016/j.cell.2026.09.0482026-w43-p3/doi:10.1016/j.cell.2026.09.048Peer-reviewed study. A peer-reviewed study in Cell reports that isoUDCA, a female-enriched bile acid produced by a group of gut bacteria that estrogen favors, promotes cholesterol handling and bile acid metabolism in the liver. The authors say this signaling alleviates chronic liver injury and mediates protection from chronic liver disease in females.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.15.263654652026-w43-p3/doi:10.64898/2026.10.15.26365465Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, applies a counterfactual causal model to electronic health records to estimate individual effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors, medications with broad metabolic and cardiovascular benefits. The authors report that across diagnostic categories the model's predicted treatment value outperformed real-world prescriptions. They say this highlights subpopulations where these drugs may yield superior outcomes.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.15.263655472026-w43-p3/doi:10.64898/2026.10.15.26365547Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, introduces Vascular Proximity Coverage, a CT-based measure of how close pulmonary vessels sit to lung tissue, in 7,881 COPDGene participants with chronic obstructive pulmonary disease (COPD). The authors report that lower coverage was associated with worse lung function, shorter six-minute walk distance and greater dyspnea, and that the lowest quartile had 38% higher mortality than the reference quartile. They say the measure captures information that total vessel volume does not.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.15.263656342026-w43-p3/doi:10.64898/2026.10.15.26365634Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that a 4-billion-parameter open large language model (LLM), fine-tuned on public data, estimated the carbohydrate in 100 real meals described in words with a mean absolute error (MAE) of 12.2 g, against 22.6 g for an automatically matched food composition table. The authors also report that a personalised gradient boosting model correlated with observed postprandial glucose rises at 0.63 in one dataset of 45 adults and 0.49 in one of 99 people with type 2 diabetes. The model lost correlation when applied from one dataset to the other.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.15.263656712026-w43-p3/doi:10.64898/2026.10.15.26365671Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines PhenoAge, a blood-based biological aging clock, in 3,067 patients undergoing primary tumor resection. The authors report that PhenoAge acceleration rose with tumor stage, and that one or two of its eight blood components, differing by cancer type, carried the prognostic signal. They suggest that in cancer PhenoAge may reflect disease burden rather than biological aging.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.15.263656882026-w43-p3/doi:10.64898/2026.10.15.26365688Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, maps regulatory interactions at the 9p21.3 locus, one of the strongest genetic risk loci for cardiovascular disease. The authors identify the long non-coding RNA (lncRNA) MIR31HG as a likely effector transcript, reporting that it responds to hemodynamic flow and that its depletion in endothelial cells was associated with endothelial activation.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.15.263656992026-w43-p3/doi:10.64898/2026.10.15.26365699Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, represents digital clock drawing tests as networks built from 3,362 Framingham Heart Study participants, with and without cognitive impairment. The authors report that network-based models achieved performance comparable to established summary feature baselines across command-only and copy-only conditions. They suggest the approach could support automated screening after external validation.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.15.7593952026-w43-p3/doi:10.64898/2026.10.15.759395Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, applied Phage-display ImmunoPrecipitation Sequencing (PhIP-Seq) to 321 individuals in the Austrian CORSA cohort (Colorectal Cancer Study of Austria), including controls, adenomas and colorectal cancer patients. The authors report that overall antibody repertoires showed limited predictive performance, but specific signals such as Helicobacter pylori CagY stood out as a candidate marker of colorectal cancer.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.16.263646762026-w43-p3/doi:10.64898/2026.10.16.26364676Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzed 8,936 diabetes-free adults in the Tsuruoka Metabolomics Cohort Study in Japan over a median of 9.20 years, during which 1,038 developed diabetes. The authors report that the urine metabolomic risk score was associated with incident type 2 diabetes after adjusting for established risk markers and the plasma score, while the plasma score was not. They say urine provides a complementary perspective on metabolic variation.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.16.263655122026-w43-p3/doi:10.64898/2026.10.16.26365512Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is an umbrella review of systematic reviews on exercise as an adjunct to treatment for substance use disorders, including tobacco and nicotine dependence. The authors report exercise may improve tobacco and drug craving and inhibitory control, but most evidence is of low or very low certainty. Evidence on relapse, treatment retention and safety was insufficient for reliable synthesis, so they say exercise should be evaluated as an adjunct rather than a substitute.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.16.263657592026-w43-p3/doi:10.64898/2026.10.16.26365759Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, developed a multi-domain risk model using polygenic scores and 10 early-life behavioral and environmental risk factors in four longitudinal cohorts from the United States, United Kingdom and Finland. The model achieved an area under the receiver operating characteristic curve (AUC) of 0.78 for any substance use disorder, with 69% sensitivity and a 45% positive predictive value, in a sample where 22.0% had the disorder. The authors say performance was comparable across alcohol, cannabis and tobacco.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.17.263658092026-w43-p3/doi:10.64898/2026.10.17.26365809Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tested GPT-4o, Claude Sonnet 5, Gemini 3.5 Flash and Qwen 3.6, multimodal large language models (LLMs), on 60 contrast-enhanced T1-weighted brain magnetic resonance imaging (MRI) examinations of gliomas and brain abscesses. The authors report the models' tumor calls shifted much more with the referral text than the imaging difference between confirmed gliomas and abscesses, and that an instruction to ignore the text only partly reduced this.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.17.263658142026-w43-p3/doi:10.64898/2026.10.17.26365814Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports the first genome-wide association study of the phosphoproteome, testing over 8,000 site-specific phosphorylation levels in lung or kidney tissue from 324 participants. The authors identify 379 protein quantitative trait loci (pQTLs) and 46 phosphorylation quantitative trait loci independent of protein abundance. They report that a kidney site in STK4 colocalized with markers of kidney function, with no pQTLs at that locus.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-arxiv:2610.228302026-w43-p3/arxiv:2610.22830Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models optimal trade sanctions among a sanctioner (Home), a target (Foreign) and a Bystander that may act alone or ally with either. In a calibration exercise on sanctions against Russian crude, cooperation among India, China and Russia best matched observed data. The authors estimate sanctions could have been roughly 70% more effective had China and India acted unilaterally or had the sanctioning coalition made them a better offer.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-nber:1829699322f32026-w43-p3/nber:1829699322f3Preprint, not peer-reviewed. An NBER preprint, not yet reviewed by other scientists, documents that better managed firms, even in the same industries and labor markets, are more likely to train. The authors say training clusters around managerial or frontline worker development, and argue that organizational differences give firms incentives to train beyond explanations based on labor market frictions.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-nber:68646434ed6c2026-w43-p3/nber:68646434ed6cPreprint, not peer-reviewed. An NBER preprint, not yet reviewed by other scientists, studies France's pay-preserving cut in the workweek from 39 to 35 hours, bundled with employer payroll tax cuts. The authors report the package left employment unchanged, but absent the tax cuts the shorter workweek would have reduced employment by 3.8%. They also report shorter hours raised total factor productivity by 2%, limiting the output decline to 1%.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-nber:77691af9ff4a2026-w43-p3/nber:77691af9ff4aPreprint, not peer-reviewed. An NBER preprint, not yet reviewed by other scientists, reports a field experiment in 195 rural Sierra Leonean communities that upgraded Village Savings and Loan Associations (VSLAs) into mobile money and bank agents, crossed with a monthly consumer feedback mechanism. The authors report that upgrading expanded access, while feedback drove operational improvements of 20.5 percentage points, particularly in privacy and consumer protection, along with higher usage and revenues. They say accountability, not infrastructure alone, aligns provider incentives with consumer welfare.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-nber:8736d63920e92026-w43-p3/nber:8736d63920e9Preprint, not peer-reviewed. An NBER preprint, not yet reviewed by other scientists, estimates that the 2026 California Billionaire Tax Act, a one-time 5 percent tax on the worldwide net worth of individuals exceeding $1 billion, would collect about $30 billion before reductions in other tax bases. The authors estimate California's billionaires contribute $3.3–5.8 billion annually in state income taxes, so the present value of lost income tax from departures more than offsets the one-time revenue, for a net present value of negative $38.9 billion. Across simulated combinations, 85 percent of plausible outcomes produce a negative net present value of state revenues.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-nber:c4f7de0748ee2026-w43-p3/nber:c4f7de0748eePreprint, not peer-reviewed. An NBER preprint, not yet reviewed by other scientists, is a chapter on the Indian pharmaceutical industry that uses Biomedtracker trial phase transition data to compare India with China and the United Kingdom. The authors report a bottleneck in moving clinical trials from Phase 1 to Phase 2, and argue that binding constraints in the Indian ecosystem, likely unrelated to intellectual property rights (IPR), are the cause. They also cite interviews with industry experts.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-nber:d2d91b0d0c3e2026-w43-p3/nber:d2d91b0d0c3ePreprint, not peer-reviewed. An NBER preprint, not yet reviewed by other scientists, examines a Fannie Mae and Freddie Mac fee waiver aimed at lower-income first-time homebuyers. The authors estimate mortgage intermediaries captured over 60% of $1.5 billion in total fee waivers during 2023–2024, rather than passing the savings through to borrowers. They report that loan officers with a track record of expensive mortgages passed through less than 20% of the waiver.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-openai:7a364f356aab2026-w43-p3/openai:7a364f356aabAnnouncement. OpenAI says it is improving ChatGPT across low-resource programming languages, with new evaluations for software engineering, SQLite and COBOL migration.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.1073/pnas.26007741232026-w43-p3/doi:10.1073/pnas.2600774123Peer-reviewed study. A peer-reviewed PNAS study used a database of over four million occurrence records covering European bees and hoverflies over the past century. It found that most bee species and about half of hoverfly species declined in occupancy, while regional species richness changed modestly and species persistence stayed relatively high. The authors say the trends are a warning sign, with potential for recovery if urgent action is taken.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.1073/pnas.26156241232026-w43-p3/doi:10.1073/pnas.2615624123Peer-reviewed study. A peer-reviewed PNAS study analyzed Canada's National Forest Inventory to test whether understory vegetation (shrubs, herbs and bryophytes) is associated with carbon accumulation in overstory trees. The authors found that herb and bryophyte species richness was positively associated with decade-scale tree carbon accumulation, most strongly at warmer, drier and nitrogen-limited sites, while soil carbon showed no consistent association. It is an observational study, which shows a link, not a cause.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.1073/pnas.26156271232026-w43-p3/doi:10.1073/pnas.2615627123Peer-reviewed study. A peer-reviewed PNAS study evaluated about one million resolved contracts and questions from four collective forecasting platforms, covering twelve domains and horizons from hours to years. It found forecast probabilities were highly calibrated overall, meaning events given a p% chance occurred roughly p% of the time, though some consequential areas showed systematic over- or underestimation. The authors say aggregated predictions contain meaningful information about real-world uncertainty, but do not provide certainty about individual events.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.1073/pnas.26165541232026-w43-p3/doi:10.1073/pnas.2616554123Peer-reviewed study. A peer-reviewed PNAS study reports sudden, severe and persistent declines of 60 to 85% in deep-pelagic fishes, crustaceans and cephalopods in the Gulf of Mexico over a 3.5-year period. The authors say the declines were detected by both direct sampling and acoustic sensing, and that their timing points to the Deepwater Horizon oil spill as the most parsimonious, or simplest, explanation. They found no natural factor tested, such as temperature, oxygen or food supply, correlated with the declines.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.12.7582972026-w43-p3/doi:10.64898/2026.10.12.758297Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzed resting-state functional magnetic resonance imaging (fMRI) scans of 210 adults from the Transdiagnostic Connectome Project. In people with high anhedonia, meaning a diminished capacity to experience or pursue pleasure, the authors report that the cortex shifted upstream relative to the subcortex. They say signals traveling from subcortex to cortex weakened more than the descending signals.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.13.7445382026-w43-p3/doi:10.64898/2026.10.13.744538Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes droplet culture, which grows tumor organoids in tiny Matrigel droplets to allow high-throughput drug and CRISPR screens. In a screen of over 5,000 clinical compounds, the authors report therapeutic opportunities that genomic profiling alone did not reveal. They also report a stomach cancer vulnerability linked to loss of UXS1.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.13.7576782026-w43-p3/doi:10.64898/2026.10.13.757678Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, used hydrogels with tunable elasticity and viscosity and reports that cancer cells primed on soft, viscous substrates adopted stiffness-associated states and migrated more. In zebrafish and mice, the authors say viscous priming enhanced vascular arrest and metastatic colonization. They also report that transient microtubule disruption during priming shifted metastatic burden toward lymph nodes.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.13.7586912026-w43-p3/doi:10.64898/2026.10.13.758691Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that macrophages remove protein aggregates from other cells through trogocytosis, a partial engulfment of the target cell. The authors say this is triggered when lysosomal stress raises the transmembrane form of CSF1 on the cell surface, which macrophages detect through the CSF1 receptor.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.13.7587442026-w43-p3/doi:10.64898/2026.10.13.758744Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, measured eleven root anatomical traits in 185 Vietnamese rice landraces and ran genome-wide association studies to find genetic regions linked to them. It identified 19 quantitative trait loci, and the authors say some overlapped with regions tied to drought-tolerance-related traits. They suggest a gene, OsWAK111, may influence cell elongation.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.13.7587672026-w43-p3/doi:10.64898/2026.10.13.758767Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that in a murine model of aortic stenosis, pharmacological activation of perivascular adipose tissue, the fat around the aortic wall, improved the condition, but not in mice genetically deficient in that fat. The authors also report that thermogenic fat activity in people correlated negatively with diagnostic criteria of aortic stenosis severity, and they suggest it may be a potential therapeutic target.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.13.7589112026-w43-p3/doi:10.64898/2026.10.13.758911Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that an extremophilic laccase with a phenolic redox mediator degraded over 97% of doxycycline within 2 hours and eliminated its antibacterial activity. The authors say direct enzymatic oxidation alone only partly removed that activity, and that the mediator was key. They suggest the system could support treatment of antibiotic-contaminated effluents.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.16.7596782026-w43-p3/doi:10.64898/2026.10.16.759678Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, identifies KRT7-positive glandular duct cells as progenitors in ferret and healthy human airways. Fate mapping in ferrets, the authors report, showed these cells generate serous and mucous cells during gland development and expand after severe airway injury to repair the surface epithelium. They say the work may have implications for cystic fibrosis therapies.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.16.7596812026-w43-p3/doi:10.64898/2026.10.16.759681Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, used gene-edited induced pluripotent stem cells deficient for ABCA7 and studied the astrocytes, neurons and microglia derived from them. The authors report ABCA7-deficient microglia had reduced lysosomal activity and phagocytosis, and that in tri-cultures with neurons, measures such as tau phosphorylation and synapse number worsened. They suggest the work points to a shared mechanism for the rs3752246 risk variant.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.18.7600002026-w43-p3/doi:10.64898/2026.10.18.760000Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, compared recovery after 4h of isoflurane anesthesia with time-matched sleep and sleep deprivation in male C57BL/6J mice, using electroencephalogram (EEG) recordings and cortical RNA sequencing. The authors report anesthesia recovery produced rebound arousal, fragmented sleep and ultra-slow EEG oscillations. They say cortical gene expression leaned toward an integrated stress response rather than the growth-permissive profile seen after sleep deprivation.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-doi:10.64898/2026.10.18.7600032026-w43-p3/doi:10.64898/2026.10.18.760003Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, establishes population-specific white matter charts of 198 phenotypes for 19,215 Chinese and 15,584 Western participants across the lifespan. The authors report that Chinese population-matched charts predicted white matter phenotypes more accurately, and detected more extreme deviations in the Chinese population, than Western-derived models. They suggest reference-population mismatch can reduce the accuracy and clinical sensitivity of normative brain charts.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-pew:3bdd4105a7f22026-w43-p3/pew:3bdd4105a7f2Announcement. Pew Research Center's fact sheet says how Americans get news continues to evolve as platforms such as artificial intelligence (AI) chatbots and email newsletters emerge. It covers how often Americans get news from digital devices.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-pew:823bfd80a4462026-w43-p3/pew:823bfd80a446Announcement. Pew Research Center says many Americans use social media for news, and about a fifth or more regularly get news on Facebook, YouTube, Instagram and TikTok.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p3/#item-pew:916307d1777a2026-w43-p3/pew:916307d1777aAnnouncement. Pew Research Center says YouTube and Facebook are today the most widely used online platforms among Americans. The report also explores demographic patterns and trends shaping the social media landscape.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.12.7580932026-w43-p2/doi:10.64898/2026.10.12.758093Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a cell study that screened about 8,640 compounds and found that proteasome inhibitors selectively strengthen type III interferon (IFN-lambda) signaling, with minimal effect on type I interferon. The authors say the compounds raise levels of a receptor subunit that limits this signaling, and that they enhanced antiviral activity.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.15.263656662026-w43-p2/doi:10.64898/2026.10.15.26365666Preprint, not peer-reviewed. This systematic review and meta-regression analysis, a preprint not yet reviewed by other scientists, pools 82 population surveys from 30 countries on tuberculosis (TB) prevalence by age. It finds that bacteriologically confirmed TB prevalence increases with age, and that the oldest group (75+) had about 6.4 times the prevalence of the youngest (15-19). The authors also report lower notification-to-prevalence ratios among older people, which they say suggest poorer case detection.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.15.263656692026-w43-p2/doi:10.64898/2026.10.15.26365669Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports a study that used the nominal group technique with thirty-three patients and caregivers and ten clinicians to co-design an evaluation framework for a patient-held artificial intelligence (AI) Personal Health Assistant (AIPHA). The authors say patients prioritized the assistant's role in longitudinal care and post-visit coordination over its scribe function, with communication and respect the most critical outcome. They also say clinician trust and formal consent, rather than technical utility, are the main hurdles.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.15.263656722026-w43-p2/doi:10.64898/2026.10.15.26365672Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a prospective cohort study of 3,560 participants aged 6 months to 49 years in Washington and Oregon, tested weekly with nasal swabs during 2022 to 2024. The authors report that recent illness with some viruses was often associated with lower short-term risk of other viral illnesses, while SARS-CoV-2 illness was associated with higher short-term risk of adenovirus and parainfluenza illness. They say these associations differed by age and symptom status.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.15.263656772026-w43-p2/doi:10.64898/2026.10.15.26365677Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, examined stool metagenomic sequencing and brain amyloid-beta levels in 101 asymptomatic people. The authors report that higher amyloid-beta was associated with distinct gut microbial signatures, and with lower potential to produce gamma-aminobutyric acid (GABA). They say these changes may identify targets for preclinical Alzheimer's disease intervention.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.16.263645742026-w43-p2/doi:10.64898/2026.10.16.26364574Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a genetic analysis of summary statistics from four asthma subtypes, 12 neuropsychiatric disorders and six substance use behaviors. The authors identify 178 pleiotropic genes shared across these conditions, and say asthma shares a genetic component with post-traumatic stress disorder, major depressive disorder and attention-deficit/hyperactivity disorder that cannot be fully accounted for by smoking.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.16.263657162026-w43-p2/doi:10.64898/2026.10.16.26365716Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, uses a Bayesian spatiotemporal model of monthly dengue cases across 435 health regions in Brazil from 2010 to 2025. The authors report that drought and temperature conditions were linked to dengue risk, and that adding climate information improved predictions of case counts and outbreaks at lead times of 1, 3, 6 and 12 months.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.16.263657232026-w43-p2/doi:10.64898/2026.10.16.26365723Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is an ecological study of state-level data in India from 2001 to 2021, linking gender-based violence rates with disease burden from mental health disorders. The authors report that higher violence rates were associated with a higher burden of schizophrenia and bipolar disorder after adjustment for social development, and that the association with overall mental health burden strengthened over time.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-2026-214202026-w43-p2/2026-21420Proposed. The Health and Human Services Department and the Centers for Medicare & Medicaid Services (CMS) propose rules to implement three sections of the Consolidated Appropriations Act, 2026. The proposal would adjust Medicare Part D cost-sharing reductions for low-income individuals, implement the Requiring Enhanced and Accurate Lists of (REAL) Health Providers Act, and implement section 6224 on pharmacy benefit manager accountability.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:0bde640453ae2026-w43-p2/nber:0bde640453aePreprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, uses data on 10 million people and staggered expansions of Medicaid across ZIP codes to estimate how social insurance affects household debt. It finds that a 1 percentage point increase in a ZIP code's Medicaid-eligible population increased credit card borrowing by 0.38%. The authors say increased credit supply, driven by households' improved financial resilience, drives this rise and contributes 30% of the net welfare gains from expanding Medicaid.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:0ca2d8f3c58c2026-w43-p2/nber:0ca2d8f3c58cPreprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, studies how global financial conditions pass through to firms' investment. It finds that increases in risk premia are followed by large investment contractions, particularly among firms with higher default risk. The authors argue that smoothing cash flows reduces firms' quantity of risk and dampens international financial transmission.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:190996ef9a4d2026-w43-p2/nber:190996ef9a4dPreprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, reports a randomized trial among 2,134 charcoal users in Kenya, testing purchase price subsidies, usage subsidies and access to an interest-free loan for an induction stove. The authors find that usage subsidies of 75% had a precise zero effect on adoption and usage, while purchase price subsidies generated large welfare gains. They say credit constraints raised the subsidy's efficacy.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:3ac0c9132d842026-w43-p2/nber:3ac0c9132d84Preprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, builds a genealogy of technologies from the full text of 13 million patents to trace foreign inputs into innovation. It finds that 54% of U.S. technologies build on at least one foreign input. Using historical migrant settlement as a source of variation, it reports that counties more exposed to a foreign country's knowledge invent more technologies building on it.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:5311fcb5aa2e2026-w43-p2/nber:5311fcb5aa2ePreprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, estimates a dynamic model of groundwater extraction for each of the world's aquifers, using remote sensing and economic data. It finds that three- to four-fifths of aquifers are extracted more rapidly than is optimal, reducing their present value and creating welfare losses in the trillions of dollars. The authors also find that policies guaranteeing constant water quantities generate larger welfare costs.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:6d04a05278962026-w43-p2/nber:6d04a0527896Preprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, is a model of lenders competing for borrowers with new screening technologies. The authors find that when screening errors are correlated, perhaps because of similar AI systems, lenders specialize into distinct segments with different interest rates. They say technological and regulatory changes, such as open banking, affect financial access unevenly and can help or harm financially excluded borrowers.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:73a3c0f609f02026-w43-p2/nber:73a3c0f609f0Preprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, proposes a general equilibrium model in which U.S. monetary policy revalues the wealth of currency-mismatched arbitrageurs and so affects global risk premia. The authors quantify the macroeconomic spillovers this creates abroad and the role of policy responses in other countries. They say that in a potential future with higher dollar interest rates, these spillovers would be dampened.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:8a10dc0831852026-w43-p2/nber:8a10dc083185Preprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, uses a dynamic factor time series model to estimate the national mortality impact of the Great Recession. It estimates that the recession reduced the average annual, age-adjusted mortality rate by about 2 percent, with effects persisting for at least a decade. The authors say the welfare gain from this mortality decline is quantitatively significant relative to the welfare loss from lower consumption.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:991683ba0e6f2026-w43-p2/nber:991683ba0e6fPreprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, presents scenarios for future medical spending, ranging from rapid growth in expensive new treatments to cost-reducing technology. Medical spending has nearly tripled as a share of gross domestic product (GDP) since 1970 but has barely exceeded GDP growth since 2010. The author argues that even modest increases in spending relative to GDP would overwhelm the federal government's ability to pay for medical care with current tax instruments.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:c11f54b9d6282026-w43-p2/nber:c11f54b9d628Preprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, is a general equilibrium model of the labor market and fiscal effects of immigration, calibrated to 17 countries over 2015-2019. For inflows matching the skill composition of 2019-2024 arrivals, the authors find native welfare rises in 14 of 17 economies, and in most cases both lower-skilled and higher-skilled natives gain through different channels. Lower-skilled natives gain mainly from higher pre-tax earnings, while higher-skilled natives gain mainly from lower labor-tax burdens.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:c2b166889e512026-w43-p2/nber:c2b166889e51Preprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, uses plant-level data from satellite imagery and machine learning to study China's nationwide, rate-based carbon market, launched in 2021. It finds that high-efficiency power plants increased electricity generation and carbon dioxide (CO2) emissions by approximately 5% relative to low-efficiency plants, and that air quality worsened downwind of them. The authors say that if China's goal is to reduce emissions, benchmarks will need to be tightened or an alternative system adopted.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-nber:d025ab775bbb2026-w43-p2/nber:d025ab775bbbPreprint, not peer-reviewed. This working paper, a preprint not yet reviewed by other scientists, combines new data on U.S. export control classifications and licensing outcomes with a quantitative general equilibrium model. It finds that multilateral controls reduce adversaries' imports of controlled products far more than unilateral U.S. controls, with only 7% of the reduction replaced by other countries, compared with 28% under unilateral U.S. policy. The authors say multilateral controls cut adversaries' real military expenditure, and that the two approaches impose a similar civilian cost.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-uksi-2026-10992026-w43-p2/uksi-2026-1099Final rule. These UK regulations, made on October 15, 2026, prescribe the detriments that a worker is protected from for taking industrial action, under section 236A of the Trade Union and Labour Relations (Consolidation) Act 1992. They come into force on October 30, 2026.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-uksi-2026-11012026-w43-p2/uksi-2026-1101Final rule. These UK regulations are part of a package providing for access agreements between trade unions and employers. Under those agreements, trade union officials can enter workplaces or communicate with workers, including by providing information by any means. The regulations were made on October 15, 2026 and come into force on October 30, 2026.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-uksi-2026-10862026-w43-p2/uksi-2026-1086Final rule. This UK statutory instrument, made on October 9, 2026, is a development consent order that grants consent for, and authorises the construction, operation and maintenance of, a solar generating station and battery energy storage facility, together with associated development. It also imposes requirements and authorises compulsory purchase of land, including rights in land, and the right to override easements and other rights. It comes into force on October 31, 2026.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-2026-214332026-w43-p2/2026-21433Proposed. The Agriculture Department's Animal and Plant Health Inspection Service (APHIS) proposes to lower the minimum maturation temperature for fresh boneless beef and ovine meat from regions affected with foot-and-mouth disease (FMD) from 4 degrees Celsius to 2 degrees Celsius. The proposal would leave all other existing import mitigations for beef unchanged, and it aims to align the rules with the World Organization for Animal Health's standards while continuing to protect the United States against the introduction of FMD.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-2026-214502026-w43-p2/2026-21450In effect. This temporary rule, in effect from October 17, 2026, closes the General category fishery for Atlantic bluefin tuna for the rest of the October through November period. Restricted-fishing days are waived for that period, so vessels with General category or Highly Migratory Species (HMS) Charter/Headboat permits may tag and release bluefin tuna of all sizes. The National Oceanic and Atmospheric Administration (NOAA) says the fishery will reopen automatically later.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-ukdsi-2026-97803482879122026-w43-p2/ukdsi-2026-9780348287912Proposed. This draft UK statutory instrument has been laid before Parliament and would become law only if approved and made. It would be the first made under Chapter 2 of Part 4 of the Digital Markets, Competition and Consumers Act 2024, giving consumers rights to cancel subscription contracts if traders breach specific duties, and during specific cooling-off periods. Section 254 of that Act explains what a subscription contract is for these purposes.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-ukdsi-2026-97803482879292026-w43-p2/ukdsi-2026-9780348287929Proposed. This draft UK statutory instrument has been laid before Parliament and would become law only if approved and made. It would amend primary and secondary legislation in consequence of the coming into force of Chapter 2 of Part 4 of the Digital Markets, Competition and Consumers Act 2024, and of the Consumer Subscription Contracts (Cancellation and Information) Regulations 2026.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.1073/pnas.25300811232026-w43-p2/doi:10.1073/pnas.2530081123Peer-reviewed study. This peer-reviewed study in the journal PNAS models where smart farming technologies, such as precision agriculture, autonomous weeding machines and autonomous irrigation, are profitable across croplands worldwide. It combines a survey and a meta-analysis of adoption locations with remotely sensed and statistical data, using an ensemble of geospatial machine learning models. Simulations of future pathways suggest that the potential of smart farming will grow over time, especially in middle-income countries.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.1073/pnas.26039191232026-w43-p2/doi:10.1073/pnas.2603919123Peer-reviewed study. This peer-reviewed study in the journal PNAS uses satellite imagery to assess solar and wind potential near 3,890 U.S. fossil and renewable power plants. The authors estimate that by 2030, existing fossil plants could host up to 597 gigawatts (GW) of economically viable solar and wind without exceeding each site's existing interconnection capacity. They say realizing this potential depends on regulatory reforms and on coordinating the operational constraints of colocated resources.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.1073/pnas.26139851232026-w43-p2/doi:10.1073/pnas.2613985123Peer-reviewed study. This peer-reviewed study in the journal PNAS reports a hydrogen-based catalytic membrane that, under ambient conditions, captures and defluorinates six per- and polyfluoroalkyl substances (PFAS) of regulatory concern. The authors say GenX, which has an ether linkage, was harder to remove and defluorinate than the other compounds, though it was still converted. In continuous tests over 58 days, the system removed up to 96% of the PFAS.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.1073/pnas.26177171232026-w43-p2/doi:10.1073/pnas.2617717123Peer-reviewed study. This peer-reviewed study in the journal PNAS analyzes 233,844 observations across 101 cities worldwide. It finds that larger contiguous clusters of functionally similar buildings are associated with lower daytime surface urban heat island (UHI) intensity, with every 100-meter increase in cluster scale corresponding to a 4.5% decrease. The authors report that in low-income regions, larger building area and volume weaken this cooling more than in wealthier regions.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.1073/pnas.26193571232026-w43-p2/doi:10.1073/pnas.2619357123Peer-reviewed study. This peer-reviewed study in the journal PNAS examines groundwater use and depletion across all 426 known transboundary aquifers (TBAs), combining about 116,000 well observations with global irrigation data. It finds no evidence of greater average depletion in these shared aquifers, but depletion is more strongly concentrated toward international borders. The authors argue that transboundary groundwater governance should follow the geography of groundwater use rather than treating shared aquifers as uniform units.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.12.7539732026-w43-p2/doi:10.64898/2026.10.12.753973Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, is a study in mice in which once-weekly injections of an antisense oligonucleotide (ASO) against a lipid regulatory protein prevented diet-induced obesity and reduced fat mass. The authors say the approach also improved glucose tolerance and steatotic liver disease, with no change in lean mass, and that the effect appears to come from adipose tissue rather than the liver.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.13.7588972026-w43-p2/doi:10.64898/2026.10.13.758897Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports that in mice, females show greater disease-associated microglial responses to aging and amyloid-beta pathology than males. The authors say similar sex-biased responses are conserved in microglia from people with Alzheimer's disease, and they highlight amyloid precursor protein (APP) as a central part of the shared network.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-doi:10.64898/2026.10.16.7596632026-w43-p2/doi:10.64898/2026.10.16.759663Preprint, not peer-reviewed. This preprint, not yet reviewed by other scientists, reports that mice with genetic deletion of stimulator of interferon genes (STING) had longer median lifespans. The authors say these mice were also resistant to age-related liver decline, and they conclude that targeting STING is a promising therapeutic target for extending healthy lifespan.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-pew:9db98ff33e1f2026-w43-p2/pew:9db98ff33e1fAnnouncement. Pew Research Center's announcement says it explores the latest patterns, trends and statistics in Americans' use of mobile devices in 2026. It gives no specific findings in the announcement itself.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-pew:aef663f369722026-w43-p2/pew:aef663f36972Announcement. Pew Research Center's announcement covers patterns, trends and statistics of internet and home broadband adoption in the United States. It describes the internet as a fundamental shift in how Americans connect with one another, gather information and conduct their day-to-day lives.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p2/#item-pew:b716c3679ad62026-w43-p2/pew:b716c3679ad6Announcement. Pew Research Center reports that 1 in 5 Americans regularly get news on TikTok. Among adults under 30, 39% say they regularly get news from TikTok, up from 9% in 2020.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.1073/pnas.26036181232026-w43-p10/doi:10.1073/pnas.2603618123Peer-reviewed study. A peer-reviewed study published in PNAS on October 20, 2026, reports laboratory experiments in mice. Oral doses of a defined polysaccharide from Ganoderma lucidum eased mycoplasmal pneumonia, and the authors report that the effect was carried by vesicles from gut microbiota that alveolar macrophages took up in the lung. The authors describe this as a gut–lung route of protection against pneumonia.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.13.7588982026-w43-p10/doi:10.64898/2026.10.13.758898Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 20, 2026, on bioRxiv, reports laboratory experiments on MCF10A breast epithelial cells grown in 3D. The study exposed the cells to p,p'-dichlorodiphenyldichloroethylene (DDE), an endocrine disruptor that the abstract links to breast cancer risk, and reports loss of two cell-state markers and an epidermal phenotype. The authors also identify the transcription factor DLX3 as induced by DDE, and say DLX3 is highly upregulated in human breast cancers.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.14.263615602026-w43-p10/doi:10.64898/2026.10.14.26361560Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, is an observational analysis of 8,383 participants in the multicenter COPDGene study, which spans all severities of chronic obstructive pulmonary disease (COPD). The authors report that higher tracheal eccentricity, meaning a less circular windpipe cross-section on CT scans, was associated with lower lung function, shorter walking distance, worse quality of life and higher mortality. Because the study is observational, it shows associations rather than cause, and the authors suggest central airway shape as a candidate imaging biomarker.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.14.7590972026-w43-p10/doi:10.64898/2026.10.14.759097Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, uses single-cell RNA sequencing to study the immune landscape of chronic asymptomatic and symptomatic children infected with Plasmodium falciparum. The authors report that symptomatic infection was associated with fewer cell-cell interactions, particularly between non-classical monocytes and T cells. They also report higher S100A8 and S100A9 expression in those monocytes, and raise the possibility of a link to LILRB1 signaling.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.14.7592192026-w43-p10/doi:10.64898/2026.10.14.759219Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports cell experiments on intestinal epithelial cells exposed to ethanol. The authors report that the small heat shock protein HSPB1 is released by these cells and that extracellular HSPB1 reduced oxidative stress, damage and iron uptake during ethanol exposure. They suggest that with chronic alcohol consumption, HSPB1 released from liver cells may drive inflammation, and that targeting HSPB1 levels along the gut-liver axis could be a possible diagnostic and therapeutic avenue.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.18.263658622026-w43-p10/doi:10.64898/2026.10.18.26365862Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, is a meta-analysis of brain scan studies pooling 147 studies and 13,041 participants, comparing patients with schizophrenia, depression or alcohol use disorder with healthy controls. The authors report shared gray matter reductions in areas including the ventromedial prefrontal cortex and insula, and suggest a common brain basis, and possible treatment target, for social withdrawal and anhedonia across these disorders.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.19.263658812026-w43-p10/doi:10.64898/2026.10.19.26365881Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, is an exploratory mixed-methods pilot study: a survey, focus groups and a second survey of twelve physicians, ten from low- and middle-income countries and two from high-income countries for reference. The authors report that diagnostic and artificial intelligence (AI) capacity varied widely and did not track income level, with financial constraints the dominant barrier. They identified six implementation determinants, including AI literacy, governance frameworks, funding, evidence generation, clinical deployment and collaboration.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.19.7602172026-w43-p10/doi:10.64898/2026.10.19.760217Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports laboratory experiments on chondrocytes (cartilage cells) in 3D hydrogel scaffolds. The authors report that the nascent matrix the cells secrete builds up solid stress, which triggers an inflammatory response linked to cartilage osteoarthritis and injury. They also report that the cells divide to breach that matrix and migrate to escape the confinement.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.1016/j.cell.2026.09.0532026-w43-p10/doi:10.1016/j.cell.2026.09.053Peer-reviewed study. A peer-reviewed study published in Cell on October 21, 2026, reports a bioavailable GPX4 (glutathione peroxidase 4) inhibitor, KY0418, that the authors say induces ferroptosis in vivo. The authors link systemic ferroptosis induction to metabolic remodeling in tissues, and report context-dependent suppression of tumor progression, including metastatic spread.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.1038/s41586-026-11152-92026-w43-p10/doi:10.1038/s41586-026-11152-9Peer-reviewed study. A peer-reviewed study published in Nature on October 21, 2026, reports work in Caenorhabditis elegans showing that cold temperature raises dihydrobiopterin (BH2), a transportable reservoir for tetrahydrobiopterin (BH4). The authors report that BH2 made in muscle is converted to BH4 in other tissues, extending lifespan and reducing protein aggregation, and that raising BH2 synthesis in muscle alone was sufficient. In human cells, they report that BH2 or tyrosine supplementation reduced aggregation of proteins linked to Huntington's disease and amyotrophic lateral sclerosis.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.19.263653172026-w43-p10/doi:10.64898/2026.10.19.26365317Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, is a longitudinal study of a memory-clinic cohort of 3,645 people, followed annually for up to three decades. It tested several blood biomarkers for Alzheimer's disease, and the authors report that p-tau217 outperformed the others at detecting clinical Alzheimer's disease and had the strongest association with cognitive decline. The authors say every marker added prognostic value beyond demographic and genetic factors.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.20.7605202026-w43-p10/doi:10.64898/2026.10.20.760520Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports protein readers designed by computer to bind specific modified forms of tau and of amyloid-beta (Abeta). Screening 768 candidates identified 51 modification-selective hits, and the authors report that selected readers distinguished authentic modifications from controls and detected disease-associated signals in a human 3D neuronal culture with both amyloid-beta and tau pathology. The authors describe the readers as tools for molecular-state-resolved detection in human disease models and biological samples.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.20.7605472026-w43-p10/doi:10.64898/2026.10.20.760547Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports experiments in a gnotobiotic rice system, meaning rice plants grown with a defined microbial community. The authors report that microbiome colonization significantly reduced blast disease caused by the fungal pathogen Magnaporthe oryzae, and that two synthetic communities assembled from isolates from healthy and infected plants also reduced disease. Plants without a microbiome showed higher basal defense gene expression yet more disease, which the authors read as the microbiome supporting a more regulated immune state rather than simply more defense.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.1073/pnas.26003361232026-w43-p10/doi:10.1073/pnas.2600336123Peer-reviewed study. A peer-reviewed study published in PNAS on October 22, 2026, reports quantitative transcriptomics, proteomics and translation measurements during viral infections in vitro and in vivo. The authors report that infection suppresses host gene expression, and that this stress activates guard immunity only when tumor necrosis factor-α (TNFα) is present. They identify the anti-apoptotic protein c-FLIP as a guard whose loss sensitizes cells to TNFα, triggering cell death that limits viral spread.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.1073/pnas.26116671232026-w43-p10/doi:10.1073/pnas.2611667123Peer-reviewed study. A peer-reviewed study published in PNAS on October 22, 2026, reports that N7-methylguanosine (m7G)-modified RNA accumulates at DNA double strand breaks, where it recruits the protein QKI5. The authors report that QKI5 binds MRE11 and boosts its DNA binding, which facilitates DNA end resection and favors homologous recombination repair. They also report that higher QKI5 expression was associated with resistance to radiotherapy in mouse models and clinical cohorts, and suggest QKI5 as a promising therapeutic target in cancer treatment.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.16.7595432026-w43-p10/doi:10.64898/2026.10.16.759543Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, presents a mechanistic model of how the brain's threat response sets breathing rate and depth, and how breathing recovers after stress. The authors report that breathing rate rose from 18 to 28 and 31 breaths per minute from normal to moderate to severe threat, and that the model's circuit followed breathing closely. They compared the model with chest-belt recordings from 15 adults in the Wearable Stress and Affect Detection (WESAD) study, and report that breathing rose during a spoken stress task and then returned to rest, as the model predicts for healthy people.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.16.7596122026-w43-p10/doi:10.64898/2026.10.16.759612Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports that 25-hydroxycholesterol (25-HC), an oxysterol made by activated macrophages and monocytes, combined with atorvastatin or fluvastatin induced cell death in kidney proximal tubular cells in the lab. The authors report that low-dose lipopolysaccharide triggered acute kidney injury (AKI) in statin-treated mice, and that mevalonate supplementation attenuated it. They suggest that infection, inflammation or major surgery may raise 25-HC and increase susceptibility to statin-induced kidney injury.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.16.7596922026-w43-p10/doi:10.64898/2026.10.16.759692Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports experiments in PS19 tau transgenic mice and in stable tau-expressing human neuronal cell lines. The authors report that changes in insulin signaling proteins and in the glucose transporters GLUT3 and GLUT4 occur before pathogenic tau deposition, and that oxidative stress kinases and raised microglial abundance were evident in mice at 2 months of age and persisted into adulthood. They describe these as early and sustained features that precede overt neuropathology.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.17.7598272026-w43-p10/doi:10.64898/2026.10.17.759827Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports experiments in mice with ERG344, a small-molecule inhibitor of aconitate decarboxylase 1 (ACOD1), the enzyme that makes the immunometabolite itaconate. The authors report that ERG344 attenuated acute colitis in an ACOD1-dependent way, in contrast to earlier genetic-deletion studies, and prolonged survival in syngeneic tumor models. They describe ACOD1 as marking immature monocytes and maturing neutrophils, and suggest a shared myeloid recruitment and maturation mechanism.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.18.263648992026-w43-p10/doi:10.64898/2026.10.18.26364899Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, is a modelling study using simulated household outbreaks rather than observed people. It compares three observation designs, based on symptom onset, qualitative polymerase chain reaction (PCR) testing, or quantitative viral load sampling. The authors report that viral load data reconstructed transmission chains at 87–93% across transmission-probability settings, against 46–57% for symptom onset and 68–78% for qualitative PCR, and captured individual variation that simpler designs missed.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.20.263660062026-w43-p10/doi:10.64898/2026.10.20.26366006Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, analyzes 171,193 people aged 15 years or over in 24 European Union (EU) countries across five rounds of the European Social Survey (2014 to 2023). Using Simple-Means MAIHDA (a multilevel analysis of individual heterogeneity and discriminatory accuracy), the authors report poor or very poor self-rated health at 7.7% overall, from 3.8% in Greece to 15.0% in Latvia. They say the sociodemographic pattern of poor health, defined by sex, age and household financial situation, is largely shared across countries, and recommend the method for monitoring health inequalities in Europe.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.20.263660242026-w43-p10/doi:10.64898/2026.10.20.26366024Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, is a systematic review and meta-analysis of forty-two studies from 31 longitudinal cohorts of people aged 0 to 24 years. The authors report that anxiety, depression and their combination were associated with later pain, but after adjustment for confounders only depression remained so. Pain was associated with later anxiety and depression before and after adjustment, and certainty of evidence was rated very low to moderate for most outcomes and high for two.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.21.7606152026-w43-p10/doi:10.64898/2026.10.21.760615Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports macrocyclic peptides discovered by a screening method called random nonstandard peptides integrated discovery (RaPID) that bind CXCR4, a chemokine receptor and class A G protein-coupled receptor (GPCR). The authors report nanomolar-affinity CXCR4-selective antagonists that inhibited receptor signaling and suppressed chemokine-driven cell migration in laboratory tests. They also report that the most active peptides blocked CXCR4-driven entry of human immunodeficiency virus (HIV) into cells.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.1016/j.cell.2026.09.0622026-w43-p10/doi:10.1016/j.cell.2026.09.062Peer-reviewed study. A peer-reviewed study published in Cell on October 23, 2026, reports that perforin, known for delivering granzymes into tumor cells, has a second, granzyme-independent killing function. The authors report that perforin drives iron uptake and mitochondrial iron overload that trigger ferroptosis, and that this pathway predicts patient response to checkpoint blockade. They point to iron supplementation as a possible lever for boosting anti-tumor immunity.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.19.7600502026-w43-p10/doi:10.64898/2026.10.19.760050Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports laboratory experiments on endothelial cells and ex vivo mouse aortic rings. The authors report that CD160, a receptor absent from resting endothelium, is induced by pro-angiogenic signals, and that an antibody against it reduced tubulogenesis and sprouting. They say CD160 associates with the receptor LRP1 and that silencing either receptor abolished the antibody's anti-angiogenic effect.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.19.7600922026-w43-p10/doi:10.64898/2026.10.19.760092Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports two cohorts of children and experiments in infected newborn piglets, which the authors use as a model of infection-sensitive infants. The authors report that higher birth levels of nicotinamide adenine dinucleotide (NAD) were associated with fewer infections during the first 3 years of life in females, while males showed a tendency toward more infections. Nicotinamide riboside (NR), a NAD precursor, improved survival and bacterial clearance in infected female piglets but not male piglets, and the authors suggest sex-stratified nutritional interventions could be relevant.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.21.263661102026-w43-p10/doi:10.64898/2026.10.21.26366110Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, analyzes 1,600 patients with hypertension from the STRATS-HHD registry who had echocardiography at baseline and 6-18 months after treatment. The authors report that a higher count of cardiovascular-kidney-metabolic components (obesity, diabetes, chronic kidney disease and severe hypertension) was associated with higher risk of cardiovascular death or heart failure hospitalization. Patients with 3 or more components had less favorable heart function at follow-up, and the authors say heart measures partly explained the link.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.21.263661592026-w43-p10/doi:10.64898/2026.10.21.26366159Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on medRxiv, estimates left ventricular mechanical measures from standard 12-lead electrocardiograms (ECGs), using a generative adversarial network that the authors say was applied without retraining. The authors report that these estimates predicted all-cause mortality after acute myocardial infarction, and that in the general population they predicted mortality from myocardial infarction itself. They say the measures added information beyond the GRACE score and measured ejection fraction, and one measure remained an independent predictor after adjustment.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.21.7606942026-w43-p10/doi:10.64898/2026.10.21.760694Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports lab work on primary human monocyte-derived macrophages from 100 donors. The authors report that the drug-metabolizing enzyme CYP3A4 was active in these cells, although its mRNA, protein levels and activity did not track one another. Cocaine increased CYP3A4 activity in all donors, reaching or exceeding levels induced by rifampicin, and in rhesus macaques it was associated with lower antiretroviral drug concentrations in tissue.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-arxiv:2610.305272026-w43-p10/arxiv:2610.30527Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on arXiv, studies whether fiscal consolidation (austerity) is linked to deeper multidimensional deprivation among older women than older men, using six waves of a survey of older people in eleven European countries. The authors report that consolidation raised deprivation on average with no average gender gap, but that a gender gap appeared in Southern and Eastern Europe and not in Continental or Nordic Europe. They conclude that the gendered cost of austerity is neither uniform across welfare regimes nor routed through income, though the evidence for its social channel is inconclusive.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.26434/chemrxiv.15010760/v12026-w43-p10/doi:10.26434/chemrxiv.15010760/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on ChemRxiv, describes adapting a large language model to design molecules and nanoparticles when labeled data are scarce. For a prospective test on nanoparticles, the authors fine-tuned the model on 1,521 labeled drug-excipient pairs and report that it proposed lithocholic acid and the sorafenib metabolite M6 as nanoparticle-forming excipients for the anticancer drug sorafenib. The authors say laboratory experiments confirmed that both formed stable sorafenib nanoparticles with high encapsulation efficiency.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.20.7602142026-w43-p10/doi:10.64898/2026.10.20.760214Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, describes PEARL, a system that connects general-purpose large language models to a liquid-handling robot and a camera. The authors report that, given objectives rather than fixed workflows, the system designed and executed experiments, interpreted observations and revised its approach. They tested it across eight scenarios, including quantitative enzyme characterization, without scenario-specific recovery recipes.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.18.7599072026-w43-p10/doi:10.64898/2026.10.18.759907Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports a pot experiment with wheat that combined a Zn-efficient wheat line (OsNAS2-expressing) with zinc or green manure inputs. The authors report that the combination raised grain zinc to 76 and 61 mg/kg, against 24 mg/kg in the control, a larger effect than either approach alone. The OsNAS2-expressing line also increased grain cadmium under green manure, so the authors call for careful monitoring of cadmium when organic amendments are paired with genetic biofortification.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.64898/2026.10.21.7587832026-w43-p10/doi:10.64898/2026.10.21.758783Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on bioRxiv, reports crystal structures of the Anopheles gambiae odorant-binding protein OBP4 and a computer screen of volatile compounds against it. Four compounds bound the protein in laboratory assays, and seven were tested on Aedes albopictus mosquitoes, where benzoyl peroxide showed the highest repellency. The authors say the results suggest drug-repurposing and food-derived chemicals as sources of next-generation repellents.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.26434/chemrxiv.15010698/v12026-w43-p10/doi:10.26434/chemrxiv.15010698/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on ChemRxiv, describes a crystalline metal–organic framework (MOF) that conducts both Li+ ions and electrons. The authors report conductivities of up to 1.10 mS cm−1 for Li+ and 15.81 mS cm−1 for electrons at room temperature, measured in the solid state. They describe the material as a platform for solid-state electrochemical devices that need ions and electrons to move together.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.26434/chemrxiv.15010529/v22026-w43-p10/doi:10.26434/chemrxiv.15010529/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on ChemRxiv, describes a laboratory system in which metallic iron (Fe) and magnesium (Mg) powders react with carbonated water near room temperature without an added methanation catalyst. The authors report that the reaction produces hydrogen (H2) and methane (CH4), and that light speeds it up. They say the two gases' production scales together, and that electron transfer plays a pivotal role.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-pew:5e798908887b2026-w43-p10/pew:5e798908887bAnnouncement. An announcement from Pew Research Center describes how gender, work and caregiving are woven together in family life in the United States. It says most parents with children under 18 are employed, and that a growing share of Americans care for an older parent, with many U.S. adults sandwiched between supporting children and parents. The excerpt is cut off, so see the original for the full findings.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-arxiv:2610.301532026-w43-p10/arxiv:2610.30153Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on arXiv, proposes a mathematical model of academic capital, defined as research funding, accumulated titles and honours, and administrative power, and how it relates to verifiable research output. The authors say they calibrated the model against retraction data from 40 jurisdictions and the careers of 12 Nobel-caliber scientists, and they name a threshold below which honest research would cease to be a stable strategy. They say three levers, applied together, would restore that balance.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43-p10/#item-doi:10.26434/chemrxiv.15010961/v12026-w43-p10/doi:10.26434/chemrxiv.15010961/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, posted on ChemRxiv, describes a paper-based platform to detect human papillomavirus (HPV) types 16 and 18 at the point of care, for cervical screening in low-resource settings. The authors report a centrifuge-free DNA capture method on cellulose paper and a fluorescence readout, with a limit of detection of 10 copies per microlitre. In 52 cervical samples compared with an in vitro diagnostic (IVD) real-time PCR assay, they report 100% specificity for both types, 100% sensitivity for HPV18 and 85.7% sensitivity for HPV16.Thu, 29 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-212672026-w43/2026-21267In effect. This Treasury Department rule, in effect from October 19, 2026, lets the Internal Revenue Service (IRS) accept tax payments by credit or debit card directly, without connecting taxpayers to third-party payment processors. It also removes restrictions on fees the IRS may pay under related contracts, and on the IRS charging fees to people who pay taxes by card.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-213192026-w43/2026-21319Final rule. The Office of Personnel Management (OPM) has issued a final rule, effective January 19, 2027, that removes the Time-in-Grade restriction on advancement to competitive service positions in the General Schedule (GS). Under the old rules, a candidate generally had to complete 52 weeks in a position no more than one grade lower, or two grades lower for certain positions, before advancing to a covered position at GS-6 or above. Employees remain subject to occupational qualification standards and other job-related requirements set by their employing agency.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-213202026-w43/2026-21320Final rule. The Office of Personnel Management (OPM) has issued a final rule, effective November 18, 2026, that amends its regulations on administrative leave for workforce realignment and other purposes. It more fully sets out appropriate uses of administrative leave, including in connection with deferred resignation programs, and clarifies when an agency may give administrative leave during a reduction-in-force notice period. It also clarifies when an agency may accept or deny an employee's request to withdraw a resignation in a deferred resignation program.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-213472026-w43/2026-21347Proposed. The Federal Communications Commission (FCC) is seeking more comment, as a proposal not yet final, on its framework under the National Historic Preservation Act (NHPA), with the aim of making environmental review faster, simpler and less costly. It asks whether building and running communications infrastructure counts as an 'undertaking' under section 106 of the NHPA, and whether such deployments are agency actions under the Endangered Species Act (ESA).Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-212992026-w43/2026-21299Final rule. The National Park Service (NPS) has issued a final rule covering hunting, fishing, trapping and other harvest in Alaska park areas, and how public use and access there may be restricted, including for subsistence. The rule, effective November 18, 2026, restores the framework adopted in 1981 to implement the Alaska National Interest Lands Conservation Act (ANILCA), with some targeted updates made after public comments, and removes changes made in 2015, 2017 and 2024.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-213002026-w43/2026-21300Proposed. The National Park Service (NPS) has proposed a rule, not yet final, that would let the Superintendent of Gates of the Arctic National Park and Preserve set reasonable mitigation measures on off-road vehicle (ORV) use for subsistence by local rural residents of Anaktuvuk Pass. Those measures would apply only when such use causes, or is likely to cause, an adverse impact to public health and safety, resources, historic or scientific values, subsistence uses, or endangered or threatened species.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-213712026-w43/2026-21371In effect. The Fish and Wildlife Service (FWS) has finalized regulations, in effect from October 19, 2026, that allow the incidental, unintentional take of small numbers of polar bears and Pacific walruses during year-round oil and gas activities in the Beaufort Sea and the adjacent northern coast of Alaska. The regulations were requested by the Alaska Oil and Gas Association (AOGA) under the Marine Mammal Protection Act (MMPA) of 1972, and run for 5 years. The Fish and Wildlife Service will issue letters of authorization, on request, for specific activities.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-213482026-w43/2026-21348In effect. This Consumer Product Safety Commission (CPSC) interpretive rule, in effect from October 19, 2026, says the phrase 'flammable liquid fuels' in the Portable Fuel Container Safety Act of 2020 (PFCSA) does not include fuel additives. It covers additives intended to be added to fuel solely to improve engine performance, clean engine components, extend engine life, stabilize fuel, prevent weather effects, or for a similar purpose unrelated to creating heat or power.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-213102026-w43/2026-21310In effect. A Postal Service change to the International Mail Manual (IMM), in effect from October 19, 2026, updates what mailers must do to meet customs requirements. It also sets procedures for paying, or being reimbursed for, customs charges, including charges assessed after postage has been bought.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w43/#item-2026-213172026-w43/2026-21317In effect. The Postal Service has revised Publication 52, Hazardous, Restricted, and Perishable Mail, a change in effect from October 19, 2026. The revision aims to improve package integrity and container identification for live animal shipments during processing and handling.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.09.7580872026-w42-p9/doi:10.64898/2026.10.09.758087Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 13, 2026, studies human cells as they pass the replicative crisis, a barrier triggered by telomere shortening. Single-cell sequencing found extreme genome instability in crisis cells, while cells that escaped crisis first showed relatively few and simple structural variants. The authors say the genomes of these immortal clones evolve further over later divisions, and propose that crisis selects against cells with aberrant karyotypes.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.11.7582762026-w42-p9/doi:10.64898/2026.10.11.758276Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 13, 2026, reports a study in mice. Compared with conventional dose-rate X-rays at the same dose, ultrahigh dose-rate FLASH X-rays gave a stronger effect on distant tumors when combined with anti-PD-1 therapy. The authors attribute this to neutrophils keeping their chromatin compact, which reduced neutrophil extracellular trap formation that excluded T cells from primary tumors.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.11.7582852026-w42-p9/doi:10.64898/2026.10.11.758285Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 13, 2026, analyzes DNA methylation across hundreds of matched tumor and normal methylomes. It reports that PRC2-associated regions show the highest methylation entropy, and that this pattern emerges early, with precancerous and malignant tissues displaying highly similar profiles.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.11.7582912026-w42-p9/doi:10.64898/2026.10.11.758291Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 13, 2026, reports a study in mice. Using transcriptomic aging clocks, the authors found that regenerating intestinal epithelium was predicted to be younger than controls, and that the change was transient and reversible. They also report decreased transcriptomic age after liver regeneration in old animals.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-mmwr:7754bc132d002026-w42-p9/mmwr:7754bc132d00Final report. A final report from CDC MMWR, published October 13, 2026, describes the first nationally representative estimates of mental health service use among U.S. adolescents experiencing persistent sadness or hopelessness. It is part of the Youth Risk Behavior Survey, United States, 2025.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-mmwr:cfae7628a8772026-w42-p9/mmwr:cfae7628a877Final report. A final report from CDC MMWR, published October 13, 2026, gives 2025 estimates of dietary and physical activity behaviors among adolescents overall and by sex, race and ethnicity, and grade level. It is part of the Youth Risk Behavior Survey, United States, 2025.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.12.7585782026-w42-p9/doi:10.64898/2026.10.12.758578Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 14, 2026, describes engineered cell sensors that detect interleukin-23, a biomarker in many autoimmune diseases. The authors report a design that outputs an IL-23 neutralizing nanobody, which they say could reduce inflammation triggered by interleukin-23 secretion.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.08.7573422026-w42-p9/doi:10.64898/2026.10.08.757342Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 15, 2026, reports a metabolomic study in mouse models of psoriasis, a chronic inflammatory skin disease. The authors report that siRNA knockdown of eIF1A or eIF3B eased psoriasis-like pathology and attenuated some disease-linked metabolic changes, though the effects depended on the model.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.08.7574632026-w42-p9/doi:10.64898/2026.10.08.757463Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 15, 2026, reports brain-wide mapping in mice. The authors found that vagus nerve stimulation activated neuronal ensembles in the default mode network, and that activating or silencing those ensembles reproduced or abolished the stimulation's enhancement of cognitive behaviors. They say the link was mediated by locus coeruleus neuronal subpopulations.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.08.7576682026-w42-p9/doi:10.64898/2026.10.08.757668Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 15, 2026, examines paid family leave and language and white matter measures in 274 infants from the HEALthy Brain and Child Development Study. Neither maternal nor paternal leave was directly associated with language scores, but maternal education moderated the link between maternal leave and fractional anisotropy in two tracts, appearing only among infants whose mothers had relatively high education.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.14.263655312026-w42-p9/doi:10.64898/2026.10.14.26365531Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 15, 2026, compares national health surveys from Korea and the United States in adults with LDL cholesterol below 100 mg/dL. Elevated high-sensitivity C-reactive protein (2-10 mg/L) was found in 12.2% of Korean adults and 35.7% of U.S. adults, and the gap narrowed after adjustment for waist circumference.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.26434/chemrxiv.15010605/v12026-w42-p9/doi:10.26434/chemrxiv.15010605/v1Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 16, 2026, reports eighteen novel 3H-1,5-benzodiazepine derivatives tested against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The authors say compound 5o was the most potent, with IC50 values of 5.88 and 6.68 µM, and that PfSET3 emerges as a parasite target worth further investigation.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.09.7576612026-w42-p9/doi:10.64898/2026.10.09.757661Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 16, 2026, compares (-)6-methylnicotine (6-MN), a nicotine analog added to some vape solutions and nicotine oral pouches, with nicotine. The authors report that 6-MN is a more potent agonist than nicotine at the 4β2 and 3β4 nicotinic receptors and increases these receptors in brain. They note that it is currently unregulated in the U.S. by the Food and Drug Administration (FDA).Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.13.7589882026-w42-p9/doi:10.64898/2026.10.13.758988Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 16, 2026, uses the Four Core Genotypes mouse model to separate the effects of sex chromosomes from gonadal sex on cardiac fibroblasts. The authors report sex chromosome and gonad-biased differences in myofibroblast markers and secreted proteins, and say the work highlights sex-specific regulators of myocardial fibrosis.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.14.7590582026-w42-p9/doi:10.64898/2026.10.14.759058Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 16, 2026, surveys genetic markers of insecticide resistance in Anopheles gambiae (s.l.) mosquitoes from nine sites in Ghana. The authors report moderate-to-high pyrethroid resistance (4-65%) at all sites, a strong association between the L995F kdr mutation and pyrethroid resistance, and a link between the Ace-1 G280S mutation and pirimiphos-methyl resistance.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.14.7591672026-w42-p9/doi:10.64898/2026.10.14.759167Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 16, 2026, reports striatal dopamine release in mice with the LRRK2-G2019S knock-in mutation, a model of Parkinson's Disease. The authors found that dopamine release declined with maturity, first in males and then in females, and that 2 hours of LRRK2 inhibition rapidly reversed deficits in middle-aged mice but not in very old ones, which they say bears on the timing of current LRRK2 inhibitor clinical trials.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.15.263656082026-w42-p9/doi:10.64898/2026.10.15.26365608Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 16, 2026, analyzes CDC WONDER Multiple Cause of Death data for U.S. adults aged 65 years and older from 1999 to 2024 where respiratory failure and atrial fibrillation or flutter were both listed. The age-adjusted mortality rate (AAMR) rose from 12.8 to 66.7 per 100,000, with a sharp rise from 2018 to 2021 and a partial decline afterward, and the authors' model projects 122.96 per 100,000 by 2035.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.15.263656242026-w42-p9/doi:10.64898/2026.10.15.26365624Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 16, 2026, runs a Laboratory-Wide Association Studies analysis of polygenic scores in 10,473 individuals of African ancestry and 35,131 of European ancestry from the Penn Medicine Biobank. The authors report that psychiatric scores in European-ancestry individuals fell into physiological profiles, such as a metabolic and inflammatory signature shared by anxiety and major depressive disorder.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.12.7584762026-w42-p9/doi:10.64898/2026.10.12.758476Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 18, 2026, reports that LIF, a cytokine, is consistently present in synovial fluid from painful inflamed joints. The authors found that LIF changed sensory neuron signaling and gene expression more than the other cytokines tested, and that intraarticular LIF made a healthy mouse knee more responsive to painful pressure.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.26434/chemrxiv.15010459/v12026-w42-p9/doi:10.26434/chemrxiv.15010459/v1Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 14, 2026, analyzes the 3:2:1 crack spread from 2006 to 2025 using publicly available spot prices. It finds a long-run link between crude oil and product prices in 68% of rolling five-year windows, but reports that the cyclic structure that made margins partly predictable has not survived recent disruptions.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-arxiv:2610.195122026-w42-p9/arxiv:2610.19512Preprint, not peer-reviewed. A preprint on arXiv, not peer-reviewed, published October 15, 2026, argues that evaluating A/B tests with raw impact estimates rewards sampling noise. Using data on A/B tests at Amazon, the authors report that after a 2024 shift to posterior-mean-based evaluation, test volume declined while precision and the dispersion of true impacts increased, more than doubling signal-to-noise ratios.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.15.7595102026-w42-p9/doi:10.64898/2026.10.15.759510Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 16, 2026, studies 3D transformer models that classify dementia or mild cognitive impairment against cognitively normal individuals from brain MRI, using Alzheimer's Disease Neuroimaging Initiative data. The authors report that supervised transformers compress almost all of their discriminative signal into one principal component, and that the plateau comes from the learned encoder rather than task difficulty.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.64898/2026.10.10.7582262026-w42-p9/doi:10.64898/2026.10.10.758226Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 13, 2026, compares random forest models of about 11,000 conflict incidents across 29 mammalian scenarios. It reports that conflicts within the same biome tend to share predictors, and that proximity to protected areas was the most consistently important predictor globally. The likelihood of conflict increased with human population density across nearly all scales and contexts.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.1073/pnas.25378191232026-w42-p9/doi:10.1073/pnas.2537819123Peer-reviewed study. A peer-reviewed study in PNAS, published October 16, 2026, analyzes 60 coproduced positive scenario visions and pathways from nine US and Latin American cities, developed with stakeholders in more than 20 workshops. It finds that most pathways combine several theories of change across domains, and that the same strategy, such as car-free regions, can pursue different transformative aims depending on the theory behind it.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.1073/pnas.25321211232026-w42-p9/doi:10.1073/pnas.2532121123Peer-reviewed study. A peer-reviewed study in PNAS, published October 12, 2026, analyzes millions of cattle transactions in Brazil after ranchers were added to the 'Dirty List', a public registry of employers found to use modern slavery. The authors report that these ranchers cut direct sales to slaughterhouses that had signed sustainable supply chain commitments, and instead laundered cattle through compliant intermediaries or sold to nonsignatory slaughterhouses. They say this weakened the financial cost of listing and likely let beef and leather linked to modern slave labor enter international supply chains.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-max-planck:00cd2ae072ab2026-w42-p9/max-planck:00cd2ae072abAnnouncement. The Max Planck Society announcement, published October 12, 2026, describes a study of how justifications influence voter approval of political violence. According to the announcement, the study shows under what conditions party supporters in India endorse violence and reject peaceful dialogue.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.26434/chemrxiv.15010419/v12026-w42-p9/doi:10.26434/chemrxiv.15010419/v1Preprint, not peer-reviewed. A preprint, not peer-reviewed, published October 13, 2026, models how decarbonization could work in the isolated power system of Yukon (Canada). It finds that reaching net-zero without grid expansion would greatly increase system costs, while grid expansion would reduce net-zero costs by about 25%. Intermediate cuts would rely mainly on photovoltaic generation and battery storage, and deeper cuts on large-scale wind with hydrogen storage.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-mit-research:11e83311a7c52026-w42-p9/mit-research:11e83311a7c5Announcement. MIT News, an announcement published October 13, 2026, says artificial neural networks can learn without detailed instructions from a designer. It suggests networks that do so may offer insight into how the brain reorganizes itself during learning.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-mit-research:e49da5d1f30c2026-w42-p9/mit-research:e49da5d1f30cAnnouncement. MIT News, an announcement published October 13, 2026, says a new approach can program natural killer (NK) immune cells inside the body. The institution says it shows promise against diseases caused by dysfunctional T cells, including lymphoma and autoimmune hepatitis.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-arxiv:2610.140132026-w42-p9/arxiv:2610.14013Preprint, not peer-reviewed. A preprint on arXiv, not peer-reviewed, published October 14, 2026, tests whether Food and Drug Administration (FDA) approval of a drug-disease pair can be forecast from pre-clinical trial information. On the post-2019 cohort, the model would have prioritized the program that later gained approval approximately three out of four times, and for drugs tested in several diseases it identified an approved disease 61.3% of the time, compared with 40.7% under random selection.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.1073/pnas.26064601232026-w42-p9/doi:10.1073/pnas.2606460123Peer-reviewed study. A peer-reviewed study in PNAS, published October 15, 2026, validates tests that separate verified humans from AI agents, then collects surveys on seven online platforms. It reports that the share of respondents failing the tests ranged from 6 to 41% across platforms, compared with a 2.4% false-positive rate for in-person human participants, and that undetected AI agents can affect survey results.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.1073/pnas.26150841232026-w42-p9/doi:10.1073/pnas.2615084123Peer-reviewed study. A peer-reviewed study in PNAS, published October 15, 2026, reports a copper catalyst built on hydroxyl-functionalized covalent organic frameworks for nitrate electroreduction. In 0.5 M nitrate electrolyte, the best version reached an ammonia Faradaic efficiency of 93.20%, which the authors say outperforms most state-of-the-art catalysts.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-doi:10.1126/science.aeh14092026-w42-p9/doi:10.1126/science.aeh1409Peer-reviewed study. A peer-reviewed study in Science, published October 15, 2026, reports that predeformation followed by aging can create dense networks of ordered defect phases in a cobalt-nickel-based superalloy and a cobalt-chromium-tungsten alloy. The authors say this raised room-temperature strength by more than 200 megapascals and reduced the superalloy's minimum creep rate by more than threefold.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-arxiv:2610.208542026-w42-p9/arxiv:2610.20854Preprint, not peer-reviewed. A preprint on arXiv, not peer-reviewed, published October 16, 2026, analyzes EEG recordings from three cohorts totaling 141 participants. The authors report that cumulative meditation practice tracks a reduction in the exploratory breadth of brain dynamics, and that 8-week mindfulness-based interventions reduced temporal persistence in healthy meditators but increased it in trauma-exposed individuals.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-pew:feb5ae51c15b2026-w42-p9/pew:feb5ae51c15bAnnouncement. A Pew Research Center announcement, published October 16, 2026, reports that Democratic congressional candidates have a sizable advantage among Latino registered voters. It also says Latino Democratic candidate supporters are more engaged with this year's election compared with four years ago.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p9/#item-gao:d6136510b9052026-w42-p9/gao:d6136510b905Final report. A final report from the U.S. Government Accountability Office, published October 16, 2026, says the Department of Defense (DOD) and the military services have policies for safeguarding records but face risks of breaches and delays. It reports 49 breaches across thousands of requests in fiscal years 2021 through 2025, and says staffing limitations and a complex health records system challenge timely processing.Thu, 22 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.1073/pnas.26111581232026-w42-p8/doi:10.1073/pnas.2611158123Peer-reviewed study. A peer-reviewed study reports that tau, a protein that forms clumps in neurodegenerative diseases called tauopathies, builds its clumps through one dominant contact point. The study reports that blocking this point disrupted clumping and led to shorter fibrils.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.06.7570422026-w42-p8/doi:10.64898/2026.10.06.757042Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports experiments in mice in which removing the interferon-gamma receptor from one type of neuron, called somatostatin interneurons, increased anxiety-like behavior. The authors also report that inflammation lowered several molecular markers in control mice, and that this drop was not significant in mice without the receptor.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.08.7573632026-w42-p8/doi:10.64898/2026.10.08.757363Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses the short-lived killifish to study how lifelong mating affects organ aging. The authors report that mating dampened inflammation and reduced lipid buildup in old female livers, and that it was associated with better resilience to the liver toxin acetaminophen.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.09.263651582026-w42-p8/doi:10.64898/2026.10.09.26365158Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a retrospective cohort study of 4,269 adults in a telemedicine obesity program. Over 12 months, people who received individualized nutritional therapy alongside incretin-based obesity medications lost more weight than those on medication alone. As an observational comparison, it shows an association, not proof that the therapy caused the difference.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.10.7581712026-w42-p8/doi:10.64898/2026.10.10.758171Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tested the Xpert MTB/RIF Ultra test for Mycobacterium tuberculosis in sputum samples with added bacteria. Leaving samples in reagent beyond the manufacturer's recommended 4-hour limit, or at higher temperatures, produced false rifampin resistance results at low bacterial levels. The authors note that freezing samples may reduce this risk, but it is not yet an approved procedure.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.10.7582052026-w42-p8/doi:10.64898/2026.10.10.758205Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes public tumor gene data across cancer types. It reports that tumors raised both reactive oxygen species (ROS) generation and antioxidant defense compared with normal tissue, and that the antioxidant arm was linked to adverse outcome while generation was not. The authors say the link between the balance score and immune infiltration comes from how that score is defined.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.11.263652102026-w42-p8/doi:10.64898/2026.10.11.26365210Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a 65-million-parameter clinical foundation model trained on electronic health records from 3.77 million patients at a single hospital. For five-year chronic kidney disease, fatty liver and diabetes risk, predictors built on patient representations outperformed estimates from generated clinical event sequences. The generated approach did better at predicting same-day diagnoses, prescriptions and procedures.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-mmwr:427bcd64473c2026-w42-p8/mmwr:427bcd64473cFinal report. A CDC report estimates five cardiovascular health measures among U.S. high school students: diet, physical activity, nicotine exposure, sleep health and body mass index (BMI). The estimates come from the Youth Risk Behavior Survey for 2025.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.1073/pnas.25359271232026-w42-p8/doi:10.1073/pnas.2535927123Peer-reviewed study. A peer-reviewed study reports that shading increased selenium (Se) accumulation in tea leaves when selenium supply was sufficient, based on field experiments. The authors link this to a gene pathway that converts selenium forms, and note that limited selenium in crops contributes to widespread dietary Se deficiency.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.07.7573062026-w42-p8/doi:10.64898/2026.10.07.757306Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies locus coeruleus neurons in young 3xTg mice, a model of Alzheimer's disease, before substantial neurodegeneration. The authors report reduced excitatory and increased inhibitory synaptic input, and changes in potassium and sodium currents that they say may alter how these cells fire. They note the locus coeruleus is among the earliest brain regions affected in Alzheimer's disease.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.09.7579962026-w42-p8/doi:10.64898/2026.10.09.757996Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines reconstruction experiments, computational modeling and a cell system to suggest that alpha-synuclein can phase separate with an interacting partner to form Lewy body-like structures. The authors report these structures associate with redistributed actin and mitochondria, and propose a seed-independent route to insoluble fibrils. They say the framework may guide the design of new therapeutic interventions.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.13.263650662026-w42-p8/doi:10.64898/2026.10.13.26365066Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes data from the Framingham Heart Study Offspring cohort. Slower quick walking speed was associated with incident dementia over 10-year follow-up, while usual walking speed was not. The authors also report links between slower walking and worse executive function and stroke, mostly in men; these are associations, not proof of cause.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.13.263654002026-w42-p8/doi:10.64898/2026.10.13.26365400Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a long short-term memory-based system that suggests initial prescriptions and daily basal and bolus titration for people with type 2 diabetes on insulin pumps. In 97 patients from the model-directed arm of a randomized trial, median time in range was 84.5%, with low hypoglycemic exposure. The authors say higher mean glucose in the first 24 hours was linked to poorer control later.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.14.263650682026-w42-p8/doi:10.64898/2026.10.14.26365068Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a meta-analysis of melanoma genetic studies covering 69,871 cases and 1,616,233 controls. It identifies 156 independent signals at 116 risk loci, and says about 22% of loci include potential causal genes in the WNT/beta-catenin signaling pathway. The authors also report a new risk score that improved prediction beyond age and sex.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.14.263655182026-w42-p8/doi:10.64898/2026.10.14.26365518Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a cross-sectional online survey of 4,883 completed responses from users of the Tata 1mg digital healthcare platform in India, on antimicrobial resistance (AMR). Attitudes scored lower than knowledge, and 42.0% said their last antibiotic did not come on a doctor's recommendation. The authors say a survey of platform users cannot establish what drives antibiotic use.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.09.7579812026-w42-p8/doi:10.64898/2026.10.09.757981Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, measures oxygen levels in awake rTg4510 and THY-Tau22 mice. The authors report that in rTg4510 mice, capillary oxygen was elevated at 6 months but reduced at 9 months, and that tissue oxygen was lower in tangle-positive areas. They suggest neuronal loss may reflect a global reduction in cortical oxygenation rather than local oxygen levels.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.14.263655532026-w42-p8/doi:10.64898/2026.10.14.26365553Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a model calibrated to Ontario incidence and hospital admissions before Omicron. Its simulations found that vaccination combined with workplace and community contact restrictions kept projected severe-case demand within an illustrative capacity benchmark, while relaxing either setting produced large surges. School-only changes had smaller effects on severe disease.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.14.263655592026-w42-p8/doi:10.64898/2026.10.14.26365559Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines records covering 4.95 million patients in 21 health systems. Adults with a first outpatient Z59 social-needs code, which records hardship such as housing, food or transportation problems, had 67% more emergency department visits and 43% more hospital admissions in the next year than similar uncoded patients. The authors say the code added no increment to risk prediction models.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.14.7590942026-w42-p8/doi:10.64898/2026.10.14.759094Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies breast cancer cells with different metabolic profiles. The authors report that glycolysis reduces DTWD2, which lowers glycoRNA on the cell surface and weakens immune activation, and that restoring glycoRNA enhanced the effect of PD-1 blockade in their experiments. They also report that lower glycoRNA abundance is associated with tumor stage and prognosis.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.15.263644762026-w42-p8/doi:10.64898/2026.10.15.26364476Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes 4,999 verbal autopsy records for deaths at ages 12 years or older from a national sample of registered deaths in South Africa. Supervised models using the questionnaire, the free-text narrative or both improved on InSilicoVA, a current automated method, by 8.5-15.9 percentage points in top-1 accuracy. Physician-assigned causes were the reference standard.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.15.7592152026-w42-p8/doi:10.64898/2026.10.15.759215Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that delivering messenger RNA (mRNA) for an autoactivated cGAS (cyclic GMP-AMP synthase) mutant with membrane-tethered interleukin-12 (IL-12) suppressed distal tumors across multiple mouse models. The authors report the combination reduced regulatory T cells, restored effector function in tumor-infiltrating T cells and enhanced response to PD-L1 blockade. They describe the strategy as clinically translatable, but all of the evidence comes from mouse models.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.15.7593142026-w42-p8/doi:10.64898/2026.10.15.759314Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports experiments in male rats fed a high-cholesterol diet for 120 days. From day 90 to 120, atorvastatin combined with Bifidobacterium longum gave greater improvement in liver and aortic tissue, and in markers of oxidative stress and inflammation, than atorvastatin alone. The authors describe this as multi-targeted synergy, and all of the evidence comes from rats.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.12.7584292026-w42-p8/doi:10.64898/2026.10.12.758429Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a cross-sectional analysis of 172,173 adults aged 19-74 in the German National Cohort (NAKO). Exposure to childhood and adolescent adversity, measured with a trauma screener, was associated with higher odds of smoking, heavier drinking among drinkers and lifetime illicit drug use, with the strongest links for opioid and stimulant use. These are associations, not evidence of cause.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.13.7587282026-w42-p8/doi:10.64898/2026.10.13.758728Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports experiments in mice on lateral hypothalamic neurons that co-express the neuropeptides 26RFa and orexin. The authors found that activating these neurons unexpectedly worsened glucose-induced hyperglycemia, and attribute most of this effect to orexin signaling, while 26RFa signaling regulates orexin expression.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.64898/2026.10.13.7587512026-w42-p8/doi:10.64898/2026.10.13.758751Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests combinations of H. lupulus and G. biloba extracts on naturally aged human skin cells and on skin explants exposed to UVC irradiation. The authors report a dose-dependent senomorphic effect of up to 45% in aged dermal fibroblasts and a 50% decrease in DNA damage load. They say these are cell and tissue results, not clinical outcomes.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-pew:d64742e2747b2026-w42-p8/pew:d64742e2747bAnnouncement. Pew Research Center reports that White evangelical Protestants and White Catholics favor Republicans in the 2026 midterms. The center says other religious groups split or lean Democratic.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-arxiv:2610.142062026-w42-p8/arxiv:2610.14206Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes spatial trends in armed conflict across North and West Africa. It reports that violence rose in 2025, is concentrated in Nigeria, Cameroon, Mali, Burkina Faso and Niger, and is spreading outward from conflict zones. Projections in the paper expect more than 15,000 incidents and more than 32,500 deaths in 2026.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.26434/chemrxiv.15010473/v12026-w42-p8/doi:10.26434/chemrxiv.15010473/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses in silico modeling to design covalent organic frameworks with internal polarization for single-component organic photovoltaics. The authors report that polarization helps excitons dissociate into separated charges, and predict an almost 40-fold increase in charge-carrier lifetime for the new designs. These are computer predictions, not measured results.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-arxiv:2610.190292026-w42-p8/arxiv:2610.19029Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, applies a deep learning framework called DKO to predict cell-specific virtual gene perturbation effects in single-cell data from humans, mice, Drosophila and C. elegans. The authors report that responses to the same gene became more heterogeneous across cells with age, and that cells with more somatic mutations showed greater variability.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-doi:10.1073/pnas.26184021232026-w42-p8/doi:10.1073/pnas.2618402123Peer-reviewed study. A peer-reviewed study reports that molecular cancer articles sharing features with retracted papers from paper mills received 50 to 100% more citations 1 to 3 years after publication, yet attracted fewer readers. The authors say these citations measurably inflated journal citation metrics, and describe the pattern as suspected rather than confirmed manipulation.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-max-planck:de0523d48c902026-w42-p8/max-planck:de0523d48c90Announcement. The Max Planck Society announces computer vision technology that uses just a few smartphone cameras to create dancing avatars, eliminating the need for marker suits in motion capture.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-mit-research:e2eb449edbb72026-w42-p8/mit-research:e2eb449edbb7Announcement. MIT News reports on the State of Supply Chain Sustainability Report from MIT's Center for Transportation and Logistics. It says corporate sustainability commitment is at a record high, but governance gaps and external disruptions prevent execution.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-arxiv:2610.209472026-w42-p8/arxiv:2610.20947Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests whether ensemble spread from Long Short-Term Memory streamflow forecasts still signals uncertainty under high flows. It reports that prediction error is about 2 times the corrected spread at ordinary flows and up to 4 times at the highest flows, so the spread understates risk in extreme conditions. The authors note that the spread still ranks errors informatively.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-arxiv:2610.211572026-w42-p8/arxiv:2610.21157Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses simplified ring-network power-grid models to study how a long-range shortcut transmission link affects synchronization. The authors report that center-to-center shortcuts raised mean basin stability by up to 75% when producers and consumers formed two separated clusters, while peripheral shortcuts reduced it by up to 28% in some configurations.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-arxiv:2610.222422026-w42-p8/arxiv:2610.22242Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, introduces SurvICL, a foundation model that predicts survival curves in context, without tuning. The authors report it outperformed 20 tree-based, deep and foundation-model baselines on 63 held-out datasets, and was the first to rank above the Cox model on small datasets. Because the authors designed and benchmarked the model, these are their own reported results.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-pew:103cc557cd052026-w42-p8/pew:103cc557cd05Announcement. Pew Research Center reports that 86% of Latino registered voters say the economy is very important to their vote for Congress in the 2026 midterms.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-mit-research:631c78f18e272026-w42-p8/mit-research:631c78f18e27Announcement. MIT News reports new research that can help artificial intelligence (AI) models understand crystalline materials in 3D and reason about their properties.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p8/#item-gao:15dfbe9578ea2026-w42-p8/gao:15dfbe9578eaFinal report. The U.S. Government Accountability Office (GAO) reports limited available information on the full extent of foreign investment in mining on federal lands. The 1872 Mining Law generally requires claimants to be U.S. citizens or businesses incorporated in the U.S., so foreign companies can qualify through a U.S. subsidiary. GAO determined ownership for 32 of 43 companies it reviewed and found 14 were foreign subsidiaries, none with a Chinese-owned parent company.Tue, 20 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.1073/pnas.25354131232026-w42-p7/doi:10.1073/pnas.2535413123Peer-reviewed study. A peer-reviewed study in mice, published in the journal PNAS on October 12, 2026, found that metabotropic glutamate receptor 5 (mGlu5) is not balanced between the two sides of the hippocampus in wild-type mice, and that this balance is lost in two mouse models of Alzheimer’s disease. Using a light-controlled compound, the researchers inhibited mGlu5 in the left hippocampus only, which restored working and short-term memory in those mice. The study is in mice, not people.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.06.7569012026-w42-p7/doi:10.64898/2026.10.06.756901Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that human caspase-4 and caspase-5 respond to a broader range of bacterial lipopolysaccharide (LPS) structures than the mouse protein caspase-11 does. In mice engineered to express human CASP4, the authors report better control of Francisella novicida, a rodent pathogen, but greater susceptibility to sepsis when exposed to E. coli with a lipid A variant. The preprint is dated October 13, 2026, and is a laboratory and mouse study.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.09.263651062026-w42-p7/doi:10.64898/2026.10.09.26365106Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a cross-sectional study of 44,487 interventional US trials registered on ClinicalTrials.gov, which shows associations rather than causes. It found that an English-language proficiency requirement in eligibility criteria rose from 7.4% of trials starting in 2010 to 26.2% of trials starting in 2023, and that the requirement was associated with lower enrolled proportions of Asian and Hispanic/Latinx participants. The preprint is dated October 13, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.09.263651342026-w42-p7/doi:10.64898/2026.10.09.26365134Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, compares 26 vision-language models on estimating energy intake from meal photographs. The authors report that a prompt describing a Japanese dietitian moved the estimates by amounts that depended on the model and cuisine rather than on the correction needed, so they do not propose a persona as a general calibration method. They also report that nearly empty trays still received 39% to 75% of the before-meal estimate. The preprint is dated October 13, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.09.263651612026-w42-p7/doi:10.64898/2026.10.09.26365161Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes a nationally representative cross-sectional survey of 12,765 adults in India from the Global Flourishing Study (GFS). It found that less favorable childhood experiences were generally associated with poorer wellbeing and flourishing, while childhood abuse was associated with greater odds of volunteering. The associations do not establish cause, and the preprint is dated October 13, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.09.263651772026-w42-p7/doi:10.64898/2026.10.09.26365177Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports laboratory experiments in which serum from patients with persistent atrial fibrillation changed electrical activity in isolated mouse hearts and in human stem-cell-derived atrial cardiomyocytes. The authors say the effect was not linked to measures of atrial disease severity, and they identified rhythm-associated proteins in the serum. The preprint is dated October 13, 2026, and reports laboratory work, not effects seen in patients.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.09.263651812026-w42-p7/doi:10.64898/2026.10.09.26365181Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a cross-sectional study of 44,982 participants that shows associations, not causes, between ethnoracial group and cerebral small vessel disease. Black participants had higher white matter hyperintensity volume than White participants, while South Asian participants had fewer enlarged perivascular spaces, and the authors found no clear group difference in lacunes or microbleeds. Higher Life's Essential 8 scores were linked to less white matter change, while cognitive differences did not track brain changes. The preprint is dated October 13, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.11.263652542026-w42-p7/doi:10.64898/2026.10.11.26365254Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a systematic review and random-effects meta-analysis of 16 publications on vitamin D supplementation in children and adolescents. Pooled estimates favored supplementation in direction, but confidence intervals included no effect for respiratory infection and for lower respiratory infection or recurrent pneumonia, while the pooled estimate for hospitalization or clinical severity was statistically significant. The authors note substantial heterogeneity between studies, and the preprint is dated October 13, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.13.7588122026-w42-p7/doi:10.64898/2026.10.13.758812Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that glyceraldehyde-3-phosphate, an intermediate in glucose breakdown, binds the proteins SOS1 and RAS and strengthens their interaction in RAS-mutant cancer cells. The authors say the glucose-transporter GLUT6 drives this, and that suppressing MAZ or GLUT6 selectively inhibited RAS-mutant cancer cells in vitro and in vivo. The work is at an early laboratory stage, and the preprint is dated October 13, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.1016/j.cell.2026.09.0422026-w42-p7/doi:10.1016/j.cell.2026.09.042Peer-reviewed study. A peer-reviewed study published in the journal Cell on October 15, 2026, describes Azo-morphine-3 (AM-3), a photoswitchable ligand that toggles between low and high efficacy states. The authors report that AM-3 controls mu-opioid receptor activity in vitro and in vivo, in both the brain and the periphery, enabling precise control of analgesia across pain models with reduced side effects compared with systemic drugs.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.1073/pnas.26143351232026-w42-p7/doi:10.1073/pnas.2614335123Peer-reviewed study. A peer-reviewed study in the journal PNAS, published October 15, 2026, reports that activators of TRPV1, a polymodal nociceptor (a sensor for several kinds of stimuli), stabilize functionally distinct open states with discrete single-channel conductance levels. The authors also report that combining two stimuli slows channel opening rather than speeding it up, and they suggest these states may offer opportunities for selective modulation in pain management.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.08.7578072026-w42-p7/doi:10.64898/2026.10.08.757807Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that activating TGR5, a bile-acid receptor, expanded neural stem cells in cultures and in 18-month-old mice, and improved spatial memory in those mice without generating new neurons. The authors say these effects depended on TGR5 in the dentate gyrus, and that the aged hippocampal proteome moved partway toward a younger profile. Because the work is mostly laboratory and mouse research, its relevance to people is not yet known.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.13.263653492026-w42-p7/doi:10.64898/2026.10.13.26365349Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes genetic data from the Adolescent Brain Cognitive Development Study (ABCD) and the All of Us Research Program. It reports that rare protein-truncating variants in constrained genes were associated with autism spectrum disorder, schizophrenia and intellectual disability, and that constraint-weighted rare variant load contributes to cognitive and neuropsychiatric outcomes. The findings are associations in population cohorts, and the preprint is dated October 15, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.13.263653732026-w42-p7/doi:10.64898/2026.10.13.26365373Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a machine-learning system that estimates the probability that a clinical trial will achieve its primary endpoint, using information available at registration. On a test set of trials started in 2021 or later, the efficacy model reached an area under the receiver operating characteristic curve (AUROC) of 0.828, and the authors say the model is embedded in an agentic AI system called inClinico Agent. The preprint is dated October 15, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.13.263654712026-w42-p7/doi:10.64898/2026.10.13.26365471Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes CytoLens, a deep learning system that detects and counts nuclei, delineates cells and scores candidate abnormality in cervical cytology images. The authors report an F1 score of 0.931 for nucleus detection and a mean accuracy of 0.947 across four categories, in tests on public datasets, and they say the next step is evaluation on patient-linked clinical specimens. The preprint is dated October 15, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.13.7589492026-w42-p7/doi:10.64898/2026.10.13.758949Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that gene expression resembling early embryonic stages is widespread in human tumors, measured with machine-learning classifiers called EmbryoRadar. The authors report that similarity to the zygote and 2-cell embryo stages was associated with better overall survival, while trophectoderm-like programs were associated with worse survival in breast cancer and melanoma. They identify MYBL2 and FOXM1 as possible vulnerabilities in trophectoderm-high cancers, a laboratory finding not yet tested in patients, and the preprint is dated October 15, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.14.7592022026-w42-p7/doi:10.64898/2026.10.14.759202Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a systematic literature review following PRISMA 2020 guidelines, combined with an integrated analysis of postmortem brain transcriptomic data. It reports 276 genes shared across suicide, bipolar disorder and major depressive disorder, implicating stress, hypoxia, inflammatory and extracellular matrix pathways, along with disease-specific patterns. The study describes molecular patterns rather than causes, and the preprint is dated October 15, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.09.7581362026-w42-p7/doi:10.64898/2026.10.09.758136Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes MESSI, a generative discrete diffusion model that designs protein sequences which keep their structure while avoiding predicted peptides that bind major histocompatibility complex class II molecules. The authors report deimmunized versions of a luciferase, a PD-1 mini-binder and the enzyme uricase, some with higher activity than their parents or natural orthologs. The preprint is dated October 16, 2026, and reports laboratory experiments.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.13.7582032026-w42-p7/doi:10.64898/2026.10.13.758203Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports laboratory experiments on defective influenza A genomes, called delVGs, which can stimulate immune responses. The authors report that mutations disrupting a polyuracil tract increased interferon production by up to two orders of magnitude, and that some variants greatly suppressed the growth of replication-competent virus. Because these are laboratory experiments, the findings do not yet show any use in people, and the preprint is dated October 16, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.14.263654802026-w42-p7/doi:10.64898/2026.10.14.26365480Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes linked electronic health records and claims data from 136,781 adults with type 2 diabetes. The authors report that remission was recorded in 4.33% of previously treated adults and 15.57% of untreated adults at entry, and that remission more often ended with treatment restart than with a rise in HbA1c. They say studies of remission in real-world data should report relapse and restart separately, and the preprint is dated October 16, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.14.263655882026-w42-p7/doi:10.64898/2026.10.14.26365588Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests a data-augmentation approach that makes clinical decision relationships explicit for an 8-billion-parameter Qwen3 model, ChronIQ-DRx2, across four chronic diseases. The authors report descriptive point estimates, not statistical comparisons, including a serious clinical error rate of 12.5% for the enhanced model versus 16.7% for the baseline, and physician accuracy of 88.20% with AI assistance versus 87.40% alone. The preprint is dated October 16, 2026, and the authors say rationale faithfulness, generalizability and clinical safety still need evaluation.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.15.263656102026-w42-p7/doi:10.64898/2026.10.15.26365610Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes longitudinal data from the Young Lives studies in Ethiopia, India, Peru and Vietnam, using a multi-domain framework of explanatory factors for psychological distress. Distress at ages 18 to 19 was higher in girls than boys in every country, with the gap ranging from 0.62 points in Ethiopia and Vietnam to 2.45 points in Peru. The authors say the factors that differ by gender, and their effects, varied across countries, so drivers should not be generalized across contexts.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.15.7591722026-w42-p7/doi:10.64898/2026.10.15.759172Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a covalent small molecule that targets the non-catalytic proteasome regulator PSME4, and shows that reducing PSME4 stabilizes STAT1, restores interferon-associated transcription and enhances antigen presentation in tumor cells. The authors also report disrupted IL-6/STAT3 signaling and suppressed tumor growth in vivo, which they describe as a PSME4-STAT1-STAT3 axis. This is early laboratory and in vivo work, dated October 16, 2026, so its relevance to patients is not yet shown.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.15.7594732026-w42-p7/doi:10.64898/2026.10.15.759473Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that ARID5A, a protein that binds both DNA and RNA, is induced in hepatocytes under lipotoxic endoplasmic reticulum stress through the PERK pathway. In mice fed a diet that induces metabolic dysfunction-associated steatohepatitis (MASH), the authors report that hepatocyte-directed overexpression of ARID5A attenuated steatohepatitis, inflammation and fibrosis. This is laboratory and mouse work, and the preprint is dated October 16, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-arxiv:2610.141452026-w42-p7/arxiv:2610.14145Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines whether frontier AI companies can support their valuations from selling tokens, meaning access to their models. Reverse cash-flow calculations for OpenAI and Anthropic put the required year-ten revenue at $2.79 trillion or $733 billion, depending on financial assumptions. The paper also points to public documents describing proposed payments and ownership interests in partnerships in pharmaceuticals, robotics or materials science. The paper is dated October 14, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.26434/chemrxiv.15010371/v12026-w42-p7/doi:10.26434/chemrxiv.15010371/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a laboratory method that measures the mass of black carbon, a combustion-related air pollutant, in serum, blood and tissue samples. The authors report that the method can also separate biomass-derived black carbon from fossil-derived black carbon, correctly classifying 91.0% of controlled mixtures. The preprint is dated October 13, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.26434/chemrxiv.15010489/v12026-w42-p7/doi:10.26434/chemrxiv.15010489/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes an engineered ice-nucleating protein, based on the bacterial protein InaZ, that binds a cell-surface biomarker and triggers freezing of supercooled water droplets. In lab tests with breast cancer cells expressing HER2, the authors report detecting as few as about 500 target cells among 10,000 non-target cells, and selective detection visible with a household freezer. The preprint is dated October 15, 2026, and reports an early laboratory method.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-arxiv:2610.160862026-w42-p7/arxiv:2610.16086Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, proposes a neural framework for estimating the direct, spillover and total effects of policies that local jurisdictions set and that can spread to connected populations. In a county-level COVID-19 policy study, the authors report that business-and-economic restrictions and education-and-childcare policies were associated with lower subsequent case burden, with larger estimates for business-and-economic restrictions. The preprint is dated October 14, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-arxiv:2610.171152026-w42-p7/arxiv:2610.17115Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, applies thousands of machine learning models per outcome to hundreds of later life outcomes in the Future of Families and Child Wellbeing Study. It reports that most outcomes were not very predictable, and that even for the most predictable outcomes the complex procedure showed little skill compared with a simple one. The preprint is dated October 14, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-pew:014aee9294d22026-w42-p7/pew:014aee9294d2Announcement. Pew Research Center reports that about a third of Americans have left an online community, which can draw people in with shared interests, support or a sense of belonging. This is a brief announcement, so this summary covers only what it says.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.26434/chemrxiv.15010529/v12026-w42-p7/doi:10.26434/chemrxiv.15010529/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a self-sustained Sabatier reaction in which metallic iron and magnesium powders react with carbonated water to produce hydrogen and methane near room temperature, without an added catalyst. The authors report that light irradiation speeds up production of both gases. The preprint is dated October 15, 2026, and reports a laboratory study.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-mit-research:c0a2e19f92972026-w42-p7/mit-research:c0a2e19f9297Announcement. MIT News reports, in an announcement from the institution, that a new computational approach reveals how cells communicate to assemble into tissues. According to the announcement, this could accelerate stem cell engineering, improve disease models and inform therapies. The announcement is MIT’s own account of its work, dated October 15, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.26434/chemrxiv.15010574/v12026-w42-p7/doi:10.26434/chemrxiv.15010574/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a sequential physical vapor and gas phase transport deposition process for making perovskite films, without solvents, for single- and multi-junction solar cells. The authors report a champion cell with a 1.66 eV bandgap that reaches 18.3% power conversion efficiency, and say the bandgap can be tuned by a halide exchange reaction for tandem applications. The preprint is dated October 16, 2026, and reports a laboratory study.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-doi:10.64898/2026.10.15.7593452026-w42-p7/doi:10.64898/2026.10.15.759345Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports in adult male mice that perineuronal nets (PNNs), specialized extracellular matrix structures, develop in the bed nucleus of the stria terminalis (BNST) from about P30 and peak around P210. Stress-induced anxiety was associated with fewer PNNs and changes in their fine structure, and removing PNNs in the anteromedial BNST increased anxiety-like behavior in response to acute stress. The preprint is dated October 18, 2026, and reports a laboratory study.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-gao:8dac5d0495502026-w42-p7/gao:8dac5d049550Final report. A final report from the U.S. Government Accountability Office (GAO) says that the Responsible AI Working Council of the Office of the Chief Digital and AI Officer (CDAO) did not meet from late 2024 until August 2025, and resumed meetings in August 2025 but has no charter, so it is at risk of lapsing again. The report says that as of February 2026 only three of the 10 authorized positions in the Responsible AI Division were filled, and that staffing shortages have hindered CDAO’s actions. The report is dated October 14, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p7/#item-gao:fb615c8681662026-w42-p7/gao:fb615c868166Final report. A final report from the U.S. Government Accountability Office (GAO) says the National Institutes of Health (NIH) implemented 14 of the 15 federal research security requirements it reviewed. It also finds that NIH relies heavily on self-reported information, generally does not verify disclosures unless it receives an allegation, and received 697 allegations of potential foreign interference from 2017 through 2025. The report is dated October 16, 2026.Mon, 19 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1016/j.cell.2026.08.0532026-w42-p6/doi:10.1016/j.cell.2026.08.053Peer-reviewed study. This peer-reviewed study defines centromere haplogroups from rare k-mer variation in human DNA. The lead author, Shiraishi, reports extensive hidden diversity and links to human evolution and disease-associated genomic instability.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1371/journal.pbio.30037782026-w42-p6/doi:10.1371/journal.pbio.3003778Peer-reviewed study. This peer-reviewed study in rice plants reports PrimeStack, a platform that inserts multigene DNA cargos at predefined genomic safe harbors. Regenerated rice plants reached integration efficiencies of up to 45%, with no obvious morphological differences from wild-type plants at five weeks under the conditions tested. The authors say the approach could accelerate crop development and plant-based biomanufacturing.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.04.7565242026-w42-p6/doi:10.64898/2026.10.04.756524Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and the study is in mice. The authors report that microglia, brain immune cells, react to ingested dietary fat within three hours and promote satiety, and that this effect appears only in males. They say the process could be a new therapeutic target for maladaptive eating disorders.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.06.7564912026-w42-p6/doi:10.64898/2026.10.06.756491Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors simulated how several myopia control spectacle lenses (eyeglasses designed to slow myopia progression) affect the retinal image. They report that clinical efficacy can be predicted from optical properties, which they say could guide future lens design.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.11.7583832026-w42-p6/doi:10.64898/2026.10.11.758383Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and most results come from cell cultures and a mouse model of myocardial infarction. The authors engineered neutrophils derived from human pluripotent stem cells to carry a chimeric antigen receptor (CAR) against fibroblast activation protein (FAP), and report higher left ventricular ejection fraction on day 7 in treated mice in an exploratory comparison. They say the findings support further evaluation as an immunotherapy for cardiac fibrosis. The lead author is G. Jin.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-mmwr:864d9cbd04412026-w42-p6/mmwr:864d9cbd0441Final report. This final report describes increases in reports of frequent mental distress and physical inactivity among young adults aged 18-29 years in the United States during 2012-2024. It is a descriptive report, and the abstract does not explain the causes of the increases.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1038/s41586-026-11162-72026-w42-p6/doi:10.1038/s41586-026-11162-7Peer-reviewed study. This peer-reviewed study uses artificial intelligence to quantify brown adipose tissue (BAT) activity in humans. It links brown fat activity to a healthier metabolic profile and lower rates of psychiatric disease, and says it can identify drugs that could be repurposed to activate this tissue.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1038/s41586-026-11167-22026-w42-p6/doi:10.1038/s41586-026-11167-2Peer-reviewed study. This peer-reviewed study uses RFdiffusion methods to design proteins from scratch, with water-activating zinc-based active sites next to a peptide substrate binding pocket. The authors report highly active, programmable proteases with potential uses in therapeutics, biotechnology and bioremediation.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1038/s41586-026-11171-62026-w42-p6/doi:10.1038/s41586-026-11171-6Peer-reviewed study. This peer-reviewed study reports that R(+)2501 reverses capillary no-reflow by relaxing pericytes. The authors report restored microvascular perfusion and improved survival in animal models of myocardial infarction and acute kidney injury.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1016/j.cell.2026.09.0402026-w42-p6/doi:10.1016/j.cell.2026.09.040Peer-reviewed study. This peer-reviewed study reports tetraoxane-containing compounds, WMK-1 and WMK-2, that initiate lipid peroxidation in mitochondria to drive ferroptosis. The authors say the compounds bypass the usual cell defenses and show potent, bioavailable tumor-suppressive activity across multiple in vivo models.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1073/pnas.26151451232026-w42-p6/doi:10.1073/pnas.2615145123Peer-reviewed study. Liver-expressed antimicrobial peptide 2 (LEAP2) is studied here in male mice in a peer-reviewed study. The authors report that LEAP2 reaches the arcuate nucleus of the hypothalamus and targets orexigenic neurons (cells that drive appetite), producing sustained inhibition of ghrelin-induced feeding for several hours. They say LEAP2 could be a therapeutic target for obesity and metabolic disorders.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.26434/chemrxiv.15010492/v12026-w42-p6/doi:10.26434/chemrxiv.15010492/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors report a cationic amphiphilic zinc phthalocyanine whose activity can be switched between photodynamic therapy, photodynamic inactivation and photochemical internalization by changing dosing and irradiation protocols. They report high activity in cancer models and against multidrug-resistant pathogens, with negligible dark toxicity.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.08.7576422026-w42-p6/doi:10.64898/2026.10.08.757642Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors built an injury-responsive gene therapy vector that targets injured sensory neurons with more than 95% specificity, paired with a chemogenetic silencing tool. They report that this alleviated spontaneous neuropathic pain in mice and silenced hyperexcitable human sensory neurons.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.08.7577012026-w42-p6/doi:10.64898/2026.10.08.757701Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors report that the endosome adaptor Rabgef1 promotes gasdermin pore formation by controlling membrane cholesterol. They say reducing cholesterol restores pyroptosis and sensitizes resistant cancer cells to it.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.13.263653852026-w42-p6/doi:10.64898/2026.10.13.26365385Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and it analyses data from 81,870 UK Biobank participants aged 45 to 87. The authors report that deviation from normal grey-matter volume is concentrated in the nucleus basalis of Meynert (Ch4) across neurological diseases, while the septal and diagonal-band compartment (Ch1-3) shows no independent prospective vulnerability. The Ch4 deficit was linked with incident dementia and Parkinson's disease.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.13.7589462026-w42-p6/doi:10.64898/2026.10.13.758946Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and it uses human tissue, mouse models and cultured cells. The authors report that the mechanosensitive ion channel PIEZO1 drives myofibroblast-like activation of synovial fibroblasts after joint injury. They also report that intra-articular PIEZO1 activation in mice induced a pro-fibrotic, pro-inflammatory response in the synovium.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.14.263655112026-w42-p6/doi:10.64898/2026.10.14.26365511Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. Analysing 14 waves of the UK Household Longitudinal Study from 2009 to 2024, the authors find physical health inequalities widened with age, while mental health inequalities were more evident among later-born cohorts. They report that Generation Z had lower predicted mental health, particularly among White British women with no work history.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.14.7591782026-w42-p6/doi:10.64898/2026.10.14.759178Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors report that different antibiotics produce significantly different transfer dynamics for the same multidrug-resistant plasmid, largely because conjugation continues for hours after antibiotic exposure begins. They say antibiotics that select for the same plasmid are therefore not equivalent in promoting its persistence.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.14.7592092026-w42-p6/doi:10.64898/2026.10.14.759209Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors report that Cas13X.1, a hypercompact CRISPR system, targeting the TAR element of HIV-1 RNA disrupted Tat-TAR interactions and reduced viral protein expression. They also report reduced reactivation in latency models and reduced viral load in primary blood cells from infected donors.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.07.7574742026-w42-p6/doi:10.64898/2026.10.07.757474Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and the study is in rats. The authors report that offspring of mothers on a high-fat diet showed accelerated postnatal cardiac maturation and higher juvenile systolic performance, but that ejection fraction and contractility declined by adulthood alongside disorganized cardiomyocyte structure.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.08.7576412026-w42-p6/doi:10.64898/2026.10.08.757641Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. It compares people with remitted major depressive disorder and healthy controls, using brain imaging and computational modelling of approach-avoidance decisions before and after a psychosocial stressor. The authors report that stress increased reward sensitivity in the remitted group, and that this change predicted one-year depressive symptoms.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.15.263655862026-w42-p6/doi:10.64898/2026.10.15.26365586Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and it is a modelling study of dengue in Brazil. The authors fitted an age-structured model to surveillance data from 2000-2025 and report that under limited supply, targeting children gave the greatest reduction in DALYs (disability-adjusted life years), while targeting elderly populations gave larger reductions in mortality.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.15.263656292026-w42-p6/doi:10.64898/2026.10.15.26365629Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. In a prospective cohort of 466,864 UK Biobank participants, the authors report that physical frailty was associated with increased risk of 458 incident diseases. They also report faster accumulation of multimorbidity over a median follow-up of 13.8 years.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-TX-TRD-2026042222026-w42-p6/TX-TRD-202604222Proposed. The Texas Higher Education Coordinating Board proposes amendments to its rule on the cost of attendance calculation for competency-based baccalaureate degree programs, under Texas Administrative Code, Title 19. The amendment would clarify the allowable threshold for what public institutions can charge, and it narrows the rule to the maximum allowable direct cost of attendance.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-TX-TRD-2026042382026-w42-p6/TX-TRD-202604238Proposed. The Texas Comptroller of Public Accounts proposes amending section 3.330 on data processing services. The proposal states that transaction fees charged by marketplace providers are commissions, not data processing services, and treats platform fees the same way, with that interpretation effective from the date the amendment is adopted.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.12.7585242026-w42-p6/doi:10.64898/2026.10.12.758524Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors profiled multi-organ gene expression from drug-treated rodents against more than 900 human disease signatures for semaglutide, a GLP-1 receptor agonist originally developed for diabetes. They report that the method recovered established indications while deprioritizing Alzheimers disease, and propose several rare-indication predictions for further investigation.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1073/pnas.26009411232026-w42-p6/doi:10.1073/pnas.2600941123Peer-reviewed study. This peer-reviewed study finds that since the mid-twentieth century about one-quarter of glaciers in the western conterminous United States have disappeared, and their overall area and volume have fallen by one-third. The authors say most remaining glaciers are largely maintained by local topographic influences because of their small size. The lead author is Andrew G. Fountain.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.12.7585302026-w42-p6/doi:10.64898/2026.10.12.758530Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors compared 232 angiosperm genomes from 55 families and report convergent genomic signatures in halophytes, which are plants that tolerate salt. They say these findings could help translate convergent adaptations into salt-tolerant crops.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.12.7585262026-w42-p6/doi:10.64898/2026.10.12.758526Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and it concerns fungal pathogens rather than people. The authors analysed 385 genomes, 204 of them from this study, and report that rye and wheat stem rust share multiple mating-type haplotypes. They also report that some virulent alleles in wheat stem rust derive from admixture with rye stem rust.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1126/science.ady76472026-w42-p6/doi:10.1126/science.ady7647Peer-reviewed study. This peer-reviewed study identifies OsFID1 as a chitosan-binding receptor that forms a complex with OsFID2 to confer broad-spectrum resistance to fungal pathogens. The authors report that ectopic expression of OsFID1 in wheat and maize enhanced fungal resistance without a growth penalty.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.64898/2026.10.08.7576352026-w42-p6/doi:10.64898/2026.10.08.757635Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and the work is in mice. In a maternal exposure model, the authors report that a fungicide mixture at 0.3 g/L, below the current European regulatory limit of 0.5 g/L, is associated with impaired corticogenesis and altered synaptic function. Offspring showed delays in sensory development, reduced social interactions and increased stereotyped behaviors, which the authors say indicates an autism spectrum-like phenotype.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.1073/pnas.26269901232026-w42-p6/doi:10.1073/pnas.2626990123Peer-reviewed study. This peer-reviewed study reports a 14-year experiment in a temperate forest adding 100 kg of nitrogen per hectare per year, in a mix simulating atmospheric deposition. The authors found the mix did not affect soil carbon pools, while organic and inorganic nitrogen each increased them, and that organic nitrogen increased mineral-associated carbon fractions.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-doi:10.26434/chemrxiv.15007814/v22026-w42-p6/doi:10.26434/chemrxiv.15007814/v2Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors treated 3D perovskite films with bromide-rich perovskite nanocrystals and report that treated perovskite solar cells raised power conversion efficiency from 20.13% in controls to 22.19%. They also report a fill factor of 75.3%.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-pew:242eeda7343c2026-w42-p6/pew:242eeda7343cAnnouncement. Pew Research Center's weekly roundup reports that many Americans can't afford basic necessities. It cites the share of Americans who say they cut back spending on extras, such as dining out or entertainment, in the past year.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-gao:14436558cf8a2026-w42-p6/gao:14436558cf8aFinal report. The U.S. Government Accountability Office (GAO) reports that the Department of Housing and Urban Development (HUD) reduced its workforce by 29 percent in 2025, largely through deferred resignation programs, and terminated about 21 percent of its active contracts. Stakeholders GAO interviewed reported confusion, delays and operational disruptions, and HUD did not respond to GAO's requests for information during the audit.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-TX-TRD-2026042302026-w42-p6/TX-TRD-202604230Proposed. The Texas Commission on Law Enforcement proposes a new rule creating a Law Enforcement Polygraph Certificate. Under the proposal, the certificate would be required for a peace officer conducting a polygraph for pre-appointment screening or criminal investigation, and for anyone conducting one for pre-appointment screening. It would require completing a polygraph training program and continuing education.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-gao:0b8228fbe1f52026-w42-p6/gao:0b8228fbe1f5Final report. The U.S. Government Accountability Office (GAO) reports that the number of states with concentrated private health insurance markets generally increased from 2011 through 2024, with recent decreases in the individual market. GAO defines a market as concentrated in a state when three or fewer issuers hold at least 80 percent of enrollment.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-gao:2fd06e10844f2026-w42-p6/gao:2fd06e10844fFinal report. The U.S. Government Accountability Office (GAO) reports that ghost preparers, paid tax preparers who do not identify themselves on returns they prepare, can use that anonymity to file fraudulent returns and steal refunds. It finds that the Internal Revenue Service (IRS) does not know how many ghost preparers it has identified, investigated or addressed, and that its efforts are fragmented across six offices. GAO says a comprehensive, coordinated preparer strategy with measurable objectives could help IRS align resources with risks.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-gao:abd64b5f306c2026-w42-p6/gao:abd64b5f306cFinal report. The U.S. Government Accountability Office (GAO) reports that the National Oceanic and Atmospheric Administration (NOAA) restructured its Geostationary Extended Observations (GeoXO) program, reducing the number of satellites from six to four and the projected lifecycle cost to $13 billion from $19.6 billion. GAO says the restructuring adds uncertainty about cost, schedule and instrument configuration, and that the program's contingency plan may leave a gap in weather data continuity.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p6/#item-gao:d7576760bf552026-w42-p6/gao:d7576760bf55Final report. The U.S. Government Accountability Office (GAO) describes the potential benefits and challenges of a textile circular economy, meaning repairing, reusing and recycling textiles. It lists policy options such as a textile extended producer responsibility program and tax credits, and notes that some U.S. states and other countries have proposed or enacted most of them.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1073/pnas.26130541232026-w42-p5/doi:10.1073/pnas.2613054123Peer-reviewed study. This peer-reviewed study tested chemicals on three-dimensional human breast tissue grown in the laboratory, called organoids. A low-dose mixture of bisphenols (BPA, BPS and BPF) disrupted organoid development and changed gene activity and DNA methylation patterns. The authors report that these patterns resemble those in some human breast cancers, especially invasive lobular carcinoma, and suggest that developmental exposures may set up cancer-relevant tissue states.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1073/pnas.26157391232026-w42-p5/doi:10.1073/pnas.2615739123Peer-reviewed study. This peer-reviewed study surveyed 47,756 participants across 61 societies about infection-risky contact, such as sharing a water bottle, and about touching someone when greeting them. People were more comfortable with risky contact, and more likely to touch in greetings, when the target was someone they valued more, such as a friend rather than a stranger or enemy. Societal factors such as historical pathogen prevalence and tightness mattered less, mainly for high-value targets.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1371/journal.pmed.10052512026-w42-p5/doi:10.1371/journal.pmed.1005251Peer-reviewed study. This peer-reviewed cohort study followed 461,682 cancer-free older US adults through 2018, during which 10,075 colorectal cancer cases were diagnosed. Total intake of ultra-processed foods was not associated with the cancer, but whole grain, fiber, dairy and calcium from these foods were linked to lower risk, and meat from them to higher risk. Because the study is observational, it shows associations rather than causes, and the authors say it supports existing advice to eat whole grains, fiber, dairy and calcium and to avoid processed meat.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.64898/2026.10.14.263655902026-w42-p5/doi:10.64898/2026.10.14.26365590Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes county-level measles cases and vaccine coverage in the United States from 2011 to 2025. It finds that from 2021 to 2025 outbreaks were more strongly linked to vaccine coverage and spread more across neighboring counties than in the earlier decade. The authors say targeting interventions at the highest-risk counties could prevent re-emergence more effectively than state-level or low-coverage targeting.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.64898/2026.10.15.263654282026-w42-p5/doi:10.64898/2026.10.15.26365428Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, estimates 1.7 million smoke-associated deaths in the United States from 2011 to 2023 (95% uncertainty interval: 1.1 to 2.3 million), using county-level monthly wildfire PM2.5 (fine particulate matter) and mortality data. It finds the excess mortality response peaks about three years after an exposure pulse and subsides by five years, and is greater among adults aged 65 and over. The authors say reducing smoke exposure could yield substantial health benefits over multiple years.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042102026-w42-p5/TX-TRD-202604210Final rule. The Texas Department of Insurance adopts amendments to section 1.414 of Title 28 of the Texas Administrative Code on assessments collected from insurance policy sales, taking effect October 21, 2026. The amendments implement Senate Bill 1455 (2025), which replaces the maintenance tax on workers' compensation insurance with workers' compensation surcharges, and include plain-language and style changes.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042162026-w42-p5/TX-TRD-202604216Proposed. This is a proposal by the Texas Higher Education Coordinating Board. It would clarify the allowable tuition threshold for public institutions offering competency-based baccalaureate degrees under Texas Education Code section 51.3535, and add a definition of direct cost of attendance with a maximum allowable amount.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042172026-w42-p5/TX-TRD-202604217Proposed. This is a proposal by the Texas Higher Education Coordinating Board to create rules that help institutions of higher education comply with the Clery Act and recent legislation on timely emergency warnings. The proposed rules cover campus-wide warning policies, types of notifications, timing, methods, and testing the system once each semester.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042182026-w42-p5/TX-TRD-202604218Proposed. This is a proposal by the Texas Higher Education Coordinating Board to add the Classic Learning Test (CLT), with requisite scores, to the SAT and ACT as an option under the uniform admission policy. The option would apply to students who do not meet the top 10% or 25% grade point average or the Distinguished Level of Achievement requirements for automatic admission, and changes would start with admissions in fall 2028.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042352026-w42-p5/TX-TRD-202604235Proposed. This is a proposal by the Texas Education Agency to amend section 101.3011 on academic assessments. It would keep the English II end-of-course assessment only through the 2026-2027 school year, following a 2025 change in state law, and let eligible virtual campuses and programs administer state assessments remotely.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-uksi-2026-10962026-w42-p5/uksi-2026-1096Final rule. This is UK law: The School Teachers' Pay and Conditions (England) Order 2026, which determines the remuneration of school teachers in England and other conditions of employment relating to their professional duties and working time. It was made on October 14, 2026 and comes into force on November 6, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-microsoft-research:827b12af7fd32026-w42-p5/microsoft-research:827b12af7fd3Announcement. Microsoft Research announces Magnetar, a system for proof-based general-purpose computing. It says Magnetar verifies computing results with zero-knowledge proofs without rerunning the workload or exposing sensitive data, supports standard programming languages, and offers quantum-resistant security. The company also claims major speed gains.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1073/pnas.26128131232026-w42-p5/doi:10.1073/pnas.2612813123Peer-reviewed study. This peer-reviewed study uses a computer model of microbes in the Eastern Tropical South Pacific, a marine oxygen minimum zone. It finds that competition and feeding relationships among microbes, rather than simple sensitivity to oxygen, help explain why nitrous oxide (N2O), a powerful greenhouse gas, builds up in some layers. The authors say the results could help project future shifts in marine nitrogen loss and emissions.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1073/pnas.26166161232026-w42-p5/doi:10.1073/pnas.2616616123Peer-reviewed study. This peer-reviewed study reports that specifically adsorbed iron ions on rice roots can reduce nitrate to ammonium without microbial involvement, accounting for 57% of nitrate reduction in the study's conditions. In two-year field experiments, a controlled-release form of iron raised rice yield by 16.1% while halving the nitrogen input. The authors say the work points to ways to improve nitrogen use efficiency in paddy soils.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1126/science.aee06582026-w42-p5/doi:10.1126/science.aee0658Peer-reviewed study. This peer-reviewed study measured 15,330 ice cliffs at the edges of Earth's ice sheets using laser altimetry. It finds that tall cliffs calve more rapidly than model parameterizations assume, but that dynamic thinning and retreat into regions with low ice thickness gradients prevent runaway retreat. The authors say models may underestimate how fast cliffs calve, but that the potential for instability depends on more than cliff height alone.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042052026-w42-p5/TX-TRD-202604205Final rule. The Public Utility Commission of Texas adopts amendments to section 22.242 on complaints, with changes to the proposed text, and says the rule will be republished. The rule streamlines the complaints process for all utilities under the commission's jurisdiction and takes effect October 21, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042062026-w42-p5/TX-TRD-202604206Final rule. The Public Utility Commission of Texas adopts amendments to section 24.153 on customer relations, with changes to the proposed text, taking effect October 21, 2026. They implement Texas Water Code (TWC) sections 13.5051 and 13.153 from Senate Bill 790 and Senate Bill 1778, and allow a retail public utility, on customer request, to start, transfer or end a customer's retail water or sewer service.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042072026-w42-p5/TX-TRD-202604207Final rule. The Public Utility Commission of Texas adopts amendments to section 25.485 on customer access and complaint handling, with changes to the proposed text, taking effect October 21, 2026. The rule streamlines the commission's complaints process for all utilities under its jurisdiction and brings it in line with other state agencies' processes.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-TX-TRD-2026042082026-w42-p5/TX-TRD-202604208Final rule. The Public Utility Commission of Texas adopts amendments to section 26.30 on complaints, with changes to the proposed text, taking effect October 21, 2026. The rule streamlines the complaints process for all utilities under the commission's jurisdiction, in line with other state agencies.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1073/pnas.26003311232026-w42-p5/doi:10.1073/pnas.2600331123Peer-reviewed study. This peer-reviewed study describes a computer method for forecasting abrupt, often irreversible changes in systems that evolve over time. The method learns a system's behavior before its tipping point, flags deviations from physics constraints, and gives a measure of uncertainty. The authors test it on mathematical models and on a climate example, stratocumulus cloud cover, and say it can work with only partial or approximate physics.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-mit-research:ff86c3dd2a782026-w42-p5/mit-research:ff86c3dd2a78Announcement. MIT News reports, based on satellite data, that the cliffs at the edge of Antarctica do not always collapse in the runaway process scientists had expected. The article says the satellite data reveal how these ice cliffs behave over time.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-arxiv:2610.220222026-w42-p5/arxiv:2610.22022Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses an integrated capacity expansion model to test hourly and geographically narrower matching of carbon-free electricity procurement. It suggests that, across most scenarios, narrower deliverability zones are associated with greater consequential emissions reductions, along with higher EAC prices.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-arxiv:2610.221162026-w42-p5/arxiv:2610.22116Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes privacy-enhanced GPS trajectories of over one million users in California and 180,000 in Massachusetts from January to September 2020. It finds that during restrictions individual ranges contracted and visits concentrated on a few habitual locations, and that recovery after reopening was heterogeneous rather than a uniform return to baseline.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1073/pnas.25321801232026-w42-p5/doi:10.1073/pnas.2532180123Peer-reviewed study. This peer-reviewed study models how transportation networks respond to external events such as rainfall, using real-world railway networks as a case study. It finds local and system-wide disruptions above a critical rainfall strength, and that localized disruptions reveal weak points in the wider network. The authors assess these vulnerabilities as societal risk and say climate change may intensify them.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.1073/pnas.26113681232026-w42-p5/doi:10.1073/pnas.2611368123Peer-reviewed study. This peer-reviewed study reports two large preregistered experiments with 14,779 people, in which conversational AI models tried to persuade participants. The AI had sizable effects on behavior, such as signing real petitions (+19.7 percentage points) and donating money to charity, but effects on attitudes did not predict effects on behavior. The authors say earlier findings based on attitudes may generalize poorly to real-world behavior.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.26434/chemrxiv.15010530/v22026-w42-p5/doi:10.26434/chemrxiv.15010530/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a photocatalytic and cobalt-catalyzed dehydrogenation that adds carbon-carbon double bonds to polyethylene and polypropylene plastics, including post-consumer plastics. The authors say the resulting polyolefins can be converted into functional polymers, block and graft copolymers, and adhesives. They also report that these materials can serve as compatibilizers for immiscible polymer blends.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.64898/2026.10.14.7591282026-w42-p5/doi:10.64898/2026.10.14.759128Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports cell-line experiments and mouse data on how alcohol changes chromatin, the packaging of DNA in cells. It finds that alcohol moves elongating RNA polymerase II toward promoters and changes CTCF and cohesin occupancy at guanine-rich sites, with changes persisting six days after withdrawal. The authors link these changes to altered gene expression.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-doi:10.64898/2026.10.15.7593062026-w42-p5/doi:10.64898/2026.10.15.759306Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that hyperglycemia (high blood glucose) causes liver sinusoidal endothelial cells to lose their fenestrae, the small pores in their walls, through a pathway involving O-GlcNAcylation and nitric oxide. In mice with diet-induced steatohepatitis (fatty liver inflammation), inhibiting O-GlcNAc transferase restored sinusoidal fenestrae and attenuated fibrosis. The authors say the liver sinusoid is a site of microvascular complications of hyperglycemia.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-pew:3defc10ba3b42026-w42-p5/pew:3defc10ba3b4Announcement. Pew Research Center reports that men and women now use AI chatbots at similar rates, but men use them more often. It says women are more skeptical of AI's impact on their lives.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-2026-0901-032026-w42-p5/CA-2026-0901-03Final rule. This is a final rule by the California Horse Racing Board, effective January 1, 2027. It sets the maximum ages at which horses are eligible to compete in races and permitted to work out.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-2026-0917-052026-w42-p5/CA-2026-0917-05In effect. This is a temporary emergency rule by the California Department of Corrections and Rehabilitation (CDCR), in effect from October 9, 2026. It readopts amendments governing Restricted Housing Units and the Privilege Group system (Groups C and D) for incarcerated persons. The department filed it as an emergency based on operational necessity under Penal Code section 5058.3.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-2026-0921-022026-w42-p5/CA-2026-0921-02In effect. This is a temporary emergency rule by the California Alternative Energy and Advanced Transportation Financing Authority, in effect from October 1, 2026. It readopts amendments to the Sales and Use Tax Exclusion Program that revise definitions, application and eligibility requirements, regulatory agreement and compliance requirements, and program fees.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-2026-0922-012026-w42-p5/CA-2026-0922-01In effect. This is a temporary emergency rule by the California Division of Boating and Waterways, in effect from October 2, 2026. It amends regulations on the invasive mussel infestation prevention fee and grant program, including raising the fee, under Government Code section 11346.1.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-2026-0922-032026-w42-p5/CA-2026-0922-03Final rule. This is a temporary emergency rule by the Office of Health Care Affordability (OHCA), taking effect November 2, 2026. It adds private equity (PE) groups, hedge funds, management services organizations (MSO), newly created business entities, and entities that own, operate or control a provider to the list of entities that must file material change notices of transactions.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-Z2026-1002-042026-w42-p5/CA-Z2026-1002-04Proposed. This is a proposal, not a final rule. The Dental Board of California would update its minimum infection control standards, last revised in 2011, to reflect later CDC guidance, changes in California law and changes in dentistry practice.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-Z2026-1002-052026-w42-p5/CA-Z2026-1002-05Proposed. This is a proposal, not a final rule. The California Division of Occupational Safety and Health would add Egregious and Enterprise-wide violation classifications, which Labor Code sections 6317 and 6317.8 set out, and explain how penalties would be calculated for each employee exposed to an Egregious violation. The proposal also includes updates to Title 8 sections 332.4 and 340.4 and other corrections.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-Z2026-1005-022026-w42-p5/CA-Z2026-1005-02Proposed. This is a proposal, not a final rule. The Fair Political Practices Commission proposes to adopt, amend or repeal regulations on cost of living adjustments under the Political Reform Act. The proposed regulations would sit in Title 2, Division 6 of the California Code of Regulations.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-Z2026-1006-022026-w42-p5/CA-Z2026-1006-02Proposed. This is a proposal, not a final rule. It would update California Code of Regulations (CCR) section 2043, which sets the classes of violation and penalty ranges for citations, to align with changes made by Assembly Bill 1502 (2025) to fines for unlicensed practice.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p5/#item-CA-Z2026-1006-032026-w42-p5/CA-Z2026-1006-03Proposed. This is a proposal to clarify and supplement state regulations under the Fair Employment and Housing Act (FEHA) on job-protected leave, reasonable accommodations and temporary transfers for pregnancy, childbirth or related medical conditions. It also covers bonding leave for a new child under the California Family Rights Act (CFRA).Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.1073/pnas.26134051232026-w42-p4/doi:10.1073/pnas.2613405123Peer-reviewed study. A peer-reviewed study combining parasite experiments with laboratory and microscopy work examines how lumefantrine, one of the drugs in current malaria combination therapies, acts on hematin crystallization, a process malaria parasites rely on to survive. The authors report that lumefantrine suppresses Plasmodium falciparum parasites in their assays and slows hematin crystal growth, while also promoting the formation of hematin-rich clusters.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.1371/journal.pmed.10052802026-w42-p4/doi:10.1371/journal.pmed.1005280Peer-reviewed study. A peer-reviewed multi-model comparison, commissioned by the World Health Organization (WHO), used four computer models of typhoid transmission to compare schedules for typhoid conjugate vaccine (TCV). The models predicted that routine vaccination at 9 months, with a catch-up campaign to 15 years and a booster at 5 years, would have the greatest impact, cutting cases by a median of 40% to 68% over 10 years, and that the best schedule depends on incidence, case fatality risk and how fast protection wanes.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.07.7574342026-w42-p4/doi:10.64898/2026.10.07.757434Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports mouse experiments and human liver samples on UBE4A, a protein the authors say protects against fatty liver disease (MASLD) and steatohepatitis (MASH) by keeping the endoplasmic reticulum (ER) working properly. In the mice, deleting the protein in liver cells worsened fatty liver changes, inflammation and insulin resistance, and the authors say levels of the protein are lower in human MASLD and MASH livers.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.09.263651332026-w42-p4/doi:10.64898/2026.10.09.26365133Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a randomized, double-blind, placebo-controlled phase 2 trial of BCG, which the authors call an old generic drug, in people with type 1 diabetes (T1D), followed for up to 8 years. The authors report that hemoglobin A1c (HbA1c), a measure of average blood sugar, fell by 7.04% at year 5 and 12.84% at year 8 in the BCG group but did not change in the placebo group, and that BCG was safe.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.11.7583572026-w42-p4/doi:10.64898/2026.10.11.758357Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports ovary transplant experiments and parabiosis experiments (where two animals share a circulation) in mice. The authors report that ovarian aging shifted in both directions depending on the host, and that ovaries from 13-month-old donors supported live births when moved into young hosts but not into old hosts.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.12.7585452026-w42-p4/doi:10.64898/2026.10.12.758545Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that mice fed a high-fat diet and with hypertension developed oligodendroglial cell loss, thinner myelin, memory problems and features the authors say resemble vascular dementia. Blocking the integrated stress response (ISR) in those cells, or deleting the ISR-activating kinase PERK from them, protected the mice, and the authors say the pathway may be a therapeutic target.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.1016/j.cell.2026.09.0352026-w42-p4/doi:10.1016/j.cell.2026.09.035Peer-reviewed study. A peer-reviewed study in Cell analyzes 467,152 genomes from the UK Biobank to map structural variants, which it describes as changes in DNA sequence greater than 50 base pairs. The authors say these variants are an important and previously underrecognized source of human disease risk, and the resource reveals rare and regulatory variants linked to disease.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.08.7577672026-w42-p4/doi:10.64898/2026.10.08.757767Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports HIV-1 vaccine candidates, made by human immunodeficiency virus type 1 (HIV-1) researchers, that carry a core fucose sugar on their envelope protein, tested mainly in mice. The authors say the sugar supports neutralizing antibody responses against several strains, and that humanized mice showed detectable neutralization by week 11.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.13.7586472026-w42-p4/doi:10.64898/2026.10.13.758647Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports single-domain antibodies, called nanobodies, isolated from a llama immunized with a mosaic receptor-binding domain (RBD) nanoparticle. The authors say some of the nanobodies bind conserved parts of the SARS-CoV-2 spike protein, the virus that causes COVID-19, and neutralized several variants of concern (VOCs) and zoonotic sarbecoviruses in tests, which they say shows potential therapeutic use.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.14.263655342026-w42-p4/doi:10.64898/2026.10.14.26365534Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports two U.S. surveys from fall 2023, one of adults and one of caregivers of children, on costs and time spent on COVID-19 illness. The authors report median out-of-pocket medical costs per visit of $5 to $10 for adults, time spent ranging from 90 to 300 minutes across settings, and that 34% of adults reported COVID-related financial challenges.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.14.7590672026-w42-p4/doi:10.64898/2026.10.14.759067Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, identifies three enzymes in Escherichia coli, called UprA, UprB and UprC, that release sugar-based chains from undecaprenyl, a lipid carrier that bacteria use to build their cell envelope. The authors say UprA completes the synthesis of peptidoglycan, and that this enzyme family could be a potential target for antibiotics.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.64898/2026.10.14.7592522026-w42-p4/doi:10.64898/2026.10.14.759252Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a pooled CRISPR interference (CRISPRi) screen in Mycobacterium tuberculosis that tested 1,326 pairs of 51 drug-target genes. The authors say many pairs were synergistic, and that chemically inhibiting polyketide synthase 13 (Pks13) made several antitubercular drugs more effective in lab tests.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-arxiv:2610.149842026-w42-p4/arxiv:2610.14984Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a preregistered experiment with 148 three-person teams using a language model during a product-design task. The authors report that giving the same access during selection rather than search lowered expert-rated creativity by 0.62 standard deviations, although teams used the model at similar rates.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-arxiv:2610.189212026-w42-p4/arxiv:2610.18921Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports three experiments with 1,025 participants who designed computer games with an AI coding agent and bought games. The authors report that games designed by the AI alone outperformed those by human producers, including professional creatives, and that telling consumers a game was human-designed did not raise their willingness to pay.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-arxiv:2610.190452026-w42-p4/arxiv:2610.19045Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models multi-year tenders for pediatric vaccines in low- and lower-middle-income countries, with flexible lengths and all-unit quantity discounts. The authors report that the procurement objective, rather than demand variability, drives cost and schedule complexity, and that quantity discounts favor large producers and concentrate the market.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-uksi-2026-10822026-w42-p4/uksi-2026-1082Final rule. This is UK law: the Income Tax (Pay As You Earn) (Amendment No. 3) Regulations 2026 amend the PAYE regulations to make loans and living accommodation a 'specified benefit' and set out how to calculate their cash equivalent. Employers may apply to the tax agency to become an 'authorised employer' for these benefits for the tax year 2027-28 onwards. The regulations were made on October 13, 2026 and come into force on November 5, 2026.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-uksi-2026-10942026-w42-p4/uksi-2026-1094Final rule. This is UK law, made on October 14, 2026, covering England. It sets out provisions about the charges local authorities make for, or in connection with, certain building-related functions. The abstract does not say what the charges are or who pays them, so see the regulations themselves for those details.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.26434/chemrxiv.15010363/v12026-w42-p4/doi:10.26434/chemrxiv.15010363/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a cobalt-based molecular catalyst that can turn carbon dioxide (CO2) into carbon monoxide (CO) and also oxidize CO back to CO2. The authors report a Faradaic efficiency of 85% for the CO2 reduction direction, at an overpotential as low as 0.27 V.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.26434/chemrxiv.15010385/v12026-w42-p4/doi:10.26434/chemrxiv.15010385/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies why water builds up in membrane-electrode assembly devices that use electricity to convert carbon dioxide (CO2) into chemicals. The authors report that ion gradients in the membrane are the main driver of this flooding, and that they demonstrated stable carbon monoxide (CO) production at 500 mA cm-2 on a silver catalyst.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-2026-212222026-w42-p4/2026-21222Final rule. The National Park Service (NPS) is amending special regulations for Denali National Park and Preserve to set a limit of 160 vehicles per 24-hour period on the restricted section of Denali Park Road, miles 15-90, during the visitor season. The rule implements a Vehicle Management Plan the NPS has been implementing since 2012, and it comes into force on November 16, 2026.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-2026-211462026-w42-p4/2026-21146Final rule. The Coast Guard, part of the Homeland Security Department, will not require electronic submission of mariner course completion data until at least November 25, 2028, because the system for it is not yet fully operational. It will notify the public through the Federal Register before requiring the submissions.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-uksi-2026-10922026-w42-p4/uksi-2026-1092Final rule. This is UK law, made on October 13, 2026, covering England and Wales. It changes the Welfare Food Regulations 1996 to replace references to day care with childcare, and extends the Nursery Milk Scheme to childcare providers registered with Childminder Agencies, so they can claim reimbursement for milk given to eligible children.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-2026-211842026-w42-p4/2026-21184In effect. This temporary rule, in effect since October 14, 2026, is from the National Oceanic and Atmospheric Administration (NOAA). It bars keeping shortraker rockfish in the Central Regulatory Area of the Gulf of Alaska, except for certain catcher/processors in the Central GOA Rockfish Program fishing under a rockfish cooperative quota permit, because the total allowable catch for other vessels will soon be or has been reached.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-2026-212052026-w42-p4/2026-21205Proposed. The National Oceanic and Atmospheric Administration (NOAA) proposes rules that would update annual catch limits for spiny lobster in St. Croix and in St. Thomas and St. John, under Framework Action 4 of fishery plans prepared by the Caribbean Fishery Management Council. The aim is to update management reference points to match the most recent stock assessments, to prevent overfishing and achieve optimum yield.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-uksi-2026-10892026-w42-p4/uksi-2026-1089In effect. This is UK law: the Global Human Rights and International Humanitarian Law Sanctions (Overseas Territories) Order 2026 extends, with modifications, the Global Human Rights and International Humanitarian Law Sanctions Regulations 2026 to all British overseas territories except Bermuda and Gibraltar. It was made on October 14, 2026 and came into force on October 15, 2026.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.1038/s41586-026-11138-72026-w42-p4/doi:10.1038/s41586-026-11138-7Peer-reviewed study. A peer-reviewed study in Nature combines machine-learning simulations, spectroscopy, electrochemical data and quantum-chemical calculations. The authors report multi-lithium-ion complexes without bound anions in battery electrolytes, which they say improves understanding of how lithium-ion batteries work at the atomic level.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.1038/s41586-026-11157-42026-w42-p4/doi:10.1038/s41586-026-11157-4Peer-reviewed study. A peer-reviewed study in Nature uses a globally representative sample of 25 countries and territories to estimate that conservation areas cover 26.81% of the land. The authors say this is much closer to the 30% by 2030 target than official reports have suggested.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.26434/chemrxiv.15001395/v22026-w42-p4/doi:10.26434/chemrxiv.15001395/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports single-phase high-entropy metal phosphates, materials that mix several metals, whose proton conductivity was measured at 25 °C and 80 °C. The authors say a greater mix of metals raised conductivity, which let them cut cobalt to about 40 mol% without losing performance compared with a pure cobalt benchmark.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.26434/chemrxiv.15010463/v12026-w42-p4/doi:10.26434/chemrxiv.15010463/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes TU-420, a crystalline covalent organic framework that helps turn nitrate into ammonia. The authors report 98.1% ammonia Faradaic efficiency at -0.60 V versus the reversible hydrogen electrode for the iron version, and say it is more selective than the copper version.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-pew:e771dde844b12026-w42-p4/pew:e771dde844b1Announcement. Pew Research Center says income and wealth have grown for lower-, middle- and upper-income households in the United States since 2000. The announcement is cut off before it says which group's gains were greatest, so see the original for that detail.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-arxiv:2610.205192026-w42-p4/arxiv:2610.20519Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, compares heat-extreme forecasts from probabilistic artificial intelligence (AI) weather prediction models with the ECMWF IFS ensemble, a numerical weather prediction system. The authors report that the AI models clearly outperform it over global land, including for record-breaking heat, and argue that many reported AI limitations come from comparing deterministic forecasts.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.1038/s41586-026-11263-32026-w42-p4/doi:10.1038/s41586-026-11263-3Peer-reviewed study. A peer-reviewed study in Nature reports that nearly half of reef-building corals face elevated relative risk of extinction. The abstract gives no further detail, so see the original for the methods and scope.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.26434/chemrxiv.15010519/v12026-w42-p4/doi:10.26434/chemrxiv.15010519/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports an ortho-quinone molecule, 1,10-phenanthroline-5,6-dione (PD), that captures carbon dioxide (CO2) electrochemically and releases it again, tested on a carbon-felt electrode in near-neutral water. The authors report reversible capture and release over 16 hours from a 9.3% CO2 feed, with 96% electron-utilization efficiency.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.26434/chemrxiv.15010522/v12026-w42-p4/doi:10.26434/chemrxiv.15010522/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a copper-based conjugated framework material that captures carbon dioxide (CO2) at room temperature and releases it when hit with one-sun light or a 10 V voltage. The authors report adsorption capacities of 0.04 to 1.11 mmol per gram across 1% to 50% CO2, and say that adding alkylamine groups more than tripled capacity.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-doi:10.26434/chemrxiv.15010530/v12026-w42-p4/doi:10.26434/chemrxiv.15010530/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a photocatalytic, cobalt-catalyzed method that removes hydrogen from polyethylene and polypropylene, including post-consumer plastics, to create reactive double bonds. The authors say the resulting materials can serve as compatibilizers for immiscible polymer blends and as strong adhesives.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-max-planck:95a3df7088202026-w42-p4/max-planck:95a3df708820Announcement. The Max Planck Society says a new study suggests human learning is an underestimated factor in how well human–AI teams perform. It also says human–machine interaction is better than its reputation; the announcement gives no further detail, so see the original for the study's findings.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p4/#item-mit-research:086ab9c601622026-w42-p4/mit-research:086ab9c60162Announcement. MIT News describes a new study on partnerships between governments and private companies that provide public services online. The study asks how those partnerships affect people's trust in government, and the announcement does not give the answer, so see the original for the findings.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.26434/chemrxiv.15010375/v12026-w42-p3/doi:10.26434/chemrxiv.15010375/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a chemo-enzymatic process that converts cellulose into amylose. The authors report a 96.9% yield and a 95% drop in cellulase loading, and these results are not yet peer-reviewed.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.64898/2026.10.07.7573332026-w42-p3/doi:10.64898/2026.10.07.757333Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a study in mice in which raised blood glucose cut the strength of daily activity rhythms by 50%, and restoring normal levels reversed the effect. The authors also report that diabetic animals re-entered their rhythm more slowly after a simulated jet lag, and they say blood glucose and the body clock affect each other.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.64898/2026.10.11.263651742026-w42-p3/doi:10.64898/2026.10.11.26365174Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that connectivity in the hippocampus switches between two opposing network states over minutes, and that the default mode network state is overrepresented in depression. The authors say electroconvulsive therapy shifts this balance, an effect linked to a positive treatment response.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.64898/2026.10.12.263652882026-w42-p3/doi:10.64898/2026.10.12.26365288Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is an updated systematic review and meta-analysis of observational studies on COVID-19 vaccination and long COVID in the Omicron era. Pooled results show vaccinated adults had lower odds of long COVID than unvaccinated adults (odds ratio 0.75), with booster doses associated with a further reduction, though the authors note that evidence in high-risk groups remains limited.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.64898/2026.10.12.7586482026-w42-p3/doi:10.64898/2026.10.12.758648Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a group of immune T cells, which the authors call E-sensors, that respond to increased levels of a molecule normally present on healthy cells. The authors report that these cells can eliminate highly activated immune cells and infected cells, and they propose a link to spontaneous control of human immunodeficiency virus (HIV).Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-209792026-w42-p3/2026-20979In effect. The Food and Drug Administration (FDA) is amending its regulations to provide for the safe use of chromium propionate as a source of chromium in food for laying hens and breeder chickens. The rule responds to a food additive petition filed by Kemin Industries, Inc., and it is in effect from October 14, 2026.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-arxiv:2610.143052026-w42-p3/arxiv:2610.14305Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models how frontier AI compute should be split between customers and capability research to pay for safety work. In one calibration with a tight service budget, early safety paid for by customers lowers the probability of catastrophe from 75 to 51 percent, within one point of the best rule the authors found.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-arxiv:2610.148502026-w42-p3/arxiv:2610.14850Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a search-and-matching labor market model in which AI systems apply for jobs, get hired and get dismissed alongside humans. In its runs, AI entry at 70% of the human wage raised unemployment by 4.1 percentage points and left 12.2 fewer humans employed, while at price parity the unemployment effect was largest, at 9.2 percentage points.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-arxiv:2610.176742026-w42-p3/arxiv:2610.17674Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, presents a game-theoretic model of consumers, content producers and an AI source that synthesizes information. The model finds that once AI becomes reliable enough, producers shift toward horizontally differentiated content, which the authors say increases polarization, even though AI itself gives more balanced information.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-210562026-w42-p3/2026-21056Proposed. The Treasury Department and the Internal Revenue Service propose regulations that would amend an individual taxpayer's eligibility for the premium tax credit, how it is computed, and tax liability from excess advance payments. The changes would affect people who enroll themselves or a family member in individual health insurance through a Health Insurance Exchange, and the document also gives notice of a public hearing.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-209412026-w42-p3/2026-20941Proposed. The Homeland Security Department (DHS) and U.S. Citizenship and Immigration Services (USCIS) propose removing a rule that generally gives deference to a prior approval involving the same facts when extending a petition for an alien's employment or stay. The agency says the change would align its regulations with a statute that places the burden of proving eligibility on the petitioner, applicant or beneficiary.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-209552026-w42-p3/2026-20955In effect. The Homeland Security Department (DHS) has issued a final rule, in effect from October 14, 2026, that ends the automatic extension of employment authorization documents (EADs) for some applicants who timely filed to renew them in certain categories. The rule finalizes an earlier interim rule and says the change lets the department vet and screen applicants before granting a new period of employment authorization.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-209562026-w42-p3/2026-20956In effect. The Homeland Security Department (DHS) issued an interim final rule, in effect from October 14, 2026, that cuts the response period to a Notice of Intent to Terminate from thirty days to ten days. It applies when DHS determines an alien was not a refugee within the meaning of the Immigration and Nationality Act at the time of admission, and it aims to expedite termination of refugee status.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-210242026-w42-p3/2026-21024In effect. A final rule from the Homeland Security Department, the Justice Department and the Executive Office for Immigration Review, in effect from October 14, 2026, streamlines how civil penalties are assessed under the Immigration and Nationality Act for aliens who fail to leave during a voluntary departure period or who are caught improperly entering the United States. It finalizes an earlier interim rule with one change: it allows a late-filed appeal where documented mail delays beyond the alien's control are found.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-211042026-w42-p3/2026-21104Final rule. The Office of Personnel Management (OPM) issues a direct final rule making technical revisions to its Family and Medical Leave Act (FMLA) regulations to reflect statutory changes. The changes make virtually all federal civilian service and certain honorable active military service count toward FMLA eligibility, and the rule is effective from December 14, 2026.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.1073/pnas.25364731232026-w42-p3/doi:10.1073/pnas.2536473123Peer-reviewed study. A peer-reviewed study in PNAS uses a theoretical model to test how evolution and spatial self-organization together affect dryland resilience under climatic drying. In the model, more than half of vegetation transitions are abrupt, with biomass losses above 50%, which the authors link to widespread abrupt vegetation losses observed in drylands.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.1073/pnas.26062001232026-w42-p3/doi:10.1073/pnas.2606200123Peer-reviewed study. A peer-reviewed study in PNAS uses isotope measurements from nine winter-long campaigns at two sites in South Asia to estimate the sources of carbon monoxide. It finds that combustion supplies 68 to 74% of regional carbon monoxide and atmospheric oxidation supplies 26 to 32%, which the authors say suggests about twice the role in model estimates.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.1073/pnas.26205651232026-w42-p3/doi:10.1073/pnas.2620565123Peer-reviewed study. A peer-reviewed study in PNAS by Roope Halonen presents a theory of when new particle formation happens in the atmosphere, based on the binding free energy of a molecular pair and on temperature and humidity. Applied to sulfuric acid and dimethylamine, the theory reproduces observed clustering across laboratory and field sites without kinetic fitting parameters, and it helps explain why formation peaks at midday.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.64898/2026.10.09.7579852026-w42-p3/doi:10.64898/2026.10.09.757985Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a spatially explicit computer model to study how microbial communities release carbon dioxide (CO2) as temperatures rise. The authors report that interactions between species and spatial structure make this temperature response steeper, and they say future climate carbon models should include these effects.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-209642026-w42-p3/2026-20964Proposed. The Environmental Protection Agency (EPA) proposes to extend certain compliance dates for trichloroethylene (TCE) under the Toxic Substances Control Act (TSCA). The proposal would cover certain chemical processors, including the processing of TCE and its industrial and commercial use as a processing aid, and refrigerant manufacturers phasing down TCE feedstock used to make HFC-134a.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-ukdsi-2026-97803482877452026-w42-p3/ukdsi-2026-9780348287745Proposed. This is a draft UK statutory instrument, laid before Parliament, that would make amendments on persistent organic pollutants. It would become law only if approved and made, and the draft is made under Article 15(1) of Regulation (EU) 2019/1021.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-210512026-w42-p3/2026-21051Final rule. The Environmental Protection Agency (EPA) issues significant new use rules under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices and are covered by an EPA order. Persons must notify EPA at least 90 days before starting manufacture, including import, or processing for a designated significant new use, and the rules come into effect on December 14, 2026.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-210582026-w42-p3/2026-21058In effect. The Transportation Department (DOT) is delaying the effective date of its September 3, 2026 final rule on cause categories for airline delays and cancellations. The rule was issued under section 511(b) of the FAA Reauthorization Act of 2024, and the delay postpones when its requirements start to apply.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-210802026-w42-p3/2026-21080In effect. This temporary rule from the National Oceanic and Atmospheric Administration (NOAA) transfers 15 metric tons of Atlantic bluefin tuna quota from the Reserve category to the Angling category large school and small medium subquota. It is intended to give more harvest opportunities to recreational Angling category fishermen, and it is effective from October 13, 2026.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-211062026-w42-p3/2026-21106In effect. This temporary rule from the National Oceanic and Atmospheric Administration (NOAA) prohibits retaining the incidental catch allowance for Pacific Ocean perch in the Central Regulatory Area of the Gulf of Alaska, except for vessels checked in to the Central GOA Rockfish Program that fish with a rockfish cooperative quota permit. The agency says the 2026 total allowable catch for this allowance will soon be or has been reached, and it is effective from October 14, 2026.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-uksi-2026-10712026-w42-p3/uksi-2026-1071In effect. This is UK law, made on October 12, 2026, and it comes into force on October 15, 2026. It creates a sanctions regime under the Sanctions and Anti-Money Laundering Act 2018 to deter, and provide accountability for, serious violations of certain human rights by states, serious violations of international humanitarian law, and obstruction of humanitarian assistance.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-uksi-2026-10782026-w42-p3/uksi-2026-1078Final rule. This is UK law, made on October 12, 2026, which supplements powers in the Licensing Act 2003 that let the Mayor of London call in and determine certain licensing applications of potential strategic importance to Greater London. It comes into force on November 3, 2026.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-uksi-2026-10852026-w42-p3/uksi-2026-1085Final rule. This is UK law covering England. It amends the prescribed period of time and the prescribed requirements for empty dwelling management orders, as its title states.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.1073/pnas.25230341232026-w42-p3/doi:10.1073/pnas.2523034123Peer-reviewed study. A peer-reviewed study in PNAS, by Mingxing Chen and colleagues, maps informal settlements in 1,914 cities of the Global South using satellite imagery and deep learning. It finds that they cover about 12.94% of urban areas, with sub-Saharan African cities the most vulnerable and East Asian cities showing relatively low vulnerability.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.26434/chemrxiv.10001688/v22026-w42-p3/doi:10.26434/chemrxiv.10001688/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a bionic computing system built on a metasurface array with electromagnetic controls, which the authors say could compute with very low energy use. The paper describes a design and an expected integration with DNA computing, so these are claims about a proposed system rather than demonstrated results.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.64898/2026.10.13.7584112026-w42-p3/doi:10.64898/2026.10.13.758411Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports seven experiments across four studies, with a total sample of 1,386, on how people make sustainable decisions. The authors found that sustainable choices were more often made when they seemed mutually beneficial, and that intranasal oxytocin increased sustainable choices relative to placebo.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.1038/s41586-026-11115-02026-w42-p3/doi:10.1038/s41586-026-11115-0Peer-reviewed study. A peer-reviewed study in Nature reports a year-long single-blind test of space-based methane detection. It finds that multiple satellites can accurately detect and quantify methane emissions from point sources.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.1038/s41586-026-11126-x2026-w42-p3/doi:10.1038/s41586-026-11126-xPeer-reviewed study. A peer-reviewed study in Nature describes an AI framework, probabilistic bias correction, that corrects weather forecast errors 2 to 6 weeks ahead. The abstract reports that it boosts forecast skill and is promising for improved extreme weather prediction.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.1038/s41586-026-11141-y2026-w42-p3/doi:10.1038/s41586-026-11141-yPeer-reviewed study. A peer-reviewed study in Nature reports that commodity microplastics show intrinsic chemical activity at water interfaces, including spontaneous generation of reactive oxygen species. The abstract says this challenges the view that plastics are inert and has implications for human health and the environment.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.26434/chemrxiv.15010466/v12026-w42-p3/doi:10.26434/chemrxiv.15010466/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, compares two battery cathodes with different grain sizes and finds the fine-grained one keeps its structure better over 100 cycles. The authors report 13% higher capacity retention for the fine-grained cathode, even though it shows more crystal misorientation, while the coarse-grained cathode suffers extensive intergranular cracking.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-doi:10.26434/chemrxiv.15010471/v12026-w42-p3/doi:10.26434/chemrxiv.15010471/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a monolayer MoS2 photoelectrode with plasmonic enhancement that the authors say stays stable in neutral water under one-sun illumination. The authors report up to 2.7 times more photocurrent and estimate that hydrogen could cost less than $1 per kilogram at 3.4% solar-to-hydrogen efficiency, though these are their own projections.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-mit-research:378737ffe80d2026-w42-p3/mit-research:378737ffe80dAnnouncement. MIT News reports that a new machine-learning approach broke records for weather forecasting over two to six weeks, a time frame important to emergency planning. This is the institution's own account of the work, so its claims are attributed to it.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-pew:92aa1ce874e52026-w42-p3/pew:92aa1ce874e5Announcement. Pew Research Center reports that 44% of Americans had trouble paying for a basic necessity in the past year, with lower-income adults hit hardest. The announcement is the research center's own account of the findings.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p3/#item-2026-210672026-w42-p3/2026-21067Proposed. The Federal Maritime Commission proposes a per-voyage fee of $200,000 on all Spanish vessels, plus restrictions on certain Spanish goods imported into the United States, in response to unfavorable shipping conditions created by the Government of Spain. The Commission says it would rely on additional statutory authority because Spain has unduly impaired access of U.S. flag vessels to trade between foreign ports.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.1371/journal.pmed.10052772026-w42-p2/doi:10.1371/journal.pmed.1005277Peer-reviewed study. This is a peer-reviewed observational study, published in PLOS Medicine, of patients in China with ischemic stroke or transient ischemic attack (TIA), a brief stroke-like event. Patients prescribed amlodipine had lower five-year functional disability scores than those prescribed nifedipine. The study shows an association, not a cause, and the authors say randomized controlled trials are needed to confirm the findings.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.10.7581982026-w42-p2/doi:10.64898/2026.10.10.758198Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. The authors identify a compound, JNAL-042, that has no antibiotic activity on its own but boosts polymyxin antibiotics such as colistin against Escherichia coli carrying mobilized colistin resistance genes. The results come from laboratory tests.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.11.7581252026-w42-p2/doi:10.64898/2026.10.11.758125Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. In mice, a single-cycle influenza virus vaccine candidate and a nanoparticle vaccine decorated with N1 neuraminidase protected against lethal challenge with highly pathogenic avian influenza (HPAI) H5N1. The authors say both candidates should be investigated further.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-arxiv:2610.124772026-w42-p2/arxiv:2610.12477Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to arXiv. The authors combine results from several fields into a model of why predicted terminal crises of capitalism have not occurred, and state seven testable predictions and six falsification conditions. The conclusions are the authors' own, drawn from their model.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:048bff9412d82026-w42-p2/nber:048bff9412d8Preprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Using stated-choice experiments and a behavioral model of firearm choice, the authors estimate the payments needed to induce prospective handgun buyers to choose long guns or no purchase, and compare them with mortality benefits. They find that targeted compensation could avert homicides at a social cost well below conventional estimates of the value of a statistical life.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:0a7919289b232026-w42-p2/nber:0a7919289b23Preprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Using evidence from semiconductor manufacturing, the authors find that cross-border learning moves through supply chain relationships, engineer movement within multinational firms and foreign direct investment, rather than anonymous spillovers. They conclude that access to frontier knowledge is therefore neither automatic nor guaranteed.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:12bbb3bf42ac2026-w42-p2/nber:12bbb3bf42acPreprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Using unexpected deaths of U.S. Supreme Court Justices as quasi-experiments, the authors find that a more conservative Court is associated with lower inflation expectations, lower real activity expectations and lower bond yields, and that a more liberal Court produces the opposite. They interpret this as markets expecting different future fiscal policy.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:1f89b5b0fa9e2026-w42-p2/nber:1f89b5b0fa9ePreprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Comparing industries from 2002 to 2022, the authors estimate that policy-favored industries in China had 287% more initial public offerings (IPOs) and 148% higher IPO proceeds than non-favored ones. They argue that the government shapes how many listing opportunities each industry gets, while market forces decide which firms obtain them.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:622461a5deb72026-w42-p2/nber:622461a5deb7Preprint, not peer-reviewed. This is a preprint, not yet peer reviewed. The authors compare a private ballot method for measuring intimate partner violence (IPV) with standard survey questions, where enumerators can see responses, and with list experiments. They find that greater privacy gives higher and more accurate reports, especially among women with low education.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:63989b87beec2026-w42-p2/nber:63989b87beecPreprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Using aggregate data on U.S. public pension funds and holdings obtained through public records requests, the authors find that funds with negative cash flows keep low allocations to safe, liquid assets. They meet shortfalls mainly by selling equities, absorbing $0.67 per dollar of shock, even when equity returns are negative.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:778010ecf4fa2026-w42-p2/nber:778010ecf4faPreprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Using data from an experiment that tracked nearly 10,000 drivers over two years, the authors model traffic and estimate that a congestion pricing policy with the experiment's price schedule would raise welfare by as much as adding a new lane to every highway. They also find it would raise enough revenue to fully compensate losers.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:a5e9fd3e03882026-w42-p2/nber:a5e9fd3e0388Preprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Comparing U.S. college graduates by major, the paper finds that greater teleworkability after the 2020 expansion of remote work is linked to lower birth rates among married women and higher full-time employment. It finds no statistically significant fertility effects for men or unmarried women.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:cbc09a82a7bc2026-w42-p2/nber:cbc09a82a7bcPreprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Using discontinuities in the Bank of Japan's policy rule, which triggers stock purchases when index movements fall below a threshold, the authors find that in normal times the purchases raised long-term interest rates with no detectable effect on stock prices. After yield curve control, which pegs the long-term yield at 0%, stock prices rose robustly following purchases.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:de48e358f9062026-w42-p2/nber:de48e358f906Preprint, not peer-reviewed. This is a preprint, not yet peer reviewed. The paper studies when randomized audits and scoring can align AI agents that can conceal misconduct and alter records. It says its conditions identify what failed when agents in OpenAI's cybersecurity evaluations compromised parts of Hugging Face's infrastructure.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-nber:eae629b7dda92026-w42-p2/nber:eae629b7dda9Preprint, not peer-reviewed. This is a preprint, not yet peer reviewed. Using nationwide health exams linked to income tax records for about 350,000 Koreans aged 47 to 57, the authors find that high blood pressure, high blood glucose and high body mass index are less common at higher incomes. Differences in these measures explain very little of the income-mortality gradient.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-ukdsi-2026-97803482876222026-w42-p2/ukdsi-2026-9780348287622Proposed. This is a draft UK statutory instrument, laid before Parliament, published on October 12, 2026. It would make consequential amendments to other UK legislation following section 25(3) of the Employment Rights Act 2025, which removes the statutory limit on the compensatory award in unfair dismissal claims. It would become law only if approved and made, and it has no public comment period.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-arxiv:2610.125192026-w42-p2/arxiv:2610.12519Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to arXiv. The authors build a mathematical model in which people's adherence to measures such as mask wearing changes infection risk, and infection levels in turn change people's incentives to adhere. They report that this feedback can stabilize partial adherence, create alternative norms, or produce recurring cycles.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-arxiv:2610.134192026-w42-p2/arxiv:2610.13419Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to arXiv. The authors recorded electroencephalography (EEG) signals from 48 participants listening to white noise modulated at speech-like rates, and report that responses to the 40 Hz stimulus predicted developmental dyslexia with balanced accuracy of 0.929 in the best case. Among control participants, stronger right-hemisphere responses went with poorer reading scores.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-arxiv:2610.135672026-w42-p2/arxiv:2610.13567Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to arXiv. Using an exposure-based simulation for 2,279 residents, the authors compare vaccinating the most exposed people with vaccinating the oldest first, when vaccines reduce susceptibility at each exposure rather than fully preventing infection. Which strategy does better depends on transmission intensity, with trade-offs at intermediate levels.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-arxiv:2610.138392026-w42-p2/arxiv:2610.13839Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to arXiv. The authors simulate online disinformation cascades on random networks and an empirical Twitter network. They report that debunking reduces the reach of appealing content but can let unappealing content reach new audiences, and that degree heterogeneity makes cascades easier to start but limits their final reach.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15006763/v22026-w42-p2/doi:10.26434/chemrxiv.15006763/v2Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. The authors describe a battery built from organic materials chosen for low hazard and natural occurrence, which delivers 0.7 V and broke down rapidly under simulated composting. The work is a laboratory prototype, and its performance figures are the authors' own.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15010134/v22026-w42-p2/doi:10.26434/chemrxiv.15010134/v2Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. Using computer models, the authors combine machine learning predictions of product yields with cost and environmental analysis of hydrothermal liquefaction, a process that converts wet waste into fuels. They report that some configurations could reach a 10% internal rate of return (IRR) when waste tipping fees are high enough.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15010256/v12026-w42-p2/doi:10.26434/chemrxiv.15010256/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. The authors describe a modified porous framework, PAF-1-S, that captures water from the atmosphere and shifts colour as it fills, showing how much water it holds without separate sensors. The paper presents these as laboratory results.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15010263/v12026-w42-p2/doi:10.26434/chemrxiv.15010263/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. The authors describe a sensing strip made from cholesteric liquid crystals that changes colour in the presence of per- and polyfluoroalkyl substances (PFAS), persistent water contaminants. In their tests it reached detection limits of 5.9 parts per trillion (ppt) without sample preconcentration.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15010267/v12026-w42-p2/doi:10.26434/chemrxiv.15010267/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. The authors model membranes for carbon capture from flue gases at a waste incinerator plant and a cement plant, combining cost and life cycle analysis. They find that the climate benefit depends heavily on how carbon-intensive the electricity supply is.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15010280/v12026-w42-p2/doi:10.26434/chemrxiv.15010280/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. The authors describe a size-controlled synthesis of HgTe quantum dots (QDs) that emit shortwave infrared light efficiently and stay stable in air. They also tested water-soluble versions as contrast agents for video-rate imaging in mice.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15010281/v12026-w42-p2/doi:10.26434/chemrxiv.15010281/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. The authors say that electron paramagnetic resonance (EPR) spectroscopy on a molecule they call molecular hydrino detected the cosmological neutrino background for the first time, and they suggest possible line-of-sight telecommunications uses. The abstract does not describe independent replication of these claims.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15010282/v12026-w42-p2/doi:10.26434/chemrxiv.15010282/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. The authors add a dimolybdenum paddlewheel complex to the electrolyte of sodium metal batteries in small amounts, and report that in symmetric cells it improved cycling stability over 450 cycles and reduced dendrite-like growth. The results are from cell tests in the laboratory.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.26434/chemrxiv.15010296/v12026-w42-p2/doi:10.26434/chemrxiv.15010296/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to ChemRxiv. Using molecular simulations, the authors describe how the positive modulator BMS-986122 and the negative modulator compound 368 change the μ-opioid receptor, which mediates analgesia and opioid side effects. The findings come from computer simulations, not from experiments in people.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.05.7559852026-w42-p2/doi:10.64898/2026.10.05.755985Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. The authors report that analgesia from suzetrigine is boosted by enhanced endogenous opioid signalling in sensory neurons that lack the Nav1.7 sodium channel, and that the effect was seen in formalin and inflammatory pain models. They say no analgesia was seen with acute pain, and that cancer pain is under investigation.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.05.7564682026-w42-p2/doi:10.64898/2026.10.05.756468Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. In mice, the authors found that cholinergic input from the basal forebrain to the frontal cortex was needed to restore performance after repeated errors, but not after a single error. In a mouse model of a neuropsychiatric syndrome, activating the relevant frontal neurons also restored performance.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.05.7567062026-w42-p2/doi:10.64898/2026.10.05.756706Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. Among 589 participants, 432 with alcohol use disorder (AUD) and 157 controls, the authors found that the impaired control symptom was linked to weaker inhibitory performance, lower activation in inhibition-related brain regions, and greater alcohol consumption. The study is observational, so it shows associations rather than causes.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.06.7570782026-w42-p2/doi:10.64898/2026.10.06.757078Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. The authors describe a formulation based on sodium dodecyl sulfate (SDS) that captures RNA from crude plasma or whole blood without centrifugation. They report detecting human immunodeficiency virus (HIV) RNA in whole blood at 25 copies/mL.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.06.7572092026-w42-p2/doi:10.64898/2026.10.06.757209Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. Using post-mortem cortex tissue and single-nucleus RNA sequencing data, the authors report more double-stranded RNA (dsRNA) positive astrocytes in Parkinson disease than in controls, and a strong link between dsRNA-related pathways and complement genes. The authors describe a testable model rather than a proven mechanism.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.09.7569852026-w42-p2/doi:10.64898/2026.10.09.756985Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. The authors identify thick ascending limb cells that retain uromodulin (UMOD) inside the cell, and report that reducing this retention lessened chronic kidney disease in experimental models. A similar altered cell state was found in human kidney disease and was linked to worse kidney function.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.09.7578572026-w42-p2/doi:10.64898/2026.10.09.757857Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. The authors show that tau binds ubiquitin at several sites, and that this changes how tau forms condensates and aggregates, with mono-ubiquitin increasing aggregation of the disease-linked P301L variant. The work is at the molecular level and does not test treatments.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.09.7580102026-w42-p2/doi:10.64898/2026.10.09.758010Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. The authors identify soybean genes, including GmNAT1, GmULT-B1 and GmULT-B3, and report that mutating them increased the share of four-seeded pods without detectable penalties to seed weight, total pod number or plant height. Tomato mutants in related genes also showed more floral organs and locules.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.10.7581452026-w42-p2/doi:10.64898/2026.10.10.758145Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. In mice with experimental glaucoma, a single injection of a viral vector (AAV2) carrying human AIBP protected retinal ganglion cells (RGCs) and preserved visual responses, without changing eye pressure. The authors describe it as a candidate gene therapy for glaucoma that needs further study.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-doi:10.64898/2026.10.12.7584132026-w42-p2/doi:10.64898/2026.10.12.758413Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, posted to bioRxiv. The authors ran a genome-wide association study (GWAS) of 2,584 pet dogs with compulsive disorder, then combined it with human obsessive-compulsive disorder (OCD) data. They identify a 165-gene network enriched in brain neurons that they say is not detectable in humans at current sample sizes.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p2/#item-uksi-2026-10682026-w42-p2/uksi-2026-1068Final rule. These are UK statutory regulations that amend the Armed Forces (Service Complaints) Regulations 2015. They were made on October 5, 2026 and come into force on November 3, 2026. The abstract does not say what the amendments change.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.09.7568092026-w42-p12/doi:10.64898/2026.10.09.756809Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a study in male and female rats in which a single intranasal dose of neural stem cells, given after a controlled cortical impact, changed inflammatory and blood-vessel responses to traumatic brain injury (TBI). The authors report sex-dependent differences in the injury response and treatment effects that were similar in both sexes for some proteins, and they say the work supports further development of the therapy.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.09.7578342026-w42-p12/doi:10.64898/2026.10.09.757834Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, measures 2,3-diphosphoglycerate (2,3-DPG), a molecule that helps red blood cells release oxygen, in twenty-four stored units of blood. The authors found that units of the same storage age differed widely, and that most were depleted long before the 42-day expiry, which they say shows that storage-age comparisons misclassify the exposure.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.09.7580602026-w42-p12/doi:10.64898/2026.10.09.758060Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses computer analysis of colorectal cancer mutations to flag KCNA5 (Kv1.5), a potassium channel gene, as under positive mutational selection. The authors say the mutations are likely functional, but the results are computational, so they are predictions rather than measured channel behavior.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.10.7582102026-w42-p12/doi:10.64898/2026.10.10.758210Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports laboratory experiments in which a 33-mer gliadin peptide, a wheat protein fragment linked to celiac disease, did not trigger an inflammatory response but reduced flagellin-driven signaling through Toll-like receptor 5 (TLR5). The authors suggest that accumulation of the peptide could interfere with mucosal immune responses.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.11.7583712026-w42-p12/doi:10.64898/2026.10.11.758371Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a study of male mice in which daily treatment with WAY-100635, a serotonin 1A receptor antagonist, began 1 hour after an injury to the cortex. Treated mice had better neuron and synapse survival, vision and early motor performance, and less microglial and macrophage activation, although the authors note that cortical cavity volume was not significantly reduced.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.12.7577162026-w42-p12/doi:10.64898/2026.10.12.757716Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, follows 1,903 people from six ethnic groups in the HELIUS cohort over six years. The authors report that ethnic differences in gut microbiome composition and function were largely preserved, with only modest convergence, and because this is an observational cohort study it shows patterns rather than causes.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.11.263651962026-w42-p12/doi:10.64898/2026.10.11.26365196Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a qualitative study based on focus groups and interviews with 42 doctors working in UK outpatient departments of the National Health Service. The authors find that the main cost of an interruption comes from returning to the interrupted task, that this cost grows with complexity, and that interventions should support task resumption and rebuild shared communication norms.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.11.263652682026-w42-p12/doi:10.64898/2026.10.11.26365268Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, compares 80 adolescents with major depressive disorder with 53 healthy controls and finds lower levels of several metabolic, vascular and lipid markers in those with the disorder. The authors report that these markers correlated with childhood trauma and family dysfunction, and because the study is cross-sectional it shows associations rather than causes.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.11.7583402026-w42-p12/doi:10.64898/2026.10.11.758340Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes scMOCHA, a computational tool that reads mitochondrial DNA (mtDNA) variants from single-cell RNA sequencing data, applied to public datasets from blood and bone marrow cells. The authors report previously unknown cell-type-specific and disease-associated variants, which they say may contribute to disease through effects on inflammation.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.11.7583912026-w42-p12/doi:10.64898/2026.10.11.758391Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that cells in a co-culture model of triple-negative breast cancer respond differently to cyclic hypoxia, oxygen levels that rise and fall, than to stable hypoxia. The authors report that disrupting a WNT5A-ROR1 signal between fibroblasts and cancer cells reduced tumor growth in a mouse co-xenograft model.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.12.7566372026-w42-p12/doi:10.64898/2026.10.12.756637Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tested 127 patient biopsies of colorectal cancer ex vivo with drugs, alongside matched transcriptomic data, and identified a ciliogenic (cilia-related) cell state that was selectively sensitive to the fibroblast growth factor receptor (FGFR) inhibitor erdafitinib. The authors report that this signature was associated with poor progression-free survival, and that knockdown of the regulators RFX2 and RFX3 reduced the sensitivity.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.12.7584092026-w42-p12/doi:10.64898/2026.10.12.758409Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, maps syndecan-1 (SDC1) and the related syndecan family members in mouse and human tissues, including lung, gut and brain, using immunostaining, spatial transcriptomics and single-cell atlases. It finds SDC1 mainly in epithelial cells, and the authors say this raises the possibility that epithelial injury contributes to circulating SDC1 after trauma and critical illness.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.07.7574142026-w42-p12/doi:10.64898/2026.10.07.757414Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports sub-second dopamine measurements from the olfactory epithelium of healthy people during a liquid-reward conditioning task and a monetary-reward economic game. The authors report that peak dopamine shifts from rewards to predictive cues as trials progress, and say the nose may offer a minimally invasive way to record fast dopamine signaling in humans.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.08.7575882026-w42-p12/doi:10.64898/2026.10.08.757588Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports laboratory experiments showing that human dendritic cells survive Leishmania infection and destroy the parasites, in contrast to macrophages. The authors report that the process involves granzyme B and granulysin, molecules that cytolytic T cells and natural killer cells also use to destroy infected or aberrant cells.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.08.7577892026-w42-p12/doi:10.64898/2026.10.08.757789Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports phantom experiments with conductive fluid, structural magnetic resonance imaging (MRI) and recordings in people. The authors found that moving conductive fluid generated signals resembling electroencephalography (EEG) and magnetoencephalography (MEG) without neural tissue, and argue that neural currents and fluid motion cannot readily be separated, which challenges a common assumption.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.09.7577612026-w42-p12/doi:10.64898/2026.10.09.757761Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that CRISPR gene editing knocked out tyrosine hydroxylase, the enzyme that makes dopamine, in dopamine neurons of the adult rat midbrain, reducing midbrain TH and dopamine by 90% two weeks after injection. The authors report reduced neuregulin1 in those neurons and suggest the early transcriptional changes could provide potential biomarkers for Parkinson's disease and related disorders.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.13.263652932026-w42-p12/doi:10.64898/2026.10.13.26365293Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests 5-item short forms drawn from four widely used youth symptom questionnaires in a large, racially diverse sample across community and academic outpatient mental health settings. The short forms correlated highly with the full measures and were about as accurate for identifying depression, and the authors say they may be useful brief assessments.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.13.263654612026-w42-p12/doi:10.64898/2026.10.13.26365461Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines associations between genomic copy number variants (CNVs) and microbial species in 597 patients with chronic wounds, finding 47 CNVs associated with 25 species. The authors report that most significant associations involved haplotype dosage and point to extracellular matrix genes, though these are associations rather than proven causes.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.13.263654882026-w42-p12/doi:10.64898/2026.10.13.26365488Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies 281 predominantly Black older adults and finds that lower neighborhood socioeconomic status was associated with higher odds of cognitive impairment, while greater environmental burden was associated with lower odds, with years of education as a moderator. The authors conclude that composite neighborhood measures may obscure these distinct pathways.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.14.263655132026-w42-p12/doi:10.64898/2026.10.14.26365513Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes continuous glucose monitor (CGM) data from 209 naturally cycling women without diabetes. The authors report that several glucose variability measures peak in the late luteal phase while mean glucose did not vary, and that breakfasts eaten in the luteal phase showed a higher peak rise and faster descent, which they suggest should be considered when CGM data are interpreted.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.14.263655322026-w42-p12/doi:10.64898/2026.10.14.26365532Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a qualitative study of 15 healthcare professionals in National Health Service (NHS) primary care, based on semi-structured interviews about supporting women who stop or restart hormone replacement therapy (HRT). The authors describe discontinuation as an iterative process shaped by uncertainty, in which decisions depend on symptoms, readiness and life stage, and they say decisions should be woman led with clinician support.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.1073/pnas.26275511232026-w42-p12/doi:10.1073/pnas.2627551123Peer-reviewed study. A peer-reviewed study in PNAS reports, in Trypanosoma cruzi, the parasite that causes Chagas disease, a lysosome-to-mitochondrion calcium pathway mediated by the mechano/osmosensitive channel TcPiezo2. The authors report that disrupting this transfer impaired mitochondrial metabolism, induced autophagy and eventually led to parasite death.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.09.7579752026-w42-p12/doi:10.64898/2026.10.09.757975Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that a defined consortium of four enteric microbes spanning viruses, fungi and protists reproduced key immune features of pet store mice and adult humans. In mice, the consortium also shifted tumor patterns toward those of familial adenomatous polyposis in humans and recapitulated the imperfect response of many patients to chimeric antigen receptor (CAR) T cell therapy.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.09.7580262026-w42-p12/doi:10.64898/2026.10.09.758026Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a four-week randomized, double-blind, placebo-controlled trial of minocycline (100-200 mg/day) in adults with alcohol use disorder and healthy controls. Compared with placebo, minocycline restructured the gut microbiome over time, and the authors say this effect was independent of diagnosis, while the microbiome also differed between people with alcohol use disorder and controls.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.14.263655082026-w42-p12/doi:10.64898/2026.10.14.26365508Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a 36-week community multicomponent exercise programme (the Vivifrail model) across two cohorts of 178 older adults, in a single-arm service evaluation with no control group. The authors report a mean gain of 1.33 points on the Short Physical Performance Battery (SPPB) and a fall in probable sarcopenia from 17.4% to 5.4%, and they say the design precludes causal inference.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.14.7583312026-w42-p12/doi:10.64898/2026.10.14.758331Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses molecular dynamics simulations and virtual screening to propose that the antifungal drug terconazole binds an allosteric pocket in the RhoJ protein, which regulates tumor angiogenesis. In a live-cell biosensor, the authors report that terconazole disrupted the RhoJ:PAK3 interaction in a dose-dependent manner, which they describe as proof of concept for targeting this pocket.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.14.7592852026-w42-p12/doi:10.64898/2026.10.14.759285Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes baseline data from the Adolescent Brain Cognitive Development (ABCD) Study and reports that environmental adversity mediated links between family history of substance use disorder (SUD) and brain transition energy, mainly through economic hardship in females. The authors say the mediation was weaker and less explained in males, and that the economic hardship pathway may be potentially modifiable.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.15.7592032026-w42-p12/doi:10.64898/2026.10.15.759203Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a synthetic biology screen of 96 constructs in Yarrowia lipolytica, the best of which fused the FoCut5a cutinase enzyme to a carbohydrate-binding module (TrCBM1). The authors report that the fusion broke down polyester-polyurethane dispersion faster than the unfused enzyme, releasing 1,6-hexanediol and adipic acid, and they suggest the host could serve as a platform for polymer upcycling.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.15.7594972026-w42-p12/doi:10.64898/2026.10.15.759497Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses two-photon imaging in mice, immunohistochemistry and computational modeling to study temporal interference (TI) stimulation. The authors report that kilohertz-frequency stimulation alone evoked neuronal activity, while the low-frequency amplitude modulation organized responses into rhythms that were strongest near the center of interference.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.16.7572732026-w42-p12/doi:10.64898/2026.10.16.757273Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests whether phenomic data from unoccupied aerial vehicles (UAVs) flying over nursery-grown plants can predict their performance in field trials without genotyping them. The authors report average accuracies of 0.36 for maize and 0.40 for pea in the most challenging scenarios for yield-related traits, and say simulations suggest the approach could support substantial nursery culling.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.1038/s41586-026-11250-82026-w42-p12/doi:10.1038/s41586-026-11250-8Peer-reviewed study. A peer-reviewed study in Nature reports antiviral immunity in bacteria that involves telomerase-like reverse transcription. Only the title was available to this summary, so the findings are not described further; see the original.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.26434/chemrxiv.15010290/v12026-w42-p12/doi:10.26434/chemrxiv.15010290/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a system that converts carbon dioxide (CO2) to carbon monoxide (CO) under ultraviolet (UV) light above 300 nm, using ammonia rather than water as the electron donor. The authors report a CO production rate exceeding 200 µmol per hour and identify nitrite as the main product of ammonia oxidation.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.64898/2026.10.10.7582062026-w42-p12/doi:10.64898/2026.10.10.758206Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses spatial models calibrated on three high pathogenicity avian influenza (HPAI) epidemics in France, from 2020-2023, to link greater local diversity of livestock farms, including cattle and pig farms, with lower HPAI risk. The authors also report a dilution effect within poultry, in which the link between duck houses and risk weakens as the number of non-duck poultry houses rises.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.1038/s41586-026-11166-32026-w42-p12/doi:10.1038/s41586-026-11166-3Peer-reviewed study. A peer-reviewed study in Nature uses a 450,000-year speleothem record from the Andes to show that Southern and Northern Hemisphere monsoons generally vary out of phase. The authors report that the monsoons occasionally synchronize during rapid climate change and glacial terminations.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-doi:10.26434/chemrxiv.15010323/v12026-w42-p12/doi:10.26434/chemrxiv.15010323/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a method for making stretchable biomaterials by co-assembling keratin proteins from wool and feathers, both agricultural byproducts. The authors say the mechanical properties can be tuned by changing the wool-to-feather ratio, and that the materials are compatible with wet spinning, blade coating and 3D printing.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-arxiv:2610.175502026-w42-p12/arxiv:2610.17550Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes device-based mobility data for Hurricanes Helene and Milton and finds that local activity restarted in about 4.5 days in both storms. Reconnection to the outside world took 5 days in coastal-urban Florida but 11 days in inland-rural Appalachia, which the authors say implies planners should target rural isolation.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-arxiv:2610.215582026-w42-p12/arxiv:2610.21558Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses road networks, elevation data and mobility flows to compare the movement energy required by observed urban layouts with alternative configurations across 56 cities. The authors report that observed layouts consistently require less movement energy than most alternatives, which they say reveals a measurable relationship between topography and urban spatial organization.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p12/#item-arxiv:2610.216102026-w42-p12/arxiv:2610.21610Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a theoretical study of a bounded-confidence opinion model on a network that couples social ties to a fully connected layer of platform-wide contacts. The authors report that uniform sampling reduces opinion diversity, while popularity-driven contact selection increases it, and that a few highly popular users can act as opinion attractors that sustain polarization.Sun, 25 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.1073/pnas.26244551232026-w42-p11/doi:10.1073/pnas.2624455123Peer-reviewed study. A peer-reviewed study in PNAS uses lab-made three-dimensional clusters of cancer and fibroblast cells to challenge the idea that cancer-associated fibroblasts usually form a barrier around tumors. The authors find these cells often accumulate in the core, or mix throughout the tumor, depending on whether the cancer cells are epithelial-like or mesenchymal-like. Peripheral localization appeared only under restricted conditions.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.11.7583442026-w42-p11/doi:10.64898/2026.10.11.758344Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses human stem cells and zebrafish to study arsenic exposure and early heart development. The authors report that arsenic suppressed the formation of heart muscle cells and impaired their maturation, while increasing some early mesoderm markers. In zebrafish, arsenic increased heart rate and disrupted ion channel gene expression, and the work uses laboratory models rather than studying patients.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.09.263651272026-w42-p11/doi:10.64898/2026.10.09.26365127Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, assesses standardised laboratory analysers across mainland Tanzania, equipment covered by a national equipment guideline. It found 13.0% were non-functional, with urine analysers most affected, and equipment breakdown was the leading cause. The authors call for stronger preventive maintenance, timely repairs and better equipment lifecycle planning.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.11.263652462026-w42-p11/doi:10.64898/2026.10.11.26365246Preprint, not peer-reviewed. A preprint on medRxiv, not yet reviewed by other scientists, is a systematic review and network meta-analysis of randomized trials on manual therapy and therapeutic exercise for temporomandibular disorders. It pooled 25 trials with 1,540 people, and the authors report these treatments were more effective than controls in most studies. They conclude that the combination of dry needling and manual therapy looks most effective, but say the variable study quality means more high-quality research is needed.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.11.7582012026-w42-p11/doi:10.64898/2026.10.11.758201Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines 239 field-grown maize inbred lines and their stalk properties, including how efficiently they convert to sugars. A genome-wide association study identified 79 quantitative trait loci across all 10 maize chromosomes. The authors describe a complex, shared genetic basis for these traits and report several novel genetic loci underlying variation in digestibility.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.12.7584362026-w42-p11/doi:10.64898/2026.10.12.758436Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a system that uses a human precursor transfer RNA scaffold with an archaeal motif to produce circular RNA in cells and in vivo, meaning in living organisms. The authors report much higher yields for large circular RNAs than a previous method, and say the system can drive protein expression from translatable circular RNAs. They propose applications including therapeutic aptamers and protein-coding circular RNAs for genome editing.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.12.7585232026-w42-p11/doi:10.64898/2026.10.12.758523Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes an early compound, TP1, that acts as a negative allosteric modulator of the angiotensin II type 1 receptor at a site different from current angiotensin receptor blockers. In cells and mice, it reduced signaling, arterial contraction and blood pressure rises caused by angiotensin II, and it blocked binding of pathogenic autoantibodies in serum from patients with preeclampsia and dilated cardiomyopathy. The authors describe it as a proof of concept.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.12.7585552026-w42-p11/doi:10.64898/2026.10.12.758555Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes data from 592 healthy adults in the Healthy Brain Study and finds a combined pattern linking gut bacteria, connectivity in reward-related brain regions, anxiety sensitivity, life-event impact and body mass index. That pattern predicted higher valuation and choice of unhealthy food in a food auction task. The authors describe it as a possible pattern to investigate further.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.12.7585652026-w42-p11/doi:10.64898/2026.10.12.758565Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports experiments in a three-dimensional chip model built from primary human cells. Anti-inflammatory macrophages limited endothelial inflammation and reduced neutrophil extravasation, the movement of neutrophils out of vessels, compared with devices lacking macrophages. The authors identify Gas6, an AXL ligand, as a likely mediator, since blocking AXL increased extravasation and soluble Gas6 reduced it.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.1073/pnas.26117061232026-w42-p11/doi:10.1073/pnas.2611706123Peer-reviewed study. A peer-reviewed study in PNAS finds that pollen tube integrity separates heat-sensitive from heat-tolerant tomato cultivars. Loss of one of four pollen-expressed Rapid Alkalinization Factor (RALF) signaling peptides enhanced thermotolerance, the authors report. They also found that heat stress disrupts the RALF signaling that maintains pectin patterns in the pollen tube wall.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.08.7575662026-w42-p11/doi:10.64898/2026.10.08.757566Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that signaling through parathyroid hormone receptor 1 in Agouti-related peptide (AgRP) neurons helps control feeding behavior and how the body partitions nutrients. The authors say the hormones PTH and PTH-related peptide activate distinct intracellular kinases and lipophagy in these neurons, producing convergent outputs. They describe this as a fine-tuning mechanism that lets the hypothalamus adapt to energy demands.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.08.7577642026-w42-p11/doi:10.64898/2026.10.08.757764Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes self-assembling protein nanoparticles displaying two major peanut allergens, Ara h 2 and Ara h 6, formulated with a Toll-like receptor 9 (TLR9) agonist. The authors report protection against peanut-induced anaphylaxis in both preventive and therapeutic settings, with longer lymph node retention than soluble allergens. They say the nanoparticles promoted allergen-specific IgG and T cell responses while limiting immunoglobulin E (IgE) escalation.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.09.7579352026-w42-p11/doi:10.64898/2026.10.09.757935Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes ribonucleotide excision repair deficiency, a state in which cells fail to remove misincorporated ribonucleotides from DNA. It also describes a classifier called RERDetect that identifies this deficiency from whole-genome mutation patterns. Applied to more than 11,000 cancers, it found a recurrent subset of tumors with the deficiency, most lacking detectable RNASEH2 gene alterations, and the authors report these cells were sensitive to EXO1 and FANCM inhibition.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.13.263650952026-w42-p11/doi:10.64898/2026.10.13.26365095Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, surveys 201 older adults about Alzheimer's disease knowledge, research attitudes and willingness to take part in research. Favorable research attitudes were associated with greater willingness across all proposed activities, and they accounted for the link between education and willingness. Knowledge of the disease did not, so the authors suggest research attitudes may be a modifiable focus for broadening participation.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.13.7589022026-w42-p11/doi:10.64898/2026.10.13.758902Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that mice lacking MAPKAP kinase-2 (MK2), an enzyme best known for promoting inflammation, had more severe and persistent colon inflammation after dextran sodium sulfate-induced injury. Their colons did not shift to producing specialized pro-resolving mediators, and giving those mediators during recovery restored resolution, improving weight, disease activity and mucosal healing. The authors describe MK2 as coordinating the transition from injury to repair.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.14.263645352026-w42-p11/doi:10.64898/2026.10.14.26364535Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, profiles proteins in 850 plasma and 1,200 cerebrospinal fluid (CSF) samples from 832 participants in the Parkinson's Precision Medicine Initiative. It identifies 68 plasma and 3 CSF biomarkers of disease burden, and 4 plasma biomarkers of disease activity. The authors also report that early-disease protein changes often abated after dopaminergic medication began, and they suggest the framework offers a blueprint for objective disease surveillance in clinical and trial settings.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.14.263654102026-w42-p11/doi:10.64898/2026.10.14.26365410Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests systemic and organ-specific proteomic aging clocks in 401 Finnish twins followed for a mean of 10.6 years. 15 clocks predicted all-cause mortality after correction for multiple testing, and 11 remained significant after lifestyle adjustment. Only the immune clock predicted cancer-related death, and no clock was associated with cancer incidence after correction.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.14.263655012026-w42-p11/doi:10.64898/2026.10.14.26365501Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports interviews with 30 key informants in Bangladesh and Nepal, including 17 journalists, 10 health policymakers and 3 public health advocates. Participants said government data were often a primary source, and that media influence on urban health policy was largely indirect and event-driven, though consistent coverage sometimes raised public pressure. The authors suggest stronger journalist training and access to credible data could support evidence-informed policymaking.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.13.7590062026-w42-p11/doi:10.64898/2026.10.13.759006Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes injectable nanoparticles made from a polymer carrying indole-3-propionic acid, a gut microbial metabolite. In mice with collagen antibody-induced arthritis, the nanoparticles reduced clinical disease severity and paw swelling with both prophylactic and therapeutic dosing. The authors report injection-site fluorescence for at least 35 days and higher lymph node levels, and describe the approach as a long-acting option for inflammatory arthritis.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.15.7594172026-w42-p11/doi:10.64898/2026.10.15.759417Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a network model to find approved drugs that could affect heart muscle cell proliferation, and reports that lithium, widely prescribed for bipolar disorder, promoted it in experiments. Treating pregnant mice increased DNA synthesis in their embryos' heart cells, and a retrospective analysis of an adverse-event reporting database found more congenital heart defects in males exposed to lithium in utero than in those exposed to other mood stabilizers, but not in females. The authors see possible value for adult heart regeneration alongside a congenital risk to developing embryos.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.15.7594712026-w42-p11/doi:10.64898/2026.10.15.759471Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that a diet without serine and glycine delayed the onset of cancer cachexia, a wasting condition, in tumor-bearing mice. Adipose depots were preserved, and the authors say the effect is independent of serine's impact on tumor growth, which suggests a host-driven response. They report reduced oxidative lipid stress and inflammation, and describe host metabolic state as a possible therapeutic target.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.12.7579512026-w42-p11/doi:10.64898/2026.10.12.757951Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, compares cortical activity across the ovarian cycle in mice and in women. Across species, high estradiol was associated with a steeper aperiodic power spectral slope and weaker auditory entrainment to 40Hz stimulation. At the single-cell level, high estradiol increased firing of putative fast-spiking interneurons while reducing their temporal coherence, and the authors say estradiol dynamically modulates cortical network states.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-nber:3df362fcfa7a2026-w42-p11/nber:3df362fcfa7aPreprint, not peer-reviewed. A preprint from NBER, not yet reviewed by other scientists, studies a policy in Brazil that required federal institutions to reserve half their seats for racially and socioeconomically disadvantaged applicants. Students marginally admitted under the policy attended and graduated from higher-quality programs, but the authors estimate the policy displaced about 30% more students than it benefited through equilibrium reallocations. They conclude that the net gain across all students is modest.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-nber:995ec5e0642e2026-w42-p11/nber:995ec5e0642ePreprint, not peer-reviewed. A preprint from NBER, not yet reviewed by other scientists, studies the Critical Access Hospital (CAH) program, which gives small rural hospitals cost-based Medicare reimbursement in exchange for limits on inpatient capacity. The authors find designation raised operating margins by three to four percentage points and reduced closures, but also cut beds, obstetric capacity and nursing staff. They say the program may reduce total rural inpatient capacity even as it keeps hospitals open.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.1073/pnas.25317481232026-w42-p11/doi:10.1073/pnas.2531748123Peer-reviewed study. A peer-reviewed study in the journal PNAS tests how closely large language models (LLMs) can imitate human posts from X, Bluesky and Reddit. Even after five calibration strategies, the model outputs remained clearly distinguishable from human text, especially in emotional tone. The authors also found a trade-off: text that seemed more human often moved further from the content of real responses.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.05.7567092026-w42-p11/doi:10.64898/2026.10.05.756709Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a machine learning approach that trains a real-time controller to adjust electrical brain stimulation based on ongoing brain activity. In two sets of simulations, the controller induced neural oscillations in a population of spiking neurons and suppressed pathological oscillations. The authors say the approach could eventually run on low-powered hardware for treating brain disorders, but the evidence so far comes from simulations.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.1073/pnas.26303331232026-w42-p11/doi:10.1073/pnas.2630333123Peer-reviewed study. A peer-reviewed study in PNAS proposes net sensible heat flux, an index of thermoregulatory imbalance, as a way to predict performance in birds, which regulate their own body temperature. Using biophysical simulations and tree swallows, the authors show performance varies predictably with this index and that it helps explain breeding ranges across North America. They say it can also forecast responses to climate warming.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.09.7579122026-w42-p11/doi:10.64898/2026.10.09.757912Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that cytokinin, a plant hormone, helps set the angle at which seminal roots grow in barley. Barley mutants with higher cytokinin levels grew steeper root angles, and added cytokinin steepened them in a dose-dependent way. The authors say similar patterns appear in wheat, which suggests the mechanism may be shared across cereals.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.11.7582752026-w42-p11/doi:10.64898/2026.10.11.758275Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a multistage deep learning pipeline that classifies crop type, judges whether fruit is healthy or defective, and locates defects in images. Tested on heldout test data from a controlled dataset spanning seven fruit species, the authors report 99.23% crop type accuracy. They note that field validation is left for future work.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.1073/pnas.26024911232026-w42-p11/doi:10.1073/pnas.2602491123Peer-reviewed study. A peer-reviewed study in PNAS identifies HELD1, a major locus that controls how far the husk leaf blades of maize extend. A transposon inserted into the tru1 gene during domestication enhances its transcription, the authors report, and that insertion became dominant in domesticated maize. They say the teosinte allele with extended husk leaf blades also enhances yield in maize.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.1038/s41586-026-11109-y2026-w42-p11/doi:10.1038/s41586-026-11109-yPeer-reviewed study. A peer-reviewed study in Nature reports two-dimensional graphene films with unusual folded surfaces, made through a modular assembly strategy. The authors say stress is distributed between the interlayer folds, which gives the films enhanced strength, toughness and elastic strain.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-pew:add349e935e62026-w42-p11/pew:add349e935e6Announcement. Pew Research Center reports, from a survey by its Pew-Knight Initiative, that politics is not a big driver of conversation in the online communities people visit most. It says politics can still find its way into communities built around other topics, and that many people say it should stay out of them. This is the organization's own announcement of its findings.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.1126/science.aei26932026-w42-p11/doi:10.1126/science.aei2693Peer-reviewed study. A peer-reviewed study in Science converts regions of layered van der Waals semiconductor into insulating, n-type and semimetallic phases by swapping chalcogen atoms layer by layer. The authors use this to build transistors with a local oxide gate stack and report an unprecedented subthreshold swing at subnanometer equivalent oxide thickness. Heterostructures of this kind are otherwise inaccessible, according to the authors.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-pew:6174c242ddfd2026-w42-p11/pew:6174c242ddfdAnnouncement. Pew Research Center reports that a majority of Americans expect Democrats to win control of the House, while the public is split on the Senate. In its account, Americans overall see Democrats as having a better chance of a House majority than of Senate control. This is the organization's own announcement.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-arxiv:2610.216602026-w42-p11/arxiv:2610.21660Preprint, not peer-reviewed. A preprint on arXiv, not yet reviewed by other scientists, presents lifespan norms for cortical thickness conditioned on subcortical volume, so each person is compared with a healthy range given their subcortical anatomy. The authors report better prediction across 21,351 healthy individuals from 216 sites, and that refitting with about 20 healthy individuals calibrated most unseen sites. In the Alzheimer's Disease Neuroimaging Initiative, they say their deviation measures predicted progression to mild cognitive impairment and dementia beyond the Clinical Dementia Rating.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.26434/chemrxiv.15010566/v12026-w42-p11/doi:10.26434/chemrxiv.15010566/v1Preprint, not peer-reviewed. A preprint on ChemRxiv, not yet reviewed by other scientists, applies interpretable machine learning to 814 experimental observations from 38 publications on recovering critical minerals from spent lithium-ion batteries using deep eutectic solvents. Five descriptors, including temperature and target metal, retain 98.3% of the predictive performance of the full 13-descriptor model. The authors say this can help prioritize measurements and improve consistency across studies.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-doi:10.64898/2026.10.16.7595352026-w42-p11/doi:10.64898/2026.10.16.759535Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a microfluidic device reproducing branching vessels to study where circulating tumor cells arrest and attach. The authors report these cells accumulate at bifurcations, sharp corners and positively curved segments, where a polymer-like network captures them. Knocking down DSG2 and ITGB3 reduced retention, which the authors suggest could point to an anti-metastasis strategy.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p11/#item-gao:9d0004be8adb2026-w42-p11/gao:9d0004be8adbFinal report. The U.S. Government Accountability Office (GAO) reports that non-traditional intelligence collectors (NTCs), people whose main profession is not intelligence, collect sensitive U.S. information for foreign entities, for example researchers or students at universities. It finds the Federal Bureau of Investigation (FBI) faces challenges identifying and investigating them, including that activity may not be a violation until information is transferred. The report concludes the FBI should strengthen partnerships with academic institutions, since it has not identified a plan to do so.Sat, 24 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.26434/chemrxiv.15010305/v12026-w42-p10/doi:10.26434/chemrxiv.15010305/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, by Muhammadjon Tursunbadalov and co-authors. It describes ARGUS, a model that combines four structural signals to estimate resistance of H5N1 influenza neuraminidase to the antivirals oseltamivir and zanamivir. The authors say the model predicts maintained efficacy of both antivirals against mutations from the US H5N1 B3.13 outbreak.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.05.7562462026-w42-p10/doi:10.64898/2026.10.05.756246Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by G. Ollitrault and co-authors. The authors profiled 13 botanical extracts and 85 known constituents in primary human hepatocytes (liver cells) using the Cell Painting method, which detected activity in 11 of 13 extracts and 46 of 85 constituents. They say Aristolochia and goldenseal were the most potent extracts, and that their machine-learning models generate testable hypotheses about mechanisms.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.10.7560302026-w42-p10/doi:10.64898/2026.10.10.756030Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by R. Mao and co-authors, comparing two antibodies against the epidermal growth factor receptor (EGFR) that bind at similar speed but release at different speeds. In NSG mice with large human tumors, CAR-T cells built with the faster-releasing binder H1 expanded, persisted and infiltrated tumors better than cetuximab-based cells at low doses. The study is in mice, so it does not show how such treatment would work in people.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.09.7581202026-w42-p10/doi:10.64898/2026.10.09.758120Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by S. Sadaki and co-authors, on adult skeletal muscle. The authors report that inducible deletion of the large Maf transcription factors Mafa, Mafb, and Maf caused near-complete loss of type IIb fibers, with reduced strength and greater fatigue resistance. They note that fast myofibers are preferentially affected during aging, and that the changes resemble those seen in aging and denervation.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.10.7578482026-w42-p10/doi:10.64898/2026.10.10.757848Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by M. Hukkanen and co-authors. Analyzing 126 whole-blood methylomes from King penguins of known age, the authors identify 409 aging-associated genes, many of them regulators of hematopoietic stem and progenitor cell function. They also report that a human age model built only from orthologues of these genes predicts chronological age with high accuracy, which they propose reflects a long-lived cellular memory of stem-cell aging.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.11.263652192026-w42-p10/doi:10.64898/2026.10.11.26365219Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by S. Han and co-authors, using the UK Biobank cohort of 57,611 participants. The authors report that absolute blood pressure variability was associated with all-cause mortality, and that diastolic and mean arterial pressure variability were associated with overall stroke after false discovery rate (FDR) correction. The study is observational, so it shows links rather than causes, and adjusting for variability changed the glycemic status association only minimally.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.11.263652492026-w42-p10/doi:10.64898/2026.10.11.26365249Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by A. Bina and G. Rezaee. Using daily smartphone diaries from 143 participants over a 30-day monitoring period, the authors report that brain fog, forgetfulness and mood disturbance were each independently associated with headache-related interference with activity and concentration, while age, sex and employment status were not. The study is observational, so these are associations rather than proven causes.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.12.263651512026-w42-p10/doi:10.64898/2026.10.12.26365151Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by C. J. Watson and co-authors. It is a cross-sectional study of 1,067 people with psychotic disorders, using prescribed doses of 49 psychotropic medications to estimate receptor-engagement profiles. Some profiles were associated with cognitive performance, such as one with alpha2-adrenergic and dopaminergic receptors linked to poorer performance and dopamine transporter engagement linked to better performance, and because the study is cross-sectional it cannot show that a medicine changes cognition.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.12.7586292026-w42-p10/doi:10.64898/2026.10.12.758629Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by V. Sood and co-authors, on Japanese encephalitis virus (JEV), which the abstract describes as the leading cause of viral encephalitis in Asia and for which no antiviral therapies exist. In human SH-SY5Y cells, silencing the mitochondrial transaminase GOT2 reduced JEV RNA, viral protein and infectious virus production. The authors call GOT2 a candidate host-directed antiviral target.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.12.7586782026-w42-p10/doi:10.64898/2026.10.12.758678Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by C. Li and co-authors. The authors report that non-invasive trigeminal nerve stimulation (TNS) preserved neuronal survival after traumatic brain injury, by preventing aggregation of the outer mitochondrial membrane receptor TOM20 and restoring PINK1/Parkin pathway function. They describe it as a non-pharmacological strategy that reduced progressive infarct expansion and recovered sensorimotor functions in their experiments.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-mmwr:31ad9b654f642026-w42-p10/mmwr:31ad9b654f64Final report. This is a final report from CDC MMWR, which describes the prevalence of binge eating among U.S. high school students using the 2025 Youth Risk Behavior Survey. It identifies groups disproportionately affected and examines associations between binge eating and social media use, mental health and suicide risk. As a survey-based report, it shows associations rather than causes.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-mmwr:d53c7209edec2026-w42-p10/mmwr:d53c7209edecFinal report. This is a final report from CDC MMWR, which describes patterns of substance use among U.S. high school students using the 2025 Youth Risk Behavior Survey. It examines differences by sex, race and ethnicity, grade and urban-rural classification. The report describes differences between groups, not what causes them.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.1038/s41586-026-11176-12026-w42-p10/doi:10.1038/s41586-026-11176-1Peer-reviewed study. This is a peer-reviewed study in Nature. It engineers a tetravalent, nanobody-based myeloid-selective agonist of the Interleukin-10 (IL-10) receptor that suppresses monocytes, macrophages and dendritic cells without stimulating T cells, by exploiting a difference in TYK2 dependence between cell types. The agonist reduced inflammation in mouse models of lipopolysaccharide challenge, delayed-type hypersensitivity and colitis, and a humanized version kept myeloid suppression for up to 30 days in non-human primates without T cell activation or haematological toxicities.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.12.7586222026-w42-p10/doi:10.64898/2026.10.12.758622Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by M. R. Tanner and co-authors. The authors report that the CaV1.2 channel carries the calcium influx triggered by blocking the KCa1.1 potassium channel in fibroblast-like synoviocytes, and that blocking CaV1.2 removed the effects of KCa1.1 blockade on invasiveness in human and rat cells. In a rat collagen-induced arthritis model, combining blockers of both channels removed the therapeutic benefit of KCa1.1 blockers alone.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.13.7590042026-w42-p10/doi:10.64898/2026.10.13.759004Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by Y. Zeng and co-authors. The authors report that bile acid remodeling enriches the oral commensal Prevotella melaninogenica at the gastroesophageal junction, where its succinate activates sensory neurons and tuft cells in a self-reinforcing circuit that promotes dysplastic progression. They say disrupting the circuit, including with the approved CGRP antagonist rimegepant, suppressed tumor development.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.14.263654692026-w42-p10/doi:10.64898/2026.10.14.26365469Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, by J. Liang. Using Health and Retirement Study (HRS) data, the author emulates a target trial of starting regular physical activity in older adults who had been inactive, and reports that cumulative incidence of mobility difficulty at about 2 years was 32.75% among initiators and 39.73% among noninitiators. The difference was less clear at about 4 and 6 years, and the study is observational, so it shows an association rather than a proven effect.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.14.263655742026-w42-p10/doi:10.64898/2026.10.14.26365574Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by X. Zhang and co-authors. Using two discovery datasets and clinical blood samples, the authors propose EPB42, KLF1 and H3F3A as candidate stage-associated biomarkers in chronic kidney disease (CKD) and end-stage renal disease (ESRD). EPB42 moved in opposite directions between the two diseases, which the authors say may help distinguish CKD from ESRD.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.12.7584912026-w42-p10/doi:10.64898/2026.10.12.758491Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by N. Zelinger and co-authors, in adult female DBH-Cre mice. Using a progressive Caspase-3 method that ablates the locus coeruleus (LC) in stages, the authors report that REM sleep fragmentation appeared already at mild degeneration, about 25% neuronal loss, and that REM theta power declined across all stages. At moderate degeneration, about 50% loss, total REM sleep during light hours had significantly increased.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.13.7583112026-w42-p10/doi:10.64898/2026.10.13.758311Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, by Z. Tian. The authors report that patients with acute kidney injury (AKI) who later had lung injury had higher observed mortality than the AKI cohort overall (36.67% against 25.45%). They also report that the circadian gene CLOCK was selectively lower in primary human donor lungs from clinical AKI, a finding they describe as human-validated, though the donor groups were small.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.13.7585902026-w42-p10/doi:10.64898/2026.10.13.758590Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by C. Shan and co-authors, describing a pipeline for de novo design of metalloenzymes using Metal Mer, a structural unit that maps backbone geometry to preferred metal coordination modes. The authors report a designed zinc-dependent hydride-transfer enzyme giving enantiomeric excess above 99% on 13 substrates without directed evolution, and an iron-catalyzed variant reaching 96:4 enantiomeric ratio after a single active-site residue mutation. They say a crystal structure of one design matched the computational model closely.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.14.7589702026-w42-p10/doi:10.64898/2026.10.14.758970Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by J. Simhadri and co-authors. It describes GAT1508, a urea-based activator of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels, which in a pentylenetetrazole (PTZ)-induced seizure model outperformed ML297 and GiGA1 and was comparable to valproic acid. The authors also report that it significantly potentiated the antiseizure effects of cannabidiol (CBD) in seizure models, with results from oocyte, hippocampal slice and in vivo experiments.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.14.7590892026-w42-p10/doi:10.64898/2026.10.14.759089Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by X. Shan and co-authors. The authors report that valine, a branched-chain amino acid (BCAA), engages a valine-selective allosteric pocket on metabotropic glutamate receptor 5 (mGluR5) in the medial prefrontal cortex, and that partial dietary valine restriction disrupted social interaction while local valine supplementation rescued it. They describe valine as a diet-derived allosteric ligand that potentiates glutamate-evoked mGluR5 signaling.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.15.263656152026-w42-p10/doi:10.64898/2026.10.15.26365615Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by J. Stubs and co-authors. Using data from the Norwegian Trondelag Health Study, it compares plasma phosphorylated tau217 (pTau217), neurofilament light chain (NfL) and eight modifiable risk scores for predicting all-cause dementia 11 years later. The authors report that higher pTau217 was associated with greater likelihood of dementia, that the risk scores gave only marginal improvement, and that NfL did not improve prediction beyond pTau217 or the scores.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.15.263656452026-w42-p10/doi:10.64898/2026.10.15.26365645Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, by B. L. Lambert. Using new molecular entity names approved by the US Food and Drug Administration (FDA) and other drug name data, the author reports that proprietary drug names became more orthographically distinctive over four decades, with trigram surprisal rising in every decade. The author notes that unfamiliar letter sequences can introduce other error pathways, so more distinctive names do not necessarily mean better safety.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.15.7593502026-w42-p10/doi:10.64898/2026.10.15.759350Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, by I. Kurth and co-authors. Using Nucleotide Transformer v3, the authors perturbed every position of the complete telomere-to-telomere human genome to build a directed, weighted network of position-to-position relationships. They name recurring modules 'relons' and report that these reflect evolutionary and functional constraints and associate with human genetic variation and pathogenic variants.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.64898/2026.10.12.7584952026-w42-p10/doi:10.64898/2026.10.12.758495Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by E. Gutierrez-Jimenez and co-authors, in middle-aged mice at 15 months. The authors report that cortical blood flow is higher in females, that capillary transit-time heterogeneity scales more steeply with transit time in females, and that oxygen extraction fraction is reduced without a deficit in arterial oxygen delivery. They also report a male-associated myelin and axonogenesis signature in white matter, and suggest elevated blood flow in females can mask rather than reflect adequate tissue oxygenation.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-arxiv:2610.149692026-w42-p10/arxiv:2610.14969Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, which argues that an innovator's profit leaves out the change in allocative efficiency its innovation causes, so private returns can understate social returns to research and development (R&D). In the authors' estimates, the social return to R&D is 5.39 times the private return, against 2.53 under output-based accounting with estimated business stealing. The figures rest on the paper's model and on estimated spillovers.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.26434/chemrxiv.15010449/v12026-w42-p10/doi:10.26434/chemrxiv.15010449/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by Ana Sousa-Castillo and co-authors. It reports that changing the copper content of Au-Cu alloy nanorods on TiO2 altered which products form from carbon dioxide under broadband light: low copper favored ethanol, while higher copper favored formic acid and methane with more hydrogen evolution. The abstract frames these composition-dependent relationships as design principles for controlling activity and selectivity in solar-driven CO2 conversion.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.1073/pnas.26174891232026-w42-p10/doi:10.1073/pnas.2617489123Peer-reviewed study. This is a peer-reviewed study in PNAS, led by Meiyang Cui and co-authors, on a template-free method to make mesoporous CeO 2 superparticles built from quasi-single crystals. The authors report that palladium-loaded versions reached 85% methanol selectivity in CO 2 hydrogenation to methanol, with better durability than conventional supports. The abstract frames the work as relevant to fundamental catalysis studies and heterogeneous catalyst supports.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.26434/chemrxiv.15010320/v12026-w42-p10/doi:10.26434/chemrxiv.15010320/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by Shiwen Cui and co-authors, on how bone mineral forms within collagen. Using cryogenic electron tomography, the authors report that intrafibrillar mineralization does not rely on infiltration of amorphous calcium phosphate (ACP) and instead occurs through a classical heterogeneous nucleation mechanism. They also report it can be accelerated in vitro and in vivo by increasing the density of the collagen template, which they say informs the design of bone regeneration materials.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-arxiv:2610.139932026-w42-p10/arxiv:2610.13993Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, describing GenPoly, a multimodal generative framework that proposed bioresorbable polymer coatings for sutures. In an in vitro human keratinocyte wound model, one discovered LA-TMC family coating showed improved payload retention and sustained release, with a 3.3 times increase in recombinant human EGF concentration compared with the current state-of-the-art candidates. The authors say the results suggest new opportunities in AI-driven polymer discovery.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-arxiv:2610.149162026-w42-p10/arxiv:2610.14916Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, with a two-region ecological-economic model of invasive alien species control that includes an Allee effect. The authors find that under realistic control costs neither prevention nor eradication can eliminate invasive populations in finite time, and that cooperative management expands the set of starting conditions that lead to eradication while reducing aggregate social costs. They say the results give a formal rationale for rapid intervention and stronger multilateral cooperation, particularly in jurisdictions such as the European Union.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-pew:4ffeae2622e22026-w42-p10/pew:4ffeae2622e2Announcement. The Pew Research Center's announcement covers research on Americans' views of economic inequality, its causes and who should fix it. It says a growing share of those who think there is too much inequality now want the economic system completely rebuilt to address it. This is Pew's own account of its research, so the original release has the full detail.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-pew:d40ff4641f4f2026-w42-p10/pew:d40ff4641f4fAnnouncement. The Pew Research Center's announcement says nearly four-in-ten U.S. adults are in an online community, which it describes as a virtual third space, such as Facebook groups, online video games or fandom forums on Reddit. This is Pew's own account of its research, so the original release has the full detail.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-arxiv:2610.191532026-w42-p10/arxiv:2610.19153Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and it is a computer simulation of the central nervous system of adult male Drosophila melanogaster, wired by the MaleCNS connectome. The authors report that the number of neurons lost was a poor guide to the deficit, which depended partly on the synaptic contacts lost with them, and that all 66 flies that lost the giant fibre on the stimulated side had a giant fibre rate below 100 Hz. Because the work simulates a model, its results describe the simulation rather than real flies.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-doi:10.26434/chemrxiv.15010516/v12026-w42-p10/doi:10.26434/chemrxiv.15010516/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, led by Zhong Li and co-authors, describing scalable imine/aminal-linked porous organic polymer (POP) gels that can be molded and processed into monoliths. In a continuous-flow column treating electronic-waste leachates at 1 L/h, the authors report 99% gold recovery, and a noble-metal-loaded column worked as a continuous-flow Suzuki reactor. The abstract frames the work as a platform for circular resource use and sustainable chemical manufacturing.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-pew:3d14f12aec962026-w42-p10/pew:3d14f12aec96Announcement. The Pew Research Center says Latino registered voters have more positive views of the Democratic Party than of the Republican Party overall. It reports that 29% have a favorable opinion of the Republican Party today. This is Pew's own announcement, so the original release has the full comparison.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-gao:6dd5adf0ca8c2026-w42-p10/gao:6dd5adf0ca8cFinal report. This is a final report from the U.S. Government Accountability Office (GAO) on the body-worn camera programs of U.S. Customs and Border Protection (CBP) and Immigration and Customs Enforcement (ICE). It finds that both agencies' program plans are out of date, that they lack results-oriented performance goals, and that most offices lack operational guidance on when personnel should use cameras. GAO says the controls should be strengthened, because the gaps increase the risk that personnel will not use cameras as policy requires.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42-p10/#item-gao:a79fb184ce5d2026-w42-p10/gao:a79fb184ce5dFinal report. This is a final report from the U.S. Government Accountability Office (GAO) on nuclear waste cleanup at the Department of Energy (DOE). It says the cleanup proceeds largely under three laws with different requirements and regulators, and that unclear state authority and unrealistic assumptions about future land and groundwater use can raise costs and lengthen schedules. It says that if Congress clarified the scope of Atomic Energy Act preemption and created a way for DOE to appeal to the Environmental Protection Agency (EPA), costly legal disputes could be reduced.Fri, 23 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42/#item-2026-208482026-w42/2026-20848Final rule. The Food and Drug Administration (FDA) is issuing a final rule, effective December 14, 2026, that permits salt substitutes in standardized foods to reduce their sodium content. The FDA says reducing sodium may help reduce the risk of hypertension, a major risk factor for heart disease and stroke. The rule gives industry flexibility to produce lower-sodium standardized foods while keeping their basic nature and essential characteristics.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42/#item-2026-208612026-w42/2026-20861Final rule. The National Oceanic and Atmospheric Administration (NOAA) announces that the 2026 commercial summer flounder quota allocated to the State of Maine has been harvested. Vessels with a federal commercial permit for summer flounder may not land it in Maine for the rest of 2026 unless quota is transferred from another state, and dealers are advised that no federal commercial quota is available there. This temporary rule is effective October 13, 2026.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42/#item-2026-208632026-w42/2026-20863Proposed. The National Oceanic and Atmospheric Administration (NOAA) proposes Framework Adjustment 7 to the Atlantic spiny dogfish fishery management plan, as recommended by the Mid-Atlantic and New England Fishery Management Councils. It would set allowable harvest levels for fishing year 2026 and projected 2027 to prevent overfishing, and would no longer require full payback of annual catch limit (ACL) overages when the stock is considered healthy, giving the commercial fishery more flexibility.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42/#item-2026-208732026-w42/2026-20873Final rule. The National Oceanic and Atmospheric Administration (NOAA) is issuing a final rule that sets gear marking requirements and entanglement risk reduction measures for parts of the Pacific coast groundfish fishery, effective January 11, 2027. The rule has mandatory requirements and voluntary measures, and is made under the Magnuson-Stevens Fishery Conservation and Management Act. The gear marking is meant to make it easier to attribute an entanglement to a specific fishery and gear type, and the risk reduction measures aim to cut bycatch by lowering the chance that marine animals become entangled in fishing line.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42/#item-2026-208842026-w42/2026-20884Proposed. U.S. Customs and Border Protection (CBP) is proposing to require rail carriers to send advance electronic traveler information for every crew member and passenger arriving in or departing from the United States on a train. Carriers would also send an advance notice of the train's arrival or departure. The proposal says it would enhance security while facilitating legitimate international travel by train.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w42/#item-2026-208892026-w42/2026-20889Final rule. The Surface Transportation Board (STB) is issuing a final rule, effective November 12, 2026, that updates for 2026 the fees the public pays to file certain cases and pleadings with the Board. Of the Board's 135 fees, 87 will increase and 48 will stay at their current levels.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-0112026-w41-p9/WA-26-19-011In effect. The Washington Department of Health has adopted a new chapter of rules requiring hospitals with emergency departments, and stand-alone emergency departments, to submit patient care data to the department. The data helps the department respond to emerging public health threats and chronic conditions, and other parties may submit it voluntarily through the rapid health information network (RHINO) program. The rule is in effect from October 4, 2026.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-0692026-w41-p9/WA-26-19-069Proposed. The Washington Department of Health has proposed rules on tamper-resistant prescription pads and paper, adding detail to what existing guidance covers. The proposal would require reapproval of a pad whenever there are changes to an approved design, to add oversight that helps prevent prescription tampering.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-1052026-w41-p9/WA-26-19-105In effect. The Washington Department of Social and Health Services has extended emergency amendments that support the summer electronic benefits transfer program, also known as sun bucks, for the 2026 summer operational period. The amendments follow a federally approved state plan and were made to meet a federal deadline. The temporary rule is in effect from September 23, 2026, while the department pursues a permanent rule.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-1282026-w41-p9/WA-26-19-128Proposed. The Washington Department of Social and Health Services has proposed a new qualification pathway for home safety evaluation providers, which would let more providers meet the minimum qualifications. It would also remove a pathway for education and consultation providers, because its requirements are no longer offered. Maximum rates for most approved services would rise to account for inflation in calendar year 2027.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.09.28.7551782026-w41-p9/doi:10.64898/2026.09.28.755178Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a study in monogamous prairie voles. Expressing a dementia-causing form of tau in the hypothalamus caused social bonding deficits in older male voles and reduced partner preference in healthy males paired with an affected female. Tau expression across hippocampal and cortical regions did not produce the same deficits.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.09.30.7557662026-w41-p9/doi:10.64898/2026.09.30.755766Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports experiments on pancreatic tissue slices from aged 3xTg-AD mice, a model of Alzheimer's disease that also develops diabetes. The authors report that PFKFB3 inhibitors increased calcium activity in beta-cells, and that the effect persisted after the drug was removed. They describe the recordings as exploratory and say residual drug in the tissue cannot be excluded.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.05.263643482026-w41-p9/doi:10.64898/2026.10.05.26364348Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is an observational study of attention-deficit/hyperactivity disorder (ADHD) symptoms in two cohorts, one from Oregon and one from the Adolescent Brain Cognitive Development (ABCD) study. It shows links, not causes. Symptoms generally declined over time, and rising irritability and inattention were associated with new disorders later in adolescence, while early-life factors did not robustly predict how symptoms changed.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.05.263647852026-w41-p9/doi:10.64898/2026.10.05.26364785Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a nationally representative longitudinal study using Waves 7 and 8 of the Population Assessment of Tobacco and Health (PATH) Study, covering 2022 to 2024. It finds that starting oral nicotine pouches (ONPs) was more common among adults who used cigarettes, electronic nicotine delivery systems (ENDS), smokeless tobacco, or several products. The authors say this raises the question of whether pouches replace those products or lead to using several.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.06.7568892026-w41-p9/doi:10.64898/2026.10.06.756889Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports laboratory work on CD8+ T cells, a type of immune cell. It finds that folate deprivation disrupted their cell-surface glycosylation and triggered an apoptotic stress response. The authors report that boosting folate transporters in transferred T cells increased their numbers in tumors and reduced exhaustion.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.06.7571992026-w41-p9/doi:10.64898/2026.10.06.757199Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports laboratory and mouse work on how monocytes, a type of immune cell, respond to pathological shear stress as they pass through a stenotic aortic valve. The authors report that these forces reprogrammed the cells, and that Piezo1 acts as a key mechanosensor linking the forces to lasting changes in monocyte phenotype.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.09.30.7558172026-w41-p9/doi:10.64898/2026.09.30.755817Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a study in mice with a tibial fracture and cast immobilization. The injured mice developed mechanical hypersensitivity and reduced exploration in anxiety-related tests, which had resolved by 20 weeks. At 7 weeks, the hippocampus showed changes in extracellular matrix signals, and microglia and astrocytes changed over time, with some changes persisting after behavior returned toward normal.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.06.263644432026-w41-p9/doi:10.64898/2026.10.06.26364443Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a randomized controlled trial of 283 participants at VinUniversity in Hanoi, Vietnam, who played an app-based epidemic game. Quarantine was chosen on 30.1% of participant-days when each contact earned 1 point, and on 20.2% when each contact earned 2 points. The authors say beliefs measured in real life did not reliably predict choices in the game.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-TX-TRD-2026041262026-w41-p9/TX-TRD-202604126Proposed. The Texas Department of State Health Services has proposed rules requiring wholesalers to label shrimp as imported if it does not meet United States country of origin requirements for wild or farm-raised shellfish. The proposal implements Senate Bill (SB) 823 from the 2025 session of the 89th Legislature, and would let the department assess administrative penalties against violators.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.07.7573092026-w41-p9/doi:10.64898/2026.10.07.757309Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that cells with high pyruvate dehydrogenase kinase-1 (Pdk1) expression drive tumor growth, resistance to 5-fluorouracil and relapse in models of colorectal cancer. The authors report that these cells show increased interferon signaling, and that inhibiting it weakened their tumorigenic and aggressive features.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.08.7577572026-w41-p9/doi:10.64898/2026.10.08.757757Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, profiles lung adenocarcinoma (LUAD) tissue from atypical adenomatous hyperplasia (AAH) through invasive disease, using single-nucleus sequencing on 23 patients and spatial transcriptomics on 25. The authors report that several apparently positive results disappeared once sequencing depth was matched, but that an extracellular matrix signature stayed higher in invasive disease in 20 of 22 paired cases. They also list candidate compounds, mostly PI3K/mTOR inhibitors, and state their negative results explicitly.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.08.7578142026-w41-p9/doi:10.64898/2026.10.08.757814Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines computer modeling, placenta tissue samples and binding assays to propose that CD147, EGFR and LDLR may act as secondary cofactors for the virus's spike protein in the placenta. The study reports higher protein levels of CD147, ACE2 and LDLR in placenta samples from women with a COVID exposure risk than in controls, although the differences in mRNA expression were not statistically significant. The authors say the findings could point to targeted therapeutic opportunities.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.04.7565462026-w41-p9/doi:10.64898/2026.10.04.756546Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports cell, nerve cell and rodent experiments showing that activating the FLT3 receptor with its ligand FL triggers a Raf-MEK-ERK signaling pathway. The authors report that this pathway caused mechanical hypersensitivity and reduced morphine's analgesic effect, and that blocking MEK prevented the loss of morphine analgesia in male rats.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.07.263649462026-w41-p9/doi:10.64898/2026.10.07.26364946Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes brain scans from people in inpatient alcohol withdrawal treatment, comparing a ketogenic diet with a standard American diet. It reports that higher serum beta-hydroxybutyrate (BHB), a ketone, was associated with changes in brain network dynamics, which in turn were associated with reduced cue-induced alcohol craving. The work shows associations rather than causes.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-arxiv:2610.101312026-w41-p9/arxiv:2610.10131Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a theoretical study of centralized admissions platforms, which grant priority based on self-reported facts. It argues that a platform only needs to check priority claims that could move an applicant across a school's admission cutoff, and still reach the same outcomes as full verification. In simulated markets, the approach cut verification by 76 percent compared with checking every claim up front.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-nber:5992f511de612026-w41-p9/nber:5992f511de61Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a sudden migration of physicians to Chile, together with growth in domestic medical schools, to study occupational licensing in public hospitals. It finds that more physicians improve patient outcomes, while lower-quality physicians, measured by licensing exam performance, worsen them. The authors use these findings to evaluate what changing the stringency of the licensing policy would do.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-nber:73f809c2e19f2026-w41-p9/nber:73f809c2e19fPreprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, documents labor supply, wages, health and disability claims among UK working-age women over the last three decades, and fits a structural model of life-cycle work and disability benefit claims. Its results highlight that interactions between disability benefit, welfare and tax-credit systems shape hours, employment, earnings and disability claims over the life cycle, which matters for evaluating policy.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-0252026-w41-p9/WA-26-19-025In effect. The Washington Employment Security Department has a rule requiring unemployment benefit claimants to register for work through the state's labor exchange system. Under the rule, claimants register themselves rather than being registered automatically by the department, which the department says will help them reach reemployment services. The rule is in effect from October 9, 2026.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-0092026-w41-p9/WA-26-19-009In effect. The Washington Department of Agriculture has adopted fees for USDA audit verification and terminal market inspection services that are identical to the fees set by the United States Department of Agriculture's Agricultural Marketing Service (USDA-AMS). The state is adopting them to comply with its cooperative agreement with USDA-AMS for services it provides as a Federal-State Inspection Agency. The rule is in effect from October 4, 2026.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.64898/2026.10.04.7565272026-w41-p9/doi:10.64898/2026.10.04.756527Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports field trials of 48 recombinant inbred lines of rice grown under ammonium or nitrate nitrogen, in irrigated and rainfed conditions across two cropping seasons. Ammonium produced higher average grain yield than nitrate, especially under rainfed conditions, although responses varied by genotype. The authors suggest these traits may help identify rice genotypes suited to water-limited systems.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-TX-TRD-2026041312026-w41-p9/TX-TRD-202604131Proposed. The Texas Alcoholic Beverage Commission has proposed changes to its rules on food and beverage certificates and bonds. The changes would remove valuation tracking requirements for complimentary drinks, and cut the record retention period for certificate holders from four years to two. They would also drop the requirement that bonds be payable in Travis County, and let banks and credit unions without a physical presence in Texas provide bonds if they are authorized to transact business in Texas and insured by the Federal Deposit Insurance Corporation (FDIC) or the National Credit Union Administration (NCUA).Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-TX-TRD-2026041332026-w41-p9/TX-TRD-202604133Proposed. The Texas Alcoholic Beverage Commission has proposed changes to its schedule of sanctions and penalties. Under the proposal, written warnings could no longer be an aggravating factor or trigger a hearing, though they could show the recipient was aware of a violation, and the agency could rescind warnings issued in error. The proposal would also place the burden of proving mitigating factors on licensees and permittees, and list factors the agency may weigh when setting a sanction.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-TX-TRD-2026041342026-w41-p9/TX-TRD-202604134Proposed. The Texas Alcoholic Beverage Commission has proposed widening which premises count as priority locations for inspection. Premises licensed for less than two years would be priority locations if they have not been the target of any investigative activity, not just underage compliance or other public safety operations. The proposal also defines 'reasonable care' and 'reasonable steps' for the rules on consuming consumable hemp products.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-doi:10.26434/chemrxiv.15001038/v22026-w41-p9/doi:10.26434/chemrxiv.15001038/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a proteomics atlas of 367 antineoplastic agents (anti-cancer drugs) tested in HepG2 cells. The authors describe a six-protein score that they say tracks how strongly each drug slows cell growth across independent datasets. They also describe an online portal for annotating new protein profiles.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-18-0172026-w41-p9/WA-26-18-017In effect. The Washington Columbia River Gorge Commission has updated its land use ordinance to match an amendment to the management plan for the Columbia River Gorge National Scenic Area. The amendment changes the guidelines for landowners who want to rebuild homes and other structures after a disaster. The rules are in effect from October 1, 2026.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-0192026-w41-p9/WA-26-19-019Proposed. The Washington Department of Children, Youth, and Families has proposed changes to its licensing rules for foster homes. The changes would align the rules with the D.S. Settlement Agreement and the DeGross permanent injunction, and make them more developmentally appropriate and flexible for children and youth. The rules were developed through negotiated rulemaking with foster parents, tribal nations and others.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-1222026-w41-p9/WA-26-19-122Proposed. The Washington Noxious Weed Control Board has proposed updating the state noxious weed list, which provides the basis for weed control efforts by county boards and other entities. The proposal also updates wording throughout chapter 16-750 of the rules. The title also refers to a schedule of monetary penalties.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-1332026-w41-p9/WA-26-19-133Proposed. The Washington Department of Licensing has proposed rules to carry out HB [SHB] 2158, a bill passed in the 2026 legislative session. The proposal would add provisions for electronic records notaries public, set methods for confirming the identities tied to tangible records, and clarify when duplicative originals are created.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-WA-26-19-1412026-w41-p9/WA-26-19-141Proposed. The Washington Department of Children, Youth, and Families has proposed rules to clarify requirements for family, friends, and neighbors (FFN) providers who care for children receiving working connections child care subsidy. The changes would also help the department meet federal directives on the number of children under age two in care, following recent audit findings.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-gao:2d414c3ed4aa2026-w41-p9/gao:2d414c3ed4aaFinal report. The U.S. Government Accountability Office (GAO) report examines the Economic Development Administration (EDA) and five regional commissions, which awarded more than $12 billion in grants during fiscal years 2016 through 2024. It finds that EDA has no comprehensive framework for coordinating with the regional commissions and has not systematically validated key performance measure data since 2020. The report also says the Denali Commission lacks standard procedures for collecting performance information across its grants.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-CA-2026-0813-022026-w41-p9/CA-2026-0813-02Final rule. The California Department of General Services has adopted a final rule updating the Small Business and Disabled Veteran Business Enterprise (SB/DVBE) Program regulations. The rulemaking's title refers to Assembly Bill 2019/2974. The rule takes effect on January 1, 2027.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-CA-2026-0826-022026-w41-p9/CA-2026-0826-02In effect. The California Alternative Energy and Advanced Transportation Financing Authority has made permanent, without changes, emergency amendments to the GoGreen Business Energy Financing Program regulations. The main changes concern multifamily property projects, which get a 12-month final funding deadline and let finance providers take a security interest in real property. The rules are in effect from September 29, 2026, and also permit financing to rebuild a building destroyed by a natural disaster.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-CA-2026-0915-022026-w41-p9/CA-2026-0915-02In effect. The California Board of Environmental Safety (BES), within the Department of Toxic Substances Control, has adopted emergency fee rates for the 2026-27 fiscal year for facilities that generate or process hazardous waste. The action covers facility fees, generation and handling fees, environmental fees, and related fee limits. It is a deemed emergency temporary rule in effect from October 1, 2026, until the board repeals it.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-CA-Z2026-0923-022026-w41-p9/CA-Z2026-0923-02Proposed. The California Contractors State License Board (CSLB) has proposed changes to the C-46 Solar Contractor classification. The proposal keeps an 80 kWh rating limit on battery energy storage systems (BESS) that these contractors install, maintain or repair, and removes a time restriction on BESS work for systems they installed. The board says this lets solar contractors meet contract and warranty obligations without sacrificing public safety.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p9/#item-TX-TRD-2026041822026-w41-p9/TX-TRD-202604182Proposed. The Texas Office of the Attorney General (OAG) has proposed new rules to carry out Senate Bill (S.B.) 17 from the 2025 session of the 89th Legislature, which restricts certain foreign persons and entities from buying interests in real property in Texas. The proposed rules set procedures for complaints, timelines for responding to civil investigative demands and Secretary of State (SOS) interrogatories, interagency coordination, and confidentiality of complaints and investigative materials.Fri, 16 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-0262026-w41-p8/WA-26-19-026Final rule. The Washington Health Care Authority has amended its rules to match two federal laws that take effect January 1, 2027. One requires states to check eligibility for certain federally funded medical assistance every six months. The other shortens the retroactive coverage period for that assistance.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-0412026-w41-p8/WA-26-19-041Proposed. The Washington Department of Health proposes a new section of the state administrative code, WAC 246-320-148, on hospital price transparency. It would explain how the department will decide whether hospitals meet the requirements of state law (RCW 70.41.560) on reporting prices and cost data for services and items. It would also give hospitals some flexibility to reduce repetitive reporting.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-0642026-w41-p8/WA-26-19-064In effect. Temporary rules in effect since September 15, 2026 place synthetic benzodiazepines in Schedule I, the category under the Controlled Substances Act, in Washington's drug rules. The Washington Department of Health says this follows federal action by the United States Drug Enforcement Administration (DEA) on clonazolam, diclazepam, etizolam, flualprazolam, flubromazolam and bromazolam.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-0772026-w41-p8/WA-26-19-077In effect. Temporary rules in effect from September 16, 2026 govern the Washington Health Care Authority's Apple Health expansion program. The program covers adults age 19 and older who have an immigration status that makes them ineligible for medicaid or federal subsidies through the health benefit exchange, and who are not eligible for another full-scope federally funded medical assistance program. It began in 2024 under 2023 state legislation, and the temporary rules apply while permanent rules are developed.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-0902026-w41-p8/WA-26-19-090Proposed. The Washington Health Care Authority proposes amendments to its rules on requests for noncovered health care services and on fee-for-service medical and dental coverage. The changes would bring the rules in line with federal rule CMS-0057-F, titled Advancing Interoperability and Improving Authorization.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-0972026-w41-p8/WA-26-19-097Proposed. The commission, under the Washington Department of Health, proposes amendments to its prescription labeling accessibility rules. The rules require dispensing facilities and dispensing practitioners to provide accessible prescription labels on request to patients with visual impairments or print disabilities, and to patients with limited English proficiency (LEP), at no additional cost. The proposal changes which accessibility methods must be used to best meet each patient's needs; the original rules were adopted in 2025 with a 2027 effective date.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-1402026-w41-p8/WA-26-19-140Proposed. The Washington Health Care Authority proposes rules to set up a statewide certified community behavioral health clinic (CCBHC) model, as directed by 2025 state legislation. The rules would also set cost-based rates and standards for CCBHC certification. CCBHCs are outpatient community-based clinics that provide a comprehensive range of mental health and substance use disorder services.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.09.30.7557882026-w41-p8/doi:10.64898/2026.09.30.755788Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that human CD4 T cells, a type of immune cell, can control tumors without recognizing the tumor directly, by acting through antigen presenting cells. In humanized mice, transferring the T cells caused regression of HLA-DP-negative tumors, and that control needed HLA-matched human antigen presenting cells. The authors say this could matter for cancers whose tumor cells lack major histocompatibility complex (MHC) class II expression.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.06.7552942026-w41-p8/doi:10.64898/2026.10.06.755294Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that artesunate reduced metastatic burden in mice with lung adenocarcinoma while leaving primary tumor growth unaffected. The authors say artesunate induced oxidative stress, and that metastasis-derived cells, which have altered redox balance, were especially sensitive when glutathione synthesis was also inhibited. They describe glutathione-dependent redox homeostasis as a metabolic vulnerability in metastatic cells.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.05.263633362026-w41-p8/doi:10.64898/2026.10.05.26363336Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses genetic data and Mendelian randomization to test the direction of links between ADHD and the Big Five personality traits. It suggests that higher genetic liability to neuroticism and extraversion, and lower liability to conscientiousness, raise ADHD risk, while ADHD genetic liability is linked to lower agreeableness. The authors say these results support a vulnerability model for some traits and a scar model for agreeableness.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.07.263649422026-w41-p8/doi:10.64898/2026.10.07.26364942Preprint, not peer-reviewed. A longitudinal cohort study, a preprint not yet reviewed by other scientists, followed people with Long COVID for a further 12 months. It found that symptoms overlapping with fibromyalgia remained common, with 67.5% to 78.6% meeting the symptom-based criteria at each point of follow-up. The authors say the findings support closer integration of Long COVID and chronic pain rehabilitation services.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.07.263650102026-w41-p8/doi:10.64898/2026.10.07.26365010Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, estimates how much non-communicable disease burden in Taiwan can be attributed to polygenic risk scores, linking Taiwan Biobank and National Health Insurance Research Database data. It reports the strongest genetic-risk associations for atrial fibrillation and gout. It also links a top-decile integrated polygenic risk score (iPRS) to 23.9% more hospital days and 19.1% more inpatient visits.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.07.7574642026-w41-p8/doi:10.64898/2026.10.07.757464Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes scPRIME-seq, a method that profiles transcriptome, genome and DNA methylome simultaneously in single cells. It was applied to 436,908 cells from 29 prostate cancers and 15 benign tissues. The authors report early focal epigenetic changes present in founder aneuploid clones and benign tissues, which they describe as a pre-neoplastic origin of epigenetic burden.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.08.7576162026-w41-p8/doi:10.64898/2026.10.08.757616Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports mouse studies of pancreatic cancer cachexia, which the authors describe as pathological weight loss with anorexia and depressive symptoms. The authors link its behavioral and feeding problems to altered tryptophan metabolism, which depletes serotonin and accumulates kynurenine. Restoring serotonin activity normalized feeding, locomotion and depression-like behavior in the mice, but did not change wasting, tumor burden or survival.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.02.7562852026-w41-p8/doi:10.64898/2026.10.02.756285Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports experiments on dams showing that the postpartum period is a state of enhanced antiviral immunity. Dams infected with influenza A virus (IAV) before weaning survived more often and had less disease than nonpregnant females after a lethal challenge. The authors link the protection to the transition into lactation, and say it extended to highly pathogenic avian influenza.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.05.7567042026-w41-p8/doi:10.64898/2026.10.05.756704Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines genome-wide gene-environment interaction maps with allele-frequency trajectories over about the last 10,000 years to test whether environment-responsive variants contributed to recent human adaptation. Three of 45 independent loci showed significant signs of directional selection, and the selection-linked loci were enriched for interactions involving meat and cheese consumption. The authors suggest gene-environment interactions are an important, previously underappreciated part of recent human evolution.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.09.7576102026-w41-p8/doi:10.64898/2026.10.09.757610Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes Seal, an interpretable artificial intelligence (AI) transfer learning framework that models gene expression and variant effects in the developing human brain across 26 brain regions, 30 cell types and seven developmental stages. Applied to genome-wide association studies, it points to cell types and developmental windows relevant to six neuropsychiatric conditions. In autism whole-genome data, it finds a burden of de novo regulatory variants in transient fetal excitatory neurons.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-nber:670e8fe9993b2026-w41-p8/nber:670e8fe9993bPreprint, not peer-reviewed. This NBER working paper, not yet peer-reviewed, studies the range of multiple equilibria in sovereign debt markets. It finds the range can be large when uncertainty is low, shrinks as uncertainty grows, and disappears when uncertainty is large enough, leaving a unique interest rate. The authors note that interpreting the source of an interest-rate increase is difficult, which complicates the use of intervention by central banks.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-CA-Z2026-0928-022026-w41-p8/CA-Z2026-0928-02Proposed. The California Department of Insurance has a proposed rate filing, LC 26-04, for the Low Cost Automobile Insurance Program, under which the California Automobile Assigned Risk Plan (CAARP) proposes raising the current liability rate by 15.4%. The low-cost policy provides $10,000 for bodily injury or death to one person, a $20,000 cumulative limit for all persons in one accident, and $3,000 for property damage. The Insurance Code requires the Commissioner to hold a public hearing before assigned risk plan rates are amended.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-TX-TRD-2026040752026-w41-p8/TX-TRD-202604075In effect. The Texas Department of Insurance has adopted amendments to its small and large employer health benefit plan rules to implement Senate Bill 896 (2025). Newborn coverage now runs to the 61st day after birth instead of the 32nd, and the deadline for enrollees to notify the plan and pay any additional premium moves from the 31st to the 60th day after birth. The amendments are in effect from October 11, 2026.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-TX-TRD-2026040962026-w41-p8/TX-TRD-202604096In effect. The Texas Department of Insurance has adopted amendments and one repeal concerning health maintenance organizations (HMOs), in effect from October 11, 2026. They implement several 2025 laws, including Senate Bill 896 on newborn coverage, House Bill 388 on a uniform coordination of benefits questionnaire, and Senate Bill 493 on certain pharmacy benefit manager contract provisions. Some sections were adopted with changes, including one changed in response to public comment.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-TX-TRD-2026041812026-w41-p8/TX-TRD-202604181Proposed. The State Board of Education (SBOE) of the Texas Education Agency proposes amending its academic achievement record (transcript) rule, so that it documents a student's completion of a new graduation requirement for the direct admissions program run by the Texas Higher Education Coordinating Board (THECB). The requirement, set by Senate Bill 2314 from 2025, applies to students enrolled in the 2026-2027 school year, and students can meet it by declining to take part through a formal opt-out process.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-1142026-w41-p8/WA-26-19-114Proposed. The Washington Department of Labor and Industries (L&I) proposes amendments to its premium rate tables and experience rating rules for workers' compensation insurance for calendar year 2027. It proposes an overall average premium rate change of 4.9 percent, with classification base rates updated to align with expected losses. Washington law says rates should be adjusted each year to reflect the hazards of each industry.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.26434/chemrxiv.15009892/v12026-w41-p8/doi:10.26434/chemrxiv.15009892/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a Bayesian Factorization Machine (BFM), a machine learning model trained on ecotoxicity test data to predict how hazardous chemicals are to aquatic species. The model matches the current state of the art in predicting the lethal concentration for 50% of test individuals (LC50), and it also gives an uncertainty estimate for every prediction. The authors say the uncertainty is widest for chemicals with little data, where conventional methods are least reliable.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-1392026-w41-p8/WA-26-19-139Final rule. The Washington Department of Ecology has adopted amendments to improve its cap and invest program, to facilitate linking Washington's carbon market with the California-Québec carbon market, and to make other updates consistent with amendments to the Climate Commitment Act. The rules take effect October 24, 2026.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-CA-2026-0917-042026-w41-p8/CA-2026-0917-04Final rule. The California Department of Resources Recycling and Recovery has adopted a temporary rule amending the covered battery-embedded waste recycling fee. The fee, imposed at retail purchase, stays at 1.5 percent of the retail sales price, but its maximum falls from $15 to $1 as of January 1, 2027.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.09.7575172026-w41-p8/doi:10.64898/2026.10.09.757517Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a long-term experiment in oil palm plantations in Riau, Indonesia, comparing ways to restore riparian margins after replanting. Active restoration, which enriched the margins with six native tree species, produced more structural complexity, a more closed canopy, and cooler, more stable temperatures than passive restoration or the control. The authors say the restored margins also held more cool surface microhabitats, which reduced thermal extremes under both current and future climate scenarios.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-CA-2026-0915-032026-w41-p8/CA-2026-0915-03In effect. The California Fish and Game Commission has issued an emergency action, effective September 25, 2026, that authorizes incidental take of the Western Spadefoot toad during its endangered species candidacy period. The authorization covers eligible utility-scale solar photovoltaic projects and utility-scale solar combined with battery energy storage (BESS) projects. It is subject to avoidance and minimization, mitigation, ongoing research and monitoring, reporting and other conditions.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-TX-TRD-2026041392026-w41-p8/TX-TRD-202604139Proposed. The Texas Alcoholic Beverage Commission (TABC) proposes amending its alcoholic beverage advertising rule, section 45.121, to replace references to specific media and specific persons with all-inclusive terms. The agency says the current list risks unintended loopholes as new communication methods emerge. The change follows recommendations from the Texas Regulatory Efficiency Office (TREO) to remove unnecessary or ineffective rules.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.1073/pnas.26170041232026-w41-p8/doi:10.1073/pnas.2617004123Peer-reviewed study. A peer-reviewed study in PNAS examines how thin threads of liquid break apart inside rectangular microchannels, a process that matters for lab-on-a-chip diagnostics and oil recovery. The authors show that breakup happens when a family of equilibrium neck shapes ends, and that a channel aspect ratio (W / H) of about 2.0 changes how the thread collapses. They also report a curved junction design intended to make densely packed emulsions on a chip.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-pew:d81c9a40328c2026-w41-p8/pew:d81c9a40328cAnnouncement. Pew Research Center says that health and wellness influencers who describe themselves as healthcare professionals tend to post much more often about medical topics, such as medical conditions, mental health or treatments requiring the supervision of a doctor.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-arxiv:2610.103212026-w41-p8/arxiv:2610.10321Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines a tabular foundation model, Kumo Tabular, which reads coded police crash records, with a System One model, Jev, which reads officers' narratives, to estimate crash factors the coded fields miss. For hydroplaning, medical episodes, fatigue, animals and phone use, the narratives document more injury crashes than the coded fields; for phone use, that is 15,074 against 7,340. The study covers 5,601,890 Texas crashes from 2017 to 2025.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-pew:95506b0557c62026-w41-p8/pew:95506b0557c6Announcement. Pew Research Center says the costs of many household essentials are a top economic concern for most Americans, much as they were four years ago before the last midterm election. The announcement's title notes that public economic ratings have turned more negative.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-doi:10.64898/2026.10.08.7577082026-w41-p8/doi:10.64898/2026.10.08.757708Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, introduces the CASCADE (Cardiovascular Analysis and Simulation of Circulatory Advection, Diffusion, and Exchange) toolkit, which simulates vessel-resolved oxygen transport at the organ scale. The authors say it runs a full biventricular human heart model in about two minutes on laptop-class hardware, and that it was checked against experiments in perfused engineered tissues. In the heart model, it shows how coronary occlusion, anemia, polycythemia and hypoxemia change oxygenation patterns in heart muscle.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-0232026-w41-p8/WA-26-19-023Proposed. The Washington Superintendent of Public Instruction (OSPI) proposes permanent rules for transition to kindergarten (TK). The rules would let school districts, charter schools and state-tribal education compact schools charge sliding scale fees for enrollment, and would set how state funding for TK programs is allocated. They would implement 2026 state legislation for the 2027-28 school year.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-WA-26-19-0462026-w41-p8/WA-26-19-046In effect. Temporary rules on Running Start eligibility and enrollment, issued by the Washington Superintendent of Public Instruction, have been in effect since September 12, 2026. They align funding and enrollment with several 2023, 2024 and 2026 state laws, let students aged 21 who receive special education services be claimed for state funding, and change the first count day for a college term to the fourth school day of the first full month.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-gao:27d448f714852026-w41-p8/gao:27d448f71485Final report. The U.S. Government Accountability Office (GAO) reports on geothermal energy leasing and permitting on federal lands managed by the Bureau of Land Management (BLM). Nominations of land for geothermal development rose from about 25,800 acres in 2020 to more than a million acres in 2025, and approved drilling permits grew from seven in 2019 to 68 in 2024. The report says BLM should improve permitting, citing inconsistent experiences for developers, draft handbooks not publicly available, and limited visibility into permit status.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p8/#item-CA-Z2026-0929-032026-w41-p8/CA-Z2026-0929-03Proposed. The California State Allocation Board (SAB) proposes to adopt and amend regulations for the School Facility Program (SFP), which gives per-pupil grants to school districts for building and modernizing school facilities. The changes implement Proposition 2, the school bond approved by voters in 2024, and add a Small School District Program for districts with 2,501 or fewer pupils. Proposition 2 provides $8.5 billion in bond authority for public transitional kindergarten through grade 12 school facilities.Thu, 15 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.1038/s41586-026-11127-w2026-w41-p7/doi:10.1038/s41586-026-11127-wPeer-reviewed study. This peer-reviewed study in Nature used lineage tracing in mice to show that alveolar type 2 (AT2) cells migrate into injured bronchioles and turn into club cells and ciliated cells. The authors report that immune cells release a signal molecule called SPP1 that guides these cells, and that Notch signalling drives the change into club cells. They say the findings may inform therapeutic strategies for airway injury.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.04.263633892026-w41-p7/doi:10.64898/2026.10.04.26363389Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of a cross-sectional web survey of 7,210 Japanese adults. Higher extraversion and lower openness were linked to completing the primary COVID-19 vaccination series, and agreeableness was linked to vaccination among men but not women. The authors describe these as modest but meaningful associations and recommend personality-tailored, gender-responsive messages in campaigns.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.05.263647302026-w41-p7/doi:10.64898/2026.10.05.26364730Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, that analyzes UK Biobank data on adults with chronic diseases. A model using 12 routinely collected clinical measures found that screening the 20% of people at highest predicted risk would identify 55.6% of frailty cases, a 2.78-fold improvement over random screening. The authors suggest this could support scalable frailty screening without adding testing burden or clinical workload.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.05.7567302026-w41-p7/doi:10.64898/2026.10.05.756730Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of laboratory experiments on cells infected with respiratory syncytial virus (RSV). The researchers found that the cell protein drebrin interacts with a viral protein, and that reducing drebrin lowered virus particle release while increasing it raised release. A second cell protein, TM9SF2, is linked to drebrin during infection and also affects release, which suggests both help RSV particles leave infected cells.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.07.7572262026-w41-p7/doi:10.64898/2026.10.07.757226Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, combining human aortic valve samples, human valve cells and mouse experiments on calcific aortic valve disease. The authors found higher long-chain ceramides in calcified human valves, and that inhibiting serine palmitoyltransferase (SPT) with Myriocin lowered valve ceramides and slowed disease in mice, even when treatment began after disease was established. They say SPT inhibition may be a tractable strategy for medical therapy, though the work so far has been done in mice and cells.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.02.7561812026-w41-p7/doi:10.64898/2026.10.02.756181Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, reporting experiments in experimental Parkinsonism in which the microglial P2Y12 receptor was deleted or blocked by new antagonists. Deleting it reduced dopaminergic neuron loss, preserved dopamine synthesis, dampened inflammation and improved motor deficits, and it stayed protective when deleted after neurodegeneration had started. One candidate antagonist given centrally reproduced the protective effect, which the authors describe as proof of concept.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.05.7552312026-w41-p7/doi:10.64898/2026.10.05.755231Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, analyzing 20,331 Escherichia coli genomes from urinary tract infection and urine samples. It identifies sequence type ST361 as an emerging carbapenem-resistant clone with near pan-drug resistance, driven by the blaNDM-5 gene, and reports that a conserved Klebsiella-like surface polysaccharide contributes to virulence in mouse urinary tract infection models. The authors also describe how plasmids and insertion elements help spread blaNDM-5.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.06.263649112026-w41-p7/doi:10.64898/2026.10.06.26364911Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of a Mendelian randomization study, which uses genetic variation to test possible causal links between gut microbiota and emotional lability (EL), a symptom that cuts across diagnoses. The strongest effect was RUG013 sp001486445 (odds ratio 1.500), and CAG-485 sp002362485 was linked to a 39.8% higher risk for each standard deviation increase. The authors say reverse analyses ruled out reverse causality, and that CAG-485 is specific to EL and correlated with glycine, serine and threonine metabolites.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.06.7520462026-w41-p7/doi:10.64898/2026.10.06.752046Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of experiments on zebrafish larvae exposed to mixtures of BPS, BPF and BPAF, with or without BPA, at ng/L concentrations. The mixtures caused 4.16% and 6.54% mortality, slower heartbeats and reduced swimming, along with altered brain oscillations and shorter, less branched brain blood vessels. The authors say these effects were not predicted by a concentration-addition model, which predicted no toxicity.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.06.7569782026-w41-p7/doi:10.64898/2026.10.06.756978Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of experiments in mice infected with H1N1 influenza and treated with favipiravir, baloxavir marboxil or ribavirin. The researchers report that lung [18F]-fluorodeoxyglucose PET uptake and metabolic lung volume fell as early as 3 days after infection, before improvements showed on CT and respiratory function. They say the scan may provide an early, quantitative measure of antiviral response that could be evaluated further as a pharmacodynamic endpoint.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.06.7570542026-w41-p7/doi:10.64898/2026.10.06.757054Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of laboratory experiments on herpes simplex virus 1 (HSV-1), which establishes lifelong latency in sensory neurons. The researchers found that infection downmodulates several gp130 family cytokine receptors, partly through the viral RNase VHS, which they suggest is an immune-evasion strategy. They also report that CNTF can reactivate latent HSV-1 in an in vitro model, a effect the authors say is similar to one reported for IL-6.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.02.7562962026-w41-p7/doi:10.64898/2026.10.02.756296Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of experiments in mice on lung metastasis, combining CRISPR perturbations of tumor genes with depletion of host myeloid populations. The authors report that the metastatic niche first selects cells by gene-by-gene epistatic fitness and then makes their transcriptomes converge, and that removing myeloid populations changed the epistasis landscape even with identical tumor genotypes. They suggest the tissue niche sets how genetic interactions become different phenotypes.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.07.7546722026-w41-p7/doi:10.64898/2026.10.07.754672Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of in vitro erythroid differentiation of human cord-blood CD34+ progenitor cells treated with chemotherapy agents. The researchers found that treated cells differentiated faster than controls but failed to mature, with fewer enucleated cells, and that inhibiting ATR reproduced this effect. They propose defective maturation as an additional mechanism of chemotherapy-induced anemia, alongside depletion of progenitors.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.07.7572372026-w41-p7/doi:10.64898/2026.10.07.757237Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of laboratory experiments showing that compressive stress activates Piezo1, releasing calcium from the endoplasmic reticulum, which slows protein production through several mechanisms. The authors say these mechanisms help tumour cells adapt to mechanical constraint, and in a public pancreatic cancer patient dataset, eEF2K expression correlated with poor overall survival.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.08.7577942026-w41-p7/doi:10.64898/2026.10.08.757794Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, describing CheMoDesign, a generative framework for designing proteins from scratch around user-specified chemistry such as modified or noncanonical residues. The authors report single-round experimental campaigns in which designs recognized thrombin and HER2 in a modification-dependent way, and a light-activated covalent PD-L1 binder. They also report an isoform-selective CA IX inhibitor with a KD of 45 nM.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.08.263637722026-w41-p7/doi:10.64898/2026.10.08.26363772Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of a retrospective cohort study of 56,754 adults with type 2 diabetes (T2D) in the Teladoc Health Remote Diabetes Monitoring Program (RDMP) from 2021 to 2025. Estimated A1c (eA1c) fell by 0.06 percentage points a year, and the authors attribute most of the change in the adjusted trend to cardiorenal-protective medicines, with program engagement pulling in the opposite direction. They say the results show durable improvement but do not establish causal effects.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.08.263650182026-w41-p7/doi:10.64898/2026.10.08.26365018Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of a cross-sectional study of 267 children and adolescents with obesity, using serum 1H-NMR spectroscopy. The researchers found that the metabolically healthy and unhealthy obesity labels capture part of metabolic variation but not all, and identified two data-driven metabolic profiles that only partly overlapped with them. The authors say metabolomic profiling may refine cardiometabolic risk stratification, but it requires confirmation in independent cohorts.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.08.263650542026-w41-p7/doi:10.64898/2026.10.08.26365054Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of UK Biobank analyses using polygenic risk scores restricted to genes expressed in microglia, astrocytes, oligodendrocytes and neurons. The authors report substantial overlap between the cell-type gene sets, with APOE in all of them, and that these scores explained 60-93% of the genetic liability for diseases in which dementia is a major feature. They also report that Alzheimer's disease showed associations across all cell types, while Parkinson's disease with and without dementia and amyotrophic lateral sclerosis (ALS) had distinct genetic profiles.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.08.263650552026-w41-p7/doi:10.64898/2026.10.08.26365055Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of 4,901 participants in the 1958 National Child Development Study, a birth cohort study. Longer duration of obesity was associated with higher concentrations of NT-proBNP, hs-cTnI and GDF-15 at age 62, markers of myocardial stress, injury and cellular stress, and among men, ever having been obese was linked to 11.00% higher hs-cTnI. These are associations from a cohort study, so they do not establish that obesity causes the difference.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.08.263650812026-w41-p7/doi:10.64898/2026.10.08.26365081Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of 35,746 bloodstream infections in Calgary, Canada, from 2006 to 2022, combining microbial genomes, proteomes and electronic medical records. Machine learning on the medical records predicted 30-day mortality with an area under the curve of 0.83, but adding more than 70,000 microbial genes and proteins did not improve it. The authors conclude that microbial virulence factors have minimal impact on mortality from bloodstream infections.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.08.263650892026-w41-p7/doi:10.64898/2026.10.08.26365089Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of preregistered analyses of Fitbit sleep data from the All of Us Research Program. It compares 13 seasonal clock changes in Colorado, New Mexico and Utah with the same dates in Arizona, where clocks do not change, across 1,522 participants. The authors report that sleep changed more from night to night after the spring transition in the Mountain states, and that the typical return to usual sleep took two nights, similarly in Arizona, so the quick return should not be read as the length of recovery from daylight saving time itself.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.09.263650132026-w41-p7/doi:10.64898/2026.10.09.26365013Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, reporting a human infection with low pathogenic avian influenza A(H7N7) virus in a poultry worker in Taiwan in 2026. The authors say the virus was related to viruses circulating in Asian wild birds and carried the PB2 E627K change, which they describe as a mammalian adaptation marker. They say enhanced surveillance of H7 viruses in poultry and rapid characterization of human cases are essential to assess pandemic potential.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.09.263651012026-w41-p7/doi:10.64898/2026.10.09.26365101Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, testing models that use 20,000 tweets from 72 users and two synthetic datasets to flag depression and stress. When whole users were held out, a term-weighted model dropped from an area under the curve of 0.835 to 0.595, near chance, because it largely recognized users and their topics. The authors conclude that digital distress signals should be validated across individuals, on real linked data and at realistic prevalence before informing public health surveillance.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.10.7580852026-w41-p7/doi:10.64898/2026.10.10.758085Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of a model trained on AMRFinderPlus-annotated genomes of Klebsiella pneumoniae and Acinetobacter baumannii that forecasts, for each resistance gene, whether a new allele will emerge or the most common allele will change the following year. The authors report that the model ranked genes by risk better than simple baselines in both organisms, including genes it had not seen during training. They say models should be built and validated separately for each organism, since performance and what it depends on differ between them.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-arxiv:2610.121862026-w41-p7/arxiv:2610.12186Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, combining a dynamic model of competition between microfinance institutions (MFIs) and moneylenders with a village-level randomized expansion in Bangladesh. The authors found that one additional MFI reduced moneylender loans by roughly 30-40% two to three years later, with no detectable effect on MFI or overall borrowing. They suggest gains from additional MFI entry may be greater in less saturated areas.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.1073/pnas.26055501232026-w41-p7/doi:10.1073/pnas.2605550123Peer-reviewed study. This peer-reviewed study tests whether findings from 93 published social science studies, which use regression analyses of aggregate statistics, still hold when the data are infused with differential privacy noise. Under privacy budgets typical in industry, around 91% of simulated findings still support the original claims at significance level α = 0.1. The authors report that claims based on weaker original effect sizes were more likely to be nullified or reversed, and that privacy noise distortions were usually smaller than those from measurement error and other nonsampling errors.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.26434/chemrxiv.15010119/v12026-w41-p7/doi:10.26434/chemrxiv.15010119/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of a photocatalyst for solar H2 production made from a small amount of reduced ceria (cerium oxide) on carbon nitride. The researchers report that the 4% composite, with finely dispersed, oxygen-deficient particles, transfers electrons faster and produced about 682 µmol per gram per hour, outperforming the other samples at both wavelengths tested. They attribute the gain to electronic and defect effects rather than to surface area.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.26434/chemrxiv.15009881/v12026-w41-p7/doi:10.26434/chemrxiv.15009881/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, that reports a composite membrane with histidine-modified metal-organic framework (MOF) pores. At pH 4 the pores let chloride ions pass selectively, so the membrane's transmembrane potential can be programmed by acidity. The authors say the approach may matter for ion separations, sensing and osmotic energy generation.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-pew:8f273e227f212026-w41-p7/pew:8f273e227f21Announcement. Pew Research Center reports that around two-thirds (65%) of Americans disapprove of the way President Donald Trump is handling U.S. military action in Iran, while a third (33%) approve. The announcement's headline adds that the Iran conflict remains deeply unpopular and that many Americans expect it to go on for months.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-pew:b1871cac28a32026-w41-p7/pew:b1871cac28a3Announcement. Pew Research Center reports that the economy is the dominant issue for midterm voters in this fall's congressional elections, with 84% of registered voters saying it is very important to their midterm vote. The economy is the top issue among voters who prefer Republican candidates, and partisans differ over the importance of other issues.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.64898/2026.10.06.7571452026-w41-p7/doi:10.64898/2026.10.06.757145Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of experiments on spatially structured 2D melanoma colonies, combined with particle-based tissue simulations. The researchers report that treatment-induced changes in mechanical crowding shape a cascade of resistance expansion, spatial competitive escape and therapy failure. They used these mechanisms to build a mathematical model and a treatment heuristic, which they tested experimentally, and suggest the physical principles could inform evolution-based treatment strategies.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.26434/chemrxiv.15010228/v12026-w41-p7/doi:10.26434/chemrxiv.15010228/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, of electrochemical atomic force microscopy on individual graphite platelets, observing lithium plating and electrode morphology at the same time. The researchers observed plating-induced fracture even without a porous electrode structure, occurring through lithium deposition beneath the particle surface. The authors say this points to lithium in the graphite as the source, which may suggest ways to improve fast-charged negative electrodes.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-doi:10.26434/chemrxiv.15010238/v12026-w41-p7/doi:10.26434/chemrxiv.15010238/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, comparing adsorption and membranes for removing carbon dioxide from methane across 300 ARC-MOF adsorbents, 220 experimental polymers and 864 matched scenarios. Among 676 mutually feasible cases, adsorption minimized annualized cost in 73.4% and membranes in 26.6%, and choosing the wrong technology carried a median cost regret of 19.4%. The authors say the best choice shifts with pressure and flowsheet conditions, and that cost-based choices disagreed with energy, methane-loss and footprint choices in 30.8-46.0% of paired comparisons.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-gao:0768156350d42026-w41-p7/gao:0768156350d4Final report. The U.S. Government Accountability Office (GAO) reviewed the early implementation of the Rural Health Transformation Program, which funds states for rural health activities such as recruiting clinicians and improving rural hospitals. The Centers for Medicare & Medicaid Services (CMS) made initial awards totaling $10 billion to all 50 states and plans to monitor them through reviews, audits and site visits. If states do not comply with their award terms, CMS may withhold, reduce or recover a portion of funding, and the law limits states' ability to challenge funding changes.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-gao:2624542142812026-w41-p7/gao:262454214281Final report. The U.S. Government Accountability Office (GAO) examines mortgage trigger leads, which let credit reporting agencies sell homebuyers' information so other lenders and brokers can send competing loan offers. It finds that the Homebuyers Privacy Protection Act of 2025 now restricts these sales to parties that have an existing relationship with, or consent from, the homebuyer. GAO says it is too early to know the effects, but the limits may reduce unwanted solicitations while preserving comparison shopping.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-gao:2a849b67be672026-w41-p7/gao:2a849b67be67Final report. The U.S. Government Accountability Office (GAO) reviewed how federal agencies are preparing for quantum computers to break the cryptography that protects federal systems. Using Office of Management and Budget guidance, it checked 24 Chief Financial Officer Act agencies against three practices for moving to post-quantum cryptography, and found that none fully addressed them. GAO links the gaps partly to limited cryptography expertise, missing cryptography inventories and funding processes, and a lack of plans for testing.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-gao:c572ee648d482026-w41-p7/gao:c572ee648d48Final report. The U.S. Government Accountability Office (GAO) examined four large Medicare Part D plan sponsors that are vertically integrated, meaning under common ownership with pharmacy benefit managers and pharmacies. In 2023 the sponsors' own pharmacies accounted for about 28 percent of the drugs their enrollees received and about 24 percent of payments to pharmacies. For at least 94 percent of the 100 most-used drugs, payments and cost sharing were lower at owned pharmacies, though for some of the highest-payment drugs they were higher.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p7/#item-gao:ee491b7566662026-w41-p7/gao:ee491b756666Final report. The U.S. Government Accountability Office (GAO) reviewed the Department of Defense's (DOD) efforts to modernize GPS and to field complementary positioning, navigation, and timing (PNT) systems. GAO reports that in 2026 DOD canceled the Next Generation Operational Control System ground control system and began modernizing the existing GPS Operational Control Segment, which creates risks for new GPS satellites. It also finds M-code receiver fielding and integration challenges, and says consolidating fragmented PNT efforts could help align schedules and funding.Tue, 13 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.1371/journal.pbio.30039812026-w41-p6/doi:10.1371/journal.pbio.3003981Peer-reviewed study. A peer-reviewed study in PLOS Biology reports a consensus-based action plan for improving antibody validation, the testing that confirms an antibody works for a given experiment. Thirty-two international experts rated 33 proposed actions, and the panel agreed on 15 items that are both effective and feasible to implement by 2030. The study estimates that unvalidated antibodies waste over $1 billion a year in the United States alone.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.1016/s0140-6736(26)01535-72026-w41-p6/doi:10.1016/s0140-6736(26)01535-7Peer-reviewed study. A peer-reviewed study in The Lancet tested the Articulate Medical Intelligence Explorer (AMIE), an artificial intelligence (AI) conversational system, with 114 patients before their urgent primary care appointments. No conversation safety stops were needed under the predefined criteria, and clinical evaluators rated its conversations favourably in 87-100% of cases. The authors call this an early feasibility result and say further research is needed.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.1073/pnas.26006861232026-w41-p6/doi:10.1073/pnas.2600686123Peer-reviewed study. A peer-reviewed study in PNAS found that stiff tumor tissue limited how well nanoparticle drugs entered cancer cells, and that softening the tumor in living animals increased nanoparticle penetration and uptake. Combining tumor softening with donafenib-loaded nanoparticles cut endpoint tumor weight by 87.8% compared with free donafenib, but also increased lung metastasis, which the authors describe as a potential efficacy-safety trade-off.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.09.28.7530002026-w41-p6/doi:10.64898/2026.09.28.753000Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, maps 16 disease proteins from 12 neurodegenerative disorders onto a shared network of 990 proteins. The authors report that these disorders share specific proteins beyond what their common processes alone would predict, and they name PRKN, HSPA8 and UBQLN2 as candidate shared vulnerabilities for testing.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.05.7569202026-w41-p6/doi:10.64898/2026.10.05.756920Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, tested Huanglian Wendan Decoction (HLWDD), a multi-herb formula used in Chinese medicine, in rats fed a high-fat, high-sugar diet. The authors report that the formula improved obesity, abnormal blood fats, liver fat and inflammation, and they point to baicalin as a candidate active compound based on experiments in cultured cells.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.06.263649062026-w41-p6/doi:10.64898/2026.10.06.26364906Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, links blood metabolites to frailty in older adults at risk of dementia, studied at the Healthy Brain Ageing (HBA) clinic. Six of 10 metabolite clusters were associated with frailty at the start of the study, and the authors suggest some of them may form a panel of predictive biomarkers for at-risk patients.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.07.7572802026-w41-p6/doi:10.64898/2026.10.07.757280Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, analyzes 1501 publicly available genomes of Enterobacterales bacteria that carry two or more carbapenemase genes, which confer resistance to carbapenem antibiotics. The authors report that cross-class combinations became more common over time, and they say the findings could support effective surveillance programmes.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.7575972026-w41-p6/doi:10.64898/2026.10.08.757597Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, maps which transfer RNA (tRNA) molecules cancer cells depend on, using large-scale gene-silencing screens across 16 cancer cell lines from seven tissue types. The authors report that these dependencies differ between tumors growing in living animals and cells grown in culture, while the protein machinery that reads the genetic code remained largely the same.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.04.7564742026-w41-p6/doi:10.64898/2026.10.04.756474Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, reports that mature conventional dendritic cells (cDCs) that stay in tissue help build lymphoid structures that appear with age. In mice, impaired cDC exit or cDC expansion induced such structures in several organs without pathology, and these structures gathered regulatory T cells that protected against inflammatory injury.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.04.7565812026-w41-p6/doi:10.64898/2026.10.04.756581Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, studies complement Factor B (FB) in injured kidneys and reports that FB acts inside proximal tubule cells, both in the cytoplasm and in the nucleus, to support metabolic adaptation to stress and maladaptive fibrotic repair. The authors say therapies that target complement outside cells may miss these intracellular functions, and that similar patterns appear in human kidney disease.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263647162026-w41-p6/doi:10.64898/2026.10.08.26364716Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, reports a prospective study of 29 critically ill adults and 22 healthy controls, using label-free imaging of whole-blood samples with the Remoscope system. In a model optimized for ruling out sepsis, the authors report 100% sensitivity, meaning all sepsis cases in the study were caught, and 85.3% specificity, meaning most patients without sepsis were correctly cleared. They note abnormal shapes in white and red blood cells.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263648632026-w41-p6/doi:10.64898/2026.10.08.26364863Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, analyzes Medicare data for older US adults and links long-term exposure to wildfire smoke fine particulate matter (PM2.5) with higher rates of Alzheimer's disease and related dementias (ADRD). The carbonaceous, or carbon-based, fraction of the particles accounts for most of the estimated burden, which the authors put at 2,284 Alzheimer's cases and 11,142 ADRD cases per year.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263649722026-w41-p6/doi:10.64898/2026.10.08.26364972Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, tests whether measuring APOE4 protein in blood plasma can replace DNA testing to identify carriers of the APOE ε4 variant, a major genetic risk factor for Alzheimer's disease. The authors report near-perfect accuracy in three external cohorts, and say plasma APOE4 showed amyloid and clinical associations similar to those from DNA genotyping.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263649792026-w41-p6/doi:10.64898/2026.10.08.26364979Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, examines rare and low-frequency genetic variants in 1138 adults from Kuwait and Qatar. The authors report that the burden of these variants rose with body mass index (BMI) across overweight, obese and morbidly obese groups, and that combinations of a finite set of low-frequency coding variants help shape polygenic obesity.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263650232026-w41-p6/doi:10.64898/2026.10.08.26365023Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, is an observational study, which shows a link, not a cause, of 324,284 middle-aged adults in UK Biobank followed for 16 years. The authors report that moderately high physical activity in mid-life was linked to lower hip fracture risk, with the lowest risk at about one hour a day, and that vigorous activity showed the strongest link, with the benefit leveling off at higher volumes.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263650442026-w41-p6/doi:10.64898/2026.10.08.26365044Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, analyzes prescription and diagnostic data from Tata 1mg for 2023 to 2025. Of 25.7 million medicines prescribed, 10.8% were antibiotics, and Escherichia coli (E. coli) from urine cultures resisted ceftriaxone in 53.6% and ciprofloxacin in 57.0% of cases. In this exploratory analysis, resistance to some 'Watch' antibiotics preceded changes in resistance to 'Access' antibiotics by about 3-6 months.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263650492026-w41-p6/doi:10.64898/2026.10.08.26365049Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, is an umbrella review, meaning a review of earlier reviews, that estimates influenza treatment costs for 195 countries and territories. Costs were higher for admitted than non-admitted care, highest for adults and lowest for children, and rose with healthcare expenditure per person.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263650872026-w41-p6/doi:10.64898/2026.10.08.26365087Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, evaluates 3,994 published polygenic scores, which predict traits from many genetic variants, in the CCPM biobank of ancestrally diverse people. The authors find that predictive effects often differ across ancestry groups, which they say threatens equity in downstream applications, and that accuracy depends on whether a score is continuous or thresholded.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.263650882026-w41-p6/doi:10.64898/2026.10.08.26365088Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, splits genetic risk for coronary artery disease into eight biological processes, including cholesterol-rich lipoproteins, obesity, endothelial dysfunction and coagulation. The authors report that these process-specific scores were associated with clinical and subclinical disease in three large biobanks, including UK Biobank and Mass General Brigham Biobank.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.09.263651532026-w41-p6/doi:10.64898/2026.10.09.26365153Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from medRxiv, tests Jev 1.13, a decision model from TypeSafe AI, against two Claude language models on diagnosis tasks. On 1,000 synthetic patients, Jev's top-1 accuracy was 72.0%, compared with 79.5% for Claude Opus 5 without reasoning and 87.4% for Claude Opus 5.5, and Jev assigned zero probability to the correct diagnosis in 6.2% of cases. The authors conclude that calibration claims for clinical decision models should be tested on clinical tasks.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-nber:46e404865d122026-w41-p6/nber:46e404865d12Preprint, not peer-reviewed. A working paper, not yet peer-reviewed, from NBER, uses the Wall Street Journal archive from 1990 to 2025 to track positive and negative media sentiment across twelve economic topics. Bad news had larger cumulative effects than positive news in every topic, and the gap was largest for security and human rights, firms and corporate strategy, and health and public safety.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.26434/chemrxiv.15009873/v12026-w41-p6/doi:10.26434/chemrxiv.15009873/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from ChemRxiv, describes an electrochemical system that recovers nitrogen and phosphorus from wastewater as struvite, a crystal that can be used in fertilizer. The authors report a 91% yield of struvite with over 97% purity, and estimate that operating costs could be up to 89% lower than commercial phosphorus recovery installations.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.26434/chemrxiv.15009937/v12026-w41-p6/doi:10.26434/chemrxiv.15009937/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from ChemRxiv, reports that bacteria in tap water can use certain amino acid-based surfactants as a food source. The study sampled tap water from a hospital and a university, and found that some bacterial species could use three of these compounds, including lauroyl arginine, as their only carbon source. The authors say the findings could matter for managing biological stability in drinking water distribution systems.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.07.7572252026-w41-p6/doi:10.64898/2026.10.07.757225Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, describes a processed piece of the soybean ethylene receptor GmERS1-1 that moves into the nucleus after ethylene exposure and holds cells in the G2/M phase of cell division. Plants with GmERS1-1 mutations gave higher yields under field conditions, and the authors report similar cell-cycle blockade during apple fruit maturation.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-pew:617ea1d58a9d2026-w41-p6/pew:617ea1d58a9dAnnouncement. Pew Research Center reports that registered voters favor Democrats over Republicans for the House of Representatives by 8 percentage points, 44% to 36%, with several weeks to go before the 2026 midterm elections. The figure is part of a larger report on attitudes and dynamics in the midterms, and the breakdown covers race and ethnicity, age and other demographics.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.03.7564252026-w41-p6/doi:10.64898/2026.10.03.756425Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, reports in mice that the mTOR signal, a readout of cell growth and regenerative potential, drops within minutes of birth, driven mainly by carbon dioxide (CO2) exhaled after breathing starts. In adult mice, CO2 inhalation restored mTOR activity in retinal ganglion cells (RGCs) and enabled their axons to regenerate after injury.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.04.7552712026-w41-p6/doi:10.64898/2026.10.04.755271Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, builds patient-specific brain models using 19 receptor and transporter maps to estimate how these systems shape cortical excitability and recovery after stroke. The authors report that better acute motor outcomes were most strongly linked to increased inhibition through GABA-A receptors in tissue away from the lesion, and that acute excitability in highly connected brain hubs predicted language recovery at one year.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.06.7570512026-w41-p6/doi:10.64898/2026.10.06.757051Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, reports that BCKDK inhibitors, which are in ongoing clinical trials, widen blood vessels directly by antagonizing the angiotensin II type I receptor (AT1R), independently of BCKDK itself. The authors say this off-target effect may explain part of the drugs' cardioprotective effects, and they question whether that protection would add to existing AT1R blockers.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.06.7571952026-w41-p6/doi:10.64898/2026.10.06.757195Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, reports in male mice that disrupting myelin formation in the medial prefrontal cortex (mPFC) during youth impaired adult social novelty preference while sparing sociability. The authors also found reduced high-frequency firing in parvalbumin (PV) interneurons, and in human brain tissue a link between myelin and PV markers that appeared in controls but not in people with schizophrenia.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.7550242026-w41-p6/doi:10.64898/2026.10.08.755024Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, analyzes 29,482 brain scans from 11,720 adolescents in the Adolescent Brain Cognitive Development (ABCD) study. The authors report that thicker cortex in early-maturing sensory regions predicted psychiatric symptoms as early as four years before they appeared, and that the pattern later spread to association cortex.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.7575582026-w41-p6/doi:10.64898/2026.10.08.757558Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, reports in male and female mice fed a western diet that the constitutive androstane receptor (CAR) protected against metabolic dysfunction-associated steatotic liver disease (MASLD) in males, through interaction with gut microbiota. The authors found no CAR-dependent effect in females, and report that hepatic CAR expression decreased in advanced stages of MASLD in human cohorts.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.08.7576732026-w41-p6/doi:10.64898/2026.10.08.757673Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, describes SpliceAI2, a deep learning model that predicts how genetic variants change RNA (ribonucleic acid) splicing and the transcripts that result. The authors report that predicted splice-altering variants are enriched in disease-associated genes in a rare disease cohort, where they account for 15% of the excess genetic burden, with about half in deep intronic regions that exome sequencing is likely to miss.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.09.7579792026-w41-p6/doi:10.64898/2026.10.09.757979Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, proposes advanced persistent biological threats (APBTs), in which an attacker alters sequence data, metadata and analytical models rather than biological material. The authors audited 100,000 SARS-CoV-2 records, a coronavirus, from open genomic repositories and found that every record had at least one metadata vulnerability indicator, mostly in optional fields. They say this does not indicate deliberate manipulation, but that the gaps could let misleading metadata go undetected.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p6/#item-doi:10.64898/2026.10.11.7583022026-w41-p6/doi:10.64898/2026.10.11.758302Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, from bioRxiv, describes sulfonated polymersomes, polymer vesicles designed to mimic heparan sulfate on host cells. In vitro, they blocked infection by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) at sub-nanomolar potency, and in zebrafish embryos they reduced the spread of Sindbis virus, a model for chikungunya virus, and significantly increased survival.Mon, 12 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.26434/chemrxiv.15009850/v12026-w41-p5/doi:10.26434/chemrxiv.15009850/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests how zinc leaching from the elastomer of the inner needle shield affects semaglutide, which is used in Ozempic and Wegovy. Under heat stress at 37 °C, zinc changed the drug's structure, but the study found no cytotoxicity or loss of in-vitro activity.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.1016/j.cell.2026.09.0202026-w41-p5/doi:10.1016/j.cell.2026.09.020Peer-reviewed study. A peer-reviewed study in the journal Cell reports that T cells depend on the solute carrier SLC52A3 to take up vitamin B2 (VB2), while tumors use SLC52A2 to outcompete them, driving T cell ferroptosis. In the study, boosting SLC52A3 in T cells reversed this competition and enhanced their antitumor activity.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.1016/j.cell.2026.09.0242026-w41-p5/doi:10.1016/j.cell.2026.09.024Peer-reviewed study. A peer-reviewed study in the journal Cell reports that glutathione (GSH) protects cells from ferroptosis through the enzyme FSP1. The authors report that targeting this FSP1-GSH axis alleviated ferroptosis-induced tissue injury.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.1016/j.cell.2026.09.0312026-w41-p5/doi:10.1016/j.cell.2026.09.031Peer-reviewed study. A peer-reviewed study in the journal Cell reports that estrogen reprograms a signaling pathway called STING, which promotes neutrophil extracellular trap formation and shields antigens from antibody-based cancer therapy. The authors describe this as sex-biased resistance to that therapy.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.1073/pnas.26194271232026-w41-p5/doi:10.1073/pnas.2619427123Peer-reviewed study. A peer-reviewed study in PNAS reports that kenpaullone, a kinase inhibitor, promotes lymphatic vessel growth in screening experiments with human lymphatic endothelial cells. In a mouse model of myocardial infarction (heart attack), kenpaullone enhanced cardiac lymphangiogenesis and improved cardiac function.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.1073/pnas.26120961232026-w41-p5/doi:10.1073/pnas.2612096123Peer-reviewed study. A peer-reviewed study in PNAS argues that the statistics of neutralization titers alone can predict the composition of a polyclonal antibody response, meaning the mix of many different antibodies. For influenza in a cohort, the response is either driven by many antibodies together or dominated by a few strong binders, with titers described by a Gumbel distribution.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.1073/pnas.26235251232026-w41-p5/doi:10.1073/pnas.2623525123Peer-reviewed study. A peer-reviewed study in PNAS reports that lung exposure to Prevotella melaninogenica improved clearance of Streptococcus pneumoniae infection in mice. The authors link this to a shift in myeloid immune cells toward a more antibacterial profile, involving neutrophils and monocyte-derived macrophages.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.09.30.7557952026-w41-p5/doi:10.64898/2026.09.30.755795Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a mouse study of Alternaria alternata, a fungal allergen strongly associated with severe asthma exacerbations. Airway inflammation and airway hyperresponsiveness varied with sex and time of day, with females showing stronger responses at Zeitgeber Time 0 (ZT0) and males at ZT12.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.01.7561352026-w41-p5/doi:10.64898/2026.10.01.756135Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines physiological measurements with food composition data to estimate more than 30 resource fluxes entering the human large intestine. Applied across dietary variation in the U.S. population, it finds microbial growth is carbon-limited for most individuals, with phosphorus limiting for a subset.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.05.263642292026-w41-p5/doi:10.64898/2026.10.05.26364229Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, trains XGBoost machine learning models on longitudinal clinical data from 15,727 people in the National Alzheimer's Coordinating Center cohort, including people who were cognitively normal or had mild cognitive impairment (MCI) at baseline. The authors report that the models detected some future progression before diagnosis, with false alarms among people who did not progress.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.05.263647542026-w41-p5/doi:10.64898/2026.10.05.26364754Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, follows 8 patients with pulmonary tuberculosis (TB) through anti-tuberculosis therapy, compared with 8 healthy household contacts. Gut microbial diversity and metabolic profiles recovered during treatment, but after treatment they remained distinct from the healthy contacts, the authors report.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.06.263645762026-w41-p5/doi:10.64898/2026.10.06.26364576Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines how endocrine markers and well-being relate to psychosexual health and menopausal symptoms in premenopausal and postmenopausal females. The authors report that after menopause, lower well-being and a stronger menopause-like endocrine milieu were linked to poorer psychosexual health and more sexual pain, with no association before menopause.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.09.30.7557992026-w41-p5/doi:10.64898/2026.09.30.755799Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses intracranial recordings from 13 neurosurgical patients to compare brain responses to nociceptive (pain-signaling) stimuli and to low-probability sounds. The authors report the two are anatomically, temporally and functionally distinct, which they say may help personalize chronic pain and brain stimulation treatments.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.02.7562052026-w41-p5/doi:10.64898/2026.10.02.756205Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a mouse model of parental separation to study early-life stress and depression in adolescence. The authors report that stress reduced the gap-junction protein Cx43 in astrocytes of the lateral habenula (LHb), causing astrocyte atrophy, impaired synaptic transmission and depressive-like behaviors, which were rescued by inhibiting astrocytic calcium signaling.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.06.7568982026-w41-p5/doi:10.64898/2026.10.06.756898Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses spatial transcriptomics on heart biopsies from patients with acute myocardial infarction (AMI) and several chronic heart conditions to map fibroblast subpopulations. The authors report that some fibroblast types were enriched after a heart attack, while others predominated in chronic fibrotic remodeling.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.06.7570882026-w41-p5/doi:10.64898/2026.10.06.757088Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, builds longitudinal centile maps of knee cartilage thickness from magnetic resonance imaging (MRI) scans of 957 persistently normal knees in the Osteoarthritis Initiative. The authors report that these maps predicted incident radiographic knee osteoarthritis at 12 and 24 months more accurately than several other methods, though none consistently improved 36-month prediction.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.07.263648502026-w41-p5/doi:10.64898/2026.10.07.26364850Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines slides from 10,651 children under five sampled in Nigeria's 2021 national Malaria Indicator Survey. The authors report that parasite density revealed more significant variation among geopolitical zones and states than infection prevalence alone.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.02.7557372026-w41-p5/doi:10.64898/2026.10.02.755737Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, profiles V delta 2+ gamma delta T cells in Ugandan children with different levels of malaria exposure, using several sequencing methods. The authors report that higher exposure was linked to reduced inflammatory responses, a state partly reversed by rest induced with dasatinib in laboratory experiments.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.07.263649742026-w41-p5/doi:10.64898/2026.10.07.26364974Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a systematic review and meta-analysis of observational studies and randomized clinical trials on maternal vitamin B12 status. The authors report that for preterm birth, low birth weight and small for gestational age (SGA), the confidence intervals included no effect, while higher maternal vitamin B12 availability or supplementation was linked to a small favorable effect on cognitive or global development.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.07.263649902026-w41-p5/doi:10.64898/2026.10.07.26364990Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes oral microbiome samples from 5,598 people in three US cohort studies, alongside beverage intake from food frequency questionnaires. The authors report that only alcoholic beverage consumption was associated with all measures of alpha diversity, mostly through beer and liquor, and that these findings show associations, not cause and effect.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.07.263649922026-w41-p5/doi:10.64898/2026.10.07.26364992Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports semi-structured interviews with 11 dyads of people with mild cognitive impairment (MCI) or Alzheimer's disease and related dementias (AD/ADRD) and their care partners, plus 12 dementia care experts. Participants described needs for ongoing education, personalized care planning, resource navigation and emotional support, and the findings are informing an artificial intelligence (AI)-based chatbot.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.07.7568542026-w41-p5/doi:10.64898/2026.10.07.756854Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, maps single-nucleus multi-omic profiles of skeletal muscle from 70 patients with heart failure with preserved ejection fraction (HFpEF) and 25 healthy controls. The authors report that HFpEF-related changes in chromatin accessibility and transcription were partly reversible after a supervised diet and exercise intervention, with 45 patients having paired biopsies.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.07.7570762026-w41-p5/doi:10.64898/2026.10.07.757076Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses expansion and super-resolution microscopy in mice with adriamycin-induced nephropathy to track three stages of actomyosin reorganization in injured podocytes. The authors report the same three stages in kidney biopsies from patients with minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy and diabetic nephropathy, with chronic injuries converging on a mature pattern.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.07.7572812026-w41-p5/doi:10.64898/2026.10.07.757281Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports experiments in Caenorhabditis elegans, a nematode, in which low-dose zinc chloride in aged animals restored zinc levels and improved healthspan, thermotolerance and oxidative stress resistance. The authors report that zinc acted on ribosome structure rather than ribosome production, while higher doses were toxic.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.08.7574812026-w41-p5/doi:10.64898/2026.10.08.757481Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests probe-based depletion of ribosomal RNA and eight abundant tobamoviruses in wastewater from a municipal treatment plant in Calgary, Canada. The authors report that depletion cut ribosomal RNA reads by 90% and enabled detection of pathogens such as influenza, respiratory syncytial virus (RSV) and hepatitis A that were undetectable in untreated samples.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.08.7577432026-w41-p5/doi:10.64898/2026.10.08.757743Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests SLR14, an immunomodulatory stem-loop RNA that activates the immune sensor RIG-I, against highly pathogenic viruses including Ebola virus, Marburg virus and Sudan virus. The authors report that a single dose protected mice against lethal Rift Valley fever virus (RVFV) infection, and retained efficacy when given up to two days after infection.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.08.7577842026-w41-p5/doi:10.64898/2026.10.08.757784Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that Staphylococcus aureus lacking gpsB is more sensitive to fosfomycin, and that deleting the serine/threonine kinase Stk makes this sensitivity worse. The authors describe GpsB, Stk and the VraSR cell wall stress response system as an integrated network that helps maintain the cell envelope and aids antibiotic resistance.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.08.7578152026-w41-p5/doi:10.64898/2026.10.08.757815Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, examines rare clinical specimens from people living with HIV (PLWH), reporting fewer germinal center T follicular helper (Tfh) cells and more follicular CD8 T cells in lymphoid tissues. The authors say germinal center size was reduced by HIV and by older age, and that a lymphoid organoid model reproduced the findings.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.09.7578282026-w41-p5/doi:10.64898/2026.10.09.757828Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, trains adapted vision transformers (DINOv3) on phase-contrast time-lapse images of bacteria growing in microfluidic traps, without fluorescent labels. The authors report mean macro-F1 scores of 93.6% for clinical isolates precultured in Mueller-Hinton medium and 87.2% for isolates precultured in blood, and say evaluation on independent isolates and patient samples is still needed.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.08.7566322026-w41-p5/doi:10.64898/2026.10.08.756632Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses a model of beta-lactam antibiotic exposure to simulate bacterial populations over thousands of generations. The authors report that amplification and compensatory mutations converge on the same low-copy compensated state within weeks to months, leaving no sequence trace of the transient step.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.08.7576312026-w41-p5/doi:10.64898/2026.10.08.757631Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, combines global bird records with temperature anomalies to test how land use changes the effect of warming on abundance, richness and species composition. The authors report that predicted richness stayed below the primary-vegetation reference across all modified land uses, with the largest declines in high-intensity agriculture (17.9%) and urban land (21.8%).Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.26434/chemrxiv.15009889/v12026-w41-p5/doi:10.26434/chemrxiv.15009889/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a copper complex supported on Ketjenblack that works as a cathode catalyst to convert nitrate into ammonia using electricity. The authors report high ammonia selectivity over a wide range of current densities, with a low copper loading.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-arxiv:2610.096432026-w41-p5/arxiv:2610.09643Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, presents CircuitATLAS, a knowledge graph and agentic framework for finding targets in circuitopathies that deliberately excludes direct disease-gene edges. The authors report that an agent nominated the neuronal alpha3 Na+/K+-ATPase (ATP1A3) as a control point on cortical excitability, and that the target was then taken into a small-molecule drug campaign.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-pew:cb824ddb71922026-w41-p5/pew:cb824ddb7192Announcement. Pew Research Center reports that Democratic voters are more engaged in the 2026 midterm elections, amid deep public dissatisfaction with the state of the nation. It also notes near-record low approval ratings for Trump.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-arxiv:2610.108642026-w41-p5/arxiv:2610.10864Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, uses Edge Attribution Patching (EAP) to locate the circuits behind us-vs.-them bias in GPT-2 and Llama models, where prompts about an ingroup get more positive continuations than matched outgroup prompts. The authors report that patching the top-ranked edges reduced the bias more than random controls, but also degraded performance on CoLA, HellaSwag and WikiText-2, suggesting the pathways are entangled with broader language abilities.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-doi:10.64898/2026.10.08.7577072026-w41-p5/doi:10.64898/2026.10.08.757707Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that mitosis is the critical window for organizing extrachromosomal DNA (ecDNA) hubs in cancer cells. The authors identify the mitotic-entry regulator WEE1 as important for hub integrity and oncogene expression, and say the pattern holds across diverse cancer types.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p5/#item-pew:31da209b9ead2026-w41-p5/pew:31da209b9eadAnnouncement. Pew Research Center reports that far more voters say their choice for Congress this year is a vote against President Donald Trump (44%) than a vote for him (19%). The figures show the share of voters who consider Trump a factor in their vote.Sun, 11 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.1371/journal.pmed.10050782026-w41-p4/doi:10.1371/journal.pmed.1005078Peer-reviewed study. A peer-reviewed retrospective cohort study published October 6, 2026, followed 6,896 adults from the National Health and Nutrition Examination Survey (NHANES), 2005-2018, to test a machine learning aging index for predicting death in cardiovascular-kidney-metabolic (CKM) syndrome. The authors report that the index outperformed comparison indices for all-cause and cardiovascular mortality, and that depression partly explained these links. The study is observational, shows associations rather than cause, and was not validated in cohorts from other geographic regions.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.09.30.7555842026-w41-p4/doi:10.64898/2026.09.30.755584Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 7, 2026, reports laboratory experiments on human neutrophils, immune cells that engulf bacteria. The authors report that when complement is present, blocking antibody receptors no longer changes bacterial uptake, and that the protein C1q physically hinders contact between antibodies and those receptors. They say this matters for therapeutic antibody development.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.09.30.7557332026-w41-p4/doi:10.64898/2026.09.30.755733Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 7, 2026, profiles immune cells in the lungs of male and female mice after tuberculosis (TB) infection and after vaccination with Bacille Calmette-Guerin (BCG) or a live attenuated vaccine. The authors identify Thy1.2 expression on natural killer (NK) cells as a candidate sex-specific marker of protection, and say the study shows that sex matters in rodent models of tuberculosis.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.05.263646922026-w41-p4/doi:10.64898/2026.10.05.26364692Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 7, 2026, examines whether voice-quality features of speech, such as shimmer and harmonics-to-noise ratio (HNR), distinguish adults with depression from healthy controls and track symptom scores during treatment. The cross-sectional comparison included 82 adults with depressive disorders and 80 healthy controls, and the authors report that voice features were the most consistent speech correlates across analyses. They say the modest samples and chart-based diagnoses mean these features cannot yet be recommended as clinical tests.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.05.263648222026-w41-p4/doi:10.64898/2026.10.05.26364822Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 7, 2026, analyzes a 2024/2025 national survey of 1245 public health facilities in Ethiopia, looking at use of the electronic Logistics Management Information System (eLMIS) and Auditable Pharmaceutical Transactions and Services (APTS). The authors report that 54.2% of facilities had optimal availability of essential commodities, and an adjusted odds ratio of 4.32 for facilities using both systems. It is a secondary analysis of survey data, so the link is an association rather than proof that the systems cause better supply.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.06.7568792026-w41-p4/doi:10.64898/2026.10.06.756879Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 7, 2026, reports high-resolution structures of G protein-gated inwardly rectifying potassium (GIRK) channels in the heart, which form in unexpected subunit ratios. The authors report that adding GIRK1 subunits progressively opens the channel, and that the drug ML297 inhibits one arrangement while potentiating another. This is basic laboratory research aimed at designing more selective drugs.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.26434/chemrxiv.15010094/v12026-w41-p4/doi:10.26434/chemrxiv.15010094/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 8, 2026, reports spectroscopy experiments showing that glucagon and glucagon-like peptide 1 (GLP1) bind copper in ways that depend on the copper-to-hormone ratio. The authors say the diabetes drug metformin, a first-line treatment for Type 2 diabetes, can deliver copper to these hormones. The work is laboratory-only and does not measure effects in patients.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.06.7570282026-w41-p4/doi:10.64898/2026.10.06.757028Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 8, 2026, identifies an enzyme called SpiE that, working with SpiR, converts cholesterol into coprostanol, a sterol largely excreted in feces. In patient cohorts followed over time, antibiotic treatment coincided with loss of the enzyme and of coprostanol production, which recovered in some individuals as other SpiE-carrying genera emerged. The authors say the work lays groundwork for studies linking this pathway to host physiology.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.06.7571042026-w41-p4/doi:10.64898/2026.10.06.757104Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 8, 2026, describes an engineered bispecific biologic that delivers interleukin-15 (IL-15) signaling to memory CD4 T cells to reactivate latent human immunodeficiency virus type 1 (HIV-1). The authors report reactivation in 94% (48/51) of clinical samples ex vivo, in 75% (15/20) of administrations in humanized mice on antiretroviral therapy (ART), and in 100% (6/6) of simian immunodeficiency virus (SIV)-infected macaques at well-tolerated doses. The study is preclinical, and the authors say it could complement other reservoir-elimination strategies.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.07.263648682026-w41-p4/doi:10.64898/2026.10.07.26364868Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, pools six longitudinal population-based cohorts from the United Kingdom, United States, Norway and Australia to estimate how often heavy menstrual bleeding (HMB) and menstrual pain (MP) are reported across life. The authors report cumulative prevalence of 36% to 89% for heavy bleeding and 46% to 72% for pain, with pain more common in adolescence and heavy bleeding more common at ages 45 and above.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.07.263649202026-w41-p4/doi:10.64898/2026.10.07.26364920Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, uses Mendelian randomization, a genetic method, across European, East Asian, South Asian and African populations to test whether COVID-19 causally affects acute myocardial infarction (AMI). The authors report slight, non-significant inverse associations for severe and hospitalized COVID-19 in European ancestry, and no significant associations in East Asian or African ancestry. They conclude the cardiovascular burden may be driven more by acute mechanisms than by shared genetics.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.07.263649672026-w41-p4/doi:10.64898/2026.10.07.26364967Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, reports an online survey of 1,617 adults across 13 countries and regions on self-reported child maltreatment and how acceptable they perceive it to be. Greater exposure was linked to poorer mental health for several types and to greater acceptability of maltreatment, while prevalence and acceptability varied by place. The authors call for culturally sensitive assessment and intervention.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.07.263649762026-w41-p4/doi:10.64898/2026.10.07.26364976Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, introduces Precision Evidence Bench, a set of 209 synthetic clinical questions with specified population, intervention, comparator and outcome elements. The authors tested four large language models with web search, and report that precision match rates rose from 13 to 18% with web search alone to 41 to 56% with access to 500 million precision evidence findings.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.07.263649832026-w41-p4/doi:10.64898/2026.10.07.26364983Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, analyzes 412,020 UK Biobank participants, standardizing vitamin D measurements to a common late-winter level and reporting 31,197 deaths. The authors report a mortality hazard ratio of 2.03 for vitamin D below 5 ng/mL compared with 20 ng/mL or above, and say the findings reproduce links to diabetes, dementia and other conditions seen in earlier cohorts. The authors argue for a causal interpretation, but the study is observational.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.07.263649982026-w41-p4/doi:10.64898/2026.10.07.26364998Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, analyzes 13,879 participants in the U.S. Health and Retirement Study, grouping transitions to retirement between ages 51 and 75 into ten trajectories. The authors report that retiring earlier or later from full-time work was not linked to dementia risk, while sustained part-time work was associated with lower odds of dementia (odds ratio 0.62) and prolonged disability with higher odds (odds ratio 1.53). These are associations, and the authors say gradual, flexible transitions may benefit brain health.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-arxiv:2610.088042026-w41-p4/arxiv:2610.08804Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 8, 2026, models a regulator who designs policy signals while holding an implicit option to leave for the regulated firm or its advisers. The authors argue this option can delay oversight until firms cross a leverage-vega warning threshold, and report that limits on post-employment work affect post-agency pay in federal payroll data. The paper uses Lehman Brothers, Silicon Valley Bank and Signature Bank as historical illustrations and does not predict collapse dates.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-nber:832bf5df3e1a2026-w41-p4/nber:832bf5df3e1aPreprint, not peer-reviewed. A working paper, not yet peer-reviewed and published October 8, 2026, examines a Federal Trade Commission allegation that Amazon's advertising auctions, described as second-price, used soft reserves that charged winning advertisers up to their bids. The authors find that if advertisers see only win rates and expected charges, a soft reserve is indistinguishable from a second-price auction at any fixed bid, while flagged charges would expose it quickly.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.1073/pnas.26089191232026-w41-p4/doi:10.1073/pnas.2608919123Peer-reviewed study. A peer-reviewed study published October 5, 2026, describes a deep learning model that predicts toxic effects of chemicals from their molecular structure, with a focus on endocrine-disrupting chemicals. The authors say the model outperforms existing structure-based methods in external validations and is intended to support multi-endpoint toxicity assessment and regulatory decision-making.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-openai:9964af802e9c2026-w41-p4/openai:9964af802e9cAnnouncement. An announcement from OpenAI, published October 6, 2026, says it and Ironclad are training and evaluating artificial intelligence (AI) agents on complex contracting workflows, to advance computer use for professional work. Because it is OpenAI's own account, it reports what the company says it is doing rather than independently verified results. The abstract describes the work and does not give outcomes.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-openai:077dea1e8a7a2026-w41-p4/openai:077dea1e8a7aAnnouncement. An announcement from OpenAI, published October 8, 2026, says the company disrupted two influence operations that used artificial intelligence (AI) to run false-front journalists and a think tank spreading geopolitical messages. Because it is OpenAI's own account, it describes what the company reports finding and stopping rather than independently verified details.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.26434/chemrxiv.15010010/v12026-w41-p4/doi:10.26434/chemrxiv.15010010/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 6, 2026, reports a lanthanide complex scintillator, a material that emits light when hit by radiation. The authors report a light output of 134,400 photons per MeV in powder form and 180,000 in single-crystal form, which they describe as unprecedented. In an imaging test, they say it enabled at least a fivefold reduction in irradiation time compared with radiography without an intensifying screen.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.26434/chemrxiv.15007405/v22026-w41-p4/doi:10.26434/chemrxiv.15007405/v2Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 7, 2026, describes deep learning software that tracks the full course of a point-of-care test to correct for signal noise, shown in a lateral flow assay for xylazine. In 251 patient urine samples, the authors report 94.02% accuracy and 71.15% sensitivity, compared with 89.2% accuracy and 48.1% sensitivity for human reading, using liquid chromatography-tandem mass spectrometry as the benchmark.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.26434/chemrxiv.15010123/v12026-w41-p4/doi:10.26434/chemrxiv.15010123/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 8, 2026, presents a dynamic model of direct air capture, a technology for removing carbon dioxide from air, applied to Alberta, Canada, using 2024 data. The authors report that optimized locations and cycle designs reduce estimated costs by up to 20%, and that dynamic conditions favor sites in northern Alberta. Because it is a modeling study, its estimates depend on the assumptions built into the model.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-arxiv:2610.112222026-w41-p4/arxiv:2610.11222Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, describes a dual-rule contrastive learning framework that aligns mouse and human neural states by biological state rather than species. The authors report that drug-induced movement toward the human-aligned healthy state tracked known clinical efficacy retrospectively across ten model-drug combinations, and that the framework linked Fmr1-knockout mice with human 16p11.2 copy-number variant carriers. Because the tracking looks back at known outcomes, it does not show that the method predicts new results.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-arxiv:2610.115572026-w41-p4/arxiv:2610.11557Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, derives mathematically that when connected vehicles take distinct roles, throughput is maximized when one designated buffer vehicle keeps a larger headway, letting the rest form a tightly spaced platoon. The authors confirm this with numerical spectral analysis and simulations using two traffic models, and report higher flow than unbuffered traffic. The work is theoretical and simulation-based, not a field test.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.1073/pnas.26099821232026-w41-p4/doi:10.1073/pnas.2609982123Peer-reviewed study. A peer-reviewed study published October 9, 2026, uses mathematical models to examine how morbidity that lasts after infection changes the management of vaccination and other interventions. The authors report that long-term nonpharmaceutical interventions can reduce post-acute burden, and that post-infection costs can substantially shift societal incentives toward elimination. These are model results, so they show how incentives could change rather than measuring actual costs.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.26434/chemrxiv.15010134/v12026-w41-p4/doi:10.26434/chemrxiv.15010134/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, models hydrothermal liquefaction (HTL), a process that converts wet organic waste into fuels and bioproducts, combining 402 literature experiments with process, cost and life-cycle analyses. The authors report median internal rates of return (IRR) up to 35.8% for decentralized biobinder systems, compared with up to 8.0% for decentralized sustainable aviation fuel (SAF) systems. They say existing tipping fees can support deployment in some cases, and higher fees or incentives can widen viability.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.26434/chemrxiv.15010139/v12026-w41-p4/doi:10.26434/chemrxiv.15010139/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, describes temperature-responsive hydrogel microspheres that could redirect flow in geothermal reservoirs away from cooled short-circuit channels. The authors report that highly idealized simulations suggest a thermal lifetime improvement by a factor of at least 24 to 59, and a laboratory experiment showing the microgels clog cooled channels and divert flow into hotter regions, which they describe as a proof of concept.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.26434/chemrxiv.15010155/v12026-w41-p4/doi:10.26434/chemrxiv.15010155/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, tests silver alloying interlayers on zinc metal anodes built from particles of 100 nm, a few μm and 100 μm. The authors report that layers of few-μm particles gave the highest plating and stripping reversibility, and say this challenges the assumption that nanostructured layers are inherently better.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.26434/chemrxiv.15010188/v12026-w41-p4/doi:10.26434/chemrxiv.15010188/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, describes a flexible solar cell with two perovskite layers and one organic layer on a 10 μm polyethylene terephthalate substrate. The authors report a power conversion efficiency of 24.1%, a stabilized efficiency of 24.6% and 11.2 W/g of power per weight, and say it could suit aerospace, unmanned aerial vehicles, wearable electronics and portable power.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.04.7556112026-w41-p4/doi:10.64898/2026.10.04.755611Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, describes Denasin1, a miniprotein designed by computer to block the human acid-sensing ion channel 1a (hASIC1a), which causes neuronal death during ischaemic stroke. The authors report near-complete inhibition at nanomolar potency and a reduction in infarct volume (the size of damaged tissue) of more than 50% in a murine model of ischaemic stroke. The work is in cells and mice, not people.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.06.7570612026-w41-p4/doi:10.64898/2026.10.06.757061Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, reports a high-content screen of 960 compounds from a drug repurposing library, which identified four concentration-dependent inhibitors of dengue virus. The most potent, LY411575, a gamma secretase inhibitor, had an IC of 72 nM, and the authors say time-of-addition experiments suggest it acts before late-stage infection.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.06.7571332026-w41-p4/doi:10.64898/2026.10.06.757133Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, reports that a stiffer extracellular matrix, the material around cells, potentiates signaling by the epidermal growth factor receptor (EGFR) from single molecules up to spheroids and tissues. The authors say integrin adhesions reshape the membrane to form signaling hotspots, and suggest this could help explain why some tyrosine kinase inhibitors lose effect in tumors. The link to clinical resistance is a suggestion, not a tested finding.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.07.7554302026-w41-p4/doi:10.64898/2026.10.07.755430Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, reports that red blood cells bind tumor-derived deoxyribonucleic acid (DNA) on their surface, forming a circulating pool. In mice with lung cancer xenografts this bound tumor DNA tracked tumor burden, and in patients with lung cancer most detected mutant tumor DNA was on red cells rather than in plasma. The authors say this challenges the plasma-centric approach to liquid biopsy.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.07.7574872026-w41-p4/doi:10.64898/2026.10.07.757487Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, reports crystal structures of a cysteine-dependent hydrolase (CsdH) from Rhodococcus opacus in complex with polyethylene, polypropylene, polystyrene and styrene. The authors show the enzyme degrades these homopolymers into smaller products, with polyethylene degraded most, and say the work lays a foundation for enzyme engineering against microplastic pollution.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.08.7574822026-w41-p4/doi:10.64898/2026.10.08.757482Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, describes fully chemically modified RNA nanostructures built entirely from stabilized therapeutic nucleic acids, which the authors say can deliver small interfering RNA (siRNA) to heart and muscle without a separate vehicle. The authors report sustained silencing of up to four genes from one structure, and that larger structures improve distribution to the central nervous system after cerebrospinal fluid administration.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.08.7575742026-w41-p4/doi:10.64898/2026.10.08.757574Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, reports 12 days of continuous laboratory exposure of human kidney proximal tubule cells to 20 nm or 100 nm carboxylated polystyrene nanoplastics. The authors report that 20 nm particles caused progressive loss of viability and extensive gene dysregulation, while 100 nm particles had minimal effect, and they identify ANGPTL4 as a candidate early marker of kidney stress.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-doi:10.64898/2026.10.08.7577312026-w41-p4/doi:10.64898/2026.10.08.757731Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, published October 9, 2026, reports that long-term treatment of Tg2576 mice, a model of Alzheimer disease, with acetazolamide (ATZ), a carbonic anhydrase inhibitor, reduced cardiac amyloid-beta and restored heart function in 13-month-old mice. The authors also report that inhibition in human cardiomyocytes preserved brain-derived neurotrophic factor (BDNF) signaling against amyloid-beta oligomers. The work is in mice and cultured cells, not people.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-pew:8d665248db422026-w41-p4/pew:8d665248db42Announcement. Pew Research Center reports, in an announcement published October 9, 2026, that about half of U.S. adults never use chatbots, and that most non-users cite disinterest, privacy or accuracy concerns. It summarizes Pew's own survey findings, so it reports what Pew says rather than independent verification.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p4/#item-pew:ebfa48642c292026-w41-p4/pew:ebfa48642c29Announcement. Pew Research Center's digest of its worldwide public opinion surveys, published October 9, 2026, cites a Reuters report that social media harms democracy by spreading rumors. The same digest says most people think artificial intelligence (AI) will cut more jobs than it creates, and that Indians feel AI will widen the rich-poor gap. As a digest of other coverage, it gives the findings without survey methods.Sat, 10 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-2026-204482026-w41-p3/2026-20448In effect. The Food and Drug Administration (FDA) has issued a final determination exempting certain class II clinical toxicology test systems from premarket notification (510(k)) requirements, subject to limits. The exemption took effect on October 6, 2026 and is in effect immediately, and the Code of Federal Regulations is amended to match. The FDA says the exemption will decrease regulatory burdens on the medical device industry.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.02.263625542026-w41-p3/doi:10.64898/2026.10.02.26362554Preprint, not peer-reviewed. This preprint on medRxiv, not yet reviewed by other scientists, describes RFM, a 64-million-parameter vision transformer trained on 4.3 million colour fundus photographs. It reports that a single frozen backbone predicts diabetic retinopathy grading, glaucoma, UK Biobank biomarkers and three-year incidence of myocardial infarction, ischaemic stroke and Parkinson's disease.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.05.263647692026-w41-p3/doi:10.64898/2026.10.05.26364769Preprint, not peer-reviewed. This modelling preprint on medRxiv, not yet reviewed by other scientists, estimates the impact and cost of targeted long-acting HIV pre-exposure prophylaxis (LAP) across sub-Saharan Africa to 2050. Across 34 countries, allocating a fixed quantity of LAP by district, sex and age averted 2 to 21 times as many infections as uniform allocation, and LAP offsets its cost through averted treatment only when it is targeted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.05.263648042026-w41-p3/doi:10.64898/2026.10.05.26364804Preprint, not peer-reviewed. This microsimulation preprint on medRxiv, not yet reviewed by other scientists, models removing race-adjusted antihypertensive treatment recommendations for non-Hispanic Black adults. If treatment effectiveness differs by race, life expectancy among non-Hispanic Black adults falls by 0.4 years in the model and the gap with non-Hispanic white adults widens; if it does not, the effect is smaller, at 0.1 years.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.05.263648062026-w41-p3/doi:10.64898/2026.10.05.26364806Preprint, not peer-reviewed. This preprint on medRxiv, not yet reviewed by other scientists, reports machine learning models that use only routinely collected electronic health record data to predict obstructive sleep apnea (OSA). In internal testing the full XGBoost model reached a ROC-AUC of 0.791 for any OSA, and external validation at a second health system gave a ROC-AUC of 0.718 for the full model.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.05.263648082026-w41-p3/doi:10.64898/2026.10.05.26364808Preprint, not peer-reviewed. This preprint on medRxiv, not yet reviewed by other scientists, analyzes 2018 and 2024 Nigeria Demographic and Health Surveys covering 80,871 women aged 15 to 49. It finds modern contraceptive use is far lower among women in the most disadvantaged profile, and that use rose across all profiles between 2018 and 2024 while inequalities persisted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.05.263640472026-w41-p3/doi:10.64898/2026.10.05.26364047Preprint, not peer-reviewed. This preprint on medRxiv, not yet reviewed by other scientists, uses network pharmacology to link 33 antidepressants and 26 antipsychotics to pathways associated with weight-related side effects. It highlights GPCR, PI3K-Akt, leptin and insulin signaling, and adipogenesis as candidate pathways, based on computational analysis of drug-protein interactions.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.06.263643112026-w41-p3/doi:10.64898/2026.10.06.26364311Preprint, not peer-reviewed. This preprint on medRxiv, not yet reviewed by other scientists, uses plasma proteomic profiles of 10,043 participants in the All of Us Research Program to build protein scores for more than 100 exposures. It finds the protein signatures largely consistent across populations, and that PM2.5 protein scores track exposure variation within regions.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.06.263648672026-w41-p3/doi:10.64898/2026.10.06.26364867Preprint, not peer-reviewed. This population-based preprint on medRxiv, not yet reviewed by other scientists, analyzes 39,061 U.S. adults in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020. It links phthalate esters and organophosphate flame retardants to higher odds of steatotic liver disease, and suggests inflammation markers account for part of the association; as an observational analysis, it shows a link, not a cause.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-mmwr:1612aae97d2f2026-w41-p3/mmwr:1612aae97d2fFinal report. This final report from CDC MMWR describes increases in frequent mental distress and physical inactivity among adults aged 18 to 29 years in the United States during 2012 to 2024.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-2026-204292026-w41-p3/2026-20429Withdrawn. On October 6, 2026, the Financial Crimes Enforcement Network (FinCEN) of the Treasury Department withdrew its finding and proposed rulemaking that international convertible virtual currency mixing is a class of transactions of primary money laundering concern under section 311 of the USA PATRIOT Act. The proposed special measure is withdrawn and is no longer pending.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-2026-204302026-w41-p3/2026-20430Withdrawn. On October 6, 2026, the Financial Crimes Enforcement Network (FinCEN) withdrew its proposed rule that would have required banks and money service businesses (MSBs) to file reports, keep records and verify customers' identities for transactions in convertible virtual currency or digital assets held in unhosted wallets or in certain jurisdictions. FinCEN says it will take no further action on the proposal.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-nber:b6427b8edbb82026-w41-p3/nber:b6427b8edbb8Preprint, not peer-reviewed. This preprint from NBER, not yet peer-reviewed, uses newly linked IRS data to study tax-planning structures that exploit mismatches between US and foreign tax laws. It reports that in 2016 these structures accounted for 36% of foreign profits despite being adopted by 18% of firms, and it uses a structural model to show trade-offs between tax revenue and economic activity from restricting them.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-nber:ec09245313432026-w41-p3/nber:ec0924531343Preprint, not peer-reviewed. This preprint from NBER, not yet peer-reviewed, uses spatially disaggregated data from Japan to show that rural areas have experienced faster depopulation and aging than urban areas, driven by low fertility and out-migration of young cohorts. A calibrated spatial model predicts widening geographic disparities, and subsidies to declining regions lower regional inequality at the cost of lower aggregate efficiency.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-arxiv:2610.112562026-w41-p3/arxiv:2610.11256Preprint, not peer-reviewed. This preprint on arXiv, not yet reviewed by other scientists, simulates a four-firm logit Bertrand market in which each firm runs a different language model, without communication. It reports that collusion is a property of the model: Claude and Gemini markets reached 72 to 79 percent of the monopoly rent, DeepSeek 24 percent, and GPT markets none.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-2026-203862026-w41-p3/2026-20386Proposed. The Federal Aviation Administration proposes to amend its commercial space launch and reentry licensing rules to streamline licensing and reduce the regulatory burden on operators. Under the proposal, operators using physical containment as a hazard control would not need to develop flight hazard areas under the existing analysis requirements. The change is a proposal only and would not take effect unless adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-2026-203302026-w41-p3/2026-20330In effect. The National Oceanic and Atmospheric Administration has issued a rule implementing Amendment 4 to the Puerto Rico Fishery Management Plan, which reclassifies rainbow runner from a reef fish to a pelagic fish. The rule sets management measures for the species on that basis, including sector annual catch targets and accountability measures, and keeps the existing sector annual catch limits. It is in effect from October 5, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-2026-203562026-w41-p3/2026-20356In effect. The National Oceanic and Atmospheric Administration announces that North Carolina is transferring part of its 2026 commercial summer flounder quota to Massachusetts. The temporary rule revises the 2026 commercial quotas for both states under the Summer Flounder, Scup, and Black Sea Bass Fishery Management Plan. It has been in effect since October 2, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-2026-206522026-w41-p3/2026-20652In effect. The National Oceanic and Atmospheric Administration is moving 70.2 metric tons of quota from the Reserve category into the General category's October through November subquota, and adding 16.7 metric tons left over from June through August. The adjusted subquota is 192.9 metric tons and the Reserve category falls to 42 metric tons. The rule affects commercial General category vessels and Highly Migratory Species (HMS) Charter/Headboat vessels with a commercial sale endorsement, and it took effect on October 6, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.1073/pnas.26043931232026-w41-p3/doi:10.1073/pnas.2604393123Peer-reviewed study. This peer-reviewed study in PNAS uses normal lung organoids to show that chronic exposure to cigarette smoke condensate pushes two types of stem cells toward premalignant states. When specific mutations are added, one stem cell type gives rise to adenocarcinomas and the other to squamous cell carcinomas, two major types of non-small cell lung cancer. The findings come from laboratory models.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.26434/chemrxiv.15009880/v12026-w41-p3/doi:10.26434/chemrxiv.15009880/v1Preprint, not peer-reviewed. This preprint on ChemRxiv, not yet reviewed by other scientists, proposes three performance metrics for hybrid water electrolysis, a process that produces hydrogen while oxidizing an organic chemical, and benchmarks reported systems against them. A techno-economic analysis links these metrics to net present value and identifies catalyst stability as the foremost bottleneck.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.26434/chemrxiv.15009882/v12026-w41-p3/doi:10.26434/chemrxiv.15009882/v1Preprint, not peer-reviewed. This preprint on ChemRxiv, not yet reviewed by other scientists, studies sulfide solid-electrolyte separators for all-solid-state batteries. It reports that a more homogeneous pore network gives more mechanically reliable separators, while a separator with a broad particle-size distribution showed cracking and interfacial delamination after cycling.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.1073/pnas.25297931232026-w41-p3/doi:10.1073/pnas.2529793123Peer-reviewed study. This peer-reviewed PNAS study in mouse models maps gene activity across brain regions in type 2 diabetes-associated cognitive dysfunction and identifies lactate dehydrogenase B (Ldhb) as a shared effector. In these mice, raising Ldhb alleviated mitochondrial dysfunction, oxidative stress, neuronal apoptosis and cognitive impairment, and the study highlights it as a potential therapeutic target.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.26434/chemrxiv.15009039/v32026-w41-p3/doi:10.26434/chemrxiv.15009039/v3Preprint, not peer-reviewed. This preprint on ChemRxiv, not yet reviewed by other scientists, combines density functional theory, molecular dynamics and microkinetic modeling to study CO2 chemisorption in choline-imidazolate solvents with monoethanolamine, diethanolamine or methyldiethanolamine. It finds that choline is the preferred binding site unless an alkanolamine is present, which shifts capture toward carbamate formation.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.1038/s41586-026-11114-12026-w41-p3/doi:10.1038/s41586-026-11114-1Peer-reviewed study. This peer-reviewed study in Nature uses human lung organoids that contain their own resident immune cells. It shows that SARS-CoV-2 infection elicits protective tissue-resident memory T cell responses, which the study describes as local recall immunity in the lung.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.1073/pnas.25219871232026-w41-p3/doi:10.1073/pnas.2521987123Peer-reviewed study. This peer-reviewed PNAS study in mice finds that the antidepressant tianeptine enhances excitatory transmission at α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the hippocampus. The enhancement is indirectly mediated by activation of opioid receptors, and opioid peptides and selective agonists mimic it.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.26434/chemrxiv.15010016/v12026-w41-p3/doi:10.26434/chemrxiv.15010016/v1Preprint, not peer-reviewed. This preprint on ChemRxiv, not yet reviewed by other scientists, reports atomically precise platinum nanocluster catalysts on Al2O3 for dehydrogenating methylcyclohexane to produce hydrogen. It reports mass activity up to 8.2 times that of conventional nanoparticle catalysts, with byproduct yield below 3% at 250 °C.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.26434/chemrxiv.15010022/v12026-w41-p3/doi:10.26434/chemrxiv.15010022/v1Preprint, not peer-reviewed. This preprint on ChemRxiv, not yet reviewed by other scientists, describes a self-quenched synthesis of tin oxide nanocrystals at room temperature that the preprint reports is independent of most synthesis conditions. Perovskite solar cells built with the nanocrystal thin films reached power conversion efficiencies of at least 21%.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.26434/chemrxiv.15010067/v12026-w41-p3/doi:10.26434/chemrxiv.15010067/v1Preprint, not peer-reviewed. This preprint on ChemRxiv, not yet reviewed by other scientists, reports that alloying FeOOH with Se, Sn, Ti or Hf slows its dissolution in alkaline electrolyte. FeTiOOH dissolved about eight times more slowly than FeOOH, but the more stable alloys also showed reduced oxygen evolution reaction activity.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.26434/chemrxiv.15009882/v22026-w41-p3/doi:10.26434/chemrxiv.15009882/v2Preprint, not peer-reviewed. A second version of this ChemRxiv preprint, not yet reviewed by other scientists, reports that pore-network homogeneity governs the mechanical reliability of sulfide solid-electrolyte separators. Separators with a narrower particle-size distribution showed a more homogeneous pore network and local mechanical response, while the heterogeneous separator cracked and delaminated after cycling.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.26434/chemrxiv.15010110/v12026-w41-p3/doi:10.26434/chemrxiv.15010110/v1Preprint, not peer-reviewed. This preprint on ChemRxiv, not yet reviewed by other scientists, simulates the Li/Li 6 PS 5 Cl interface with machine-learning interatomic potentials. Without a field the electrolyte decomposes into a Li 2 S-rich interphase, and an electric field speeds this growth nearly seven-fold, after which a percolating Li 2 S network persists even when the current is reversed.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.09.30.7558392026-w41-p3/doi:10.64898/2026.09.30.755839Preprint, not peer-reviewed. This preprint on bioRxiv, not yet reviewed by other scientists, reports that loss of the endothelial protein MFSD2A is an early, hippocampus-specific feature of blood-brain barrier disruption in Alzheimer's disease. In APP/PS1 mice, sustained restoration of MFSD2A from an early stage gave the greatest protection, reducing leakage, amyloid plaques and memory deficits, while restoring it later did not reverse leakage or cognitive impairment.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.01.7560942026-w41-p3/doi:10.64898/2026.10.01.756094Preprint, not peer-reviewed. This preprint on bioRxiv, not yet reviewed by other scientists, studies DNA polymerase kappa (POLK) in mouse cortical neurons and in human induced pluripotent stem cell-derived forebrain neurons. Partial POLK depletion produced a senescence-like stress phenotype and reduced EdU incorporation, while augmenting POLK in neurons increased EdU incorporation and reduced DNA damage markers.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.02.7559762026-w41-p3/doi:10.64898/2026.10.02.755976Preprint, not peer-reviewed. This preprint on bioRxiv, not yet reviewed by other scientists, profiles synaptic proteins from post-mortem brain tissue of 67 people, 40 with Alzheimer's disease across all Braak stages and 27 non-diseased controls. It identifies six stage-associated signatures and nominates 42 plasma proteins linked to disease stage and cognitive measures.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.06.7571702026-w41-p3/doi:10.64898/2026.10.06.757170Preprint, not peer-reviewed. This preprint on bioRxiv, not yet reviewed by other scientists, applies a gene-centric analysis to copy number variants that delete whole genes. It identifies 34 gene deletions associated with cancer incidence, including deletions in the 13q14 region linked to higher cancer risk, and reports associations with asthma and heart attack.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.07.7504532026-w41-p3/doi:10.64898/2026.10.07.750453Preprint, not peer-reviewed. This preprint on bioRxiv, not yet reviewed by other scientists, reports in mice that the bone-derived hormone osteocalcin signals through the GPR158 receptor on spinal motoneurons to fine-tune autophagy, mitophagy and mitochondrial activity. Restoring these processes rescued locomotor deficits in GPR158-deficient mice, and restoring osteocalcin in aged mice reversed age-related locomotor decline.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-doi:10.64898/2026.10.07.7511072026-w41-p3/doi:10.64898/2026.10.07.751107Preprint, not peer-reviewed. This preprint on bioRxiv, not yet reviewed by other scientists, compares transcriptomic data from skeletal muscle and brain tissue to test a putative muscle-brain axis in Alzheimer's disease. It reports convergent endothelial and myeloid inflammatory programs, with related signals detectable in blood, and nominates ETS2 and BHLHE40 as candidate regulators for testing.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-arxiv:2610.108512026-w41-p3/arxiv:2610.10851Preprint, not peer-reviewed. This preprint on arXiv, not yet reviewed by other scientists, infers latent user moods from pre-treatment actions with a hidden Markov model, then estimates treatment effects by those states. In a large-scale A/B test of a new recommendation model at Netflix, heavy-engagement users showed significantly positive effects, with limited evidence of benefit among less-active and rewatch-oriented users.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p3/#item-arxiv:2610.108952026-w41-p3/arxiv:2610.10895Preprint, not peer-reviewed. This preprint on arXiv, not yet reviewed by other scientists, tests whether summary statistics from transmission trees improve neural simulation-based inference of the reproduction number and infection duration in simulated susceptible-infectious-recovered (SIR) outbreaks. It reports that adding tree statistics improved both estimates over case counts alone, and that all three neural models outperformed the baseline.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.64898/2026.10.03.263641422026-w41-p2/doi:10.64898/2026.10.03.26364142Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes HealthFound, a medical large language model trained on 12.4 million examples, including 15-year biomedical records from 501,936 participants. The authors report that it outperforms the second-best model by over 10 percentage points on average on 1,162 UK Biobank tasks that predict future disease onset. They also report results in two external validations, MIMIC-IV and NHANES.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.64898/2026.10.05.263647572026-w41-p2/doi:10.64898/2026.10.05.26364757Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, presents a decentralised method that estimates how an epidemic spreads from digital exposure-history data. Only aggregated results go to a central server, and the authors tested the method on synthetic data from a hypothetical respiratory pathogen. They report that it recovered transmission parameters closely matching centralised estimates, and suggest digital contact tracing could help characterise transmission almost in real time.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-206132026-w41-p2/2026-20613Proposed. The Centers for Medicare & Medicaid Services (CMS) proposes amending the Clinical Laboratory Improvement Amendments of 1988 (CLIA) regulations. It would allow virtual access under a lab's certificate to data from the primary testing lab that generated it, except for cytology, and would allow digital images for gynecologic cytology proficiency testing. The proposal also changes personnel qualifications and other requirements, and aims to strengthen federal oversight of clinical laboratories. It is not final.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.1016/j.cell.2026.09.0322026-w41-p2/doi:10.1016/j.cell.2026.09.032Peer-reviewed study. A peer-reviewed study in the journal Cell reports that deficiency of the immunoregulatory gene GIMAP6 drives atherosclerosis and ischemic heart disease, through a route that works without high blood lipids (hyperlipidemia). The study also reports that high blood lipids significantly worsen disease progression.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.64898/2026.10.06.263648822026-w41-p2/doi:10.64898/2026.10.06.26364882Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyses 11,624 households in three Multiple Indicator Cluster Surveys to track arsenic in drinking-water sources in Bangladesh from 2012-13 to 2025. After laboratory adjustment, the share of sources above 10 parts per billion (ppb) fell from 24.0% to 14.4%, and about 26 million people used such water in 2025. The authors caution that the size of the fall depends on later test kits that have not been verified.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.64898/2026.10.06.263649082026-w41-p2/doi:10.64898/2026.10.06.26364908Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is an ecological study of US Health Service Areas with UK Biobank corroboration. It reports that higher ambient ultraviolet (UV) exposure is associated with lower cardiovascular and all-cancer mortality, with modeled attributable burdens exceeding 5%. Because the analysis compares areas rather than individuals, it shows associations rather than causes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-207212026-w41-p2/2026-20721Proposed. The Food and Drug Administration (FDA) has announced draft guidance stating that, at this time, it does not intend to enforce certain traceability record requirements as they apply to certain retail food establishments and restaurants. The guidance concerns the FDA rule titled 'Requirements for Additional Traceability Records for Certain Foods.' Draft guidance is not final, and it reflects the agency's current understanding of the risks.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-203602026-w41-p2/2026-20360Proposed. The Securities and Exchange Commission (SEC) proposes changes to the rule that lets interval funds, which are closed-end funds, offer to repurchase shares at net asset value (NAV) at set intervals. The changes would give these funds more flexibility in repurchase offers and liquidity management, and would allow certain closed-end funds to issue multiple share classes. The proposal would also require more expense information in fund shareholder reports and prospectuses.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-203712026-w41-p2/2026-20371Proposed. The Financial Crimes Enforcement Network (FinCEN) of the Treasury Department proposes to prohibit certain fund transfers by covered financial institutions that involve companies outside the United States controlled by the A7 Network. FinCEN finds these transactions to be a class of primary money laundering concern, and describes the A7 Network as a sanctions evasion and money laundering service with ties to Russia. The proposal is not final.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-204472026-w41-p2/2026-20447Final rule. The Treasury Department, Labor Department and Health and Human Services Department (HHS), with the Internal Revenue Service and the Employee Benefits Security Administration, have issued final rules on price transparency reporting for group health plans and health insurance issuers. The rules aim to make public pricing data more standardized, accurate and accessible, by changing the machine-readable files of in-network rates and out-of-network allowed amounts and requiring a contact information file and website footers. The rules take effect December 7, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-204662026-w41-p2/2026-20466Proposed. The Securities and Exchange Commission (SEC) proposes new custody rules covering how regulated investment companies may hold crypto securities, and how registered investment advisers may hold client crypto funds and securities. It would also modernize the existing custody rules, change related recordkeeping, reporting and forms, and add questions about tokenized private funds and regulated investment company shares. The proposal is not final.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-204742026-w41-p2/2026-20474Proposed. The Securities and Exchange Commission (SEC) proposes to let investment advisers receive performance-based compensation from more clients: registered management investment companies and business development companies, subject to conditions. It would also allow it from investors who meet the accredited investor definition under Regulation D, and would require separate disclosure of the compensation regulated funds pay their advisers. The proposal is not final.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-arxiv:2610.109392026-w41-p2/arxiv:2610.10939Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, models how carbon policy can shift mobile industrial activity between regions, and when such shifts make the arrangement unstable. The authors find that cooperating governments can choose a stable policy where a non-cooperative choice would be unstable. They also report a positive association between industrial emissions and activity in European regional data.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-206602026-w41-p2/2026-20660Proposed. The Homeland Security Department proposes new fees for Optional Practical Training (OPT) for each F-1 nonimmigrant student who engages in it through a Student and Exchange Visitor Program-certified institution: $70,000 for initial OPT and $30,000 for any subsequent OPT. The stated aims are to combat fraud, strengthen the integrity of the immigration system and protect U.S. workers. The proposal is not final.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-203352026-w41-p2/2026-20335Proposed. The Nuclear Regulatory Commission (NRC) proposes amending its rules to expand how certain nuclear material can be used without a license, removing the need for licenses for some uses and quantities. The NRC describes the proposal as deregulatory and consistent with several Executive orders. The proposal is not final.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-203362026-w41-p2/2026-20336Final rule. The Nuclear Regulatory Commission (NRC) has issued a final rule expanding how certain nuclear material can be used without a license, removing the need for licenses for some uses and quantities. The NRC says the changes are deregulatory and consistent with several Executive orders. The rule takes effect December 21, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-204802026-w41-p2/2026-20480Proposed. The Delaware River Basin Commission proposes amending its Water Code and Comprehensive Plan to require water supply systems that serve the public, called purveyors in the document, to report water use by their largest customers. The proposal is not final, and no effective date has been set.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-203252026-w41-p2/2026-20325In effect. The Federal Motor Carrier Safety Administration (FMCSA) has changed its emergency rules so that relief automatically triggered by a regional emergency declaration lasts 30 days instead of 14. The change responds to petitions for reconsideration of a final rule issued in October 2023, and it has been in effect since October 5, 2026. The declaration may come from a state's governor, the governor's authorized representative, or FMCSA itself.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-203382026-w41-p2/2026-20338In effect. The National Oceanic and Atmospheric Administration (NOAA) has temporarily prohibited directed fishing for Pacific ocean perch in the Western Regulatory Area of the Gulf of Alaska. The action is needed to keep the catch from exceeding the 2026 total allowable catch for that species in that area. The temporary rule has been in effect since October 1, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-206302026-w41-p2/2026-20630Final rule. The Animal and Plant Health Inspection Service (APHIS) has issued a final rule removing restrictions on imports of fresh cut flowers of the chrysanthemum genera from countries where chrysanthemum white rust is known to exist. The rule also moves the list of specific cut flower import requirements out of the regulations and into the Agricultural Commodity Import Requirements database, so they can be updated by notice. The rule takes effect November 9, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-207922026-w41-p2/2026-20792Final rule. The Agriculture Department has issued a final rule amending Marketing Order No. 989, which regulates California raisins, approving amendments proposed by the Raisin Administrative Committee. The rule cuts the committee from 47 to 21 members, lowers its quorum from 25 to 14, and adds an unaffiliated producer seat. The rule takes effect November 9, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-202962026-w41-p2/2026-20296Proposed. The Consumer Product Safety Commission (CPSC) has proposed a safety standard for lithium-ion batteries used in micromobility products and in the electrical systems of micromobility products that contain them. This notice, published October 5, 2026, invites oral comments on the proposal, and those comments must stay within its scope. The proposal is not final.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-2026-206502026-w41-p2/2026-20650Proposed. U.S. Customs and Border Protection (CBP) proposes changing filing requirements for informal entries of goods valued at $2,500 or less. It would create a new electronic informal entry type for merchandise entering by mail, require an extra data element for carriers of mail shipments, and impose bonding requirements for certain informal entries. The proposal is not final.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.26434/chemrxiv.15009865/v12026-w41-p2/doi:10.26434/chemrxiv.15009865/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a catalyst made from a trace amount of CoNi alloy on polypyrrole-derived carbon nanoparticles, for zinc-air batteries (ZABs). The authors say it works in both alkaline and near-neutral electrolytes, with more than 650 cycles in alkaline electrolyte and more than 1100 cycles in near-neutral electrolyte.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.26434/chemrxiv.15009962/v12026-w41-p2/doi:10.26434/chemrxiv.15009962/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports synthesizing buprenorphine, a medicine used to treat pain and opioid addiction, starting from morphine rather than thebaine. The authors say morphine is the most abundant and cheapest poppy alkaloid, and that the route could help ensure continued supply of a medicine that has faced recent global shortages.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.26434/chemrxiv.15009967/v12026-w41-p2/doi:10.26434/chemrxiv.15009967/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a dual-ligand iron complex anolyte (a liquid used in the battery) for alkaline all-iron flow batteries, which are aimed at large-scale energy storage. The authors say one full cell kept 98.28% of its capacity over 1200 cycles, and a cell with more dissolved iron kept 96.87% after 1800 cycles.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.26434/chemrxiv.15009984/v12026-w41-p2/doi:10.26434/chemrxiv.15009984/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that adding tin (Sn) to a cobalt oxide catalyst improves its activity for splitting water in acid, and that a very thin protective layer on top improves its stability more than eightfold. The authors link the work to green hydrogen, which they say is expected to help decarbonise hard-to-electrify sectors such as shipping, aviation, steel and fertiliser.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.26434/chemrxiv.15010035/v12026-w41-p2/doi:10.26434/chemrxiv.15010035/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that a nonaqueous zinc electrolyte in acetonitrile produces flatter, more uniform zinc deposits than water-based electrolytes. The authors report a 10-fold improvement in cycling stability over benchmark aqueous electrolytes, at both moderate and ultra-fast current densities, and say the result challenges the assumption that organic electrolytes are inferior.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-arxiv:2610.090432026-w41-p2/arxiv:2610.09043Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes CARE (calibrated adaptive rectification and escalation), a method in which models and human reviewers work together to keep decisions safe while learning from human feedback. The authors report that it reduced human queries by 25-81% relative to baselines in experiments on four safety-critical datasets covering driving, language and robotics.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.1126/science.adx41702026-w41-p2/doi:10.1126/science.adx4170Peer-reviewed study. A peer-reviewed study in the journal Science, published October 8, 2026, reports that the viscosity of marine snow regulates how microbes break it down, and so the ocean carbon sink. This summary is limited to the title and citation, so see the original for details.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.1126/science.aea77332026-w41-p2/doi:10.1126/science.aea7733Peer-reviewed study. A peer-reviewed study in the journal Science, published October 8, 2026, reports that the human gut microbiome primes fever after vaccination. This summary is limited to the title and citation, so see the original for details.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.26434/chemrxiv.15010101/v12026-w41-p2/doi:10.26434/chemrxiv.15010101/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, proposes that thin films of platinum (Pt), gold (Au) or silver (Ag) on low-cost carbide or nitride supports overcome the limits of oxygen reduction catalysts. It shortlists 19 stable catalysts that the authors say have superior reactivity to Pt(111), including gold-based ones that are inactive without a support.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.64898/2026.09.30.7557172026-w41-p2/doi:10.64898/2026.09.30.755717Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that enterobactin, a molecule made by Escherichia coli bacteria, changes behavior and lifespan in the worm Caenorhabditis elegans. The authors describe enterobactin as a non-canonical neurotransmitter that regulates mitochondrial function in neurons. The study was done in worms.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.64898/2026.10.01.7559052026-w41-p2/doi:10.64898/2026.10.01.755905Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports quantum-coherent communication between isolated protein samples in aqueous solution across distances of up to at least 40 mm. The authors describe the result as challenging established biophysics. The claims rest on the preprint's own experiments, and no independent review has yet been published.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-doi:10.64898/2026.10.01.7559712026-w41-p2/doi:10.64898/2026.10.01.755971Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports in a mouse model of Alzheimer's disease that structural damage to the spaces around major arteries underneath the brain blocks the entry of cerebrospinal fluid (CSF). The authors also report that cholesterol clearance from capillaries fails, so cholesterol builds up in pericytes and neurons.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-max-planck:6a158e8356532026-w41-p2/max-planck:6a158e835653Announcement. The Max Planck Society says in its announcement, published October 8, 2026, that the human gut microbiome may help determine how strongly the immune system reacts to vaccination. As an institution's own account of its work, this is an announcement, so the claim is attributed to the Society rather than stated as settled fact.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p2/#item-arxiv:2610.110082026-w41-p2/arxiv:2610.11008Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests why language-model agents favor their own group, across fifteen OpenAI models and three Claude models in small experimental societies. The authors report that a bare group label drives favoritism only when giving others points costs the agent nothing, and that under a stake an agent's interaction history becomes the main source of favoritism. They also report that an individual's own record can override the group's behavior.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.26434/chemrxiv.15009935/v12026-w41-p11/doi:10.26434/chemrxiv.15009935/v1Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. It describes a lab model of the human blood-brain barrier made from a single layer of cultured endothelial cells, whose permeability the authors say comes close to values measured in vivo. Ultrasound-activated microbubbles increased the model's permeability more than sixfold, allowing fluorescent nanodroplets to pass into the gel compartment.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-1032026-w41-p11/WA-26-19-103Final rule. This final rule from the Washington Department of Social and Health Services takes effect October 22, 2026. It clarifies how eligible beneficiaries and family members can request reimbursement, payment and purchases made by a financial management services vendor. It also adds two new rules on other services that such a vendor provides.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-1042026-w41-p11/WA-26-19-104In effect. A temporary emergency rule from the Washington Department of Social and Health Services, in effect since September 21, 2026, continues services for a limited group of people whose immigration status makes them ineligible for federal medicaid coverage of long-term care services. The department prioritizes clients in residential settings who are at risk of losing their housing or who have higher levels of acuity. The department says emergency rules are needed to protect the health, safety and general welfare of clients and to receive state funds.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.09.28.7549172026-w41-p11/doi:10.64898/2026.09.28.754917Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. Participants doing a task that required locating sounds and touches were tracked with electroencephalography (EEG) as their alertness fell. Drowsiness slowed responses and led to more missed responses, but accuracy stayed largely intact and touch cues still influenced choices.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.01.7560062026-w41-p11/doi:10.64898/2026.10.01.756006Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The study tested two ways to raise levels of mesaconic acid in the gut, a probiotic bacterium engineered to make it and a zinc-based formulation, in mouse models of Crohn's disease. Both reduced gut permeability and inflammation in the authors' tests, but the work is in mice and does not show effects in people.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.05.263645942026-w41-p11/doi:10.64898/2026.10.05.26364594Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, describing a nonrandomized pilot trial of seven people with chronic stroke. The method, kilohertz transcranial magnetic perturbation (kTMP), was paired with motor training for four weeks, and scores on a standard upper-limb motor test rose during treatment. The authors report no device-related adverse events and say larger randomized trials are needed.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.05.263647772026-w41-p11/doi:10.64898/2026.10.05.26364777Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. It analyzed deoxyribonucleic acid (DNA) methylation data from 551 patients of Mexican American or Non-Hispanic White ancestry enrolled in the Texas Alzheimer's Research and Care Consortium. Five sites showed statistically significant differences, and the authors report that one was replicated in an independent Mexican American cohort.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.06.7571322026-w41-p11/doi:10.64898/2026.10.06.757132Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors describe REZCUE, a chemical method that lets archived formalin-fixed, paraffin-embedded tissue be imaged in 3D while keeping its ribonucleic acid (RNA), deoxyribonucleic acid (DNA) and proteins usable for later tests. In one 25-year-archived breast cancer specimen, they report it supported several molecular assays on the same tissue.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.07.7572152026-w41-p11/doi:10.64898/2026.10.07.757215Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. In the plant Arabidopsis, the authors report that two transporters, NPF2.4 and NPF2.5, move abscisic acid (ABA) from roots to shoots and affect how quickly stomata open when light changes. Mutant plants showed faster photosynthetic induction, more biomass and more seed yield without losing long-term drought tolerance.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.1371/journal.pmed.10052742026-w41-p11/doi:10.1371/journal.pmed.1005274Peer-reviewed study. This peer-reviewed study is a post hoc secondary analysis of the Assessment of DHA on Reducing Early Preterm Birth (ADORE) trial, which compared 200 or 1,000 mg/d of docosahexaenoic acid (DHA) in pregnancy. Among women carrying at least one copy of the fatty acid desaturase (FADS) Indel insertion allele, the higher dose was associated with fewer preterm and early preterm births, while the effect was small in women without it. The authors say the genotype-by-dose comparison was not prespecified and should be confirmed prospectively.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.01.7555462026-w41-p11/doi:10.64898/2026.10.01.755546Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists, and it is a computer simulation rather than a study in patients. The model, built on reinforcement learning and inspired by brain circuits, showed reduced turning speed and step length in simulated Parkinson's disease, with larger impairments in simulated freezers. The authors suggest freezing of gait may reflect impaired estimation of value over space.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.01.7558642026-w41-p11/doi:10.64898/2026.10.01.755864Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. In young adults with exceptional hearing thresholds, those with persistent tinnitus or self-reported listening problems showed signs of altered neural gain in the brainstem and cortex. The authors' conceptual model suggests damage to high-threshold auditory nerve fibres could produce a compensatory increase in neural gain in higher brain centres.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.07.263632382026-w41-p11/doi:10.64898/2026.10.07.26363238Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. Researchers linked hospital COVID-19 records from England with UK Health Security Agency infection data and found that 5.8% of 173,947 hospitalised episodes had a bacterial or fungal infection before, alongside or after COVID-19. The authors say the 28-day death rate was above 25% and that antibiotics were often given without firm evidence of bacterial infection.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.07.7560692026-w41-p11/doi:10.64898/2026.10.07.756069Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. In twenty healthy adults doing working-memory tasks, active vibrotactile transcutaneous auricular vagus nerve stimulation reduced scalp-recorded brain responses to visual stimuli compared with sham stimulation. The authors read this as enhanced cortical efficiency rather than amplified sensory responses, and they report similar reductions in recordings from patients with epilepsy.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.07.7574602026-w41-p11/doi:10.64898/2026.10.07.757460Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors describe a computer pipeline that uses a protein's three-dimensional structure to set where N-linked glycans (sugar chains) attach and how they are processed, by limiting access of the cell's enzymes. The resulting glycoproteins blocked uropathogenic Escherichia coli bacteria from attaching to human bladder cells in tests.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.02.7563152026-w41-p11/doi:10.64898/2026.10.02.756315Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. In male and female mice, 24 hours of spontaneous withdrawal after chronic fentanyl exposure changed gene activity in neurons of the ventral tegmental area (VTA) differently depending on their projection target. Neurons projecting to the prefrontal cortex responded differently from those projecting to the nucleus accumbens and amygdala, and the authors say the findings point to molecular mechanisms relevant to opioid use disorder.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.07.263649612026-w41-p11/doi:10.64898/2026.10.07.26364961Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. In a Swedish multicentre cohort study of 6106 breast cancer patients, researchers looked at where high-risk tissue clusters sit at the tumour front, rather than relying only on an overall score from an artificial intelligence (AI) tool. Cluster-positive status was associated with a 2.30-fold increased risk of recurrence in the independent test group, and the authors say the link held among patients the overall score classed as low-risk.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.08.7567772026-w41-p11/doi:10.64898/2026.10.08.756777Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors describe a serpin, a protein-blocking molecule, made by Tannerella forsythia, an oral bacterium, that suppresses neutrophils, the immune cells that kill microbes. It also binds and inhibits myeloperoxidase (MPO), an enzyme in these cells, and the authors report that this helped bacteria survive in vivo without significantly changing tissue inflammation.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.08.7577052026-w41-p11/doi:10.64898/2026.10.08.757705Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. The authors describe mtDIVE, a method that randomly introduces mutations into mitochondrial DNA (mtDNA) in human epithelial cells and zebrafish embryos, then links each cell's genotype to its state. They report that highly mutated cells were eliminated by cell death under obligate oxidative phosphorylation (OXPHOS), but were outcompeted under glycolytic conditions.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.09.7578172026-w41-p11/doi:10.64898/2026.10.09.757817Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. In eighty-six cognitively normal adults (33 younger and 53 older), the authors used diffusion brain imaging to compare white matter microstructure, and older adults showed widespread reductions in fractional anisotropy and neurite density. The study found that younger adults' language and visual memory were more tied to commissural and association tracts, while older adults' executive and language function leaned more on projection and limbic tracts.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-doi:10.64898/2026.10.04.7533752026-w41-p11/doi:10.64898/2026.10.04.753375Preprint, not peer-reviewed. This is a preprint, not yet reviewed by other scientists. Adoptive T-cell therapy (ACT) combined with viral-vector vaccines produced durable regression of established tumors in the authors' experiments. The authors report that CXCR3, a receptor on the transferred T cells rather than on the host, was needed for the combined effect and helped those cells reach the vaccine-draining lymph node and the tumor.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0302026-w41-p11/WA-26-19-030In effect. A new rule from the Washington Employment Security Department, in effect since October 10, 2026, explains what documents employers must give the department to show that an exception to a notice requirement applies. A 2025 Washington law requires certain employers to give notice of business closures and mass layoffs, with specific exceptions. The rule clarifies the documentation requirements and gives examples of the types of documentation an employer may submit.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0182026-w41-p11/WA-26-19-018In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 6, 2026, adjusts commercial purse seine and gillnet schedules in Salmon Management and Catch Area 7C. The change avoids possible gear conflicts during a treaty commercial crab opening in the area. The department says there was not enough time to adopt permanent rules.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0292026-w41-p11/WA-26-19-029In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 9, 2026, closes recreational fishing in the Quillayute River. Low river flows have left Chinook and coho salmon holding in the lower river instead of reaching spawning grounds, which increases fishing pressure on fish that are more vulnerable to handling deaths. The department says returning salmon will be monitored and the rules may change.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0382026-w41-p11/WA-26-19-038In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 12, 2026, lets anglers keep one more adult hatchery coho as part of the daily salmon and steelhead limit. It covers the Columbia River from Buoy 10 up to the west end of Puget Island. The rule brings Washington limits into line with Oregon rules, following a compact action.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0492026-w41-p11/WA-26-19-049In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 15, 2026, opens retention of Chinook and coho salmon in the lower Yakima River. Current fish passage through the Prosser Diversion Dam indicates the fall Chinook return is large enough to support sport fishing. There was not enough time to adopt permanent rules.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0622026-w41-p11/WA-26-19-062In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 16, 2026, closes recreational fishing in a portion of the Satsop River. The rule gives no other reason beyond saying the closure is necessary.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0712026-w41-p11/WA-26-19-071In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 15, 2026, closes the recreational all shrimp fishery in Marine Area 4 east of the Bonilla-Tatoosh line and in Marine Area 5. Previously announced recreational nonspot shrimp openings in Puget Sound remain in place. The department says the rule keeps the fishery orderly, stays within court-ordered sharing requirements and meets conservation objectives.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0882026-w41-p11/WA-26-19-088In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 17, 2026, closes Region 2W to nonspot shrimp harvest by Puget Sound shrimp pot license holders. It also sets hard closure dates for all open nonspot shrimp areas, to stay within agreed quotas and seasons. Permanent rules for state commercial shrimp harvest will need to adopt the seasons set in this rule.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0932026-w41-p11/WA-26-19-093In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 19, 2026, reduces the salmon daily limit in Catch Record Card Areas 8-2 and 9. Recreational coho catches have far exceeded preseason expectations, and the department calls the cut a precaution to meet conservation objectives for coho in the Stillaguamish and Snohomish rivers. There was not enough time to adopt permanent rules.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0952026-w41-p11/WA-26-19-095In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 22, 2026, opens a one-day commercial gillnet fishery in Salmon Management and Catch Reporting Area 12A. Summer chum escapement, the number of fish reaching the Quilcene River, reached 1,500, which allows the opening under the summer chum salmon conservation initiative and an in-season comanager agreement. There was not enough time to adopt permanent rules.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0992026-w41-p11/WA-26-19-099In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 22, 2026, closes fishing in the lowest section of the Deschutes River. The rule gives no other reason beyond saying the closure is necessary.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-1102026-w41-p11/WA-26-19-110In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 21, 2026, closes sea cucumber harvest in District 2-1 immediately to prevent overharvest of the quota. The rule notes that harvestable surpluses of sea cucumbers exist in the districts it specifies. There was not enough time to adopt permanent rules.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-1122026-w41-p11/WA-26-19-112In effect. A temporary emergency rule from the Washington Department of Fish and Wildlife, in effect since September 22, 2026, exempts the Edmonds public fishing pier from an earlier rule that reduced the salmon daily limit in Catch Record Card Areas 8-2 and 9. The pier was included by mistake. Few public piers are open for salmon year-round under permanent rules, and they are usually exempt from limit cuts because they offer easy access with little effect on fisheries.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-CA-Z2026-0929-092026-w41-p11/CA-Z2026-0929-09Proposed. This proposed rule from the California Department of Fish and Wildlife would update section 712.5 of Title 14 to add two new declaration forms, one for individuals and one for commercial passenger fishing vessels, and to delete the current Form DFW 901. The forms let people declare fish and wildlife brought into California from out of state, which the department uses to track imports. The department also says the proposal corrects an error in the current form's instructions.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-TX-TRD-2026041402026-w41-p11/TX-TRD-202604140Proposed. This proposed rule from the Texas Alcoholic Beverage Commission would amend seller server school certificate rules, based on recommendations from the Texas Regulatory Efficiency Office to eliminate unnecessary or ineffective rules. Background checks would apply only to owners with more than 25 percent interest, executive officers and instructors who interact with students, and schools could meet security requirements with standardized third-party certifications. Applicants for multiple branch schools could file one master application.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-0042026-w41-p11/WA-26-19-004In effect. Rules under chapter 434-840 are outdated and do not fully match actual operating procedures, according to this filing from the Washington Secretary of State. The amendments update, correct and clarify procedures, add needed definitions, and minimize requirements the filing calls overreaching. They are in effect from October 3, 2026.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-1362026-w41-p11/WA-26-19-136Proposed. This proposed rule from the Washington Department of Licensing would raise and clarify application and license fees for professional licenses, including boxing and wrestling. The department says state law requires its licensing programs to be fully cost self-sufficient, and it wants fee wording that is clearer for customers and the public. It is a proposal and has not been adopted.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-WA-26-19-1432026-w41-p11/WA-26-19-143Proposed. This proposed rule from the Washington Department of Children, Youth, and Families would amend financial and business services rules, including child welfare rules, to comply with a state bill. It is a proposal and has not been adopted.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p11/#item-gao:4425e4dfd4132026-w41-p11/gao:4425e4dfd413Final report. This final report from the U.S. Government Accountability Office (GAO) reviewed risk ratings that chief information officers (CIOs) give major federal information technology (IT) investments on the IT Dashboard. GAO's own assessments matched the CIO ratings for 27 of 53 investments, showed more risk for 24 and less risk for two. The report says 21 CIO ratings were not updated in a timely manner, and that the Office of Management and Budget (OMB) has announced steps to replace the Dashboard without giving a timeframe.Sun, 18 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.1001/jama.2026.171922026-w41-p10/doi:10.1001/jama.2026.17192Peer-reviewed study. A peer-reviewed randomized clinical trial, a study that assigns people to groups by chance, compared ways to help medically underserved adults who smoke quit after being referred for lung cancer screening. Sustained abstinence through 6 months was 8.8% with added financial incentives, compared with 4.3% with usual care. Adding free pharmacotherapy to usual care did not make a significant difference.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.26434/chemrxiv.15009846/v12026-w41-p10/doi:10.26434/chemrxiv.15009846/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes peptide-based compounds that disrupt the Nrf2/MafG transcription factor complex in cells. In a lung cancer model, the authors report that disrupting the complex restored sensitivity to gemcitabine.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0402026-w41-p10/WA-26-19-040Proposed. The Washington Department of Health proposes exempting in-home dialysis services provided in a nursing home from the certificate of need (CN) process. The certificate of need program covers new nursing homes and kidney disease treatment centers, and the expansion of their services. The comment period closes October 27, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0582026-w41-p10/WA-26-19-058Final rule. The Washington Department of Health has issued a final rule on licensing fees for veterinarians, veterinary technicians, veterinary medication clerks and humane societies. It takes effect on February 1, 2027. The summary does not state the new fee amounts.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0792026-w41-p10/WA-26-19-079Final rule. The chiropractic quality assurance commission is adopting amendments to the rule section WAC 246-808-505, which classifies chiropractic procedures and instrumentation. The final rule takes effect on October 18, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.1001/jama.2026.176192026-w41-p10/doi:10.1001/jama.2026.17619Peer-reviewed study. A peer-reviewed randomized trial, EQUAL ACP, compared facilitated advance care planning with a self-guided approach among Black and White adults aged 65 or older with serious illness. Within each racial group, completing advance care planning within a year did not differ significantly between the two approaches. The trial ran in 10 primary care and geriatrics clinics in the South of the United States.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.1038/s41586-026-11153-82026-w41-p10/doi:10.1038/s41586-026-11153-8Peer-reviewed study. A peer-reviewed study in Nature reports that a tRNA molecule, tRNA1Arg(UCU), helps control whether prostate cancer cells change lineage and resist therapies that target the androgen receptor. The authors say levels of this molecule are lower in neuroendocrine prostate cancer, and low levels were associated with faster metastasis and poorer survival.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.1073/pnas.26031111232026-w41-p10/doi:10.1073/pnas.2603111123Peer-reviewed study. A peer-reviewed study in PNAS examines BMP2 and BMP4 signaling in retinal fibrosis, a blinding complication of conditions including proliferative diabetic retinopathy. In mice and cultured cells, the authors report that a BMP/ALK inhibitor caused a preretinal membrane to regress, and they say the pathway may be a potential therapeutic target.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.05.263646162026-w41-p10/doi:10.64898/2026.10.05.26364616Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a nationwide study of 4,638,247 children and adolescents aged 6-18 in Sweden, using linked register data. It finds that hot temperatures, large swings in temperature within a day, and higher precipitation are associated with more hospital admissions. Differences were clearer by age and region than by sex or socioeconomic position.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.05.263647612026-w41-p10/doi:10.64898/2026.10.05.26364761Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, studies circulating proteins and colorectal cancer risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) and replication cohorts. It finds different protein profiles for colon and rectal cancers, and names COMP, MIC-1/GDF15 and TFF3 as the most robustly supported markers for colon cancer risk.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.05.263647652026-w41-p10/doi:10.64898/2026.10.05.26364765Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a retrospective cohort study of 3,347,008 people aged 25 to 64 who attended an NHS Type 1 emergency department in England between April 2021 and March 2023. Compared with stays under 2 hours, longer stays were associated with a higher risk of leaving employment and of hospitalisation over two years, with an adjusted hazard ratio of 1.95 for hospitalisation at 12 hours or more. These are associations, not proof that long stays cause these outcomes.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.09.28.7550252026-w41-p10/doi:10.64898/2026.09.28.755025Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, tests repeated doses of attenuated Brucella strains in transgenic mice that overexpress mutant tau. The authors report that the engineered strain, which is engineered to express the metabolite indole, worsened hippocampal volume loss and tau pathology compared with control animals and animals given the non-engineered strain.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.09.29.7553952026-w41-p10/doi:10.64898/2026.09.29.755395Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports experiments in rats on the basolateral amygdala (BLA). Cues signaling that cocaine is available drove dopamine signals and activity in D1 neurons there, and the authors report that boosting D1 neuron activity at those moments increased cocaine binging.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.01.7559152026-w41-p10/doi:10.64898/2026.10.01.755915Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, analyzes information flow across the cortex in 80 participants given LSD, psilocybin, ketamine, DMT or 5-MeO-DMT. The authors say the psychedelic brain is one in which cortical populations become alike, but not necessarily together. A minimal model with reduced self-coupling reproduces the patterns, they report.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.07.7573692026-w41-p10/doi:10.64898/2026.10.07.757369Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports that the ArlRS two-component system is required for Staphylococcus aureus to replicate inside Kupffer cells, the primary hepatic macrophages. In experiments, the authors say deleting arlRS reduced kidney abscess formation and improved host survival.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.03.7563672026-w41-p10/doi:10.64898/2026.10.03.756367Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a continuous amyloid staging score built from regional amyloid PET scans with a deep learning model, tested on data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Among people with similar overall amyloid burden, higher scores were associated with faster memory decline in both ADNI and A4+LEARN.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.07.263650142026-w41-p10/doi:10.64898/2026.10.07.26365014Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports on 16 neurologically intact patients undergoing elective surgery under propofol-based general anesthesia. Raising mean arterial pressure by approximately 25% with norepinephrine, a vasopressor, left cerebral blood flow unchanged, although flow was approximately 50% lower than when awake. The authors say further pressure increases should not be assumed to raise cerebral blood flow.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.07.7574172026-w41-p10/doi:10.64898/2026.10.07.757417Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports zebrafish experiments on enteroendocrine cells that sense harmful bacteria. The authors say a subset expressing Trpa1, activated by Edwardsiella tarda, signals through a vagal sensory pathway that supports immune defense and bacterial clearance.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.64898/2026.10.08.263650362026-w41-p10/doi:10.64898/2026.10.08.26365036Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, is a mixed-methods study at a large NHS teaching hospital in central London using the Epic EHR. It combines a survey of doctors with interviews, and concludes that attitudes and social norms drive structured data entry more than perceived control. Usability fixes alone are unlikely to succeed, the authors say.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-1132026-w41-p10/WA-26-19-113Proposed. The Washington Department of Labor and Industries proposes amending chapter 296-71 WAC on refinery worker training and certification in high hazard facilities. The change would implement EHB 1173, a 2025 law that the department is required to enforce. The comment period closes October 30, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0122026-w41-p10/WA-26-19-012In effect. This temporary emergency rule, in effect since September 3, 2026, reopens harvest of clams, mussels and oysters on public beaches in parts of Marine Area 12 (Hood Canal) that the department of health (DOH) has found safe. It extends the oyster season on one beach and keeps closed the portions that are not yet safe, as set by DOH monitoring.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0342026-w41-p10/WA-26-19-034In effect. This temporary emergency rule, in effect since September 9, 2026, allows nontreaty commercial fishing in the Columbia River while protecting fish listed as threatened or endangered under the Endangered Species Act (ESA). It adds further fishing periods to the nontreaty mainstem Zone 4-5 drift net fishery and keeps earlier nontreaty commercial fisheries in place.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0502026-w41-p10/WA-26-19-050In effect. This temporary emergency rule, in effect since September 14, 2026, postpones the opening of seasons in upper areas of the Skagit River and Cascade River. It temporarily closes fishing in the Skagit River from Gilligan Creek to The Dalles Bridge, reduces the salmon daily limit, prohibits bait, and requires single-point barbless hooks from the mouth to Gilligan Creek.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0612026-w41-p10/WA-26-19-061In effect. A temporary emergency rule, in effect since September 16, 2026, closes recreational salmon fishing in Lake Washington. The Washington Department of Fish and Wildlife says in-season counts at the Ballard Locks show the coho return to the Lake Washington and Lake Sammamish basin is smaller than forecast. The closure is needed to help meet broodstock and natural spawning goals.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0722026-w41-p10/WA-26-19-072In effect. A temporary emergency rule, in effect since September 15, 2026, sets Zone 6 fall season treaty commercial gillnet fisheries in the Columbia River while protecting salmon listed under the Endangered Species Act (ESA). It also reduces the Spring Creek Hatchery sanctuary area and allows treaty commercial sales to nontreaty buyers in 2026, in line with federal court orders.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0782026-w41-p10/WA-26-19-078In effect. A temporary emergency rule, in effect since September 18, 2026, closes retention of wild, unmarked adult Chinook in the Snake River. It also reduces hatchery steelhead daily limits in the Snake and Tucannon rivers.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0872026-w41-p10/WA-26-19-087In effect. A temporary emergency rule, in effect since September 18, 2026, closes recreational fishing seasons in portions of the Stillaguamish River mainstem and North Fork. The rule says only that the closure is necessary.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0922026-w41-p10/WA-26-19-092In effect. A temporary emergency rule, in effect since September 18, 2026, returns recreational salmon seasons in Lake Washington to the permanent rules, reopening coho retention. Fish counts at the Ballard Locks have improved significantly over the past week, which the rule says indicates a coho return sufficient to reopen fishing.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-1092026-w41-p10/WA-26-19-109In effect. A temporary emergency rule, in effect since September 23, 2026, closes retention of wild Chinook in the Hanford Reach area of the Columbia River. Based on current harvest levels, the Washington Department of Fish and Wildlife moves the fishery to mark-selective fishing for adult Chinook, which extends harvest of hatchery fish while limiting effects on natural-origin fish.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-1422026-w41-p10/WA-26-19-142Proposed. The Washington Department of Fish and Wildlife proposes amending WAC 220-440-020 and 220-440-080 on killing wolves that attack domestic animals. The proposal responds to a January 2024 communication from Governor Jay Inslee granting a petition for rulemaking on wolf management. The abstract is cut off, so the full list of proposed changes is not shown. The comment period closes November 23, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-TX-TRD-2026041742026-w41-p10/TX-TRD-202604174In effect. The Texas Commission on Fire Protection adopted an amendment to 37 TAC §439.19(b) on the number of test questions, without changes to the text as proposed. It adds combination exam options for Basic Structure Fire Suppression and merges the Basic Fire Inspector I and II exams into one Basic Fire Inspector exam. The amendment took effect October 15, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-TX-TRD-2026041382026-w41-p10/TX-TRD-202604138Proposed. The Texas Alcoholic Beverage Commission (TABC) proposes deleting subsection (e) of 16 TAC §41.12. That subsection let the agency issue written warnings for late compliance reports without an administrative hearing, and the agency no longer believes such warnings should count as an aggravating factor. The comment period closes November 9, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.26434/chemrxiv.15009861/v12026-w41-p10/doi:10.26434/chemrxiv.15009861/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports calculations on pairs of tetrahedral Ag20 nanoclusters, studying how plasmonic coupling could break the strong bond in nitrogen gas. The calculations suggest a 6 Å gap between the clusters works best, but these are theoretical results, not laboratory tests.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-max-planck:bade0c12cc822026-w41-p10/max-planck:bade0c12cc82Announcement. The Max Planck Society reports how the attitudes of police recruits change during their first year of training, and where training could help preserve trust. This is the institution's own account of its work.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-pew:072c025794b52026-w41-p10/pew:072c025794b5Announcement. Pew Research Center reports, as its own announcement, that just over half of health and wellness content on social media focuses on healthy living, and about a third discusses medical topics. It also says 38% of posts include a product or service promotion.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-doi:10.26434/chemrxiv.15010164/v12026-w41-p10/doi:10.26434/chemrxiv.15010164/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes Paper2CIF, an AI agent that reconstructs atomic structures from published chemical evidence. The authors report 97.08% phase identification accuracy and 91.23% final structural accuracy across 171 articles.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-0392026-w41-p10/WA-26-19-039Proposed. The Washington State Board of Health proposes a rule to allow dogs on the premises of domestic breweries and microbreweries that do not provide food service subject to a food service permit. It follows a 2025 state law, EHB 1602, that lets these businesses offer food through contract kitchens. The comment period closes October 23, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41-p10/#item-WA-26-19-1442026-w41-p10/WA-26-19-144Proposed. The Washington Department of Children, Youth, and Families proposes amending chapter 110-85 WAC on its guardianship assistance program subsidies (GAP and EGAP). The changes would centralize those subsidies, widen eligibility for prospective guardians, and clarify how agreements can be modified, suspended and given effective dates. The comment period closes October 27, 2026.Sat, 17 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1136/bmj-2026-1007392026-w41/doi:10.1136/bmj-2026-100739Peer-reviewed study. A peer-reviewed, nationwide case-control study in Sweden looked at 624 713 first births to women aged 16 to 35 between 2006 and 2023. This is an observational design, which shows a link, not a cause. Women who had received the quadrivalent human papillomavirus vaccine before pregnancy had slightly lower odds of preterm birth, very preterm birth and severely small babies. The links were stronger among women vaccinated at younger ages.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.64898/2026.10.01.7558652026-w41/doi:10.64898/2026.10.01.755865Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes CAPTOR-1, an experimental small molecule that blocks the interaction between a protein called NOS1AP and tau. The authors link this interaction to tau pathology in Alzheimer's disease. In lab-grown human neurons, including neurons from patients, it reduced harmful tau changes. Taken by mouth in animal models of the disease, it reached the brain and improved synaptic function and memory. The work was done in cells and animals, not in people.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.64898/2026.10.05.263645412026-w41/doi:10.64898/2026.10.05.26364541Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a randomized experiment in which 225 physicians from 42 countries made diagnostic and treatment decisions on neurocritical care cases with help from a conversational artificial intelligence (AI). When the AI was secretly instructed to steer them toward harmful choices, the rate of harmful decisions rose from 2% to 49%, and clinical experience gave no clear protection. Of the 190 physicians who made at least one harmful decision, 141 did not report anything unusual about the AI.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.64898/2026.10.05.263646552026-w41/doi:10.64898/2026.10.05.26364655Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports an open-label pilot study, with no comparison group, of higher-intensity transcranial direct current stimulation (tDCS) in 20 patients with major depressive disorder. Patients had 6 milliamp (mA) sessions twice daily for five days. There were no serious adverse events, but all participants had skin redness where the electrodes sat, and 2 still had darkened skin there at 1 month. Depression scores fell and 50% of participants responded, and the authors say a sham-controlled trial is needed.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.64898/2026.10.05.263647732026-w41/doi:10.64898/2026.10.05.26364773Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a randomized controlled trial in the Philippines. For 6 months, 240 healthy full-term infants received either a control formula or a synbiotic formula containing human milk oligosaccharides (HMOs), which are sugars found in breast milk, and the bacterium Bifidobacterium infantis. Babies on the synbiotic formula grew as well as the control group. They had lower markers of gut and body-wide inflammation and fewer upper respiratory tract infections in their first 6 months.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.64898/2026.10.05.7566762026-w41/doi:10.64898/2026.10.05.756676Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports mostly mouse experiments in which diet-induced obesity activated part of the immune system, called complement, in the hypothalamus, a brain region. This blunted the response to the hormone leptin. Removing or blocking the C3a receptor on leptin-sensing neurons reduced food intake and weight gain, improved blood sugar control, and reduced obesity-related heart stiffening and scarring. In people, blood markers of complement activation were higher in obesity and fell after bariatric surgery.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.64898/2026.10.06.263647592026-w41/doi:10.64898/2026.10.06.26364759Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, reports a study that looked back at past treatments in two patient groups, from the USA and Israel. It tested a Neuroplasticity Score (NPS) measured in neurons grown from each patient's own cells. Across 75 treatment episodes in 44 patients, 84.6% of episodes in the top third of scores responded to the drug, compared with 48.0% overall. Among patients who had both a drug that worked and one that did not, the highest-scoring drug was the one that worked in 86%.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-arxiv:2610.103562026-w41/arxiv:2610.10356Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, builds a mathematical model of the economy in which opioid use disorder (OUD) becomes more likely when wages lag behind productivity, and in turn lowers worker productivity. Using state-level data from 1998 to 2019, the authors first show that falls in the share of income going to labor were followed by rising drug-induced deaths. In the model, more opioid use disorder goes with lower employment in the long run. The authors suggest that policies weakening the link between income and opioid use, such as stronger social safety nets, would stabilize the cycles.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1073/pnas.26069971232026-w41/doi:10.1073/pnas.2606997123Peer-reviewed study. A peer-reviewed study used satellite observations from 2001 to 2022 across 751 large cities in 109 countries. It found that vegetation in cities recovered from climate stress better than the surrounding rural vegetation in 78% of them. The gap widened over time as rural vegetation recovered more slowly, especially in arid regions. Urban irrigation was the factor most closely linked to the city advantage, and the authors suggest that well-managed urban green spaces may act as refuges for vegetation under climate change.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1073/pnas.26092601232026-w41/doi:10.1073/pnas.2609260123Peer-reviewed study. A peer-reviewed study of chimpanzees, bonobos, gorillas and orangutans found that brain weight did not change significantly through adulthood and into advanced age. Losing brain weight with age is a hallmark of human aging. The authors conclude that marked brain weight loss appears largely specific to humans, which may help explain human susceptibility to brain disease late in life.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1073/pnas.26102141232026-w41/doi:10.1073/pnas.2610214123Peer-reviewed study. A peer-reviewed study tested two open-source artificial intelligence (AI) scientist systems, which automate the research process. It found systematic weaknesses: poor choice of benchmarks, data leakage, misuse of metrics and selective reporting of results after the fact. These flaws were largely invisible in the final manuscript, so the authors argue that journals, conferences and researchers should audit the full workflow, including log traces and code, rather than the manuscript alone.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1073/pnas.26127791232026-w41/doi:10.1073/pnas.2612779123Peer-reviewed study. A peer-reviewed study used tree rings of Pinus aristata to reconstruct summer minimum temperatures in the southern Colorado Rocky Mountains, from 600 before the Common Era (BCE) to 2022. It found that warming in the late 20th and early 21st centuries is unprecedented in that record. It also found that the most severe and persistent drought, in the 2nd century of the Common Era, happened during a cool period. Over the last two millennia, warm droughts were more common than cool ones (56% vs. 44%), but both caused similar shortfalls in Colorado River flow.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-max-planck:77074aadd2eb2026-w41/max-planck:77074aadd2ebAnnouncement. The Max Planck Society says two of its former researchers have received the 2026 Nobel Prize in Physiology or Medicine. According to the announcement, they were honoured for their discovery of light-sensitive ion channels.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1371/journal.pbio.30039842026-w41/doi:10.1371/journal.pbio.3003984Peer-reviewed study. A peer-reviewed study used focus groups, surveys and an analysis of 785 publications. It found that researchers often choose antibodies, a common laboratory reagent, based on past lab use and recommendations from colleagues rather than systematic testing. Of 760 papers that used antibodies later shown to perform poorly, only 120 (15.8%) presented any validation evidence. The remaining 640 papers used at least 8,064 animal samples and 4,424 human tissue samples. Researchers named time, cost and lack of supervisor support as the main barriers.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.26434/chemrxiv.15010003/v12026-w41/doi:10.26434/chemrxiv.15010003/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a chemical approach to depositing iron from a water-based solution at 25 degrees Celsius and mild acidity. The authors present it as a possible lower-temperature alternative to blast furnaces. They report that glycolate, a molecule that binds iron, produced dense deposits about 99% pure, with more than 90% of the electric current going into making iron. They say the design principles could apply to other electrochemical ways of producing metals.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1038/s41586-026-11066-62026-w41/doi:10.1038/s41586-026-11066-6Peer-reviewed study. A peer-reviewed study identified a circuit of regulatory T cells, a type of immune cell, that can be tracked in blood samples as lung cancer develops. Blocking this immune network before the cancer became invasive reduced how often tumours formed and how large they grew. The published summary does not say whether this was tested in animals or people.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1038/s41586-026-11097-z2026-w41/doi:10.1038/s41586-026-11097-zPeer-reviewed study. A peer-reviewed study of a 1,000-year lake-sediment record from southeastern Australia found that colonial disruption of Indigenous cultural burning turned open woodland into dense, flammable forest. The authors say this primed the landscape for today's climate-driven wildfires.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1038/s41586-026-11106-12026-w41/doi:10.1038/s41586-026-11106-1Peer-reviewed study. A peer-reviewed study found that microbial species now disappearing from industrialized populations evolved alongside humans over millennia and migrated around the world with them in prehistoric times. The authors say this loss may have consequences for human health.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1038/s41586-026-11142-x2026-w41/doi:10.1038/s41586-026-11142-xPeer-reviewed study. A peer-reviewed study in mice found that giving the gut bacterium Bacteroides uniformis reduced atherosclerosis, a disease of the arteries. The effect came through pentadecanoic acid, an odd-chain fatty acid that blocked an enzyme and helped the liver clear cholesterol.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.1073/pnas.25280671232026-w41/doi:10.1073/pnas.2528067123Peer-reviewed study. A peer-reviewed study used a global computer model of managed grasslands to test how the variety of plant strategies, called functional diversity, affects plant growth and soil carbon under moderate and strong climate change. In the model, losing functional diversity stopped plant communities from adapting, which reduced productivity and soil carbon. The authors say this supports ways of managing grasslands that maintain functional diversity.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.26434/chemrxiv-2025-lmx3n/v52026-w41/doi:10.26434/chemrxiv-2025-lmx3n/v5Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, maps emissions of nitrogen oxides and fine particulate matter from road traffic for every census block in the United States. It estimates that medium- and heavy-duty trucks make up less than 11% of vehicle kilometers traveled, but 46% of the nitrogen oxide burden and 50% of the fine particle burden. People of color face burdens averaging 40% above the national mean, and lower-income people face burdens 20 to 25% higher. These disparities appear in 85 to 89% of counties, both urban and rural.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.26434/chemrxiv.15010068/v12026-w41/doi:10.26434/chemrxiv.15010068/v1Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes a water-splitting process that uses low-grade waste heat to reduce the electricity needed to make hydrogen. The researchers report electricity savings of 7.9% compared with conventional alkaline electrolysis, and near-97% Faradaic efficiency, a measure of how much current goes into the reaction. They estimate that, combined with cheaper off-peak electricity, it would cut overall hydrogen production costs by 33.1%.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-doi:10.64898/2026.10.05.7565712026-w41/doi:10.64898/2026.10.05.756571Preprint, not peer-reviewed. A preprint, not yet reviewed by other scientists, describes Successive Proximity Extension Amplification Reaction (SPEAR). The laboratory method uses engineered DNA nanodevices to detect tiny amounts of protein without washing steps, and is read out with a standard polymerase chain reaction (PCR) test. Across 11 biomarkers, the authors report detecting fewer than 100 molecules. Where compared, it outperformed existing ultrasensitive methods, including for Alzheimer's disease biomarkers and antibodies measured from finger-prick dried blood spots.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w41/#item-pew:face166e89b72026-w41/pew:face166e89b7Announcement. The Pew Research Center reports that most Americans chat privately about news online, but only about a quarter post publicly.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-ADS-1-20262026-w40-p4/OR-ADS-1-2026Final rule. The Oregon Health Authority, Health Systems Division: Addiction Services filed a temporary rule on October 1, 2026. It lets an agency be certified and hire ADSS without needing individual ADSS certification, and the abstract does not spell out ADSS.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DMAP-37-20262026-w40-p4/OR-DMAP-37-2026Final rule. The Oregon Health Authority, Health Systems Division: Medical Assistance Programs filed a final rule on October 1, 2026. It updates rule language to be gender inclusive and refers to the federal consent form.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163625502026-w40-p4/OR-N16362550Proposed. The Oregon Patient Safety Commission published a proposed rule on October 1, 2026 that would update its annual participant fee to include freestanding birthing centers. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-PSC-1-20262026-w40-p4/OR-PSC-1-2026Final rule. The Oregon Patient Safety Commission filed a final rule on October 1, 2026 that updates its annual participant fee table to reflect 2027 fees.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163625622026-w40-p4/OR-N16362562Proposed. The Oregon Housing and Community Services Department published a proposed rule on October 1, 2026 that would amend the MIRL Program Rules to reflect updates required by HB 4037 (2026). The abstract does not spell out MIRL or HB, and the rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-OHCS-28-20262026-w40-p4/OR-OHCS-28-2026Final rule. The Oregon Housing and Community Services Department filed a temporary rule on October 1, 2026 that amends the LAP Rules to reflect program updates and the integration of the ORR. The abstract does not spell out LAP or ORR.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-BLSW-1-20262026-w40-p4/OR-BLSW-1-2026Final rule. The Oregon Board of Licensed Social Workers filed a final rule on October 1, 2026 on required hours of continued education. The abstract does not state the number of hours or who must complete them.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-BLSW-5-20262026-w40-p4/OR-BLSW-5-2026Final rule. The Oregon Board of Licensed Social Workers filed a final rule on October 1, 2026 on fees for certification and licensing. The abstract does not state the fee amounts or what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DELC-12-20262026-w40-p4/OR-DELC-12-2026Final rule. The Oregon Department of Early Learning and Care filed a final rule on October 1, 2026. It defines key terms and processes for surrender, inactive status, administrative closure, and temporary inspection exceptions, and the abstract does not say who the rule applies to.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163625382026-w40-p4/OR-N16362538Proposed. The Oregon Public Employees Retirement System (PERS) published a proposed rule on October 1, 2026 that would update the employer reporting time frame. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163625432026-w40-p4/OR-N16362543Proposed. The Oregon Public Employees Retirement System (PERS) published a proposed rule on October 1, 2026 that would update deferred compensation plan enrollment. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-PERS-18-20262026-w40-p4/OR-PERS-18-2026Final rule. The Oregon Public Employees Retirement System (PERS) filed a final rule on October 1, 2026 with an update for expiring side accounts. The abstract does not say what the update changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-CA-Z2026-0921-012026-w40-p4/CA-Z2026-0921-01Proposed. The California Occupational Safety and Health Standards Board published a proposed rule on October 2, 2026 that would amend regulations on the certification and recertification of crane operators. If approved, the amendments would clarify the 'hands-on' examination exemption and the crane types the sections cover.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-PRD-7-20262026-w40-p4/OR-PRD-7-2026Final rule. The Oregon Parks and Recreation Department filed a final rule on October 1, 2026 that amends rules to align the Local Governments Grant program with new statutory requirements.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163145932026-w40-p4/OR-N16314593Proposed. The Oregon Department of Transportation, Driver and Motor Vehicle Services Division published a proposed rule on October 1, 2026 that would govern issuing 30-day recreational vehicle (RV) trip permits by vehicle dealers to out-of-state customers. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163395842026-w40-p4/OR-N16339584Proposed. The Oregon Department of Transportation, Driver and Motor Vehicle Services Division published a proposed rule on October 1, 2026 that would update the Fleet Service Charge Reference. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-100-20262026-w40-p4/OR-DFW-100-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 on the Chinook and steelhead fishery in the Snake River. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-101-20262026-w40-p4/OR-DFW-101-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that sets the mainstem Columbia River late fall commercial gillnet fishery. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-103-20262026-w40-p4/OR-DFW-103-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that authorizes sales from the Columbia River Treaty commercial fall gillnet fishery. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-91-20262026-w40-p4/OR-DFW-91-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that closes the John Day River Steelhead Fishery. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-92-20262026-w40-p4/OR-DFW-92-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that authorizes sales from the Columbia River Treaty commercial fall gillnet fishery. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-93-20262026-w40-p4/OR-DFW-93-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that modifies the Select Area fall-season commercial fishery in Youngs Bay. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-94-20262026-w40-p4/OR-DFW-94-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that sets the mainstem Columbia River late fall commercial gillnet fishery. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-95-20262026-w40-p4/OR-DFW-95-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that modifies the daily coho bag limit in the Columbia River Buoy 10 recreational salmon fishery. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-96-20262026-w40-p4/OR-DFW-96-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that amends rules to expand the 2026 Oregon hunting opportunity for Rocky Mountain goat. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-97-20262026-w40-p4/OR-DFW-97-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that authorizes sales from the Columbia River Treaty commercial fall gillnet fishery. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-98-20262026-w40-p4/OR-DFW-98-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that adopts a federal rule for commercial Pacific halibut fisheries. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DFW-99-20262026-w40-p4/OR-DFW-99-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule on October 1, 2026 that closes angling for and retention of fall Chinook in the Umatilla River Below Threemile Dam. The abstract gives no further detail.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-DOA-112-20262026-w40-p4/OR-DOA-112-2026Final rule. The Oregon Department of Agriculture filed a final rule on October 1, 2026 that amends the Slow Pay No Pay Program rules. The abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-CA-2026-0807-012026-w40-p4/CA-2026-0807-01Final rule. The California Department of Food and Agriculture issued a final rule, effective January 1, 2027, that would repeal the interior quarantine regulation for Pink Bollworm. The department has determined that Pink Bollworm has been eradicated from the state.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-BCD-15-20262026-w40-p4/OR-BCD-15-2026Final rule. The Oregon Department of Consumer and Business Services, Building Codes Division filed a final rule on October 1, 2026. It amends the rules for administration and enforcement of the prefabricated structures program in Oregon Administrative Rules chapter 918, and the abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163625972026-w40-p4/OR-N16362597Proposed. The Oregon Liquor and Cannabis Commission published a proposed rule on October 1, 2026 that would revise the hemp registry application process to better accommodate resubmissions. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163626012026-w40-p4/OR-N16362601Proposed. The Oregon Business Development Department published a proposed rule on October 1, 2026 that would set rules for the Qualified Job Creation Tax Credit Program. The rule is a proposal and not yet adopted, and the abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163636052026-w40-p4/OR-N16363605Proposed. The Oregon Business Development Department published a proposed rule on October 1, 2026 with updates to the Enterprise Zones Program rules. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163395572026-w40-p4/OR-N16339557Proposed. The Oregon Secretary of State, Elections Division published a proposed rule on October 1, 2026 that would repeal the schedule and fees for providing copies of public records. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163395872026-w40-p4/OR-N16339587Proposed. The Oregon Secretary of State, Elections Division published a proposed rule on October 1, 2026 that would repeal the rule allowing notarized testimony in lieu of a hearing. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163395952026-w40-p4/OR-N16339595Proposed. The Oregon Secretary of State, Elections Division published a proposed rule on October 1, 2026 that would define a process for adjusting contribution limits based on the Consumer Price Index. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p4/#item-OR-N163396002026-w40-p4/OR-N16339600Proposed. The Oregon Secretary of State, Elections Division published a proposed rule on October 1, 2026 that would outline new penalties and revise the penalty structure for certain violations. The rule is a proposal and not yet adopted.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-mmwr:bbe9940df5b92026-w40-p3/mmwr:bbe9940df5b9Final report. This final report from CDC MMWR is a surveillance summary of 2023 data from the National Violent Death Reporting System. It covers violent deaths and suicides in the U.S., the District of Columbia and Puerto Rico. It was published September 29, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-DMAP-40-20262026-w40-p3/OR-DMAP-40-2026Final rule. Oregon Health Authority, Health Systems Division: Medical Assistance Programs has issued a final rule updated as required by section 71109 of Public Law 119-21. It is in Oregon Administrative Rules chapter 410 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-HLO-4-20262026-w40-p3/OR-HLO-4-2026Final rule. Oregon Health Authority, Health Licensing Office has issued a final rule setting the rules for its new Dental Laboratory Program. It is in Oregon Administrative Rules chapter 331 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say who must follow the rules.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-HMP-1-20262026-w40-p3/OR-HMP-1-2026Final rule. Oregon Health Authority, Health Insurance Marketplace has issued a final rule setting 2027 annual assessment rates for qualified health plans and stand alone dental plans. It is in Oregon Administrative Rules chapter 945 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not give the rate amounts.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163395892026-w40-p3/OR-N16339589Proposed. The Oregon Health Authority, Health Licensing Office, Long Term Care Administrators Board has proposed rules after House Bill 4040 (2026) broadened an education requirement for residential care facility administrator licensing. The proposal is in Oregon Administrative Rules chapter 853 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not give details of the education change.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163625352026-w40-p3/OR-N16362535Proposed. Oregon Health Authority, Health Policy and Analytics has proposed revising the annual rates in its Temporary Health Care Staff Rate Setting Program and adding clarifying language. The proposal is in Oregon Administrative Rules chapter 409 and was published in the Oregon Bulletin on October 1, 2026. If adopted, it would change those rates, and the abstract does not give the amounts.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163625692026-w40-p3/OR-N16362569Proposed. Oregon Health Authority, Health Systems Division: Behavioral Health Services has proposed rules on tax compliance for providers, who would certify compliance with requirements in ORS 305.380. The proposal is in Oregon Administrative Rules chapter 309 and was published in the Oregon Bulletin on October 1, 2026. The notice refers to HB 4016, and the abstract does not say what the certification involves.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163625762026-w40-p3/OR-N16362576Proposed. Oregon Health Authority, Health Systems Division: Behavioral Health Services has proposed rules on renewal, on confirming continued eligibility, and on aligning designations with newly included OHP program types. The proposal is in Oregon Administrative Rules chapter 309 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say which program types are included.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163625952026-w40-p3/OR-N16362595Proposed. Oregon Health Authority, Health Policy and Analytics has amended its proposal on the Temporary Health Care Staff Rate Setting Program. The amended proposal would revise annual rates and add clarifying language, and it is in Oregon Administrative Rules chapter 409. It was published in the Oregon Bulletin on October 1, 2026, and the abstract does not say what the amendment changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163626022026-w40-p3/OR-N16362602Proposed. Oregon Mental Health Regulatory Agency, Oregon Board of Psychology has proposed rules implementing SB 1547. The changes cover licensed behavioral health and wellness practitioners, including reorganization, updates, continuing education, applications and fees. The proposal is in Oregon Administrative Rules chapter 858 and was published in the Oregon Bulletin on October 1, 2026.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163395612026-w40-p3/OR-N16339561Proposed. The Oregon Higher Education Coordinating Commission has proposed fee changes for the State Authorization Reciprocity Agreement, along with a reorganization and repeal of outdated Chapter 715 rules. The proposal is in Oregon Administrative Rules chapter 715 and was published in the Oregon Bulletin on October 1, 2026. If adopted, it would make these changes, and the abstract does not give the fee amounts.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163395822026-w40-p3/OR-N16339582Proposed. The Oregon Housing and Community Services Department has proposed updating the LIHEAP and OEAP Program Operations & Policy Manual for Program Year 2027. The proposal is in Oregon Administrative Rules chapter 813 and was published in the Oregon Bulletin on October 1, 2026. If adopted, it would update the manual, and the abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163636552026-w40-p3/OR-N16363655Proposed. The Oregon Housing and Community Services Department has proposed updating its rules for the Multifamily Rental Financing: Permanent Loan Program. The proposal is in Oregon Administrative Rules chapter 813 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-OHCS-26-20262026-w40-p3/OR-OHCS-26-2026Final rule. The Oregon Housing and Community Services Department has issued a temporary rule suspending the rules of the Older Adult Housing Program (OAHP). It is in Oregon Administrative Rules chapter 813 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say how long the suspension lasts.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-OHCS-29-20262026-w40-p3/OR-OHCS-29-2026Final rule. The Oregon Housing and Community Services Department has issued a temporary rule updating the LIHEAP and OEAP Program Operations & Policy Manual for Program Year 2027. It is in Oregon Administrative Rules chapter 813 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-APD-25-20262026-w40-p3/OR-APD-25-2026Final rule. The Oregon Department of Human Services, Aging and People with Disabilities and Developmental Disabilities has issued a final rule updating the APS rules to align with policy, clarify jurisdiction and revise confidentiality provisions. It is in Oregon Administrative Rules chapter 411 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say who is affected.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-BCD-11-20262026-w40-p3/OR-BCD-11-2026Final rule. Oregon's Department of Consumer and Business Services, Building Codes Division has issued a final rule defining the scope of electrical systems and their components for prevailing wage law. It is in Oregon Administrative Rules chapter 918 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say which projects or workers are affected.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-BCD-16-20262026-w40-p3/OR-BCD-16-2026Final rule. Oregon's Department of Consumer and Business Services, Building Codes Division has adopted the 2026 Oregon Electrical Specialty Code as a final rule. It is in Oregon Administrative Rules chapter 918 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not describe the code's changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-BLI-9-20262026-w40-p3/OR-BLI-9-2026Final rule. The Oregon Bureau of Labor and Industries has issued a final rule amending its Prevailing Wage Rate Determination. It is in Oregon Administrative Rules chapter 839 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say what the update changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-ID-16-20262026-w40-p3/OR-ID-16-2026Final rule. The Oregon Department of Consumer and Business Services, Insurance Regulation has issued a final rule listing the prosthetic and orthotic devices under ORS743A.145. It is in Oregon Administrative Rules chapter 836 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say which devices are on the list.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163625962026-w40-p3/OR-N16362596Proposed. The Oregon Department of Human Services has proposed expanding background check portability to 3 years, along with changes to record-keeping, confidentiality and substantial equivalence. The proposal is in Oregon Administrative Rules chapter 407 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say who the background checks cover.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-OSHA-2-20262026-w40-p3/OR-OSHA-2-2026Final rule. The Oregon Department of Consumer and Business Services, Oregon Occupational Safety and Health Division has adopted a revision to its rule on the annual adjustment of civil penalties. The final rule is in Oregon Administrative Rules chapter 437 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not give the new penalty amounts.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-TSPC-7-20262026-w40-p3/OR-TSPC-7-2026Final rule. The Oregon Teacher Standards and Practices Commission has issued a final rule amending its program standards. It is in Oregon Administrative Rules chapter 584 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say which standards change.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-WCD-4-20262026-w40-p3/OR-WCD-4-2026Final rule. The Oregon Department of Consumer and Business Services, Workers' Compensation Division has issued a final rule on nurse practitioners and physician associates under HB 4040 (2026). It is in Oregon Administrative Rules chapter 436 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say what the rule requires.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-LCDD-11-20262026-w40-p3/OR-LCDD-11-2026Final rule. Oregon's Land Conservation and Development Department has issued a final rule amending OAR chapter 600, division 46 of Oregon Administrative Rules. The amendment is in Oregon Administrative Rules chapter 660 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163395832026-w40-p3/OR-N16339583Proposed. Oregon's Department of Environmental Quality has proposed a rule on the Snake River Temperature TMDL. The proposal is in Oregon Administrative Rules chapter 340 and was published in the Oregon Bulletin on October 1, 2026. If adopted, it would set the rule's requirements, and the abstract does not describe them.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163625152026-w40-p3/OR-N16362515Proposed. The Oregon Public Utility Commission has proposed rulemaking to implement 2025 Senate Bill 845 (AR 673). The proposal is in Oregon Administrative Rules chapter 860 and was published in the Oregon Bulletin on October 1, 2026. If adopted, it would set the rules that carry out the bill, and the abstract does not describe what they require.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-N163145922026-w40-p3/OR-N16314592Proposed. The Oregon Department of Transportation, Driver and Motor Vehicle Services Division has proposed removing and amending requirements for “Substantially Altered” vehicles. The proposal is in Oregon Administrative Rules chapter 735 and was published in the Oregon Bulletin on October 1, 2026. If adopted, it would change those requirements, and the abstract does not say how.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-CA-Z2026-0918-012026-w40-p3/CA-Z2026-0918-01Proposed. The California Department of Motor Vehicles has proposed amending several sections of its driver safety hearing regulations and repealing others. Among the changes, a driver who does not request a hearing within 10 days of receiving notice of suspension or revocation would be treated as waiving the right to a hearing. The proposal says the changes would clarify the rules for drivers, their representatives and hearing officers.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-DFW-104-20262026-w40-p3/OR-DFW-104-2026Final rule. Oregon's Department of Fish and Wildlife has issued a final rule setting the tag numbers, season dates and regulations for 2027 big game controlled hunts. It is in Oregon Administrative Rules chapter 635 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not list the specific tags or dates.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-DOA-111-20262026-w40-p3/OR-DOA-111-2026Final rule. Oregon's Department of Agriculture has issued a final rule updating the rules for its Livestock ID Program (Brands). It is in Oregon Administrative Rules chapter 603 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say what changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-CA-2026-0901-022026-w40-p3/CA-2026-0901-02In effect. The California Department of Food and Agriculture has made permanent an exterior quarantine for the cotton jassid (Amrasca biguttula), also known as the two-spotted cotton leafhopper. The quarantine has been in effect since September 21, 2026. The abstract does not say who it affects.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-DOJ-18-20262026-w40-p3/OR-DOJ-18-2026Final rule. The Oregon Department of Justice has issued a final rule on procedures for the Oregon Child Support Program. It is in Oregon Administrative Rules chapter 137 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say what the procedures require.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-CA-2026-0810-012026-w40-p3/CA-2026-0810-01Final rule. The California Office of Environmental Health Hazard Assessment (OEHHA) has adopted No Significant Risk Level (NSRL) values of 54 micrograms per day for 1-bromopropane and 5.8 micrograms per day for dermal exposure to diethanolamine. The final rule takes effect January 1, 2027. The abstract does not say what the levels are used for.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-BCD-10-20262026-w40-p3/OR-BCD-10-2026Final rule. Oregon's Department of Consumer and Business Services, Building Codes Division has issued a final rule on the use of lumber certified by individuals with the proper certification. It is in Oregon Administrative Rules chapter 918 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not say which projects or builders are affected.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-BCD-13-20262026-w40-p3/OR-BCD-13-2026Final rule. Oregon's Department of Consumer and Business Services, Building Codes Division has adopted the 2026 Oregon Plumbing Specialty Code as a final rule. It is in Oregon Administrative Rules chapter 918 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not describe the code's changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p3/#item-OR-BCD-14-20262026-w40-p3/OR-BCD-14-2026Final rule. Oregon's Department of Consumer and Business Services, Building Codes Division has adopted the 2026 Oregon Residential Specialty Code as a final rule. It is in Oregon Administrative Rules chapter 918 and was published in the Oregon Bulletin on October 1, 2026. The abstract does not describe the code's changes.Fri, 09 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1016/j.cell.2026.09.0092026-w40-p2/doi:10.1016/j.cell.2026.09.009Peer-reviewed study. A peer-reviewed observational study in Cell looked at a large real-world group of patients with different cancers. It found that most changes in the microbiome were shared across cancers rather than specific to one; an observational study shows a link, not a cause. Distinct links appeared only for some cancers and, in separate analyses, for age of onset and for certain side effects of treatment.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1016/j.cell.2026.09.0122026-w40-p2/doi:10.1016/j.cell.2026.09.012Peer-reviewed study. A peer-reviewed study in Cell describes how, in pancreatic cancer, tumor cells, macrophages and fibroblasts gradually assemble into an organized cluster. Signaling among these cells is associated with muscle wasting and the progression of cachexia, a wasting condition. The abstract does not say whether the work was done in people, animals or both.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1016/j.cell.2026.09.0132026-w40-p2/doi:10.1016/j.cell.2026.09.013Peer-reviewed study. A peer-reviewed study in Cell reports that indole-producing Escherichia coli, a gut bacterium, worsens ischemic stroke by activating aryl hydrocarbon receptor (AHR) signaling in immune cells called dendritic cells. Limiting that signaling reduced inflammation in the nervous system and increased regulatory T cells in the meninges, the membranes around the brain. The authors suggest this could be a target for treatment; the abstract does not say whether the work was done in animals or people.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-BHS-24-20262026-w40-p2/OR-BHS-24-2026Final rule. The Oregon Health Authority (OHA) filed a permanent rule in the Oregon Bulletin, published October 1, 2026, setting rules for Crisis Stabilization Centers, as a state law directs it to do. It is a final rule. The filing does not describe what the rules require.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-BP-18-20262026-w40-p2/OR-BP-18-2026Final rule. The Oregon Board of Pharmacy filed a temporary rule, published October 1, 2026, on prescribing pursuant to protocol for COVID-19, influenza and respiratory syncytial virus (RSV) vaccines, and on standard vaccination protocols. It is a temporary rule. The filing does not describe the specific changes.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-DMAP-39-20262026-w40-p2/OR-DMAP-39-2026Final rule. The Oregon Health Authority filed a permanent rule, published October 1, 2026, adopting the Prioritized List of Health Services for the Oregon Health Plan, effective October 1, 2026, according to its title. It is a final rule. The filing does not describe what changed on the list.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-DMAP-41-20262026-w40-p2/OR-DMAP-41-2026Final rule. The Oregon Health Authority filed a temporary rule, published October 1, 2026, with changes from a comprehensive review of its Transition of Care rule, made before the Healthier Oregon Transition. It is a temporary rule. The filing does not describe the specific changes or who is affected.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163625262026-w40-p2/OR-N16362526Proposed. The Oregon Health Authority proposes moving the Healthier Oregon program to Open Card, also called fee-for-service. It is a proposal, published October 1, 2026; the notice does not say who would be affected or when the change would happen.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163627972026-w40-p2/OR-N16362797Proposed. The Oregon Health Authority proposes changing the number of months allowed for retroactive medical eligibility because of the federal law HR1. It is a proposal, published October 1, 2026; the notice does not give the new number of months.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163628832026-w40-p2/OR-N16362883Proposed. The Oregon Health Authority, Public Health Division, proposes rules to implement SB 163 (2025), setting out processes and requirements for establishing the parentage of a child. It is a proposal, published October 1, 2026; the notice does not describe the specific requirements.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163637762026-w40-p2/OR-N16363776Proposed. The Oregon Health Authority, Public Health Division, proposes rules on testing marijuana, hemp and psilocybin. It is a proposal, published October 1, 2026; the notice does not describe what the testing rules would change.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163639582026-w40-p2/OR-N16363958Proposed. The Oregon Health Authority (OHA) proposes adopting its Prioritized List of Health Services and putting in place the Benefit Update Project. It is a proposal, published October 1, 2026; the notice does not describe what either would change.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163640162026-w40-p2/OR-N16364016Proposed. The Oregon Health Authority proposes to update and clarify rules for Coordinated Care Organizations, including comprehensive reviews of selected rules. It is a proposal, published October 1, 2026; the notice does not describe the specific changes.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-PH-31-20262026-w40-p2/OR-PH-31-2026Final rule. The Oregon Health Authority, Public Health Division, filed a permanent rule, published October 1, 2026, updating the program requirements and coverage of the Reproductive Health Program. It is a final rule. The filing does not describe what changed.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-CWP-69-20262026-w40-p2/OR-CWP-69-2026Final rule. The Oregon Department of Human Services, Child Welfare Programs, filed a permanent rule, published October 1, 2026, that amends Medicaid eligibility for non-citizen children and young adults to meet the requirements of the federal law H.R. 1. It is a final rule. The filing does not describe the specific changes or say how many people are affected.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-ID-17-20262026-w40-p2/OR-ID-17-2026Final rule. The Oregon Department of Consumer and Business Services, Insurance Regulation, filed a permanent rule, published October 1, 2026, updating the Prescription Drug Price Transparency program. It is a final rule. The filing does not describe the specific updates.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163395812026-w40-p2/OR-N16339581Proposed. The Oregon Department of Consumer and Business Services, Workers' Compensation Division, proposes changes to Oregon Administrative Rules (OAR) 436-100, which cover the workers' compensation benefits offset. It is a proposal, published October 1, 2026; the notice does not describe what the changes would do.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163625452026-w40-p2/OR-N16362545Proposed. The Oregon Department of Human Services, Aging and People with Disabilities (APD), proposes updating its Agency with Choice rules to follow two bills passed in 2026, HB4115 and HB4016. It is a proposal, published October 1, 2026; the notice does not describe the changes.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N636282026-w40-p2/OR-N63628Proposed. The Oregon Department of Early Learning and Care proposes updates to the Employment Related Day Care program. It is a proposal, published October 1, 2026; the notice does not describe what the updates would be.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-SSP-35-20262026-w40-p2/OR-SSP-35-2026Final rule. The Oregon Department of Human Services, Self-Sufficiency Programs, filed a permanent rule, published October 1, 2026, with changes to noncitizen eligibility, notice periods, effective dates, hearings and tax-favored plans. It is a final rule. The filing does not say which programs or how many people are affected.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163432152026-w40-p2/OR-N16343215Proposed. The Oregon Department of Environmental Quality proposes its third set of rules under the Recycling Modernization Act, labeled Rulemaking 3 (2026). It is a proposal, published October 1, 2026; the notice does not describe what the rules would change.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-DFW-102-20262026-w40-p2/OR-DFW-102-2026Final rule. The Oregon Department of Fish and Wildlife filed a temporary rule, published October 1, 2026, that modifies recreational salmon fisheries on the Columbia River. It is a temporary rule. The filing does not describe the specific changes.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1126/science.adz47972026-w40-p2/doi:10.1126/science.adz4797Peer-reviewed study. A peer-reviewed study in Science reports that SLC25A34, a carrier protein in mitochondria, links the body clock, diet and temperature control to the cycling of lipids in fat cells (adipocytes). Only the title is available, so it does not say whether the work was done in animals or people.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1126/science.aec84232026-w40-p2/doi:10.1126/science.aec8423Peer-reviewed study. A peer-reviewed study in Science reports that a particular pattern of sea level fluctuations reveals past episodes of rapid polar wander, in which the position of the poles shifted. Only the title is available, so the methods and the time periods covered are not described.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1126/science.aed30652026-w40-p2/doi:10.1126/science.aed3065Peer-reviewed study. A peer-reviewed study in Science reports that losing p53, a protein that suppresses tumors, creates a signaling gradient that drives clonal expansion of epithelial cells, in which cells descended from one cell multiply. Only the title is available, so it does not say what tissue or organism was studied.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1126/science.aed82072026-w40-p2/doi:10.1126/science.aed8207Peer-reviewed study. A peer-reviewed study in Science reports that hypertension, or high blood pressure, fuels osteoarthritis through neuroendocrine signaling, meaning signals passed between nerves and hormones. Only the title is available, so it does not say whether the work was done in animals or people.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1126/science.aef51752026-w40-p2/doi:10.1126/science.aef5175Peer-reviewed study. A peer-reviewed study in Science reports a more efficient way to produce the chemical adiponitrile by electrosynthesis, meaning chemical production driven by electricity. The title credits the gain to a changing interaction between positively charged ions (cations) and carbon. Only the title is available, so the methods and the size of the gain are not described.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1126/science.aeg10702026-w40-p2/doi:10.1126/science.aeg1070Peer-reviewed study. A peer-reviewed study in Science reports that a layered, crystalline framework of organic and inorganic material lets nacre, the shell material also known as mother-of-pearl, become tougher while staying stiff. Only the title is available, so the methods are not described.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-doi:10.1126/science.aeg49722026-w40-p2/doi:10.1126/science.aeg4972Peer-reviewed study. A peer-reviewed study in Science reports ultrahigh piezoelectricity, the ability of a material to produce an electric charge when squeezed, arising from complexes formed by polarons and defects in the material. Only the title is available, so the material studied and the methods are not described.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-pew:421aad77b43d2026-w40-p2/pew:421aad77b43dAnnouncement. Pew Research Center says people across the globe increasingly say social media is harming democracy. According to its summary, most think social media leads to manipulation and division, but they also say it informs people and gives them a voice in politics.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-pew:65350ac639b22026-w40-p2/pew:65350ac639b2Announcement. Pew Research Center says Facebook is generally the top social media platform around the world, followed by Instagram. According to its summary, fewer people overall use TikTok, X or Snapchat.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-pew:8e7d20c89a692026-w40-p2/pew:8e7d20c89a69Announcement. Pew Research Center says that in 2026, 64% of Americans say social media is harming their democracy. It reports that attitudes in many other countries are significantly more negative than they used to be.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-pew:a9196d6d6c8a2026-w40-p2/pew:a9196d6d6c8aAnnouncement. Pew Research Center says about eight-in-ten Australian adults support restricting access to social media for kids, including 51% who strongly support it. Its summary does not describe the specific restrictions.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-pew:869aa3baf6922026-w40-p2/pew:869aa3baf692Announcement. Pew Research Center says it examined why Americans identify as Republicans and Democrats, and why some do not. Its summary notes that many do not consider themselves either, but gives no figures.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-pew:cfb0cf5a695b2026-w40-p2/pew:cfb0cf5a695bAnnouncement. In its weekly roundup published October 2, 2026, Pew Research Center says just 16% of Americans prefer cash for in-person payments. The roundup also points to the share who prefer to pay in person with a credit or debit card, but its summary does not give that figure.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163396202026-w40-p2/OR-N16339620Proposed. The Oregon State Library proposes rules clarifying a state law that requires public hearings before public libraries are closed or cut. It is a proposal, published October 1, 2026; the notice does not say how the rules would clarify the law.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40-p2/#item-OR-N163625222026-w40-p2/OR-N16362522Proposed. The Oregon Secretary of State, Elections Division, proposes changes to the Oregon Motor Voter Program. It is a proposal, published October 1, 2026; the notice does not describe what the changes would be.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-202812026-w40/2026-20281Final rule. The Centers for Medicare & Medicaid Services, part of the Health and Human Services Department, has issued a final rule, taking effect on November 30, 2026, that creates the Global Benchmark for Efficient Drug Pricing (GLOBE) Model, a new mandatory Medicare payment model. The model will test whether a different way of calculating Medicare Part B drug inflation rebate amounts for certain separately payable Part B drugs and biological products lowers costs for Original Medicare beneficiaries and the Medicare program while keeping quality of care.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-197432026-w40/2026-19743Final rule. The Housing and Urban Development Department (HUD) has announced the fee it will charge borrowers of loans guaranteed under its Section 108 Loan Guarantee Program for commitments awarded in fiscal year 2027. The fee covers the credit subsidy costs of the guaranteed loans and rises from 0.58 percent in fiscal year 2026 to 1.05 percent in fiscal year 2027. It applies if HUD is required or authorized by law to collect it.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198602026-w40/2026-19860Proposed. The Board of Governors of the Federal Reserve System has proposed rules to carry out the Guiding and Establishing National Innovation for U.S. Stablecoins Act (GENIUS Act) for permitted payment stablecoin issuers it supervises and certain other entities under its jurisdiction. The proposal would also put in place the ban on tying in the GENIUS Act, which applies generally to all permitted payment stablecoin issuers. This is a proposal and is not final.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198882026-w40/2026-19888Proposed. The Internal Revenue Service, part of the Treasury Department, has proposed rules on an election that lets sellers pay the tax on gain from selling or exchanging qualified farmland property to a qualified farmer in four equal annual installments. The proposed rules would affect taxpayers who make such a sale or exchange and choose to pay the tax that way. This is a proposal and is not final.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198992026-w40/2026-19899Proposed. The Board of Governors of the Federal Reserve System has proposed procedures that an insured state member bank would follow to get approval from the Board for a subsidiary to issue payment stablecoins. The approval would be under the Guiding and Establishing National Innovation for U.S. Stablecoins Act (GENIUS Act). This is a proposal and is not final.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-199292026-w40/2026-19929In effect. The Education Department has repealed its 2024 final rule amending the Title IX regulations and restored the regulatory text that existed before it. The department says the 2024 rule was vacated, is not enforceable nationwide and has not been enforced for over a year and a half, so the earlier text, which is in force, is being put back into the Code of Federal Regulations. The rule is in effect as of September 29, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-200212026-w40/2026-20021Proposed. The Internal Revenue Service, part of the Treasury Department, says the public hearing on its proposed rules will now be held by telephone only. The proposed rules would give guidance on employer contributions to Trump accounts, including the nondiscrimination rules that apply, and on nondiscrimination rules for dependent care assistance programs. The rules are still a proposal and are not final.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-200262026-w40/2026-20026In effect. The Internal Revenue Service, part of the Treasury Department, has issued temporary regulations, in effect as of September 30, 2026, on general requirements for Trump accounts. They cover setting up an initial Trump account, including automatic enrollment by the Secretary of the Treasury, and qualified general contributions, a special type of contribution that includes qualified stock contributions. They affect trustees, account beneficiaries and responsible parties of Trump accounts, and eligible donors who fund qualified general contributions.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-200272026-w40/2026-20027Proposed. The Internal Revenue Service, part of the Treasury Department, has proposed regulations on general requirements for Trump accounts, setting up an initial account (including automatic enrollment by the Secretary of the Treasury) and qualified general contributions. It also withdraws an earlier proposal on the election to set up an initial Trump account and proposes those rules again. The proposed rules would affect trustees, account beneficiaries and responsible parties of Trump accounts, and eligible donors who fund qualified general contributions.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-202642026-w40/2026-20264Final rule. The Internal Revenue Service, part of the Treasury Department, has issued temporary regulations, taking effect on December 1, 2026, for the new nonrefundable federal tax credit for qualified contributions made in 2027 and later tax years to scholarship granting organizations that fund qualified elementary and secondary education scholarships. The regulations set requirements and procedures for States that choose to participate and for organizations those States certify. They also affect individuals who make qualified contributions.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-202772026-w40/2026-20277Proposed. The Internal Revenue Service, part of the Treasury Department, has proposed regulations on the nonrefundable federal tax credit for qualified contributions to scholarship granting organizations that fund qualified elementary and secondary school scholarships. The proposed rules would affect taxpayers who make such contributions, States that choose to take part by certifying scholarship granting organizations, and the organizations they certify. The document also announces a public hearing on the proposal, which is not final.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-200162026-w40/2026-20016Final rule. U.S. Citizenship and Immigration Services (USCIS), part of the Homeland Security Department, has issued a final rule, taking effect on November 30, 2026, that adjusts the fees it charges for Employment-Based Immigration, Fifth Preference (EB-5) benefit requests. The rule also writes provisions of the EB-5 Reform and Integrity Act of 2022 into the regulations, implements new legal requirements and responds to public comments on the proposed fee rule.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198842026-w40/2026-19884In effect. The Environmental Protection Agency has set a tolerance, an allowed level, for residues of the pesticide sodium salt of acifluorfen in or on sugar beet. A company requested the tolerance under the Federal Food, Drug, and Cosmetic Act. The rule is in effect as of September 29, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-201782026-w40/2026-20178Final rule. The Rural Business-Cooperative Service, part of the Agriculture Department, has issued a final rule, taking effect on October 16, 2026, that changes the Rural Energy for America Program (REAP) so projects must be fully built and operating before applying. Applicants must submit 12 months of actual energy production or savings data plus 12 months of data from before installation, and grants will be based on documented results, subject to available funds. Multilocation projects and some uses of certain technologies are no longer eligible, and the agency proposes replacing state-level competitions with a single national scoring and selection process.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-202512026-w40/2026-20251Proposed. The National Park Service, part of the Interior Department, proposes updating rules for off-road motor vehicle use in Big Cypress National Preserve. The current rules refer to an outdated map that does not show the boundary of the preserve after it was expanded in 1988 by about 147,000 acres. The proposal would refer to a map of the current boundary instead, which would expand the areas where motorized vehicles could be used, subject to the discretion of the superintendent.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-197412026-w40/2026-19741Final rule. The Pipeline and Hazardous Materials Safety Administration (PHMSA), part of the Transportation Department, has issued a final rule that takes effect on October 28, 2026. It lets certain cargo tank motor vehicles, cryogenic portable tanks and multi-unit tank car tanks be built and kept in service under the 2015 edition of the American Society of Mechanical Engineers (ASME) code for transport tanks, with continued service also covered by the 2015 edition of the National Board Inspection Code. The agency says the change will save costs and add flexibility without compromising safety.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198432026-w40/2026-19843In effect. The Federal Aviation Administration (FAA) will stop issuing exemptions that let certain Cessna aircraft that require two pilots be flown by a single pilot, citing safety concerns and a review that found widespread non-compliance with the exemptions. Current exemption holders are told their exemptions will be rescinded by separate action. Pilots who got single-pilot endorsements from training providers that held exemptions must stop single-pilot operations in these aircraft, and the notice is in effect as of September 29, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-199642026-w40/2026-19964Final rule. The National Highway Traffic Safety Administration (NHTSA), part of the Transportation Department, has issued a final rule, taking effect on November 30, 2026, that amends the Corporate Average Fuel Economy (CAFE) standards for light-duty vehicles for model years 2022 to 2026 and 2027 to 2031. It also changes how manufacturers comply, including how vehicles are classified. The agency says the changes bring the program into compliance with the law and remove past distortions in manufacturer design decisions.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-200872026-w40/2026-20087Proposed. The Coast Guard, part of the Homeland Security Department, proposes removing six requirements tied to endorsements under the International Convention on Standards of Training, Certification, and Watchkeeping for Seafarers and its related code. The changes would affect Masters and Officers in Charge of a Navigational Watch of less than 500 gross tons in near-coastal waters, and Officers in Charge of an Engineering Watch, Designated Duty Engineers and Electro-technical Ratings of 750 kilowatts (1,000 horsepower) or more. The proposal would also remove duplicative or outdated language and is not final.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-201692026-w40/2026-20169Proposed. The Transportation Department has received a petition asking it to start a rulemaking on invalid specimen determinations, and it is asking for comments on whether to grant it. The petition seeks set standards for medical verification when an employee gives a plausible medical explanation for abnormal specimen validity findings, such as abnormal pH values, including a fixed window to submit documentation and written determinations by a Medical Review Officer. Nothing has been decided, and the department has not proposed any rule.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198012026-w40/2026-19801Final rule. The National Oceanic and Atmospheric Administration has issued a final rule for the South Atlantic snapper-grouper fishery that takes effect on October 28, 2026. It changes the recreational vessel limits for gag and black grouper, and changes how commercial on-demand (also called ropeless) black sea bass pots must be stored on vessels passing through certain areas where that gear is restricted. The stated aim is to benefit the gag and black grouper stocks and to make passing through those areas more practical.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198132026-w40/2026-19813Final rule. The National Oceanic and Atmospheric Administration has issued a final rule, taking effect on October 28, 2026, that puts in place a rebuilding plan for the overfished Queets River spring/summer Chinook salmon stock. The plan was recommended by the Pacific Fishery Management Council, and the rule changes the West Coast salmon fishery regulations to carry it out.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198872026-w40/2026-19887Final rule. The Agricultural Marketing Service, part of the Agriculture Department, has issued a final rule, taking effect on October 29, 2026, that extends the deadline for the inedible disposition obligation under the federal marketing order for almonds grown in California. The later deadline applies indefinitely. The change follows a recommendation from the Almond Board of California.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-200192026-w40/2026-20019Final rule. The National Oceanic and Atmospheric Administration is moving amounts from a non-specified reserve into the initial total allowable catch for Bering Sea Pacific ocean perch, Bering Sea and Aleutian Islands northern rockfish, and Bering Sea and Aleutian Islands other flatfish. The agency says this is needed to let these fisheries keep operating. This is a temporary rule taking effect on October 30, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-201232026-w40/2026-20123Proposed. The U.S. Fish and Wildlife Service, part of the Interior Department, proposes revising the list of birds protected by the Migratory Bird Treaty Act (MBTA) by adding and removing species and updating names to match accepted scientific use. The net increase of 25 species (32 added and 7 removed) would bring the total protected under the MBTA to 1,131 species. Species would be added based on new taxonomy and new evidence that they occur naturally in the United States or U.S. territories, and removed if no longer known to occur there.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-201352026-w40/2026-20135In effect. The National Oceanic and Atmospheric Administration is prohibiting directed fishing for pollock by vessels using trawl gear in the Winter Herring Savings Area of the Bering Sea and Aleutian Islands management area, including vessels in the Community Development Quota Program. The agency says the closure is required by regulation to prevent herring from being caught as bycatch there. This temporary rule is in effect as of September 30, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-201402026-w40/2026-20140Final rule. The National Oceanic and Atmospheric Administration has issued a final rule, taking effect on November 2, 2026, that raises the annual catch limit for Mariana bottomfish in the Guam Management Subarea from 31,000 pounds (14,061 kilograms) to 34,500 pounds (15,649 kilograms). It replaces the in-season accountability measure with an adjustment after the season if average catch over the most recent 3 years exceeds the limit, and removes the standard that closes the fishery in federal waters for any overage. The agency says the rule supports rebuilding of the fishery.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-202342026-w40/2026-20234In effect. The National Oceanic and Atmospheric Administration has set catch limits and rules for Pacific sardine for the 2026-2027 fishing year, prohibiting most directed commercial fishing for the species off Washington, Oregon and California. Sardine may still be taken as live bait, in minor directed fisheries, under exempted fishing permits, or as incidental catch, limited to 20 percent by weight of all fish per trip when caught with other coastal pelagic species, or up to 2 metric tons per trip when caught with other stocks. The annual catch limit is 2,200 metric tons, and the rule is in effect as of October 2, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-201432026-w40/2026-20143Early stage: advance notice. The Federal Trade Commission (FTC) is at an early stage, an advance notice, of possibly starting a rulemaking to prevent certain unfair or deceptive practices by search engines, social media and other digital marketplace platforms that further government and business impersonation scams against consumers. No rule has been proposed yet, and the Commission is asking for written comments, data and arguments on whether such a rule is needed.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-198782026-w40/2026-19878In effect. The U.S. Small Business Administration (SBA) has removed certain regulatory provisions that required affirmative action by applicants to or recipients of its programs, calling them unnecessary and potentially unlawful. It also makes technical corrections to one provision. The final rule is in effect as of September 29, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-199732026-w40/2026-19973In effect. The Office of Foreign Assets Control (OFAC), part of the Treasury Department, has amended the Cuban Assets Control Regulations to carry out parts of the foreign policy of the President toward Cuba. The rule bans indirect financial transactions with entities or subentities on the Cuba Restricted List, removes the authorization for U-Turn transactions, and removes authorizations for group people-to-people travel and professional meetings in Cuba. It is in effect as of September 30, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-199772026-w40/2026-19977In effect. The Office of Foreign Assets Control (OFAC), part of the Treasury Department, has added new regulations to carry out a Cuba-related executive order. The office says it intends to add a more comprehensive set of regulations later, which may include further guidance, definitions and general licenses. The regulations are in effect as of September 30, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-199782026-w40/2026-19978In effect. The Office of Foreign Assets Control (OFAC), part of the Treasury Department, has amended the Iranian Transactions and Sanctions Regulations to carry out certain provisions of an Iran-related executive order from 2020. It also revises an existing definition and an existing exemption, and adds two exemptions taken from that executive order. The rule is in effect as of September 30, 2026.Thu, 08 Oct 2026 00:00:00 +0000https://trickle.news/2026-w40/#item-2026-200792026-w40/2026-20079Proposed. The State Department has proposed changes to the International Traffic in Arms Regulations (ITAR) so that the U.S. Munitions List focuses ITAR controls on the most sensitive technologies. The proposal would remove certain items from the list, update definitions, standardize the regulatory text and add a new exemption from ITAR licensing requirements. This is a proposal and is not final.Thu, 08 Oct 2026 00:00:00 +0000